Page last updated: 2024-11-01

nicardipine and Brain Vascular Disorders

nicardipine has been researched along with Brain Vascular Disorders in 23 studies

Nicardipine: A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents.
nicardipine : A racemate comprising equimolar amounts of (R)- and (S)-nicardipine. It is a calcium channel blocker which is used to treat hypertension.
2-[benzyl(methyl)amino]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate : A dihydropyridine that is 1,4-dihydropyridine substituted by a methyl, {2-[benzyl(methyl)amino]ethoxy}carbonyl, 3-nitrophenyl, methoxycarbonyl and methyl groups at positions 2, 3, 4, 5 and 6, respectively.

Research Excerpts

ExcerptRelevanceReference
"This retrospective review compared nicardipine with clevidipine for hypertension in acute stroke patients from March 17, 2015 to December 23, 2016."7.88Comparison of Nicardipine with Clevidipine in the Management of Hypertension in Acute Cerebrovascular Diseases. ( Conklen, K; Deshpande, M; Ferrill, D; Jones, B; Rosenfeldt, Z; Siddiqui, FM, 2018)
"Nicardipine is a second generation dihydropyridine-type Ca2+ antagonist with high vascular selectivity and strong cerebral and coronary vasodilatory activity."6.39Nicardipine and treatment of cerebrovascular diseases with particular reference to hypertension-related disorders. ( Amenta, F; Sabbatini, M; Strocchi, P, 1995)
" Controlling acute hypertension (HTN) by antihypertensive drugs such as clevidipine and nicardipine can be a highly efficient method of lowering the incidence of CVDs."5.41Comparison between clevidipine and nicardipine in cerebrovascular diseases: A systematic review and meta-analysis. ( Asgarzadeh, S; Azari Jafari, A; Azari Jafari, M; Godoy, DA; Mirmoeeni, S; Nazari, S; Seifi, A; Shah, M, 2023)
"Drug-induced gingival hyperplasia is usually associated with the administration of hydantoin in individuals with epilepsy."5.30[Nicardipine-induced gingival hyperplasia]. ( Pascual Pascual, SI; Pascual-Castroviejo, I, 1997)
"This retrospective review compared nicardipine with clevidipine for hypertension in acute stroke patients from March 17, 2015 to December 23, 2016."3.88Comparison of Nicardipine with Clevidipine in the Management of Hypertension in Acute Cerebrovascular Diseases. ( Conklen, K; Deshpande, M; Ferrill, D; Jones, B; Rosenfeldt, Z; Siddiqui, FM, 2018)
" DESIGN OF STUDIES: Mean cerebral circulation parameters were studied in chronic stroke patients with hypertension and treated acutely or chronically (2 weeks) with nicardipine or nifedipine retard."3.68Effects of dihydropyridines on cerebral blood vessels. ( Hashimoto, H; Kuriyama, Y; Nagatsuka, K; Omae, T; Sawada, T, 1993)
"Nicardipine is a dihydropyridine-type Ca(2+) channel blocker (CCB) with strong antihypertensive activity and with a peculiar cerebrovascular profile."2.45Nicardipine use in cerebrovascular disease: a review of controlled clinical studies. ( Amenta, F; Lanari, A; Mignini, F; Silvestrelli, G; Tomassoni, D; Traini, E, 2009)
"Nicardipine is a dihydropyridine-type calcium channel blocker (CCB) with a peculiar cerebrovascular profile developed approximately 30 years ago."2.44Nicardipine: a hypotensive dihydropyridine-type calcium antagonist with a peculiar cerebrovascular profile. ( Amenta, F; Mignini, F; Tomassoni, D; Traini, E; Veglio, F, 2008)
"Nicardipine is a second generation dihydropyridine-type Ca2+ antagonist with high vascular selectivity and strong cerebral and coronary vasodilatory activity."2.39Nicardipine and treatment of cerebrovascular diseases with particular reference to hypertension-related disorders. ( Amenta, F; Sabbatini, M; Strocchi, P, 1995)
"Nicardipine has no clinically significant negative inotropic effect."2.39Concomitant diseases in elderly hypertensives: the position of nicardipine. ( Zannad, F, 1996)
"Drug-induced gingival hyperplasia is usually associated with the administration of hydantoin in individuals with epilepsy."1.30[Nicardipine-induced gingival hyperplasia]. ( Pascual Pascual, SI; Pascual-Castroviejo, I, 1997)
"In the drug-untreated group, recurrence of stroke was repeated, deterioration and amelioration of neurological deficits (ND) were repeated, and histological examination and measurement of regional blood flow (rBF) using nonradioactive colored microspheres performed at the end of treatment revealed severe damages and significantly decreased rBF in brain and kidney, respectively."1.30Therapeutic effects of a calcium antagonist, lacidipine, on stroke-prone spontaneously hypertensive rats with cerebrovascular lesions. ( Funato, H; Uemura, A; Watanabe, M, 1999)
"Hypertension is a primary aggravating factor in cerebral infarction."1.29M1 receptors in blood pressure-controlled ischemic spontaneously hypertensive rats. ( Asanuma, M; Hirata, H; Kondo, Y; Ogawa, N; Tanaka, K, 1995)
" Chronic administration of YM-09730-5 (3 mg/kg) reduced the severity of glomerular lesions in the kidney and vasculitis in the mesenteric artery."1.28Antihypertensive and diuretic effects of YM-09730-5, a new calcium antagonist, in stroke-prone spontaneously hypertensive rats. ( Fujimoto, K; Inagaki, O; Kawashima, K; Oohata, H; Suzuki, T; Toda, H, 1991)

