nicardipine has been researched along with Brain Ischemia in 64 studies
Nicardipine: A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents.
nicardipine : A racemate comprising equimolar amounts of (R)- and (S)-nicardipine. It is a calcium channel blocker which is used to treat hypertension.
2-[benzyl(methyl)amino]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate : A dihydropyridine that is 1,4-dihydropyridine substituted by a methyl, {2-[benzyl(methyl)amino]ethoxy}carbonyl, 3-nitrophenyl, methoxycarbonyl and methyl groups at positions 2, 3, 4, 5 and 6, respectively.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nicardipine was associated with an increased risk of short-term mortality after acute ischemic stroke." | 7.91 | Nicardipine Associated Risk of Short-Term Mortality in Critically Ill Patients with Ischemic Stroke. ( Desai, A; Hanni, C; Mohamed, W; Parker, D; Saber, H; Sadeghi, M; Singh, A, 2019) |
| "Nicardipine is a dihydropyridine calcium-channel blocker that is frequently used in the acute treatment of hypertension in the emergency department (ED)." | 7.83 | Bradycardia caused by intravenous nicardipine in an elderly patient with acute ischemic infarct. ( Abboud, ME; Frasure, SE, 2016) |
| "This study aimed to compare the effects of labetalol, nicardipine, or hydralazine on time to target blood pressure before alteplase administration in patients with acute ischemic stroke." | 7.81 | Time to Blood Pressure Control Before Thrombolytic Therapy in Patients With Acute Ischemic Stroke: Comparison of Labetalol, Nicardipine, and Hydralazine. ( Cortes, J; Hall, AB; McKay, C, 2015) |
| "To report experience with intra-arterial (IA) calcium channel blocker (nicardipine) in patients with acute ischemic stroke with and without reteplase, mechanical thrombectomy (snare), and primary angioplasty to achieve maximal recanalization." | 7.74 | Preliminary experience with intra-arterial nicardipine in patients with acute ischemic stroke. ( Georgiadis, A; Qureshi, AI; Rodriguez, G; Shah, QA; Suri, MF, 2007) |
| "Evaluate the ease of use and tolerability of labetalol (L) and nicardipine (N) for hypertension management in patients with acute stroke." | 7.74 | A comparison of nicardipine and labetalol for acute hypertension management following stroke. ( Coplin, WM; Janisse, J; Liu-Deryke, X; Norris, G; Parker, D; Rhoney, DH, 2008) |
| "The anti-ischemic and anti-anoxic effects of efonidipine, a dihydropyridine calcium antagonist, were studied in several models for cerebral ischemia and anoxia in mice and rats, and the effects were compared with those of nicardipine and flunarizine." | 7.69 | [Effect of efonidipine hydrochloride, a calcium channel blocker, on the experimental cerebral ischemia/anoxia]. ( Furuichi, H; Ito, S; Izumi, J; Kurimoto, T; Matsumura, T; Mori, T; Nishi, N; Suda, H; Takei, M; Tanaka, Y, 1995) |
| "To study the effects of tetrandrine (Tet) vs nicardipine (Nic) on cerebral ischemia-reperfusion damages." | 7.69 | Tetrandrine vs nicardipine in cerebral ischemia-reperfusion damages in gerbils. ( Liu, TP; Sun, F, 1995) |
| "Combined therapy, using hyperbaric oxygenation with nicardipine administration, given after 15 mins of complete global cerebral ischemia, accelerates neurologic recovery in dogs." | 7.69 | Hyperbaric oxygen combined with nicardipine administration accelerates neurologic recovery after cerebral ischemia in a canine model. ( Iwatsuki, N; Ono, K; Tajima, T; Takahashi, M, 1994) |
| "An experiment was carried out in nine piglets within 24 h after birth (control group: four, nicardipine group: five) for the purpose of evaluating the effects of a calcium antagonist, nicardipine, on cerebral blood flow changes induced by asphyxia neonatorum." | 7.69 | Effect of calcium antagonist, nicardipine, on cerebral blood flow in postasphyxial newborn piglets. ( Imai, T; Isobe, K; Itoh, S; Kondo, M; Kusaka, T; Onishi, S; Sugihara, S, 1995) |
| "Acute cerebral ischemia was produced in rats by injection of arachidonic acid (AA) into the internal carotid artery." | 7.68 | Protective effects of benidipine on arachidonic acid-induced acute cerebral ischemia in rats. ( Karasawa, A; Kubo, K; Sano, J; Shirakura, S, 1992) |
| "The effects of two dihydropyridine type calcium entry blockers, nilvadipine and nicardipine hydrochloride (nicardipine), on the liberation of free fatty acids (FFAs) were investigated using an experimental model of global cerebral ischemia in rats, and were compared with their pharmacokinetic properties." | 7.68 | Nilvadipine as a neuroprotective calcium entry blocker in a rat model of global cerebral ischemia. A comparative study with nicardipine hydrochloride. ( Fujiwara, T; Kohsaka, M; Mori, J; Satoh, H; Sogabe, K; Takakura, S; Tokuma, Y; Totsuka, Z, 1992) |
