niacinamide has been researched along with Seizures in 27 studies
nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In adult male albino BALB/c mice inosine (INS, 100 and 200 micrograms, intraventricularly) prolonged the latency of pentylenetetrazol (PTZ) seizures while nicotinamide (NAM) exerted an opposite effect." | 7.66 | Dissimilar effects of nicotinamide and inosine, putative endogenous ligands of the benzodiazepine receptors, on pentylenetetrazol seizures in four strains of mice. ( Lapin, IP, 1980) |
| "Nicotinamide (NAM, 1000 mg/kg), inosine (INS, 1000 mg/kg), hypoxanthine (HXT, 500 mg/kg), putative endogenous ligands of the benzodiazepine receptor, and nicotinic acid (NA, 500 mg/kg) diminished DL-kynurenine-(DL-K, 50 micrograms ICV) induced seizures in C57BL/6 adult male mice and only prolonged the latency of pentylenetetrazol (PTZ, 500 micrograms iCV) seizures." | 7.66 | Nicotinamide, inosine and hypoxanthine, putative endogenous ligands of the benzodiazepine receptor, opposite to diazepam are much more effective against kynurenine-induced seizures than against pentylenetetrazol-induced seizures. ( Lapin, IP, 1981) |
| " Here we assessed CBD dose-response effects in the Genetically Epilepsy Prone Rats (GEPR-3) strain, which exhibits two types of epileptic seizures, brainstem-dependent generalized tonic-clonic seizures and limbic seizures." | 5.91 | Cannabidiol attenuates generalized tonic-clonic and suppresses limbic seizures in the genetically epilepsy-prone rats (GEPR-3) strain. ( Campos-Rodriguez, C; Forcelli, PA; Garcia-Cairasco, N; Lazarini-Lopes, W; N'Gouemo, P, 2023) |
| " A 5 d treatment of epileptic mice with systemic injections of the centrally available, potent, and specific P2X7 receptor antagonist JNJ-47965567 (30 mg/kg) significantly reduced spontaneous seizures during continuous video-EEG monitoring that persisted beyond the time of drug presence in the brain." | 3.83 | Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy. ( Alves, M; Arribas-Blázquez, M; Artalejo, AR; Bhattacharya, A; Conroy, RM; Delanty, N; Diaz-Hernandez, M; Engel, T; Farrell, MA; Henshall, DC; Jimenez-Pacheco, A; Letavic, M; Miras-Portugal, MT; O'Brien, DF; Olivos-Oré, LA; Sanz-Rodriguez, A, 2016) |
| "The anticonvulsive action of diazepam, carbamazepine, sodium valproate and their combinations with pyridoxal-5-phosphate, nicotinamide, and alpha-tocopherol were investigated in acute experiments on mice with corazole-induced seizures." | 3.67 | [Effect of diazepam, carbamazepine, sodium valproate and their combinations with vitamin preparations on epileptic activity]. ( Kryzhanovskiĭ, GN; Shandra, AA, 1985) |
| " It has been found in experimental primary-generalized epileptic activity induced by bemegride that preliminary injection of nicotinamide increased the latency of the emergence of the first epileptic seizures." | 3.66 | [Effect of nicotinamide on focal and generalized epileptic activity in the cerebral cortex]. ( Braslavskiĭ, VE; Germanov, SB; Kryzhanovskiĭ, GN; Nikushkin, EV; Shchavelev, VA, 1982) |
