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nicardipine and Asthma

nicardipine has been researched along with Asthma in 11 studies

Nicardipine: A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents.
nicardipine : A racemate comprising equimolar amounts of (R)- and (S)-nicardipine. It is a calcium channel blocker which is used to treat hypertension.
2-[benzyl(methyl)amino]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate : A dihydropyridine that is 1,4-dihydropyridine substituted by a methyl, {2-[benzyl(methyl)amino]ethoxy}carbonyl, 3-nitrophenyl, methoxycarbonyl and methyl groups at positions 2, 3, 4, 5 and 6, respectively.

Asthma: A form of bronchial disorder with three distinct components: airway hyper-responsiveness (RESPIRATORY HYPERSENSITIVITY), airway INFLAMMATION, and intermittent AIRWAY OBSTRUCTION. It is characterized by spasmodic contraction of airway smooth muscle, WHEEZING, and dyspnea (DYSPNEA, PAROXYSMAL).

Research Excerpts

ExcerptRelevanceReference
"The bronchodilatory activity of one beta 2-stimulation (procaterol) and one calcium antagonist (nicardipine) both recently introduced was compared in a group of chronic asthmatics in the clinical remission phase."9.06[Comparison of the bronchodilating activity of procaterol and nicardipine in chronic forms of bronchial asthma]. ( Ardizzi, A; Barberis, S; Ciotta, D; Galietti, F; Giorgis, GE; Oliaro, A, 1987)
"The inhibitory effect of nicardipine, a calcium antagonist, on the antigen- and anti-IgE-induced histamine release from basophilic leucocytes of patients with bronchial asthma was examined."7.67The calcium antagonist, nicardipine, inhibits antigen-stimulated and anti-IgE-induced histamine release from basophilic leucocytes of atopic asthmatics. ( Kimura, I; Kitani, H; Komagoe, H; Maeda, M; Morinaga, H; Nakagawa, S; Ohtani, J; Takahashi, K; Tanizaki, Y, 1985)
"A study was carried out in 10 patients with chronic non-severe asthma to investigate the effects of prolonged treatment with the calcium blocker, nicardipine."7.67Some effects of prolonged treatment with nicardipine in chronic bronchial asthma. ( Bottino, G; Gianotti, A; Moscatelli, P, 1987)
"The bronchodilatory activity of one beta 2-stimulation (procaterol) and one calcium antagonist (nicardipine) both recently introduced was compared in a group of chronic asthmatics in the clinical remission phase."5.06[Comparison of the bronchodilating activity of procaterol and nicardipine in chronic forms of bronchial asthma]. ( Ardizzi, A; Barberis, S; Ciotta, D; Galietti, F; Giorgis, GE; Oliaro, A, 1987)
"A comparison is presented of the protective effect of ultrasound mist induced by nicardipine + fenoterol and nicardipine + fenoterol + ipratropium bromide in a group of 11 patients with chronic bronchial asthma in a phase of relative clinical stability."5.06[Comparison of protective effects induced by the ultrasonic mist of nicardipine + fenoterol versus nicardipine + fenoterol + ipratropium bromide]. ( Barberis, S; Ciotta, D; Galietti, F; Giorgis, GE; Miravalle, C; Oliaro, A, 1988)
"We tested the effect of nicardipine in experimental allergic asthma."3.74Calcium channel blocker prevents T helper type 2 cell-mediated airway inflammation. ( Cabral, MD; Druet, P; Gallard, A; Gomes, B; Guéry, JC; Leclerc, C; Mariamé, B; Moreau, M; Paulet, P; Pelletier, L; Savignac, M, 2007)
"The inhibitory effect of nicardipine, a calcium antagonist, on the antigen- and anti-IgE-induced histamine release from basophilic leucocytes of patients with bronchial asthma was examined."3.67The calcium antagonist, nicardipine, inhibits antigen-stimulated and anti-IgE-induced histamine release from basophilic leucocytes of atopic asthmatics. ( Kimura, I; Kitani, H; Komagoe, H; Maeda, M; Morinaga, H; Nakagawa, S; Ohtani, J; Takahashi, K; Tanizaki, Y, 1985)
"A study was carried out in 10 patients with chronic non-severe asthma to investigate the effects of prolonged treatment with the calcium blocker, nicardipine."3.67Some effects of prolonged treatment with nicardipine in chronic bronchial asthma. ( Bottino, G; Gianotti, A; Moscatelli, P, 1987)
"In 43 patients suffering from bronchial asthma, the data on patients with normal and high systemic arterial pressure were correlated on the basis of studying external respiratory function and pulmonary circulation."1.28[The characteristics of the lung microcirculation and external respiratory function in bronchial asthma patients with systemic arterial hypertension]. ( Amosov, VI; Iartseva, EE; Sinitsyna, TM; Zhdanov, VF, 1991)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19908 (72.73)18.7374
1990's1 (9.09)18.2507
2000's1 (9.09)29.6817
2010's1 (9.09)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Baraldi, PG1
Preti, D1
Materazzi, S1
Geppetti, P1
Gomes, B1
Cabral, MD1
Gallard, A1
Savignac, M1
Paulet, P1
Druet, P1
Mariamé, B1
Moreau, M1
Leclerc, C1
Guéry, JC1
Pelletier, L1
Koshino, T2
Zhdanov, VF1
Amosov, VI1
Sinitsyna, TM1
Iartseva, EE1
Tanizaki, Y2
Komagoe, H2
Morinaga, H1
Ohtani, J2
Nakagawa, S1
Maeda, M1
Kitani, H2
Takahashi, K2
Kimura, I2
Sudo, M1
Tada, S1
Ardizzi, A1
Barberis, S2
Giorgis, GE2
Oliaro, A2
Galietti, F2
Ciotta, D2
Miravalle, C1
Moscatelli, P2
Bottino, G2
Gianotti, A2
Costa, E1
Fujimura, M1
Nishioka, S1
Okafuji, K1
Minami, S1
Kanamori, K1
Matsuda, T1
Ishizaki, T1
Saga, T1
Miyabo, S1

