niacinamide has been researched along with Rhabdomyosarcoma in 5 studies
nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.
Rhabdomyosarcoma: A malignant solid tumor arising from mesenchymal tissues which normally differentiate to form striated muscle. It can occur in a wide variety of sites. It is divided into four distinct types: pleomorphic, predominantly in male adults; alveolar (RHABDOMYOSARCOMA, ALVEOLAR), mainly in adolescents and young adults; embryonal (RHABDOMYOSARCOMA, EMBRYONAL), predominantly in infants and children; and botryoidal, also in young children. It is one of the most frequently occurring soft tissue sarcomas and the most common in children under 15. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p2186; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, pp1647-9)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sorafenib, 200 mg/m(2) /dose, was administered every 12 hr continuously for 28 day cycles using a two-stage design in two primary strata (rhabdomyosarcoma and Wilms tumor) and two secondary strata (HCC and PTC)." | 5.20 | Phase 2 trial of sorafenib in children and young adults with refractory solid tumors: A report from the Children's Oncology Group. ( Blaney, SM; Fox, E; Jayaprakash, N; Kim, A; Krailo, M; Weigel, B; Widemann, BC, 2015) |
| "We have analyzed the expression of SIRT1 and SIRT2 in a series of pediatric sarcoma tumor cell lines and normal cells, and we have evaluated the activity of the sirtuin inhibitor and p53 activator tenovin-6 (Tv6) in synovial sarcoma and rhabdomyosarcoma cell lines." | 3.80 | SIRT1 and SIRT2 inhibition impairs pediatric soft tissue sarcoma growth. ( Brodin, B; D'Arcy, P; de Milito, A; Kis, L; Lain, S; Ma, L; Maruwge, W; Pellegrini, P; Strambi, A, 2014) |
| "Subcutaneous tumours and artificially induced pulmonary metastases of the rhabdomyosarcoma R1H of the rat were treated either with fractionated irradiation alone or in combination with nicotinamide and carbogen." | 3.69 | Combination of fractionated irradiation with nicotinamide and carbogen in R1H-tumours of the rat and its pulmonary metastases. ( Beck-Bornholdt, HP; Krüll, A; Raabe, A; Rett, M, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dolgikh, N | 1 |
| Fulda, S | 1 |
| Ma, L | 1 |
| Maruwge, W | 1 |
| Strambi, A | 1 |
| D'Arcy, P | 1 |
| Pellegrini, P | 1 |
| Kis, L | 1 |
| de Milito, A | 1 |
| Lain, S | 1 |
| Brodin, B | 1 |
| Kim, A | 1 |
| Widemann, BC | 1 |
| Krailo, M | 1 |
| Jayaprakash, N | 1 |
| Fox, E | 1 |
| Weigel, B | 1 |
| Blaney, SM | 1 |
| Murray, MF | 1 |
| Nghiem, M | 1 |
| Srinivasan, A | 1 |
| Raabe, A | 1 |
| Rett, M | 1 |
| Krüll, A | 1 |
| Beck-Bornholdt, HP | 1 |
1 trial available for niacinamide and Rhabdomyosarcoma
| Article | Year |
|---|---|
Phase 2 trial of sorafenib in children and young adults with refractory solid tumors: A report from the Children's Oncology Group.
Topics: Adolescent; Angiogenesis Inhibitors; Antineoplastic Agents; Child; Child, Preschool; Female; Humans; | 2015 |
4 other studies available for niacinamide and Rhabdomyosarcoma
| Article | Year |
|---|---|
Rhabdomyosarcoma cells are susceptible to cell death by LDK378 alone or in combination with sorafenib independently of anaplastic lymphoma kinase status.
Topics: Anaplastic Lymphoma Kinase; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Death; Cel | 2017 |
SIRT1 and SIRT2 inhibition impairs pediatric soft tissue sarcoma growth.
Topics: Acetylation; Animals; Autophagy; Benzamides; Caspase 3; Caspase 7; Cell Line, Tumor; Cell Proliferat | 2014 |
HIV infection decreases intracellular nicotinamide adenine dinucleotide [NAD].
Topics: Cell Line; Cells, Cultured; HIV Infections; HIV-1; Humans; Lymphocyte Activation; Lymphocytes; NAD; | 1995 |
Combination of fractionated irradiation with nicotinamide and carbogen in R1H-tumours of the rat and its pulmonary metastases.
Topics: Animals; Carbon Dioxide; Combined Modality Therapy; Disease Models, Animal; Dose Fractionation, Radi | 1997 |