| "The effect of benidipine on experimental cerebral ischemia was investigated in rats subjected to occlusion of the bilateral common carotid arteries." | 7.68 | Effect of benidipine hydrochloride (KW-3049), on cerebral ischemia induced by bilateral occlusion of the common carotid arteries in rats. ( Karasawa, A; Kubo, K; Shirakura, S, 1993) |
| "The effect of nitrendipine, an antihypertensive calcium antagonist, on the impairment of cerebral blood flow and EEG observed after 10-min complete cerebral ischemia in anesthetized rabbits was compared with those of nicardipine." | 7.68 | Nitrendipine facilitates recovery of cerebral blood flow, EEG and metabolites following cerebral ischemia in anesthetized rabbits. ( Aihara, K; Inui, J, 1991) |
| "The effects of the calcium entry blocker nicardipine on CBF, CMRO2, and neurologic outcome following 10 min of complete cerebral ischemia were examined in dogs." | 7.67 | Nicardipine increases cerebral blood flow but does not improve neurologic recovery in a canine model of complete cerebral ischemia. ( Ishikawa, T; Masuda, T; Matsumoto, M; Nagai, I; Sakabe, T; Takeshita, H; Tateishi, A, 1986) |
| "Nicardipine has long been recognized as a potent cerebrovascular vasodilator with a history off-label use to prevent vasospasm and DCI." | 6.72 | Nicardipine Prolonged Release Implants for Prevention of Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage: A Meta-Analysis. ( Akbik, F; Jaja, BNR; Macdonald, RL; Moore, R; Sadan, O; Samuels, OB; Waddel, H, 2021) |
| "The compound is used in the treatment of hypertension, primarily in the elderly." | 6.39 | Nicardipine and treatment of cerebrovascular diseases with particular reference to hypertension-related disorders. ( Amenta, F; Sabbatini, M; Strocchi, P, 1995) |
| "Nicardipine treatment significantly reduced Ca2+ accumulation in the middle cerebral artery territory by 60% compared with six untreated rats 6 hours after arterial occlusion." | 5.27 | Nicardipine reduces calcium accumulation and electrolyte derangements in regional cerebral ischemia in rats. ( Flamm, ES; Hadani, M; Young, W, 1988) |
| "The degree of cerebral ischemia 4 hr after BLCL was estimated by the levels of brain energy metabolites (ATP, lactate, c-AMP) and brain water content." | 5.27 | [Influence of long-term antihypertensive treatment on cerebral ischemia induced by bilateral common carotid artery ligation in SHRSR--protective effect of nicardipine hydrochloride]. ( Katayama, Y; Memezawa, H; Nagazumi, A; Sugimoto, S; Suzuki, S; Terashi, A, 1987) |
| " Clazosentan, nicardipine, fasudil, and magnesium showed beneficial effects on delayed cerebral ischemia and vasospasm but they were not found to reduce mortality or disability." | 5.22 | Prophylactic Therapies for Morbidity and Mortality After Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Network Meta-Analysis of Randomized Trials. ( Ahmadvand, S; Amin-Hanjani, S; Dayyani, M; Grotta, JC; Guyatt, GH; Sadeghirad, B; Wang, Y; Zabihyan, S, 2022) |
| "One of the challenges in bringing new therapeutic agents (since nimodipine) in for the treatment of cerebral ischemia associated with aneurysmal subarachnoid hemorrhage (aSAH) is the incongruence in therapeutic benefit observed between phase II and subsequent phase III clinical trials." | 5.22 | Lessons Learned from Phase II and Phase III Trials Investigating Therapeutic Agents for Cerebral Ischemia Associated with Aneurysmal Subarachnoid Hemorrhage. ( Broderick, JP; Cassarly, CN; Huang, W; Ishfaq, MF; Lobanova, I; Macdonald, RL; Martin, RH; Qureshi, AI; Suarez, JI, 2022) |
| "Nicardipine was associated with an increased risk of short-term mortality after acute ischemic stroke." | 3.91 | Nicardipine Associated Risk of Short-Term Mortality in Critically Ill Patients with Ischemic Stroke. ( Desai, A; Hanni, C; Mohamed, W; Parker, D; Saber, H; Sadeghi, M; Singh, A, 2019) |
| "Nicardipine is a dihydropyridine calcium-channel blocker that is frequently used in the acute treatment of hypertension in the emergency department (ED)." | 3.83 | Bradycardia caused by intravenous nicardipine in an elderly patient with acute ischemic infarct. ( Abboud, ME; Frasure, SE, 2016) |
| "This study aimed to compare the effects of labetalol, nicardipine, or hydralazine on time to target blood pressure before alteplase administration in patients with acute ischemic stroke." | 3.81 | Time to Blood Pressure Control Before Thrombolytic Therapy in Patients With Acute Ischemic Stroke: Comparison of Labetalol, Nicardipine, and Hydralazine. ( Cortes, J; Hall, AB; McKay, C, 2015) |
