Page last updated: 2024-10-19

niacinamide and Stroke

niacinamide has been researched along with Stroke in 26 studies

nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.

Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)

Research Excerpts

ExcerptRelevanceReference
" Only three drugs, nicaravene, ebselen and edaravone, all radical scavengers, were judged effective by small-sized trials with a wide therapeutic window, 48-72 hours after stroke, in Japan."4.81[Neuroprotective therapy for the treatment of acute ischemic stroke]. ( Naritomi, H, 2001)
"We have analyzed the results of treatment of 1450 stroke patients."2.79[The use of neurometabolic treatment in the complex rehabilitation in poststroke patients]. ( Galkin, AS; Khafizova, TL; Kovalchuck, VV, 2014)
"Ischemic stroke is one of the leading causes of human death and disability."1.72Acutely Inhibiting AQP4 With TGN-020 Improves Functional Outcome by Attenuating Edema and Peri-Infarct Astrogliosis After Cerebral Ischemia. ( Hao, X; Li, C; Lin, L; Ren, Y; Sun, C; Tian, J; Yang, Y; Yin, L; Zhang, X, 2022)
"Hyperglycemia was induced in rats by the administration of nicotinamide and streptozotocin."1.51Intravenous delivery of adipose tissue-derived mesenchymal stem cells improves brain repair in hyperglycemic stroke rats. ( Detante, O; Diekhorst, L; Díez-Tejedor, E; Fuentes, B; Gómez-de Frutos, MC; Gutiérrez-Fernández, M; Jolkkonen, J; Laso-García, F; Martínez-Arroyo, A; Moisan, A; Otero-Ortega, L, 2019)
"Stroke is a leading cause of morbidity and mortality."1.46Nicotinamide Administration Improves Remyelination after Stroke. ( Ding, J; Luan, Y; Qian, C; Teng, GJ; Wang, C; Zhang, Y; Zhao, Z, 2017)
"TGN-020 significantly reduced oedema, glial scar, albumin effusion, and apoptosis, at both 3 and 7 days after MCAO."1.46Inhibition of Aquaporin-4 Improves the Outcome of Ischaemic Stroke and Modulates Brain Paravascular Drainage Pathways. ( Balsanu, TA; Bogdan, C; Carare, RO; Divan, T; Margaritescu, C; Mogoanta, L; Muresanu, DF; Pirici, D; Pirici, I; Vitalie, V, 2017)
"The use of cytoflavin in the treatment of stroke was accompanied by the earlier and more intense activation of neurotrophic mechanisms in astrocytes, delayed activation of neurotrophic mechanisms in endothelial cells, which promoted neuroprotection in acute ischemic stroke."1.42[Characteristics of the regulation of neurotrophic mechanisms in ischemic stroke]. ( Gracheva, EV; Kovalenko, AL; Malkova, VM; Trashkov, AP; Tsygan, NV; Vasiliev, AG; Yakovleva, VA, 2015)
"It was analysed the results of treatment of 1450 stroke patients."1.42[Therapeutic possibilities of improvement of cognitive functions, psychoemotional condition and a quality of life in post-stroke patients]. ( Kovalchuk, VV, 2015)
" However, the dosage and time of treatment require clarification."1.31Nicotinamide therapy protects against both necrosis and apoptosis in a stroke model. ( Adams, JD; Chan, P; Chang, ML; Kem, S; Klaidman, LK; Sugawara, T; Yang, J, 2002)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (23.08)29.6817
2010's15 (57.69)24.3611
2020's5 (19.23)2.80

