Page last updated: 2024-10-19

niacinamide and Uveal Neoplasms

niacinamide has been researched along with Uveal Neoplasms in 4 studies

nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.

Uveal Neoplasms: Tumors or cancer of the UVEA.

Research Excerpts

ExcerptRelevanceReference
"The aim of the study was to analyse efficacy, safety, and health-related quality of life (HRQoL) for sorafenib treatment in patients with metastatic uveal melanoma."9.22Sorafenib in metastatic uveal melanoma: efficacy, toxicity and health-related quality of life in a multicentre phase II study. ( Delcambre, C; Dutriaux, C; Heutte, N; Joly, F; Lesimple, T; Mouriaux, F; Neidhart-Berard, EM; Parienti, JJ; Penel, N; Peyro Saint Paul, L; Pham, AD; Piperno-Neumann, S; Servois, V; Thyss, A, 2016)
"Sorafenib, a multikinase inhibitor of cell proliferation and angiogenesis, inhibits the mitogen-activated protein kinase pathway that is activated in most uveal melanoma tumors."9.16Phase II trial of sorafenib in combination with carboplatin and paclitaxel in patients with metastatic uveal melanoma: SWOG S0512. ( Aparicio, AM; Bhatia, S; Lao, CD; Margolin, KA; Moon, J; Othus, M; Ribas, A; Sondak, VK; Weber, JS, 2012)
"The aim of the study was to analyse efficacy, safety, and health-related quality of life (HRQoL) for sorafenib treatment in patients with metastatic uveal melanoma."5.22Sorafenib in metastatic uveal melanoma: efficacy, toxicity and health-related quality of life in a multicentre phase II study. ( Delcambre, C; Dutriaux, C; Heutte, N; Joly, F; Lesimple, T; Mouriaux, F; Neidhart-Berard, EM; Parienti, JJ; Penel, N; Peyro Saint Paul, L; Pham, AD; Piperno-Neumann, S; Servois, V; Thyss, A, 2016)
"Sorafenib, a multikinase inhibitor of cell proliferation and angiogenesis, inhibits the mitogen-activated protein kinase pathway that is activated in most uveal melanoma tumors."5.16Phase II trial of sorafenib in combination with carboplatin and paclitaxel in patients with metastatic uveal melanoma: SWOG S0512. ( Aparicio, AM; Bhatia, S; Lao, CD; Margolin, KA; Moon, J; Othus, M; Ribas, A; Sondak, VK; Weber, JS, 2012)

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (75.00)24.3611
2020's1 (25.00)2.80

Authors

AuthorsStudies
Zhang, H1
Liu, X1
Chen, Y1
Xu, R1
He, S1
Niederkorn, A1
Wackernagel, W1
Artl, M1
Schwantzer, G1
Aigner, B1
Richtig, E1
Mouriaux, F1
Servois, V1
Parienti, JJ1
Lesimple, T1
Thyss, A1
Dutriaux, C1
Neidhart-Berard, EM1
Penel, N1
Delcambre, C1
Peyro Saint Paul, L1
Pham, AD1
Heutte, N1
Piperno-Neumann, S1
Joly, F1
Bhatia, S1
Moon, J1
Margolin, KA1
Weber, JS1
Lao, CD1
Othus, M1
Aparicio, AM1
Ribas, A1
Sondak, VK1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Phase II Trial of BAY 43-9006 (Sorafenib; NSC-724772) in Combination With Carboplatin and Paclitaxel in Patients With Metastatic Uveal Melanoma[NCT00329641]Phase 225 participants (Actual)Interventional2011-02-28Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

6-month Progression-free Survival

Measured from the date of registration to the first of progression or death due to any cause with patients last known to be alive and progression-free censored at the date of last contact (NCT00329641)
Timeframe: Every 6 weeks for the first 8 cycles of therapy, and then every 9 weeks until disease progression for up to 3 years after registration or until death

InterventionPercent of population (Number)
Sorafenib, Carboplatin, Paclitaxel29

One-year Overall Survival

Measured from date of registration to study until death due to any caused with observations last known to be alive censored at the date of last contact (NCT00329641)
Timeframe: Every 6-9 weeks until progression, after progression every six months for first two years and annually thereafter up to 3 for up to 3 years after registration or until death

InterventionPercentage of population (Number)
Sorafenib, Carboplatin, Paclitaxel42

Response Rate (Complete and Partial Response)

Complete response corresponds to complete disappearance of all measurable and non-measurable lesions with no new lesions. Partial response corresponds to greater than or equal to 30fi decrease of sum of longest diameter of all target measurable lesions with no new lesion and non unequivocal progression of non-measurable disease. (NCT00329641)
Timeframe: Every 6 weeks for the first 8 cycles of therapy, then every three cycles (9 weeks) until progression

Interventionparticipants (Number)
Sorafenib, Carboplatin, Paclitaxel0

Toxicity

Number of patients with Grade 3-5 adverse events that are related to study drug by given type of adverse event (NCT00329641)
Timeframe: Weekly during the first cycle of therapy, then prior to each cycle (one cycle = 3 weeks)

InterventionParticipants with a given type of AE (Number)
Calcium, serum-low (hypocalcemia)CataractDiarrheaFatigue (asthenia, lethargy, malaise)Febrile neutropeniaHemoglobinInfec w/ Gr 3/4 neut-Urinary tractLeukocytes (total WBC)LymphopeniaMucositis/stomatitis (func/symp) - PharynxNeuropathy: sensoryNeutrophils/granulocytes (ANC/AGC)PlateletsPruritus/itchingRash/desquamationVision-blurred vision
Intervention11211214212104151

Trials

2 trials available for niacinamide and Uveal Neoplasms

ArticleYear
Sorafenib in metastatic uveal melanoma: efficacy, toxicity and health-related quality of life in a multicentre phase II study.
    British journal of cancer, 2016, Jun-28, Volume: 115, Issue:1

    Topics: Aged; Antineoplastic Agents; Disease-Free Survival; Female; Humans; Male; Melanoma; Niacinamide; Phe

2016
Phase II trial of sorafenib in combination with carboplatin and paclitaxel in patients with metastatic uveal melanoma: SWOG S0512.
    PloS one, 2012, Volume: 7, Issue:11

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Pharmacological; Carboplatin; Dise

2012

Other Studies

2 other studies available for niacinamide and Uveal Neoplasms

ArticleYear
KDOAM-25 Overcomes Resistance to MEK Inhibitors by Targeting KDM5B in Uveal Melanoma.
    BioMed research international, 2022, Volume: 2022

    Topics: Annexins; Cell Line, Tumor; Cell Proliferation; Epigenesis, Genetic; Glycine; Histones; Humans; Jumo

2022
Response of patients with metastatic uveal melanoma to combined treatment with fotemustine and sorafenib.
    Acta ophthalmologica, 2014, Volume: 92, Issue:8

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Liver Neoplasms; Lymphatic Met

2014