nialamide has been researched along with Down Syndrome in 6 studies
Nialamide: An MAO inhibitor that is used as an antidepressive agent.
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| VAZQUEZ, HJ | 1 |
| PIAN, EB | 1 |
| HOJMAN, N | 1 |
| FELDMANN, H | 1 |
| DESIGNOLLE, L | 2 |
| BRAUNER, F | 1 |
| LAUNAY, C | 1 |
| Bettschart, W | 1 |
| Broché, JP | 1 |
| Tissot, R | 1 |
| Alderson, MR | 1 |
2 trials available for nialamide and Down Syndrome
| Article | Year |
|---|---|
[Correlation of the clinical and pharmaco-dynamic effects of Niamid in the treatment of severely mentally retarded children].
Topics: 5-Hydroxytryptophan; Adolescent; Adult; Child; Clinical Trials as Topic; Down Syndrome; Female; Huma | 1965 |
Are clinical trials required.
Topics: Aspirin; Clinical Trials as Topic; Common Cold; Diphtheria Toxoid; Down Syndrome; Drug Evaluation; H | 1974 |
4 other studies available for nialamide and Down Syndrome
| Article | Year |
|---|---|
[The use of nialamide in mongoloid children. (Preliminary report)].
Topics: Child; Down Syndrome; Humans; Nialamide; Psychopharmacology | 1961 |
[THE PLACE OF NIAMID IN INFANTILE NEUROPSYCHIATRY].
Topics: Adolescent; Brain; Brain Damage, Chronic; Brain Injuries; Child; Down Syndrome; Drug Therapy; Educat | 1963 |
[THERAPEUTIC TRIAL OF THE EFFECT OF A MONOAMINE OXIDASE INHIBITOR ON APATHY OF MENTALLY DEFECTIVE CHILDREN].
Topics: Adaptation, Psychological; Adolescent; Apathy; Biomedical Research; Brain; Brain Damage, Chronic; Br | 1963 |
[Study of the action of an M. A. O. inhibitor (Nialamide) on apathy in mentally deficient children and mongoloids].
Topics: Apathy; Asian People; Child; Diet, Reducing; Down Syndrome; Humans; Intellectual Disability; Monoami | 1962 |