| "To report experience with intra-arterial (IA) calcium channel blocker (nicardipine) in patients with acute ischemic stroke with and without reteplase, mechanical thrombectomy (snare), and primary angioplasty to achieve maximal recanalization." | 3.74 | Preliminary experience with intra-arterial nicardipine in patients with acute ischemic stroke. ( Georgiadis, A; Qureshi, AI; Rodriguez, G; Shah, QA; Suri, MF, 2007) |
| "Evaluate the ease of use and tolerability of labetalol (L) and nicardipine (N) for hypertension management in patients with acute stroke." | 3.74 | A comparison of nicardipine and labetalol for acute hypertension management following stroke. ( Coplin, WM; Janisse, J; Liu-Deryke, X; Norris, G; Parker, D; Rhoney, DH, 2008) |
| " We studied the effects of (1) duration of cerebral ischemia, (2) the Ca2+ channel blocker, nicardipine, and (3) the immunosuppressant, FK506, on PDH activity and energy metabolites during ischemia and reperfusion." | 3.70 | [Studies on brain pyruvate dehydrogenase (PDH) activity and energy metabolites during ischemia and reperfusion]. ( Fukuchi, T; Igarashi, H; Kamiya, T; Katayama, Y; Katsura, K, 1999) |
| "The anti-ischemic and anti-anoxic effects of efonidipine, a dihydropyridine calcium antagonist, were studied in several models for cerebral ischemia and anoxia in mice and rats, and the effects were compared with those of nicardipine and flunarizine." | 3.69 | [Effect of efonidipine hydrochloride, a calcium channel blocker, on the experimental cerebral ischemia/anoxia]. ( Furuichi, H; Ito, S; Izumi, J; Kurimoto, T; Matsumura, T; Mori, T; Nishi, N; Suda, H; Takei, M; Tanaka, Y, 1995) |
| "To study the effects of tetrandrine (Tet) vs nicardipine (Nic) on cerebral ischemia-reperfusion damages." | 3.69 | Tetrandrine vs nicardipine in cerebral ischemia-reperfusion damages in gerbils. ( Liu, TP; Sun, F, 1995) |
| "An experiment was carried out in nine piglets within 24 h after birth (control group: four, nicardipine group: five) for the purpose of evaluating the effects of a calcium antagonist, nicardipine, on cerebral blood flow changes induced by asphyxia neonatorum." | 3.69 | Effect of calcium antagonist, nicardipine, on cerebral blood flow in postasphyxial newborn piglets. ( Imai, T; Isobe, K; Itoh, S; Kondo, M; Kusaka, T; Onishi, S; Sugihara, S, 1995) |
| "Combined therapy, using hyperbaric oxygenation with nicardipine administration, given after 15 mins of complete global cerebral ischemia, accelerates neurologic recovery in dogs." | 3.69 | Hyperbaric oxygen combined with nicardipine administration accelerates neurologic recovery after cerebral ischemia in a canine model. ( Iwatsuki, N; Ono, K; Tajima, T; Takahashi, M, 1994) |
| "The effects of two dihydropyridine type calcium entry blockers, nilvadipine and nicardipine hydrochloride (nicardipine), on the liberation of free fatty acids (FFAs) were investigated using an experimental model of global cerebral ischemia in rats, and were compared with their pharmacokinetic properties." | 3.68 | Nilvadipine as a neuroprotective calcium entry blocker in a rat model of global cerebral ischemia. A comparative study with nicardipine hydrochloride. ( Fujiwara, T; Kohsaka, M; Mori, J; Satoh, H; Sogabe, K; Takakura, S; Tokuma, Y; Totsuka, Z, 1992) |
| "Acute cerebral ischemia was produced in rats by injection of arachidonic acid (AA) into the internal carotid artery." | 3.68 | Protective effects of benidipine on arachidonic acid-induced acute cerebral ischemia in rats. ( Karasawa, A; Kubo, K; Sano, J; Shirakura, S, 1992) |
| "The effect of nilvadipine, a dihydropyridine-type calcium entry blocker, on neuronal function during and following ischemia was investigated with a model of focal cerebral ischemia in cats and was compared with that of nicardipine." | 3.68 | Effects of nilvadipine on neuronal function in the ischemic cat brain. ( Furuichi, Y; Kohsaka, M; Mori, J; Satoh, H; Takakura, S, 1992) |
| "Our results demonstrate that MK-801 plus nicardipine significantly attenuates CA1 cell death after forebrain ischemia in the gerbil." | 3.68 | Combined treatment with MK-801 and nicardipine reduces global ischemic damage in the gerbil. ( Corbett, D; Hewitt, K, 1992) |
| "The effects of nilvadipine, a dihydropyridine type calcium channel blocker, on cerebral infarction induced by focal brain ischemia was studied in rats." | 3.68 | Nilvadipine, a new calcium channel blocker, reduces ischemic brain injury in rats. ( Handa, J; Mori, J; Satoh, H; Shiino, A; Susumu, T; Takakura, S, 1991) |
| "The effect of nitrendipine, an antihypertensive calcium antagonist, on the impairment of cerebral blood flow and EEG observed after 10-min complete cerebral ischemia in anesthetized rabbits was compared with those of nicardipine." | 3.68 | Nitrendipine facilitates recovery of cerebral blood flow, EEG and metabolites following cerebral ischemia in anesthetized rabbits. ( Aihara, K; Inui, J, 1991) |