| "In adult male albino BALB/c mice inosine (INS, 100 and 200 micrograms, intraventricularly) prolonged the latency of pentylenetetrazol (PTZ) seizures while nicotinamide (NAM) exerted an opposite effect." | 3.66 | Dissimilar effects of nicotinamide and inosine, putative endogenous ligands of the benzodiazepine receptors, on pentylenetetrazol seizures in four strains of mice. ( Lapin, IP, 1980) |
| "Nicotinamide (NAM, 1000 mg/kg), inosine (INS, 1000 mg/kg), hypoxanthine (HXT, 500 mg/kg), putative endogenous ligands of the benzodiazepine receptor, and nicotinic acid (NA, 500 mg/kg) diminished DL-kynurenine-(DL-K, 50 micrograms ICV) induced seizures in C57BL/6 adult male mice and only prolonged the latency of pentylenetetrazol (PTZ, 500 micrograms iCV) seizures." | 3.66 | Nicotinamide, inosine and hypoxanthine, putative endogenous ligands of the benzodiazepine receptor, opposite to diazepam are much more effective against kynurenine-induced seizures than against pentylenetetrazol-induced seizures. ( Lapin, IP, 1981) |
| " Here we assessed CBD dose-response effects in the Genetically Epilepsy Prone Rats (GEPR-3) strain, which exhibits two types of epileptic seizures, brainstem-dependent generalized tonic-clonic seizures and limbic seizures." | 1.91 | Cannabidiol attenuates generalized tonic-clonic and suppresses limbic seizures in the genetically epilepsy-prone rats (GEPR-3) strain. ( Campos-Rodriguez, C; Forcelli, PA; Garcia-Cairasco, N; Lazarini-Lopes, W; N'Gouemo, P, 2023) |
| "Patients with renal cell and breast carcinoma metastases to the brain were identified from the prospective database at the Penn State Hershey Medical Center and Penn State Cancer Institute." | 1.35 | Brain magnetic resonance imaging changes after sorafenib and sunitinib chemotherapy in patients with advanced renal cell and breast carcinoma. ( Hill, KL; Lipson, AC; Sheehan, JM, 2009) |
| "The antiseizure effects of nicotinamide depended on the time of its injection." | 1.26 | [Effect of pantogam, nicotinamide, and phenazepam on seizure activity]. ( Godlevskiĭ, LS; Kryzhanovskiĭ, GN; Nikushkin, EV; Shandra, AA, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (77.78) | 18.7374 |
| 1990's | 1 (3.70) | 18.2507 |
| 2000's | 1 (3.70) | 29.6817 |
| 2010's | 3 (11.11) | 24.3611 |
| 2020's | 1 (3.70) | 2.80 |
| Authors | Studies |
|---|---|
| Lazarini-Lopes, W | 1 |
| Campos-Rodriguez, C | 1 |
| Garcia-Cairasco, N | 1 |
| N'Gouemo, P | 1 |
| Forcelli, PA | 1 |
| Sinha, R | 1 |
| Sara, UV | 1 |
| Khosa, RL | 1 |
| Stables, J | 1 |
| Jain, J | 1 |
| Jimenez-Pacheco, A | 1 |
| Diaz-Hernandez, M | 1 |
| Arribas-Blázquez, M | 1 |
| Sanz-Rodriguez, A | 1 |
| Olivos-Oré, LA | 1 |
| Artalejo, AR | 1 |
| Alves, M | 1 |
| Letavic, M | 1 |
| Miras-Portugal, MT | 1 |
| Conroy, RM | 1 |
| Delanty, N | 1 |
| Farrell, MA | 1 |
| O'Brien, DF | 1 |
| Bhattacharya, A | 1 |
| Engel, T | 1 |
| Henshall, DC | 1 |
| Hill, KL | 1 |
| Lipson, AC | 1 |
| Sheehan, JM | 1 |
| Rook, JM | 1 |
| Noetzel, MJ | 1 |
| Pouliot, WA | 1 |
| Bridges, TM | 1 |
| Vinson, PN | 1 |
| Cho, HP | 1 |
| Zhou, Y | 1 |
| Gogliotti, RD | 1 |
| Manka, JT | 1 |
| Gregory, KJ | 1 |
| Stauffer, SR | 1 |
| Dudek, FE | 1 |
| Xiang, Z | 1 |
| Niswender, CM | 1 |
| Daniels, JS | 1 |
| Jones, CK | 1 |
| Lindsley, CW | 1 |
| Conn, PJ | 1 |
| RUSSO, A | 1 |
| MARINO, M | 1 |
| Skolnick, P | 1 |