Research

Studies (23)

TimeframeStudies, this research(%)All Research%
pre-19904 (17.39)18.7374
1990's13 (56.52)18.2507
2000's3 (13.04)29.6817
2010's2 (8.70)24.3611
2020's1 (4.35)2.80

Authors

AuthorsStudies
Seifi, A1
Azari Jafari, A1
Mirmoeeni, S1
Shah, M1
Azari Jafari, M1
Nazari, S1
Asgarzadeh, S1
Godoy, DA1
Rosenfeldt, Z1
Conklen, K1
Jones, B1
Ferrill, D1
Deshpande, M1
Siddiqui, FM1
Amenta, F3
Tomassoni, D2
Traini, E2
Mignini, F2
Veglio, F1
Lanari, A1
Silvestrelli, G1
Fletcher, JJ1
Kramer, AH1
Bleck, TP1
Solenski, NJ1
Samaniego, EA1
Dabus, G1
Generoso, GM1
Tari-Capone, F1
Fuentes, K1
Linfante, I1
Hirata, H1
Asanuma, M1
Tanaka, K1
Kondo, Y1
Ogawa, N1
Sabbatini, M1
Strocchi, P1
Kuramoto, K1
Ueda, M1
Masui, M1
Kawakami, M1
Matsunaga, K1
Gemba, T1
Ninomiya, M1
Nakano, A1
Torii, M1
Adachi, I1
Ito, H1
Kuriyama, Y1
Hashimoto, H1
Nagatsuka, K1
Sawada, T1
Omae, T1
Brown, CM1
Calder, C1
Alps, BJ1
Spedding, M1
Zannad, F1
Pascual-Castroviejo, I1
Pascual Pascual, SI1
Shinyama, H1
Nagai, H1
Kawamura, T1
Narita, Y1
Nakamura, N1
Kagitani, Y1
Funato, H1
Watanabe, M1
Uemura, A1
Ribas Mundó, M1
Lozano, R1
Rosenbaum, D1
Zabramski, J1
Frey, J1
Yatsu, F1
Marler, J1
Spetzler, R1
Grotta, J1
Kawashima, K1
Toda, H1
Oohata, H1
Fujimoto, K1
Suzuki, T1
Inagaki, O1
Puccinelli, F1
Pieraccini, F1
Tomei, GP1
Gargiulo, L1
Morimoto, S1
Ohyama, T1
Hisaki, K1
Matsumura, Y1
del Ser, T1
Bermejo, F1
Gomara, S1
Calandre, L1
Gascón Ramón, G1