| "To provide evidence to support the calcium hypothesis of cerebral ischemia, we examined the effects of extracellular calcium and calcium antagonists (verapamil, flunarizine, nicardipine) on in vitro 'ischemia' using guinea pig hippocampal slices." | 3.68 | Effects of calcium and calcium antagonists against deprivation of glucose and oxygen in guinea pig hippocampal slices. ( Amagasa, M; Ogawa, A; Yoshimoto, T, 1990) |
| "The effect of benidipine on experimental cerebral ischemia was investigated in rats subjected to occlusion of the bilateral common carotid arteries." | 3.68 | Effect of benidipine hydrochloride (KW-3049), on cerebral ischemia induced by bilateral occlusion of the common carotid arteries in rats. ( Karasawa, A; Kubo, K; Shirakura, S, 1993) |
| "The efficacy of intravenous nicardipine in the prevention of vasospasm after subarachnoid hemorrhage has been investigated in a dose escalation study in 67 patients admitted within 1 week of subarachnoid hemorrhage." | 3.67 | The potential use of nicardipine in cerebrovascular disease. ( Flamm, ES, 1989) |
| "Dihydropyridine calcium channel blockers such as nicardipine are under evaluation for treating acute cerebral ischemia because they may increase cerebral blood flow by causing vasodilation and because they may be cytoprotective in part by limiting production of arachidonic acid metabolites." | 3.67 | Efficacy and mechanism of action of a calcium channel blocker after global cerebral ischemia in rats. ( Grotta, JC; McCandless, D; Pettigrew, LC; Reid, C; Rhoades, H; Rosenbaum, D, 1988) |
| "Using a model of global cerebral ischemia in rats, we examined the effects of a dihydropyridine Ca2+ antagonist, nicardipine, on the liberation of free fatty acids (FFAs)." | 3.67 | Ca2+ antagonist and protection of the brain against ischemia. Effects of nicardipine on free fatty acid liberation in the ischemic brain in rats. ( Handa, J; Kidooka, M; Matsuda, M, 1987) |
| "The effects of the calcium entry blocker nicardipine on CBF, CMRO2, and neurologic outcome following 10 min of complete cerebral ischemia were examined in dogs." | 3.67 | Nicardipine increases cerebral blood flow but does not improve neurologic recovery in a canine model of complete cerebral ischemia. ( Ishikawa, T; Masuda, T; Matsumoto, M; Nagai, I; Sakabe, T; Takeshita, H; Tateishi, A, 1986) |
| "We studied the effect of nicardipine (NC) on canine cerebral blood flow (CBF) after cerebral ischemia induced by cardiac arrest." | 3.67 | Prevention of postischemic hypoperfusion after canine cardiac arrest by nicardipine. ( Amaha, K; Iwatsuki, N; Koga, Y; Ono, K, 1987) |
| "Nicardipine has long been recognized as a potent cerebrovascular vasodilator with a history off-label use to prevent vasospasm and DCI." | 2.72 | Nicardipine Prolonged Release Implants for Prevention of Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage: A Meta-Analysis. ( Akbik, F; Jaja, BNR; Macdonald, RL; Moore, R; Sadan, O; Samuels, OB; Waddel, H, 2021) |
| "The compound is used in the treatment of hypertension, primarily in the elderly." | 2.39 | Nicardipine and treatment of cerebrovascular diseases with particular reference to hypertension-related disorders. ( Amenta, F; Sabbatini, M; Strocchi, P, 1995) |
| "Captopril pretreatment for 28 days decreased the infarct area by 25%." | 1.31 | Protection against ischemia and improvement of cerebral blood flow in genetically hypertensive rats by chronic pretreatment with an angiotensin II AT1 antagonist. ( Bregonzio, C; Falcón-Neri, A; Ito, T; Saavedra, JM; Terrón, JA; Yamakawa, H, 2002) |
| "As soon as the subarachnoid hemorrhage diagnosis is confirmed by computed tomography (or if unconfirmed, by lumbar puncture), we assume that each patient may have an aneurysm." | 1.29 | Are the calcium antagonists really useful in cerebral aneurysmal surgery? A retrospective study. ( Alhayek, G; Fournier, D; Guy, G; Menei, P; Mercier, P; Rizk, T, 1994) |
| "Nicardipine was initially administered as an intravenous bolus injection of 10 mg/kg/hr 15 minutes before or 15 minutes after occlusion, followed by continuous infusion at 8 mg/kg/hr for the 5 hours of the experiment." | 1.28 | Nicardipine reduces ischemic brain injury. Magnetic resonance imaging/spectroscopy study in cats. ( Berry, I; Chew, W; Derugin, N; Kucharczyk, J; Moseley, M; Norman, D; Rollin, C, 1989) |
| "Nicardipine treatment significantly reduced Ca2+ accumulation in the middle cerebral artery territory by 60% compared with six untreated rats 6 hours after arterial occlusion." | 1.27 | Nicardipine reduces calcium accumulation and electrolyte derangements in regional cerebral ischemia in rats. ( Flamm, ES; Hadani, M; Young, W, 1988) |