| Paul, SM | 1 |
| Kryzhanovskiĭ, GN | 8 |
| Shandra, AA | 8 |
| Nikushkin, EV | 3 |
| Braslavskiĭ, VE | 1 |
| Shchavelev, VA | 1 |
| Germanov, SB | 1 |
| Godlevskiĭ, LS | 5 |
| Lapin, IP | 3 |
| Makul'kin, RF | 2 |
| Lokasiuk, BA | 1 |
| Beliaeva, AI | 1 |
| Gantenbein, M | 1 |
| Attolini, L | 1 |
| Bruguerolle, B | 1 |
| Chen, C | 1 |
| Gates, GR | 1 |
| Mazarati, AM | 1 |
| Barthez, MA | 1 |
| Autret, E | 1 |
| Billard, C | 1 |
| Santini, JJ | 1 |
| Ramzan, I | 1 |
| DeDonato, V | 1 |
| Geller, LM | 1 |
| Cowen, D | 1 |
| Wolf, A | 1 |
| Taylor, WJ | 1 |
| Bleandonu, G | 1 |
| Boye, J | 1 |
| Herken, H | 1 |
1 review available for niacinamide and Seizures
| Article | Year |
|---|---|
The mechanism(s) of action of the benzodiazepines.
Topics: Adenosine; Animals; Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Caffeine; Carbolines; C | 1981 |
26 other studies available for niacinamide and Seizures
| Article | Year |
|---|---|
Cannabidiol attenuates generalized tonic-clonic and suppresses limbic seizures in the genetically epilepsy-prone rats (GEPR-3) strain.
Topics: Acoustic Stimulation; Animals; Brain Stem; Cannabidiol; Disease Models, Animal; Epilepsy, Reflex; Ki | 2023 |
In silico validation and structure activity relationship study of a series of pyridine-3-carbohydrazide derivatives as potential anticonvulsants in generalized and partial seizures.
Topics: Animals; Anticonvulsants; Computer Simulation; Cornea; Dose-Response Relationship, Drug; Drug Design | 2013 |
Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy.
Topics: Adenosine Triphosphate; Adolescent; Adult; Animals; Brain; Calcium-Binding Proteins; Disease Models, | 2016 |
Brain magnetic resonance imaging changes after sorafenib and sunitinib chemotherapy in patients with advanced renal cell and breast carcinoma.
Topics: Aged; Antineoplastic Agents; Benzenesulfonates; Brain; Brain Edema; Brain Neoplasms; Breast Neoplasm | 2009 |
Unique signaling profiles of positive allosteric modulators of metabotropic glutamate receptor subtype 5 determine differences in in vivo activity.
Topics: Allosteric Regulation; Animals; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; HE | 2013 |
[Nicotinamide in experimental asthmatic seizure].
Topics: Asthma; Niacin; Niacinamide; Nicotinic Acids; Seizures | 1952 |
[Antiepileptic effects of complex therapy with vitamins and anticonvulsant preparations (experimental findings)].
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Drug Therapy, Com | 1982 |
[Effect of nicotinamide on focal and generalized epileptic activity in the cerebral cortex].
Topics: Animals; Bemegride; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; | 1982 |
[Effect of pantogam, nicotinamide, and phenazepam on seizure activity].
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Benzodiazepinones; Dose-Response Relationship, Drug; | 1982 |
[Effect of vitamin preparations on epileptic activity].
Topics: Animals; Drug Evaluation, Preclinical; Drug Therapy, Combination; Epilepsy; Kindling, Neurologic; Mi | 1984 |
Dissimilar effects of nicotinamide and inosine, putative endogenous ligands of the benzodiazepine receptors, on pentylenetetrazol seizures in four strains of mice.
