niacinamide has been researched along with Uveal Neoplasms in 4 studies
nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.
Uveal Neoplasms: Tumors or cancer of the UVEA.
Excerpt | Relevance | Reference |
---|---|---|
"The aim of the study was to analyse efficacy, safety, and health-related quality of life (HRQoL) for sorafenib treatment in patients with metastatic uveal melanoma." | 9.22 | Sorafenib in metastatic uveal melanoma: efficacy, toxicity and health-related quality of life in a multicentre phase II study. ( Delcambre, C; Dutriaux, C; Heutte, N; Joly, F; Lesimple, T; Mouriaux, F; Neidhart-Berard, EM; Parienti, JJ; Penel, N; Peyro Saint Paul, L; Pham, AD; Piperno-Neumann, S; Servois, V; Thyss, A, 2016) |
"Sorafenib, a multikinase inhibitor of cell proliferation and angiogenesis, inhibits the mitogen-activated protein kinase pathway that is activated in most uveal melanoma tumors." | 9.16 | Phase II trial of sorafenib in combination with carboplatin and paclitaxel in patients with metastatic uveal melanoma: SWOG S0512. ( Aparicio, AM; Bhatia, S; Lao, CD; Margolin, KA; Moon, J; Othus, M; Ribas, A; Sondak, VK; Weber, JS, 2012) |
"The aim of the study was to analyse efficacy, safety, and health-related quality of life (HRQoL) for sorafenib treatment in patients with metastatic uveal melanoma." | 5.22 | Sorafenib in metastatic uveal melanoma: efficacy, toxicity and health-related quality of life in a multicentre phase II study. ( Delcambre, C; Dutriaux, C; Heutte, N; Joly, F; Lesimple, T; Mouriaux, F; Neidhart-Berard, EM; Parienti, JJ; Penel, N; Peyro Saint Paul, L; Pham, AD; Piperno-Neumann, S; Servois, V; Thyss, A, 2016) |
"Sorafenib, a multikinase inhibitor of cell proliferation and angiogenesis, inhibits the mitogen-activated protein kinase pathway that is activated in most uveal melanoma tumors." | 5.16 | Phase II trial of sorafenib in combination with carboplatin and paclitaxel in patients with metastatic uveal melanoma: SWOG S0512. ( Aparicio, AM; Bhatia, S; Lao, CD; Margolin, KA; Moon, J; Othus, M; Ribas, A; Sondak, VK; Weber, JS, 2012) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 3 (75.00) | 24.3611 |
2020's | 1 (25.00) | 2.80 |
Authors | Studies |
---|---|
Zhang, H | 1 |
Liu, X | 1 |
Chen, Y | 1 |
Xu, R | 1 |
He, S | 1 |
Niederkorn, A | 1 |
Wackernagel, W | 1 |
Artl, M | 1 |
Schwantzer, G | 1 |
Aigner, B | 1 |
Richtig, E | 1 |
Mouriaux, F | 1 |
Servois, V | 1 |
Parienti, JJ | 1 |
Lesimple, T | 1 |
Thyss, A | 1 |
Dutriaux, C | 1 |
Neidhart-Berard, EM | 1 |
Penel, N | 1 |
Delcambre, C | 1 |
Peyro Saint Paul, L | 1 |
Pham, AD | 1 |
Heutte, N | 1 |
Piperno-Neumann, S | 1 |
Joly, F | 1 |
Bhatia, S | 1 |
Moon, J | 1 |
Margolin, KA | 1 |
Weber, JS | 1 |
Lao, CD | 1 |
Othus, M | 1 |
Aparicio, AM | 1 |
Ribas, A | 1 |
Sondak, VK | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Phase II Trial of BAY 43-9006 (Sorafenib; NSC-724772) in Combination With Carboplatin and Paclitaxel in Patients With Metastatic Uveal Melanoma[NCT00329641] | Phase 2 | 25 participants (Actual) | Interventional | 2011-02-28 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Measured from the date of registration to the first of progression or death due to any cause with patients last known to be alive and progression-free censored at the date of last contact (NCT00329641)
Timeframe: Every 6 weeks for the first 8 cycles of therapy, and then every 9 weeks until disease progression for up to 3 years after registration or until death
Intervention | Percent of population (Number) |
---|---|
Sorafenib, Carboplatin, Paclitaxel | 29 |
Measured from date of registration to study until death due to any caused with observations last known to be alive censored at the date of last contact (NCT00329641)
Timeframe: Every 6-9 weeks until progression, after progression every six months for first two years and annually thereafter up to 3 for up to 3 years after registration or until death
Intervention | Percentage of population (Number) |
---|---|
Sorafenib, Carboplatin, Paclitaxel | 42 |
Complete response corresponds to complete disappearance of all measurable and non-measurable lesions with no new lesions. Partial response corresponds to greater than or equal to 30fi decrease of sum of longest diameter of all target measurable lesions with no new lesion and non unequivocal progression of non-measurable disease. (NCT00329641)
Timeframe: Every 6 weeks for the first 8 cycles of therapy, then every three cycles (9 weeks) until progression
Intervention | participants (Number) |
---|---|
Sorafenib, Carboplatin, Paclitaxel | 0 |
Number of patients with Grade 3-5 adverse events that are related to study drug by given type of adverse event (NCT00329641)
Timeframe: Weekly during the first cycle of therapy, then prior to each cycle (one cycle = 3 weeks)
Intervention | Participants with a given type of AE (Number) | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Calcium, serum-low (hypocalcemia) | Cataract | Diarrhea | Fatigue (asthenia, lethargy, malaise) | Febrile neutropenia | Hemoglobin | Infec w/ Gr 3/4 neut-Urinary tract | Leukocytes (total WBC) | Lymphopenia | Mucositis/stomatitis (func/symp) - Pharynx | Neuropathy: sensory | Neutrophils/granulocytes (ANC/AGC) | Platelets | Pruritus/itching | Rash/desquamation | Vision-blurred vision | |
Intervention | 1 | 1 | 2 | 1 | 1 | 2 | 1 | 4 | 2 | 1 | 2 | 10 | 4 | 1 | 5 | 1 |
2 trials available for niacinamide and Uveal Neoplasms
Article | Year |
---|---|
Sorafenib in metastatic uveal melanoma: efficacy, toxicity and health-related quality of life in a multicentre phase II study.
Topics: Aged; Antineoplastic Agents; Disease-Free Survival; Female; Humans; Male; Melanoma; Niacinamide; Phe | 2016 |
Phase II trial of sorafenib in combination with carboplatin and paclitaxel in patients with metastatic uveal melanoma: SWOG S0512.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Pharmacological; Carboplatin; Dise | 2012 |
2 other studies available for niacinamide and Uveal Neoplasms
Article | Year |
---|---|
KDOAM-25 Overcomes Resistance to MEK Inhibitors by Targeting KDM5B in Uveal Melanoma.
Topics: Annexins; Cell Line, Tumor; Cell Proliferation; Epigenesis, Genetic; Glycine; Histones; Humans; Jumo | 2022 |
Response of patients with metastatic uveal melanoma to combined treatment with fotemustine and sorafenib.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Liver Neoplasms; Lymphatic Met | 2014 |