Authors

AuthorsStudies
Sun, C1
Lin, L1
Yin, L1
Hao, X1
Tian, J1
Zhang, X1
Ren, Y1
Li, C1
Yang, Y1
Chung, JJ1
Jin, T1
Poltavskaya, TS1
Bazhenov, VA1
Volojanin, AV1
Belkin, AA1
Leiderman, IN1
Kovalenko, AL3
Rizakhanova, OA1
Parfenov, SA1
Sapozhnikov, KV1
Willyard, C1
Wang, C1
Zhang, Y1
Ding, J1
Zhao, Z1
Qian, C1
Luan, Y1
Teng, GJ1
Pirici, I1
Balsanu, TA1
Bogdan, C1
Margaritescu, C1
Divan, T1
Vitalie, V1
Mogoanta, L1
Pirici, D1
Carare, RO1
Muresanu, DF1
Gómez-de Frutos, MC1
Laso-García, F1
Diekhorst, L1
Otero-Ortega, L1
Fuentes, B1
Jolkkonen, J1
Detante, O1
Moisan, A1
Martínez-Arroyo, A1
Díez-Tejedor, E1
Gutiérrez-Fernández, M1
Zuloaga, KL1
Krasnow, SM1
Zhu, X1
Zhang, W1
Jouihan, SA1
Shangraw, RE1
Alkayed, NJ1
Marks, DL1
Kovalchuck, VV1
Khafizova, TL1
Galkin, AS1
Rumiantseva, SA3
Silina, EV2
Tsukurova, LA1
Stupin, VA1
Chichanovskaia, LV1
Nazarov, MV1
Kabaeva, EN1
Tsygan, NV2
Trashkov, AP1
Yakovleva, VA1
Malkova, VM1
Gracheva, EV1
Vasiliev, AG1
Kovalchuk, VV1
Trofimova, SA1
Balunov, OA1
Dubinina, EE1
Odinak, MM1
Skvortsova, VI1
Vozniuk, IA1
Stakhovskaia, LV1
Klocheva, EG1
Novikova, LB1
Ianishevskiĭ, SN1
Golokhvastov, SIu1
Guo, JM1
Dong, WZ1
Liu, AJ1
Cheng, MH1
Su, DF1
Tsuruta, D1
Nishikawa, T1
Yamagami, J1
Hashimoto, T1
Bolevich, SB1
Men'shova, NI1
Asadullaev, MM1
Saidvaliev, FS1
Shermukhamedova, FK1
Rizvonov, ZhK1
Vakhabova, NM1
Erkebaeva, SK1
Nurguzhaev, ES1
Gafurov, BG1
Tuksanbaeva, GU1
Yang, J2
Klaidman, LK1
Chang, ML2
Kem, S2
Sugawara, T1
Chan, P1
Adams, JD2
Naritomi, H1
Leker, RR1
Klaidman, L1
Morales, M1
Macleod, MR1
O'Collins, T1
Howells, DW1
Donnan, GA1
Mokudai, T1
Ayoub, IA1
Sakakibara, Y1
Lee, EJ1
Ogilvy, CS1
Maynard, KI1

Reviews

3 reviews available for niacinamide and Stroke

ArticleYear
[Neuroprotective therapy for the treatment of acute ischemic stroke].
    Rinsho shinkeigaku = Clinical neurology, 2001, Volume: 41, Issue:12

    Topics: Animals; Antioxidants; Antipyrine; Clinical Trials as Topic; Edaravone; Free Radical Scavengers; Hum

2001
Nicaraven Chugai.
    Current opinion in investigational drugs (London, England : 2000), 2003, Volume: 4, Issue:1

    Topics: Animals; Antioxidants; Brain Edema; Brain Ischemia; Cerebral Hemorrhage; Clinical Trials, Phase I as

2003
Pooling of animal experimental data reveals influence of study design and publication bias.
    Stroke, 2004, Volume: 35, Issue:5

    Topics: Animals; Brain Ischemia; Disease Models, Animal; Humans; Meta-Analysis as Topic; Neuroprotective Age

2004

Trials

5 trials available for niacinamide and Stroke

ArticleYear
[The efficacy of metabolic treatment in the early recovery period of patients with ischemic stroke].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2020, Volume: 120, Issue:3. Vyp. 2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Pressure; Brain Ischemia; Cognition; Drug Combinat

2020
[The use of neurometabolic treatment in the complex rehabilitation in poststroke patients].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2014, Volume: 114, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Drug Combinations; Emotions; Female; Flavin Mononucleotide; Humans;

2014
[Modern methods of energy homeostasis correction in elderly patients].
    Advances in gerontology = Uspekhi gerontologii, 2014, Volume: 27, Issue:4

    Topics: Aged; Aged, 80 and over; Antioxidants; Ascorbic Acid; Dose-Response Relationship, Drug; Drug Adminis

2014
[Efficacy of cytoflavin in patients in the acute ischemic stroke].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2010, Volume: 110, Issue:12

    Topics: Aged; Drug Combinations; Female; Flavin Mononucleotide; Humans; Inosine Diphosphate; Magnetic Resona

2010
[Assessment of multimodal effect of cytoflavin in the acute brain stroke in patients with metabolic syndrome].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2012, Volume: 112, Issue:10

    Topics: Administration, Intravenous; Aged; Antioxidants; Drug Combinations; Female; Flavin Mononucleotide; H

2012

Other Studies

18 other studies available for niacinamide and Stroke

ArticleYear
Acutely Inhibiting AQP4 With TGN-020 Improves Functional Outcome by Attenuating Edema and Peri-Infarct Astrogliosis After Cerebral Ischemia.
    Frontiers in immunology, 2022, Volume: 13

    Topics: Animals; Aquaporin 4; Brain Edema; Brain Ischemia; Gliosis; Infarction, Middle Cerebral Artery; Magn

2022
Average saturation efficiency filter ASEF-CEST MRI of stroke rodents.
    Magnetic resonance in medicine, 2023, Volume: 89, Issue:2

    Topics: Amides; Animals; Magnetic Resonance Imaging; Niacinamide; Protons; Rats; Rodentia; Stroke