Reviews

1 review available for nicardipine and Asthma

ArticleYear
Transient receptor potential ankyrin 1 (TRPA1) channel as emerging target for novel analgesics and anti-inflammatory agents.
    Journal of medicinal chemistry, 2010, Jul-22, Volume: 53, Issue:14

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Asthma; Humans; Ion Channel Gating; Neurons; Pain; Pe

2010

Trials

3 trials available for nicardipine and Asthma

ArticleYear
[Comparison of the bronchodilating activity of procaterol and nicardipine in chronic forms of bronchial asthma].
    Minerva medica, 1987, Oct-15, Volume: 78, Issue:19

    Topics: Adult; Asthma; Bronchodilator Agents; Chronic Disease; Double-Blind Method; Ethanolamines; Female; H

1987
[Comparison of protective effects induced by the ultrasonic mist of nicardipine + fenoterol versus nicardipine + fenoterol + ipratropium bromide].
    Minerva medica, 1988, Volume: 79, Issue:12

    Topics: Aerosols; Asthma; Atropine Derivatives; Clinical Trials as Topic; Double-Blind Method; Drug Combinat

1988
Effect of nicardipine on acetylcholine-induced bronchoconstriction in asthmatic subjects.
    Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques, 1988, Volume: 10, Issue:4

    Topics: Acetylcholine; Adolescent; Adult; Asthma; Bronchial Spasm; Double-Blind Method; Hemodynamics; Humans

1988

Other Studies

7 other studies available for nicardipine and Asthma

ArticleYear
Calcium channel blocker prevents T helper type 2 cell-mediated airway inflammation.
    American journal of respiratory and critical care medicine, 2007, Jun-01, Volume: 175, Issue:11

    Topics: Administration, Intranasal; Animals; Asthma; Bronchoalveolar Lavage Fluid; Calcium; Calcium Channel

2007
[The effects of Ca++ antagonists nifedipine and nicardipine on slow reacting substance of anaphylaxis (SRS-A) mediated bronchoconstriction in guinea pig].
    Arerugi = [Allergy], 1984, Volume: 33, Issue:1

    Topics: Animals; Asthma; Calcium Channel Blockers; Depression, Chemical; Guinea Pigs; Male; Mast Cells; Nica

1984
[The characteristics of the lung microcirculation and external respiratory function in bronchial asthma patients with systemic arterial hypertension].
    Terapevticheskii arkhiv, 1991, Volume: 63, Issue:10

    Topics: Adult; Asthma; Fenoterol; Humans; Hypertension; Lung; Microcirculation; Middle Aged; Nicardipine; Re

1991
The calcium antagonist, nicardipine, inhibits antigen-stimulated and anti-IgE-induced histamine release from basophilic leucocytes of atopic asthmatics.
    Acta medica Okayama, 1985, Volume: 39, Issue:4

    Topics: Antibodies, Anti-Idiotypic; Antigens; Asthma; Basophils; Calcium Channel Blockers; Histamine Release

1985
[Inhibition of a calcium antagonist, nicardipine, of histamine release from basophil leukocytes of patients with bronchial asthma].
    Nihon Kyobu Shikkan Gakkai zasshi, 1985, Volume: 23, Issue:5

    Topics: Adolescent; Adult; Aged; Asthma; Basophils; Calcium Channel Blockers; Child; Depression, Chemical; F

1985
Some effects of prolonged treatment with nicardipine in chronic bronchial asthma.
    Current medical research and opinion, 1987, Volume: 10, Issue:6

    Topics: Administration, Oral; Adolescent; Adult; Asthma; Chronic Disease; Drug Evaluation; Female; Forced Ex

1987
Effects of Ca2+ antagonist, nicardipine, on experimental asthma with special reference to slow reacting substance of anaphylaxis.
    Allergy, 1985, Volume: 40, Issue:5

    Topics: Airway Resistance; Animals; Antigens; Asthma; Calcium Channel Blockers; Guinea Pigs; Male; Nicardipi

1985