nicardipine has been researched along with Aging in 16 studies
Nicardipine: A potent calcium channel blockader with marked vasodilator action. It has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents.
nicardipine : A racemate comprising equimolar amounts of (R)- and (S)-nicardipine. It is a calcium channel blocker which is used to treat hypertension.
2-[benzyl(methyl)amino]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate : A dihydropyridine that is 1,4-dihydropyridine substituted by a methyl, {2-[benzyl(methyl)amino]ethoxy}carbonyl, 3-nitrophenyl, methoxycarbonyl and methyl groups at positions 2, 3, 4, 5 and 6, respectively.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The effects of omega-conotoxin (CTX) GVIA, omega-agatoxin (Aga) IVA, and the dihydropyridine nicardipine were studied on synaptic transmission in the hippocampus during aging." | 3.69 | Calcium channel types mediating synaptic transmission during aging. ( Griffith, WH; Hall, SC, 1997) |
| "Nicardipine has no clinically significant negative inotropic effect." | 2.39 | Concomitant diseases in elderly hypertensives: the position of nicardipine. ( Zannad, F, 1996) |
| "Pretreatment with nicardipine prevented the inhibitory effect of exogenous calcium on the testicular CR activity in 3-week-old rats, indicating that the suppressing action of calcium on the enzyme activity was mediated by the entry of extracellular calcium via calcium channels." | 1.29 | Effects of age and calcium ion on testis carbonyl reductase in rats. ( Fujii, T; Inazu, N, 1993) |
| " In conclusion, the present study suggests that there is an altered Ca++ homeostasis in the SAMP8 brain that is effectively attenuated by chronic administration of nimodipine and nicardipine." | 1.29 | Alterations in calcium antagonist receptors and calcium content in senescent brain and attenuation by nimodipine and nicardipine. ( Kimura, R; Ohkura, T; Suzuki, M; Uchida, S; Yamada, S; Yamaguchi, M; Yamamoto, M, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (12.50) | 18.7374 |
| 1990's | 12 (75.00) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vercruysse, I | 1 |
| Vermeulen, AM | 1 |
| Belpaire, FM | 1 |
| Massart, DL | 1 |
| Dupont, AG | 1 |
| Inazu, N | 1 |
| Fujii, T | 1 |
| Kumagai, K | 1 |
| Suzuki, H | 1 |
| Ichikawa, M | 1 |
| Jimbo, M | 1 |
| Nishizawa, M | 1 |
| Ryuzaki, M | 1 |
| Saruta, T | 1 |
| Yamada, S | 1 |
| Uchida, S | 1 |
| Ohkura, T | 1 |
| Kimura, R | 1 |
| Yamaguchi, M | 1 |
| Suzuki, M | 1 |
| Yamamoto, M | 1 |
| Shudo, C | 1 |
| Masuda, Y | 1 |
| Sugita, H | 1 |
| Tamura, T | 1 |
| Furukawa, S | 1 |
| Hayashi, K | 1 |
| Hirata, H | 1 |
| Shikada, K | 1 |
| Tanaka, S | 1 |
| Tomita, K | 1 |
| Hall, SC | 1 |
| Griffith, WH | 1 |
| Zannad, F | 1 |
| Prados, P | 1 |
| Santa, T | 1 |
| Fukushima, T | 1 |
| Homma, H | 1 |
| Kasai, C | 1 |
| Martin, MA | 1 |
| del Castillo, B | 1 |
| Imai, K | 1 |
| Kageyama, S | 1 |
| Fujita, K | 1 |
| Suzuki, K | 1 |
| Shinbo, H | 1 |
| Masuda, N | 1 |
| Uchida, W | 1 |
| Ricci, A | 1 |
| Bronzetti, E | 1 |
| El-Assouad, D | 1 |
| Felici, L | 1 |
| Greco, S | 1 |
| Mariotta, S | 1 |
| Sabbatini, M | 1 |
| Amenta, F | 1 |
| Agata, N | 1 |
| Tanaka, H | 1 |
| Shigenobu, K | 1 |
| Antonicelli, R | 1 |
| Pagelli, P | 1 |
| Paciaroni, E | 1 |
| Kuramoto, K | 1 |
| Ikeda, M | 1 |
| Kaneko, Y | 1 |
| Omae, T | 1 |
| Yoshinaga, K | 1 |
| Yamada, K | 1 |
| Astorri, E | 1 |
| Takahashi, K | 1 |
| Tateishi, N | 1 |
| Kaneda, M | 1 |
| Akaike, N | 1 |
| Pruneau, D | 1 |
| Roy, F | 1 |
1 review available for nicardipine and Aging
| Article | Year |
|---|---|
Concomitant diseases in elderly hypertensives: the position of nicardipine.