2023
[Cytoflavin as a modulator of rehabilitation treatment of patients with ischemic stroke complicated by post-intensive care syndrome].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2020, Volume: 120, Issue:10

    Topics: Brain Ischemia; Critical Care; Drug Combinations; Flavin Mononucleotide; Humans; Inosine Diphosphate

2020
How gut microbes could drive brain disorders.
    Nature, 2021, Volume: 590, Issue:7844

    Topics: alpha-Synuclein; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Autism Spectrum Disorder

2021
Nicotinamide Administration Improves Remyelination after Stroke.
    Neural plasticity, 2017, Volume: 2017

    Topics: Animals; Demyelinating Diseases; Infarction, Middle Cerebral Artery; Mice; Mice, Inbred C57BL; Niaci

2017
Inhibition of Aquaporin-4 Improves the Outcome of Ischaemic Stroke and Modulates Brain Paravascular Drainage Pathways.
    International journal of molecular sciences, 2017, Dec-23, Volume: 19, Issue:1

    Topics: Albumins; Animals; Apoptosis; Aquaporin 4; Arteries; Brain; Brain Ischemia; Caspase 3; Disease Model

2017
Intravenous delivery of adipose tissue-derived mesenchymal stem cells improves brain repair in hyperglycemic stroke rats.
    Stem cell research & therapy, 2019, 07-17, Volume: 10, Issue:1

    Topics: Administration, Intravenous; Animals; Brain; Disease Models, Animal; Doublecortin Protein; Humans; H

2019
Mechanism of protection by soluble epoxide hydrolase inhibition in type 2 diabetic stroke.
    PloS one, 2014, Volume: 9, Issue:5

    Topics: Analysis of Variance; Animals; Benzoates; Blood Glucose; Blotting, Western; Brain; Diabetes Mellitus

2014
[Characteristics of the regulation of neurotrophic mechanisms in ischemic stroke].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2015, Volume: 115, Issue:7

    Topics: Animals; Astrocytes; Disease Models, Animal; Drug Combinations; Flavin Mononucleotide; Inosine Dipho

2015
[Therapeutic possibilities of improvement of cognitive functions, psychoemotional condition and a quality of life in post-stroke patients].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2015, Volume: 115, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Anxiety; Cognition; Drug Combinations; Female; Flavin Mononucleotide

2015
[Perspectives of treatment of patients with ischemic stroke: the place and the role of cytoflavin].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2010, Volume: 110, Issue:6

    Topics: Aged; Antioxidants; Drug Combinations; Female; Flavin Mononucleotide; Humans; Inosine Diphosphate; I

2010
Nicotinamide postpones stroke in stroke-prone spontaneously hypertensive rats.
    CNS neuroscience & therapeutics, 2012, Volume: 18, Issue:3

    Topics: Animals; Genetic Predisposition to Disease; Male; Membrane Potential, Mitochondrial; Niacinamide; Ra

2012
Unilateral bullous pemphigoid without erythema and eosinophil infiltration in a hemiplegic patient.
    The Journal of dermatology, 2012, Volume: 39, Issue:9

    Topics: Adrenal Cortex Hormones; Aged; Aged, 80 and over; Autoantigens; Collagen Type XVII; Eosinophils; Hem

2012
[Course of free radical processes and prognosis of ischemic and hemorrhagic stroke].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2011, Volume: 111, Issue:12 Pt 2

    Topics: Aged; Antioxidants; Biomarkers; Brain Ischemia; Drug Combinations; Female; Flavin Mononucleotide; Fr

2011
[The preventive treatment of stroke in patients with discirculatory encephalopathy with a depressive syndrome].
    Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova, 2012, Volume: 112, Issue:11

    Topics: Cerebrovascular Disorders; Depressive Disorder; Drug Combinations; Female; Flavin Mononucleotide; Hu

2012
Nicotinamide therapy protects against both necrosis and apoptosis in a stroke model.
    Pharmacology, biochemistry, and behavior, 2002, Volume: 73, Issue:4

    Topics: Animals; Apoptosis; Brain; Dose-Response Relationship, Drug; Male; Necrosis; Niacinamide; Rats; Rats

2002
Nicotinamide offers multiple protective mechanisms in stroke as a precursor for NAD+, as a PARP inhibitor and by partial restoration of mitochondrial function.
    Pharmacology, 2003, Volume: 69, Issue:3

    Topics: Adenosine Triphosphate; Animals; Brain; Brain Ischemia; Disease Models, Animal; Mice; Mice, Inbred B

2003
Delayed treatment with nicotinamide (Vitamin B(3)) improves neurological outcome and reduces infarct volume after transient focal cerebral ischemia in Wistar rats.
    Stroke, 2000, Volume: 31, Issue:7

    Topics: Animals; Brain; Cerebral Infarction; Energy Metabolism; Ischemic Attack, Transient; Male; Motor Acti

2000