| "The degree of cerebral ischemia 4 hr after BLCL was estimated by the levels of brain energy metabolites (ATP, lactate, c-AMP) and brain water content." | 1.27 | [Influence of long-term antihypertensive treatment on cerebral ischemia induced by bilateral common carotid artery ligation in SHRSR--protective effect of nicardipine hydrochloride]. ( Katayama, Y; Memezawa, H; Nagazumi, A; Sugimoto, S; Suzuki, S; Terashi, A, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (32.81) | 18.7374 |
| 1990's | 27 (42.19) | 18.2507 |
| 2000's | 7 (10.94) | 29.6817 |
| 2010's | 6 (9.38) | 24.3611 |
| 2020's | 3 (4.69) | 2.80 |
| Authors | Studies |
|---|---|
| Qureshi, AI | 2 |
| Lobanova, I | 1 |
| Huang, W | 1 |
| Ishfaq, MF | 1 |
| Broderick, JP | 1 |
| Cassarly, CN | 1 |
| Martin, RH | 1 |
| Macdonald, RL | 3 |
| Suarez, JI | 1 |
| Dayyani, M | 1 |
| Sadeghirad, B | 1 |
| Grotta, JC | 5 |
| Zabihyan, S | 1 |
| Ahmadvand, S | 1 |
| Wang, Y | 1 |
| Guyatt, GH | 1 |
| Amin-Hanjani, S | 1 |
| Akbik, F | 1 |
| Waddel, H | 1 |
| Jaja, BNR | 1 |
| Moore, R | 1 |
| Samuels, OB | 1 |
| Sadan, O | 1 |
| Mistry, EA | 1 |
| Mayer, SA | 2 |
| Khatri, P | 1 |
| Sadeghi, M | 1 |
| Saber, H | 1 |
| Singh, A | 1 |
| Hanni, C | 1 |
| Parker, D | 2 |
| Desai, A | 1 |
| Mohamed, W | 1 |
| Abboud, ME | 1 |
| Frasure, SE | 1 |
| McKay, C | 1 |
| Hall, AB | 1 |
| Cortes, J | 1 |
| Powers, WJ | 1 |
| Videen, TO | 1 |
| Diringer, MN | 1 |
| Aiyagari, V | 1 |
| Zazulia, AR | 1 |
| Strong, AJ | 1 |
| Woitzik, J | 1 |
| Dreier, JP | 1 |
| Hecht, N | 1 |
| Fiss, I | 1 |
| Sandow, N | 1 |
| Major, S | 1 |
| Winkler, M | 1 |
| Dahlem, YA | 1 |
| Manville, J | 1 |
| Diepers, M | 1 |
| Muench, E | 1 |
| Kasuya, H | 1 |
| Schmiedek, P | 1 |
| Vajkoczy, P | 1 |
| Ito, T | 1 |
| Yamakawa, H | 1 |
| Bregonzio, C | 1 |
| Terrón, JA | 1 |
| Falcón-Neri, A | 1 |
| Saavedra, JM | 1 |
| Wong, GK | 1 |
| Poon, WS | 1 |
| Shah, QA | 1 |
| Georgiadis, A | 1 |
| Suri, MF | 1 |
| Rodriguez, G | 1 |
| Mocco, J | 1 |
| Rose, JC | 1 |
| Komotar, RJ | 1 |
| Goodson, K | 1 |
| Lapointe, M | 1 |
| Monroe, T | 1 |
| Chalela, JA | 1 |
| Liu-Deryke, X | 1 |
| Janisse, J | 1 |
| Coplin, WM | 1 |
| Norris, G | 1 |
| Rhoney, DH | 1 |
| Matsumura, T | 1 |
| Furuichi, H | 1 |
| Izumi, J | 1 |
| Suda, H | 1 |
| Ito, S | 1 |
| Takei, M | 1 |
| Nishi, N | 1 |
| Mori, T | 1 |
| Tanaka, Y | 1 |
| Kurimoto, T | 1 |
| Sun, F | 1 |
| Liu, TP | 1 |
| Imai, T | 1 |
| Kondo, M | 1 |
| Kusaka, T | 1 |
| Sugihara, S | 1 |
| Isobe, K | 1 |
| Itoh, S | 1 |
| Onishi, S | 1 |
| Sabbatini, M | 1 |
| Strocchi, P | 1 |
| Amenta, F | 1 |
| Golfinos, JG | 1 |
| Thompson, BG | 1 |
| Zabramski, JM | 1 |
| Spetzler, RF | 1 |
| Weir, B | 1 |
| MacDonald, L | 1 |
| Mercier, P | 1 |
| Alhayek, G | 1 |
| Rizk, T | 1 |
| Fournier, D | 1 |
| Menei, P | 1 |
| Guy, G | 1 |
| Iwatsuki, N | 3 |
| Takahashi, M | 1 |
| Ono, K | 3 |
| Tajima, T | 1 |
| Tomimoto, H | 1 |
| Wakita, H | 1 |
| Akiguchi, I | 1 |
| Kimura, J | 1 |
| Shirakura, S | 2 |
| Karasawa, A | 2 |
| Kubo, K | 2 |
| Brown, CM | 1 |
| Calder, C | 2 |
| Alps, BJ | 2 |
| Spedding, M | 1 |
| Akopov, SE | 1 |
| Simonian, NA | 1 |
| Kazarian, AV | 1 |
| Moltó-Jordà, JM | 1 |
| Matías-Guiu, J | 1 |
| Katayama, Y | 2 |
| Kamiya, T | 1 |
| Katsura, K | 1 |
| Igarashi, H | 1 |
| Fukuchi, T | 1 |
| Takakura, S | 3 |
| Sogabe, K | 1 |
| Satoh, H | 4 |
| Mori, J | 3 |
| Fujiwara, T | 1 |
| Totsuka, Z | 1 |
| Tokuma, Y | 1 |
| Kohsaka, M | 2 |
| Sano, J | 1 |
| Aktan, S | 1 |
| Aykut, C | 1 |
| Oktay, S | 1 |
| Yegen, B | 1 |
| Ercan, S | 1 |
| Furuichi, Y | 1 |
| Hewitt, K | 1 |
| Corbett, D | 1 |
| Susumu, T | 1 |
| Shiino, A | 1 |
| Handa, J | 4 |
| Aihara, K | 1 |
| Inui, J | 1 |
| Asano, T | 2 |
| Ikegaki, I | 2 |
| Satoh, S | 1 |
| Mochizuki, D | 1 |
| Hidaka, H | 2 |
| Suzuki, Y | 2 |
| Shibuya, M | 2 |
| Sugita, K | 1 |
| Rosenbaum, D | 2 |
| Zabramski, J | 2 |
| Frey, J | 1 |
| Yatsu, F | 1 |
| Marler, J | 2 |
| Spetzler, R | 2 |
| Grotta, J | 1 |
| Amagasa, M | 1 |
| Ogawa, A | 1 |
| Yoshimoto, T | 1 |
| Kasaba, T | 1 |
| Saito, Y | 1 |
| Sakura, S | 1 |
| Kosaka, Y | 1 |
| Picone, CM | 2 |
| Dedman, JR | 1 |
| Rhoades, HM | 1 |
| Strong, RA | 1 |
| Earls, RM | 1 |
| Yao, LP | 1 |
| Rosenbaum, DM | 1 |
| Yatsu, FM | 1 |
| Pettigrew, LC | 3 |
| Bratina, P | 1 |
| Lopez, L | 1 |
| Kidooka, M | 4 |
| Matsuda, M | 3 |
| Abe, K | 1 |
| Okada, T | 1 |
| Kageyama, N | 1 |
| Yamazaki, M | 1 |
| Yamamoto, M | 1 |
| Masuda, A | 1 |
| Ito, Y | 1 |
| Kawahara, M | 1 |
| Kuwaki, T | 1 |
| Ono, T | 1 |
| Shibayama, F | 1 |
| Yamashita, T | 1 |
| Nishimura, T | 1 |
| Flamm, ES | 2 |
| Kucharczyk, J | 1 |
| Chew, W | 1 |
| Derugin, N | 1 |
| Moseley, M | 1 |
| Rollin, C | 1 |
| Berry, I | 1 |
| Norman, D | 1 |
| Reid, C | 2 |
| Rhoades, H | 1 |
| McCandless, D | 1 |
| Obara, S | 1 |
| Hashimoto, Y | 1 |
| Hass, WK | 1 |
| Wilson, AD | 1 |
| Lyden, PD | 1 |
| Zivin, JA | 1 |
| Kochhar, A | 1 |
| Mazzarella, V | 1 |
| Hadani, M | 1 |
| Young, W | 1 |
| Suzuki, S | 2 |
| Sakabe, T | 1 |
| Nagai, I | 1 |
| Ishikawa, T | 1 |
| Takeshita, H | 1 |
| Masuda, T | 1 |
| Matsumoto, M | 1 |
| Tateishi, A | 1 |
| Lozano, R | 1 |
| Balaguer, A | 1 |
| Koga, Y | 1 |
| Amaha, K | 1 |
| Lockwood, AH | 1 |
| Reich, C | 1 |
| Memezawa, H | 1 |
| Sugimoto, S | 1 |
| Nagazumi, A | 1 |
| Terashi, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| the Effect of Different Modes of Mechanical Ventilation on Cerebral Blood Flow During Thoracoscopic Surgeries in Neonates (RCT)[NCT04507295] | 30 participants (Anticipated) | Interventional | 2020-08-08 | Not yet recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 reviews available for nicardipine and Brain Ischemia
| Article | Year |
|---|---|
Lessons Learned from Phase II and Phase III Trials Investigating Therapeutic Agents for Cerebral Ischemia Associated with Aneurysmal Subarachnoid Hemorrhage.
Topics: Brain Ischemia; Cerebral Infarction; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III | 2022 |
Prophylactic Therapies for Morbidity and Mortality After Aneurysmal Subarachnoid Hemorrhage: A Systematic Review and Network Meta-Analysis of Randomized Trials.
Topics: Adult; Brain Ischemia; Cilostazol; Humans; Magnesium; Morbidity; Network Meta-Analysis; Nicardipine; | 2022 |
Nicardipine Prolonged Release Implants for Prevention of Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage: A Meta-Analysis.
Topics: Brain Ischemia; Drug Implants; Humans; Incidence; Network Meta-Analysis; Nicardipine; Recovery of Fu | 2021 |
Blood pressure management in patients with intracerebral and subarachnoid hemorrhage.
Topics: Antihypertensive Agents; Blood Flow Velocity; Blood Pressure; Blood Volume; Brain; Brain Ischemia; E | 2006 |
Nicardipine and treatment of cerebrovascular diseases with particular reference to hypertension-related disorders.
Topics: Aged; Animals; Brain; Brain Ischemia; Calcium Channels; Cerebrovascular Disorders; Humans; Hypertens | 1995 |
Cerebral vasospasm.
Topics: Aneurysm, Ruptured; Blood Pressure; Blood Volume; Brain Ischemia; Catheterization; Cerebral Infarcti | 1993 |
[Nicardipine and its indications in neurology].
Topics: Brain Ischemia; Calcium Channel Blockers; Dementia; Epilepsy; Humans; Migraine Disorders; Moyamoya D | 1997 |
2 trials available for nicardipine and Brain Ischemia
| Article | Year |
|---|---|
Effects of nifedipine and nicardipine on regional cerebral blood flow distribution in patients with arterial hypertension.
Topics: Adult; Aged; Blood Pressure; Brain Ischemia; Calcium Channel Blockers; Cerebrovascular Circulation; | 1996 |
Early treatment of ischemic stroke with a calcium antagonist.
Topics: Blood Pressure; Brain Ischemia; Cerebrovascular Disorders; Drug Evaluation; Feasibility Studies; Hum | 1991 |
55 other studies available for nicardipine and Brain Ischemia
| Article | Year |
|---|---|
Blood Pressure Management after Mechanical Thrombectomy for Acute Ischemic Stroke: A Survey of the StrokeNet Sites.
Topics: Blood Pressure; Brain Ischemia; Cardiovascular Agents; Critical Care; Disease Management; Humans; Me | 2018 |
Nicardipine Associated Risk of Short-Term Mortality in Critically Ill Patients with Ischemic Stroke.
Topics: Aged; Antihypertensive Agents; Blood Pressure; Brain Ischemia; Critical Illness; Databases, Factual; | 2019 |
Bradycardia caused by intravenous nicardipine in an elderly patient with acute ischemic infarct.
Topics: Aged; Antihypertensive Agents; Bradycardia; Brain Ischemia; Calcium Channel Blockers; Humans; Hypert | 2016 |
Time to Blood Pressure Control Before Thrombolytic Therapy in Patients With Acute Ischemic Stroke: Comparison of Labetalol, Nicardipine, and Hydralazine.
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Brain Ischemia; Female; Fib | 2015 |
Autoregulation after ischaemic stroke.
Topics: Aged; Brain Ischemia; Female; Humans; Male; Middle Aged; Nicardipine; Positron-Emission Tomography; | 2009 |
Cortical spreading ischemia in the absence of proximal vasospasm after aneurysmal subarachnoid hemorrhage: evidence for a dual mechanism of delayed cerebral ischemia.
Topics: Antihypertensive Agents; Brain Ischemia; Cortical Spreading Depression; Female; Humans; Male; Nicard | 2012 |
Delayed cerebral ischemia and spreading depolarization in absence of angiographic vasospasm after subarachnoid hemorrhage.
Topics: Adult; Aged; Angiography, Digital Subtraction; Antihypertensive Agents; Brain; Brain Ischemia; Corti | 2012 |
Protection against ischemia and improvement of cerebral blood flow in genetically hypertensive rats by chronic pretreatment with an angiotensin II AT1 antagonist.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensiv | 2002 |
Symptomatic autoregulatory failure in acute ischemic stroke.
Topics: Acute Disease; Antihypertensive Agents; Blood Pressure; Brain; Brain Ischemia; Cerebral Arteries; Ce | 2007 |
Preliminary experience with intra-arterial nicardipine in patients with acute ischemic stroke.
Topics: Adult; Aged; Aged, 80 and over; Angioplasty; Brain Ischemia; Calcium Channel Blockers; Combined Moda | 2007 |
Intraventricular nicardipine for refractory cerebral vasospasm after subarachnoid hemorrhage.
Topics: Adult; Aged; Brain; Brain Ischemia; Female; Humans; Injections, Intraventricular; Male; Middle Aged; | 2008 |
A comparison of nicardipine and labetalol for acute hypertension management following stroke.
Topics: Acute Disease; Aged; Antihypertensive Agents; APACHE; Blood Pressure; Brain Ischemia; Cerebral Hemor | 2008 |
[Effect of efonidipine hydrochloride, a calcium channel blocker, on the experimental cerebral ischemia/anoxia].
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Dihydropyridines; Flunarizine; Hypoxia; Male; Mic | 1995 |
Tetrandrine vs nicardipine in cerebral ischemia-reperfusion damages in gerbils.
Topics: Alkaloids; Animals; Benzylisoquinolines; Brain; Brain Ischemia; Calcium; Calcium Channel Blockers; E | 1995 |
Effect of calcium antagonist, nicardipine, on cerebral blood flow in postasphyxial newborn piglets.
Topics: Animals; Asphyxia; Blood Pressure; Brain Ischemia; Cerebrovascular Circulation; Laser-Doppler Flowme | 1995 |
Are the calcium antagonists really useful in cerebral aneurysmal surgery? A retrospective study.
Topics: Brain Ischemia; Calcium Channel Blockers; Humans; Intracranial Aneurysm; Neuropsychological Tests; N | 1994 |
Are the calcium antagonists really useful in cerebral aneurysmal surgery? A retrospective study.
Topics: Activities of Daily Living; Adult; Aged; Brain Ischemia; Calcium Channel Blockers; Cerebral Angiogra | 1994 |
Hyperbaric oxygen combined with nicardipine administration accelerates neurologic recovery after cerebral ischemia in a canine model.
Topics: Animals; Blood Gas Analysis; Body Temperature; Brain Ischemia; Chi-Square Distribution; Combined Mod | 1994 |
[Protective effect of nicardipine hydrochloride on the evolution of delayed neuronal death--an immunohistochemical study].
Topics: Animals; Brain; Brain Ischemia; Cell Death; Gerbillinae; Immunohistochemistry; Male; Microtubule-Ass | 1994 |
Effect of benidipine hydrochloride (KW-3049), on cerebral ischemia induced by bilateral occlusion of the common carotid arteries in rats.
Topics: Adenosine Triphosphate; Animals; Behavior, Animal; Brain; Brain Chemistry; Brain Ischemia; Calcium C | 1993 |
The effect of lifarizine (RS-87476), a novel sodium and calcium channel modulator, on ischaemic dopamine depletion in the corpus striatum of the gerbil.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Carotid Arteries; Cerebrovascular Disorders; Corp | 1993 |
[Studies on brain pyruvate dehydrogenase (PDH) activity and energy metabolites during ischemia and reperfusion].
Topics: Animals; Brain; Brain Ischemia; Calcium Channel Blockers; Energy Metabolism; Gerbillinae; Immunosupp | 1999 |
Nilvadipine as a neuroprotective calcium entry blocker in a rat model of global cerebral ischemia. A comparative study with nicardipine hydrochloride.
Topics: Animals; Brain; Brain Ischemia; Calcium Channel Blockers; Decerebrate State; Fatty Acids, Nonesterif | 1992 |
Protective effects of benidipine on arachidonic acid-induced acute cerebral ischemia in rats.
Topics: Animals; Arachidonic Acid; Benzoquinones; Blood-Brain Barrier; Brain Edema; Brain Ischemia; Calcium | 1992 |
Nicardipine reduces the levels of leukotriene C4 and prostaglandin E2, following different ischemic periods in rat brain tissue.
Topics: Animals; Biological Assay; Brain Ischemia; Dinoprostone; Male; Nicardipine; Prosencephalon; Rats; SR | 1992 |
Effects of nilvadipine on neuronal function in the ischemic cat brain.
Topics: Animals; Brain; Brain Ischemia; Calcium Channel Blockers; Cats; Cerebrovascular Circulation; Evoked | 1992 |
Combined treatment with MK-801 and nicardipine reduces global ischemic damage in the gerbil.
Topics: Animals; Body Temperature; Brain Ischemia; Cell Death; Dizocilpine Maleate; Drug Combinations; Femal | 1992 |
Nilvadipine, a new calcium channel blocker, reduces ischemic brain injury in rats.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Cerebral Infarction; Nicardipine; Nifedipine; Rat | 1991 |
Nitrendipine facilitates recovery of cerebral blood flow, EEG and metabolites following cerebral ischemia in anesthetized rabbits.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Electroencephalography; Energy Metaboli | 1991 |
Blockade of intracellular actions of calcium may protect against ischaemic damage to the gerbil brain.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brain Ischemia; Calcimycin; Calcium Channel | 1991 |
Effects of calcium and calcium antagonists against deprivation of glucose and oxygen in guinea pig hippocampal slices.
Topics: Action Potentials; Animals; Brain Ischemia; Calcium; Calcium Channel Blockers; Disease Models, Anima | 1990 |
[The effects of thiamylal, ketamine and nicardipine on the hippocampal theta waves produced by cerebral ischemia in cats].
Topics: Animals; Brain Ischemia; Cats; Hippocampus; Ketamine; Nicardipine; Theta Rhythm; Thiamylal | 1990 |
Neuronal protection correlates with prevention of calcium-calmodulin binding in rats.
Topics: Animals; Brain Ischemia; Calcium; Calmodulin; Hippocampus; Neurons; Nicardipine; Nimodipine; Pipecol | 1990 |
Pilot study of nicardipine for acute ischemic stroke.
Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Blood Pressure; Brain Ischemia; Dose-Response Relatio | 1990 |
Effect of calcium antagonist and agonist on free fatty acid liberation in the ischemic brain of rats.
Topics: Animals; Arachidonic Acids; Brain; Brain Ischemia; Disease Models, Animal; Fatty Acids, Nonesterifie | 1987 |
[Effect of nicardipine hydrochloride on ischemic brain edema].
Topics: Animals; Brain Edema; Brain Ischemia; Male; Nicardipine; Rats | 1987 |
Effect of the intracellular calcium antagonist HA1004 on cerebral blood flow in rats.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Cerebrovascular Circulation; Intracellular Fluid; | 1988 |
[The effects of nicardipine on morphological changes and calcium accumulation during ischemic hypoxia in pyramidal nerve cells in the rat cerebral cortex].
Topics: Animals; Brain Ischemia; Calcium; Hypoxia, Brain; Male; Nicardipine; Pyramidal Tracts; Rats; Rats, I | 1989 |
Nilvadipine attenuates ischemic degradation of gerbil brain cytoskeletal proteins.
Topics: Animals; Brain; Brain Ischemia; Calmodulin-Binding Proteins; Clathrin; Cytoskeletal Proteins; Dose-R | 1989 |
The potential use of nicardipine in cerebrovascular disease.
Topics: Animals; Body Water; Brain; Brain Ischemia; Calcium; Humans; Ischemic Attack, Transient; Nicardipine | 1989 |
Nicardipine reduces ischemic brain injury. Magnetic resonance imaging/spectroscopy study in cats.
Topics: Animals; Brain; Brain Ischemia; Cats; Energy Metabolism; Magnetic Resonance Imaging; Magnetic Resona | 1989 |
Efficacy and mechanism of action of a calcium channel blocker after global cerebral ischemia in rats.
Topics: Adenosine Triphosphate; Animals; Biomechanical Phenomena; Brain Ischemia; Calcium Channel Blockers; | 1988 |
[Cerebral protective effects by continuous administration of a calcium antagonist after canine global brain ischemia--change in cerebral blood flow and metabolism].
Topics: Animals; Brain; Brain Ischemia; Calcium Channel Blockers; Cerebrovascular Circulation; Dogs; Nicardi | 1988 |
Comparative protective effects of nicardipine, flunarizine, lidoflazine and nimodipine against ischaemic injury in the hippocampus of the Mongolian gerbil.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Cerebrovascular Circulation; Female; Flunarizine; | 1988 |
Effects of calcium channel blockers on neurologic outcome after focal ischemia in rabbits.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Lidoflazine; Nervous System; Nicardipine; Nimodip | 1988 |
Nicardipine reduces calcium accumulation and electrolyte derangements in regional cerebral ischemia in rats.
Topics: Animals; Body Water; Brain; Brain Ischemia; Calcium; Carbon Radioisotopes; Electrolytes; Ions; Nicar | 1988 |
Ca2+ antagonist and protection of brain against ischemia. Nicardipine levels in rat brain following intraperitoneal administration.
Topics: Animals; Brain; Brain Chemistry; Brain Ischemia; Injections, Intraperitoneal; Male; Nicardipine; Rat | 1988 |
[Influence of duration of antihypertensive treatment on experimental cerebral ischemia in SHRSR].
Topics: Animals; Brain; Brain Ischemia; Cerebral Arteries; Male; Microscopy, Electron, Scanning; Nicardipine | 1987 |
[Effects of calcium antagonist on ischemic cell injury of the rat brain].
Topics: Animals; Brain; Brain Ischemia; Calcium Channel Blockers; Fatty Acids, Nonesterified; Male; Nicardip | 1987 |
Ca2+ antagonist and protection of the brain against ischemia. Effects of nicardipine on free fatty acid liberation in the ischemic brain in rats.
Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Decerebrate State; Fatty Acids, Nonesterified; Ma | 1987 |
Nicardipine increases cerebral blood flow but does not improve neurologic recovery in a canine model of complete cerebral ischemia.
Topics: Animals; Blood Pressure; Brain; Brain Ischemia; Cerebrovascular Circulation; Dogs; Nicardipine; Oxyg | 1986 |
[Nicardipine as treatment of chronic cerebral vascular insufficiency].
Topics: Brain Ischemia; Chronic Disease; Humans; Nicardipine | 1986 |
Prevention of postischemic hypoperfusion after canine cardiac arrest by nicardipine.
Topics: Animals; Blood Pressure; Brain Ischemia; Cardiac Output; Cerebrovascular Circulation; Dogs; Heart Ar | 1987 |
Brain extraction of a calcium channel blocker.
Topics: Animals; Brain; Brain Ischemia; Calcium Channel Blockers; Hippocampus; Male; Nicardipine; Rats; Rats | 1987 |
[Influence of long-term antihypertensive treatment on cerebral ischemia induced by bilateral common carotid artery ligation in SHRSR--protective effect of nicardipine hydrochloride].
Topics: Animals; Blood Pressure; Brain; Brain Ischemia; Carotid Arteries; Cerebral Arteries; Hypertension; L | 1987 |