Topics: Aging; Calcium Channel Blockers; Cerebrovascular Disorders; Humans; Hypertension; Kidney Diseases; N | 1996 |
2 trials available for nicardipine and Aging
| Article | Year |
|---|---|
Nicardipine retard in the therapy of elderly diabetic hypertensives: final report of observational study.
Topics: Aged; Aging; Analysis of Variance; Blood Glucose; Blood Pressure; Delayed-Action Preparations; Diabe | 1992 |
Analysis of advancing age on the response to nicardipine among 467 adult hypertensive patients.
Topics: Aging; Blood Pressure; Double-Blind Method; Female; Humans; Hypertension; Male; Middle Aged; Nicardi | 1991 |
13 other studies available for nicardipine and Aging
| Article | Year |
|---|---|
The effect of different calcium antagonists and a calcium agonist on the metabolism of propranolol by isolated rat hepatocytes.
Topics: Aging; Animals; Calcium Channel Agonists; Calcium Channel Blockers; Drug Interactions; Liver; Male; | 1994 |
Effects of age and calcium ion on testis carbonyl reductase in rats.
Topics: Aging; Alcohol Oxidoreductases; Animals; Antibodies, Monoclonal; Blotting, Western; Calcium Chloride | 1993 |
Comparison of early and late start of antihypertensive agents and baroreceptor reflexes.
Topics: Aging; Animals; Antihypertensive Agents; Atenolol; Baroreflex; Blood Pressure; Enalapril; Heart Rate | 1996 |
Alterations in calcium antagonist receptors and calcium content in senescent brain and attenuation by nimodipine and nicardipine.
Topics: Aging; Animals; Binding Sites; Brain; Calcium Channel Blockers; Calcium Channels; Isradipine; Mice; | 1996 |
Effects of efonidipine, nicardipine and captopril on proteinuria in aged spontaneously hypertensive rats.
Topics: Aging; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Calcium Channel Blockers; | 1996 |
Calcium channel types mediating synaptic transmission during aging.
Topics: Agatoxins; Aging; Animals; Calcium Channel Blockers; Calcium Channels; Male; Membrane Potentials; Ni | 1997 |
Age-related weakening of baroreflex-mediated sympathetic activity in spontaneously hypertensive rats in response to blood pressure reduction.
Topics: Aging; Animals; Baroreflex; Blood Pressure; Calcium Channel Blockers; Catecholamines; Chromatography | 1998 |
Effect of age on the responses of rat bladder detrusor strips to adenosine triphosphate.
Topics: Acetylcholine; Adenosine Triphosphate; Aging; Animals; Dose-Response Relationship, Drug; Egtazic Aci | 2000 |
Influence of age on L-type Ca2+ channels in the pulmonary artery and vein of spontaneously hypertensive rats.
Topics: Aging; Animals; Autoradiography; Calcium Channel Blockers; Calcium Channels, L-Type; Hypertension; K | 2000 |
Effect of Mn2+ on neonatal and adult rat heart: initial depression and late augmentation of contractile force.
Topics: Aging; Animals; Animals, Newborn; Cardiotonic Agents; Drug Interactions; Manganese; Myocardial Contr | 1992 |
[Left ventricular function in arterial hypertension in relation to age. The short-term effects of nicardipine].
Topics: Adult; Aged; Aging; Drug Evaluation; Gated Blood-Pool Imaging; Humans; Hypertension; Male; Middle Ag | 1991 |
Comparison of low-threshold Ca2+ currents in the hippocampal CA1 neurons among the newborn, adult and aged rats.
Topics: Aging; Animals; Animals, Newborn; Calcium Channels; Electric Conductivity; Hippocampus; Neurons; Nic | 1989 |
Comparative antihypertensive effects of nifedipine and nicardipine in adult and aged spontaneously hypertensive rats.
Topics: Aging; Animals; Antihypertensive Agents; Blood Pressure; Heart Rate; Hypertension; Nicardipine; Nife | 1987 |