Topics: Animals; Anticonvulsants; Injections, Intraperitoneal; Injections, Intraventricular; Inosine; Ligand | 1980 |
Nicotinamide, inosine and hypoxanthine, putative endogenous ligands of the benzodiazepine receptor, opposite to diazepam are much more effective against kynurenine-induced seizures than against pentylenetetrazol-induced seizures.
Topics: Animals; Anticonvulsants; Binding, Competitive; Diazepam; Hypoxanthines; Inosine; Kynurenine; Ligand | 1981 |
Non-specific, non-selective and mild increase in the latency of pentylenetetrazol seizures produced by large doses of the putative endogenous ligands of the benzodiazepine receptor.
Topics: Animals; Hypoxanthines; Injections, Intraperitoneal; Injections, Intraventricular; Inosine; Ligands; | 1981 |
[Effect of nicotinamide on epileptic activity in the cerebral cortex].
Topics: Animals; Anticonvulsants; Cats; Cerebral Cortex; Electroencephalography; Niacinamide; Seizures; Stry | 1980 |
[Further study of the antiepileptic properties of nicotinamide].
Topics: 3-Mercaptopropionic Acid; Acetylcholine; Animals; Anticonvulsants; Brain; Cats; gamma-Aminobutyric A | 1981 |
[Use of nicotinamide and pyridoxal-5-phosphate to treat experimental epilepsy].
Topics: Animals; Cats; Drug Therapy, Combination; gamma-Aminobutyric Acid; Niacinamide; Penicillins; Pyridox | 1981 |
Effect of four potassium channel agonists on bupivacaine-induced toxicity in mice.
Topics: Animals; Benzopyrans; Bupivacaine; Cromakalim; Diazoxide; Dose-Response Relationship, Drug; Guanidin | 1995 |
Effects of 6-aminonicotinamide on abolition and induction of audiogenic seizures.
Topics: 6-Aminonicotinamide; Age Factors; Animals; Dose-Response Relationship, Drug; Mice; Mice, Inbred BALB | 1977 |
[Effect of delta sleep-inducing peptide, anticonvulsant preparations and nicotinamide on generalized seizure activity].
Topics: Animals; Anticonvulsants; Convulsants; Delta Sleep-Inducing Peptide; Dose-Response Relationship, Dru | 1989 |
[Effect of diazepam, carbamazepine, sodium valproate and their combinations with vitamin preparations on epileptic activity].
Topics: Animals; Anticonvulsants; Carbamazepine; Diazepam; Drug Therapy, Combination; Male; Niacinamide; Pen | 1985 |
[A very strange seizure].
Topics: Antitussive Agents; Child, Preschool; Cough; Female; Humans; Niacinamide; Seizures | 1987 |
Effect of nicotinamide on theophylline seizures in rats.
Topics: Animals; Male; Niacinamide; Rats; Rats, Inbred Strains; Seizures; Theophylline | 1988 |
Effect of the antimetabolite, 6-aminonicotinamide, on sound-induced seizures in mice.
Topics: Animals; Antimetabolites; Brain Stem; Mice; Niacinamide; Pentylenetetrazole; Seizures; Sound | 1966 |
Inhibition of nikethamide by nicotinamide.
Topics: Animals; Mice; Niacinamide; Nikethamide; Seizures; Tachyphylaxis | 1969 |
[Neuropsychiatric incidences in antitubercular treatment consisting of isoniazid or isoniazid and ethionamide (8 cases)].
Topics: Acidosis; Adult; Alcoholism; Ammonia; Avitaminosis; Carboxy-Lyases; Chromatography, Paper; Chromatog | 1969 |
[Pharmacologic studies on the problem of the selective vulnerability of the brain].
Topics: Animals; Antimetabolites; Brain; Central Nervous System Diseases; Electroencephalography; Hippocampu | 1965 |