niacinamide has been researched along with Reperfusion Injury in 34 studies
nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.
Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Ischemia-reperfusion injury (IRI) is a model for AKI, which results in tubular damage, dysfunction of the mitochondria and autophagy, and in decreased cellular nicotinamide adenine dinucleotide (NAD+) with progressing fibrosis resulting in CKD." | 8.02 | Effect of NAD+ boosting on kidney ischemia-reperfusion injury. ( Andersen, CB; Egstrand, S; Lewin, E; Mace, ML; Morevati, M; Nordholm, A; Olgaard, K; Salmani, R, 2021) |
| " Here we investigated the effect of nicaraven (2(R,S)-1,2-bis(nicotinamido)propane), a known hydroxyl radical scavenger compound and neuroprotective agent, on several NO- and peroxynitrite related pathways in vitro, and in shock and inflammation in vivo." | 7.70 | Effects of nicaraven on nitric oxide-related pathways and in shock and inflammation. ( Hake, P; Salzman, AL; Scott, GS; Szabo, C; Zingarelli, B, 2000) |
| "Nicaraven exerted hepatic protection against warm ischemia and reperfusion injury." | 7.70 | A novel hydroxyl radical scavenger, nicaraven, protects the liver from warm ischemia and reperfusion injury. ( Fukai, M; Furukawa, H; Hayashi, T; Kishida, A; Nagashima, K; Shimamura, T; Suzuki, T; Todo, S; Watanabe, Y; Yokota, R, 2000) |
| " The results provide, to our knowledge, the first evidence that nicaraven is effective against ischemia-reperfusion injury in the brain and demonstrate that oxygen free radicals generated during reperfusion are important triggers of ischemic brain damage." | 7.69 | Attenuation of ischemia-reperfusion injury in the rat neocortex by the hydroxyl radical scavenger nicaraven. ( Kassell, NF; Lee, KS; Toyoda, T, 1997) |
| " Ischemia-reperfusion injury (IRI) is a model for AKI, which results in tubular damage, dysfunction of the mitochondria and autophagy, and in decreased cellular nicotinamide adenine dinucleotide (NAD+) with progressing fibrosis resulting in CKD." | 4.02 | Effect of NAD+ boosting on kidney ischemia-reperfusion injury. ( Andersen, CB; Egstrand, S; Lewin, E; Mace, ML; Morevati, M; Nordholm, A; Olgaard, K; Salmani, R, 2021) |
| " Here we investigated the effect of nicaraven (2(R,S)-1,2-bis(nicotinamido)propane), a known hydroxyl radical scavenger compound and neuroprotective agent, on several NO- and peroxynitrite related pathways in vitro, and in shock and inflammation in vivo." | 3.70 | Effects of nicaraven on nitric oxide-related pathways and in shock and inflammation. ( Hake, P; Salzman, AL; Scott, GS; Szabo, C; Zingarelli, B, 2000) |
| "Nicaraven exerted hepatic protection against warm ischemia and reperfusion injury." | 3.70 | A novel hydroxyl radical scavenger, nicaraven, protects the liver from warm ischemia and reperfusion injury. ( Fukai, M; Furukawa, H; Hayashi, T; Kishida, A; Nagashima, K; Shimamura, T; Suzuki, T; Todo, S; Watanabe, Y; Yokota, R, 2000) |
| " The results provide, to our knowledge, the first evidence that nicaraven is effective against ischemia-reperfusion injury in the brain and demonstrate that oxygen free radicals generated during reperfusion are important triggers of ischemic brain damage." | 3.69 | Attenuation of ischemia-reperfusion injury in the rat neocortex by the hydroxyl radical scavenger nicaraven. ( Kassell, NF; Lee, KS; Toyoda, T, 1997) |
| "Inflammation has been demonstrated to promote cancer metastasis." | 1.56 | Nicaraven Attenuates Postoperative Systemic Inflammatory Responses-Induced Tumor Metastasis. ( Goto, S; Guo, CY; Kawabata, T; Li, TS; Liu, KX; Moriwaki, T; Zhang, X, 2020) |
| "Sorafenib was acutely administered to NASH rats with IR liver injury that were or were not chronically pretreated with the Rho-kinase-specific inhibitor fasudil." | 1.38 | Rho-kinase-dependent pathway mediates the hepatoprotective effects of sorafenib against ischemia/reperfusion liver injury in rats with nonalcoholic steatohepatitis. ( Chan, CC; Huang, YT; Lee, KC; Lee, TY; Lin, HC; Yang, YY; Yeh, YC, 2012) |
| "Lung malondialdehyde (MDA) levels were significantly depressed in ischaemic and ONOO(-) preconditioning groups." | 1.33 | Preconditioning effects of peroxynitrite in the rat lung. ( Demiryürek, AT; Turan, NN, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.94) | 18.7374 |
| 1990's | 8 (23.53) | 18.2507 |
| 2000's | 14 (41.18) | 29.6817 |
| 2010's | 8 (23.53) | 24.3611 |
| 2020's | 3 (8.82) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, X | 1 |
| Moriwaki, T | 1 |
| Kawabata, T | 1 |
| Goto, S | 1 |
| Liu, KX | 1 |
| Guo, CY | 1 |
| Li, TS | 1 |
| Faivre, A | 1 |
| Katsyuba, E | 1 |
| Verissimo, T | 1 |
| Lindenmeyer, M | 1 |
| Rajaram, RD | 1 |
| Naesens, M | 1 |
| Heckenmeyer, C | 1 |
| Mottis, A | 1 |
| Feraille, E | 1 |
| Cippà, P | 1 |
| Cohen, C | 1 |
| Longchamp, A | 1 |
| Allagnat, F | 1 |
| Rutkowski, JM | 1 |
| Legouis, D | 1 |
| Auwerx, J | 1 |
| de Seigneux, S | 1 |
| Morevati, M | 1 |
| Egstrand, S | 1 |
| Nordholm, A | 1 |
| Mace, ML | 1 |
| Andersen, CB | 1 |
| Salmani, R | 1 |
| Olgaard, K | 1 |
| Lewin, E | 1 |
| Martens, S | 1 |
| Jeong, M | 1 |
| Tonnus, W | 1 |
| Feldmann, F | 1 |
| Hofmans, S | 1 |
| Goossens, V | 1 |
| Takahashi, N | 1 |
| Bräsen, JH | 1 |
| Lee, EW | 1 |
| Van der Veken, P | 1 |
| Joossens, J | 1 |
| Augustyns, K | 1 |
| Fulda, S | 1 |
| Linkermann, A | 1 |
| Song, J | 1 |
| Vandenabeele, P | 1 |
| Toropova, YG | 1 |
| Pechnikova, NA | 1 |
| Zelinskaya, IA | 1 |
| Zhuravsky, SG | 1 |
| Kornyushin, OV | 1 |
| Gonchar, AI | 1 |
| Ivkin, DY | 1 |
| Leonova, YV | 1 |
| Karev, VE | 1 |
| Karabak, IA | 1 |
| Yan, H | 1 |
| Jihong, Y | 1 |
| Feng, Z | 1 |
| Xiaomei, X | 1 |
| Xiaohan, Z | 1 |
| Guangzhi, W | 1 |
| Zhenhai, M | 1 |
| Dongyan, G | 1 |
| Xiaochi, M | 1 |
| Qing, F | 1 |
| Kexin, L | 1 |
| Xiaofeng, T | 1 |
| Bagnenko, SF | 1 |
| Sinenchenko, GI | 1 |
| Kurygin, AA | 1 |
| Chupris, VG | 1 |
| Khodosovskiĭ, MN | 1 |
| Zinchuk, VV | 1 |
| Chlopicki, S | 1 |
| Ponomarev, EA | 2 |
| Maskin, SS | 2 |
| