nicardipine has been researched along with Brain Injuries in 7 studies
Nicardipine: A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents.
nicardipine : A racemate comprising equimolar amounts of (R)- and (S)-nicardipine. It is a calcium channel blocker which is used to treat hypertension.
2-[benzyl(methyl)amino]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate : A dihydropyridine that is 1,4-dihydropyridine substituted by a methyl, {2-[benzyl(methyl)amino]ethoxy}carbonyl, 3-nitrophenyl, methoxycarbonyl and methyl groups at positions 2, 3, 4, 5 and 6, respectively.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| " However, the short retention time at the absorption site and slow drug transport in intranasal gel influence the drug bioavailability and outcome of ICH." | 5.51 | An enhanced charge-driven intranasal delivery of nicardipine attenuates brain injury after intracerebral hemorrhage. ( Deng, J; Gong, Y; Guo, T; Guo, Y; Hao, S; Ji, J; Wang, B, 2019) |
| "Nicardipine was effective in 87% of the patients (with intravenous beta blockers in 4 patients), with a 19." | 2.73 | Management of hypertensive emergencies in acute brain disease: evaluation of the treatment effects of intravenous nicardipine on cerebral oxygenation. ( Narotam, PK; Nathoo, N; Puri, V; Roberts, JM; Taylon, C; Vora, Y, 2008) |
| "In the case of hypertensive encephalopathy, the lowering of blood pressure is therapeutic as well as diagnostic." | 2.43 | [Antihypertensive management in acute cerebral stroke]. ( Ziliene, V, 2005) |
| " However, the short retention time at the absorption site and slow drug transport in intranasal gel influence the drug bioavailability and outcome of ICH." | 1.51 | An enhanced charge-driven intranasal delivery of nicardipine attenuates brain injury after intracerebral hemorrhage. ( Deng, J; Gong, Y; Guo, T; Guo, Y; Hao, S; Ji, J; Wang, B, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guo, T | 1 |
| Guo, Y | 1 |
| Gong, Y | 1 |
| Ji, J | 1 |
| Hao, S | 1 |
| Deng, J | 1 |
| Wang, B | 1 |
| Lee, DJ | 1 |
| Moftakhar, P | 1 |
| Glenn, TC | 1 |
| Vespa, PM | 1 |
| Martin, NA | 1 |
| Narotam, PK | 1 |
| Puri, V | 1 |
| Roberts, JM | 1 |
| Taylon, C | 1 |
| Vora, Y | 1 |
| Nathoo, N | 1 |
| Ziliene, V | 1 |
| Lin, SZ | 1 |
| Chiou, TL | 1 |
| Chiang, YH | 1 |
| Song, WS | 1 |
| Lassié, P | 1 |
| Tentillier, E | 1 |
| Thicoïpé, M | 1 |
| Pinaquy, C | 1 |
| Laborde, N | 1 |
| Hirotani, T | 1 |
| Kameda, T | 1 |
| Kumamoto, T | 1 |
| Shirota, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| NICardipine Neuroprotection in AortiC Surgery (NICNACS)[NCT00508118] | Phase 2 | 7 participants (Actual) | Interventional | 2008-01-31 | Terminated (stopped due to 3/7 subjects experienced hypotension. Study was terminated.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00508118)
Timeframe: Day of surgery
| Intervention | Time (minutes) (Median) |
|---|---|
| NICARDIPINE GROUP | 45 |
1 review available for nicardipine and Brain Injuries
| Article | Year |
|---|---|
[Antihypertensive management in acute cerebral stroke].
Topics: Acute Disease; Adult; Antihypertensive Agents; Brain Injuries; Cerebrovascular Circulation; Emergenc | 2005 |
1 trial available for nicardipine and Brain Injuries
| Article | Year |
|---|---|
Management of hypertensive emergencies in acute brain disease: evaluation of the treatment effects of intravenous nicardipine on cerebral oxygenation.
Topics: Acute Disease; Adult; Aged; Antihypertensive Agents; Blood Pressure; Brain; Brain Injuries; Cerebral | 2008 |
5 other studies available for nicardipine and Brain Injuries
| Article | Year |
|---|---|
An enhanced charge-driven intranasal delivery of nicardipine attenuates brain injury after intracerebral hemorrhage.
Topics: Administration, Intranasal; Animals; Brain Injuries; Cerebral Hemorrhage; Chitosan; Drug Carriers; D | 2019 |
Intra-arterial calcium channel blocker infusion for treatment of severe vasospasm in traumatic brain injury: case report.
Topics: Accidents, Traffic; Adult; Brain Injuries; Calcium Channel Blockers; Cerebral Angiography; Cerebral | 2008 |
Combined treatment with nicardipine, phenobarbital, and methylprednisolone ameliorates vasogenic brain edema.
Topics: Animals; Blood Proteins; Blood-Brain Barrier; Brain Edema; Brain Injuries; Drug Therapy, Combination | 1994 |
[Traumatic rupture of the aortic isthmus in a patient with severe head injury].
Topics: Adult; Aortic Rupture; Blood Pressure; Brain Injuries; Constriction; Emergencies; Humans; Intracrani | 1993 |
Aortic arch repair using hypothermic circulatory arrest technique associated with pharmacological brain protection.
Topics: Adult; Aged; Aged, 80 and over; Aortic Aneurysm, Thoracic; Aortic Dissection; Aortic Rupture; Blood | 2000 |