Reviews

6 reviews available for nicardipine and Brain Vascular Disorders

ArticleYear
Comparison between clevidipine and nicardipine in cerebrovascular diseases: A systematic review and meta-analysis.
    Clinical neurology and neurosurgery, 2023, Volume: 227

    Topics: Adult; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cerebrovascular Disorders;

2023
Nicardipine: a hypotensive dihydropyridine-type calcium antagonist with a peculiar cerebrovascular profile.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 2008, Volume: 30, Issue:8

    Topics: Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cerebrovascular Disorders; Dement

2008
Nicardipine use in cerebrovascular disease: a review of controlled clinical studies.
    Journal of the neurological sciences, 2009, Aug-15, Volume: 283, Issue:1-2

    Topics: Antihypertensive Agents; Calcium Channel Blockers; Cerebrovascular Disorders; Cognition; Cognition D

2009
Postpartum cerebral angiopathy treated with intra-arterial nicardipine and intravenous immunoglobulin.
    Journal of neurointerventional surgery, 2013, Volume: 5, Issue:3

    Topics: Adult; Cerebrovascular Disorders; Female; Humans; Immunoglobulins, Intravenous; Infusions, Intra-Art

2013
Nicardipine and treatment of cerebrovascular diseases with particular reference to hypertension-related disorders.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 1995, Volume: 17, Issue:5

    Topics: Aged; Animals; Brain; Brain Ischemia; Calcium Channels; Cerebrovascular Disorders; Humans; Hypertens

1995
Concomitant diseases in elderly hypertensives: the position of nicardipine.
    Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1996, Volume: 14, Issue:3

    Topics: Aging; Calcium Channel Blockers; Cerebrovascular Disorders; Humans; Hypertension; Kidney Diseases; N

1996

Trials

3 trials available for nicardipine and Brain Vascular Disorders

ArticleYear
Treatment of elderly hypertensives in Japan: National Intervention Cooperative Study in Elderly Hypertensives. The National Intervention Cooperative Study Group.
    Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1994, Volume: 12, Issue:6

    Topics: Aged; Cardiovascular Diseases; Cerebrovascular Disorders; Double-Blind Method; Female; Humans; Hyper

1994
The influence of nicardipine in patients with high risk of stroke.
    Journal of cardiovascular pharmacology, 1990, Volume: 16 Suppl 2

    Topics: Aged; Aged, 80 and over; Cerebrovascular Disorders; Disease Susceptibility; Female; Humans; Male; Mi

1990
Early treatment of ischemic stroke with a calcium antagonist.
    Stroke, 1991, Volume: 22, Issue:4

    Topics: Blood Pressure; Brain Ischemia; Cerebrovascular Disorders; Drug Evaluation; Feasibility Studies; Hum

1991

Other Studies

14 other studies available for nicardipine and Brain Vascular Disorders

ArticleYear
Comparison of Nicardipine with Clevidipine in the Management of Hypertension in Acute Cerebrovascular Diseases.
    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2018, Volume: 27, Issue:8

    Topics: Acute Disease; Aged; Antihypertensive Agents; Cerebrovascular Disorders; Cross-Sectional Studies; Fe

2018
Overlapping features of eclampsia and postpartum angiopathy.
    Neurocritical care, 2009, Volume: 11, Issue:2

    Topics: Adult; Cerebrovascular Disorders; Eclampsia; Female; Headache; Humans; Methylprednisolone; Nicardipi

2009
M1 receptors in blood pressure-controlled ischemic spontaneously hypertensive rats.
    Stroke, 1995, Volume: 26, Issue:7

    Topics: Animals; Blood Pressure; Cerebrovascular Circulation; Cerebrovascular Disorders; Frontal Lobe; Hippo

1995
Pharmacological studies on a new dihydrothienopyridine calcium antagonist. 4th communication: prophylactic and therapeutic effects of S-(+)-methyl-4,7-dihydro-3-isobutyl-6-methyl-4-(3-nitrophenyl)thieno[2, 3- b]pyridine-5-carboxylate in stroke-prone spont
    Arzneimittel-Forschung, 1993, Volume: 43, Issue:12

    Topics: Animals; Behavior, Animal; Blood Pressure; Body Weight; Brain; Calcium Channel Blockers; Cerebrovasc

1993
Effects of dihydropyridines on cerebral blood vessels.
    Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1993, Volume: 11, Issue:6

    Topics: Administration, Oral; Blood Pressure; Cerebral Infarction; Cerebrovascular Circulation; Cerebrovascu

1993
The effect of lifarizine (RS-87476), a novel sodium and calcium channel modulator, on ischaemic dopamine depletion in the corpus striatum of the gerbil.
    British journal of pharmacology, 1993, Volume: 109, Issue:1

    Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Carotid Arteries; Cerebrovascular Disorders; Corp

1993
[Nicardipine-induced gingival hyperplasia].
    Neurologia (Barcelona, Spain), 1997, Volume: 12, Issue:1

    Topics: Calcium Channel Blockers; Cerebrovascular Disorders; Child; Gingival Hyperplasia; Humans; Male; Nica

1997
Therapeutic effects of AE0047, a novel calcium antagonist, on progression of brain damage after stroke in stroke-prone spontaneously hypertensive rats.
    General pharmacology, 1998, Volume: 30, Issue:3

    Topics: Animals; Brain; Calcium Channel Blockers; Cerebrovascular Disorders; Dihydropyridines; Hydralazine;

1998
Therapeutic effects of a calcium antagonist, lacidipine, on stroke-prone spontaneously hypertensive rats with cerebrovascular lesions.
    Japanese journal of pharmacology, 1999, Volume: 80, Issue:3

    Topics: Animals; Blood Pressure; Body Weight; Brain; Calcium Channel Blockers; Cerebellum; Cerebrovascular D

1999
Antihypertensive and diuretic effects of YM-09730-5, a new calcium antagonist, in stroke-prone spontaneously hypertensive rats.
    General pharmacology, 1991, Volume: 22, Issue:2

    Topics: Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cerebrovascular Disorder

1991
[Arterial hypertension during the rehabilitation phase of cerebral stroke. Study with nicardipine].
    La Clinica terapeutica, 1989, Jul-15, Volume: 130, Issue:1

    Topics: Aged; Aged, 80 and over; Cerebrovascular Disorders; Female; Humans; Hypertension; Male; Middle Aged;

1989
Effects of CV-4093, a new dihydropyridine calcium channel blocker, on renal hemodynamics and function in stroke-prone spontaneously hypertensive rats (SHRSP).
    Japanese journal of pharmacology, 1989, Volume: 51, Issue:2

    Topics: Animals; Body Weight; Calcium Channel Blockers; Cerebrovascular Disorders; Dihydropyridines; Hemodyn

1989
[Does nicardipine improve chronic cerebrovascular insufficiency?].
    Medicina clinica, 1986, Feb-22, Volume: 86, Issue:7

    Topics: Cerebrovascular Disorders; Humans; Nicardipine; Nifedipine; Vasodilator Agents

1986
[Chronic cerebral vascular pathology].
    Medicina clinica, 1985, Sep-21, Volume: 85, Issue:8

    Topics: Age Factors; Brain Diseases; Cerebrovascular Disorders; Diagnosis, Differential; Humans; Nicardipine

1985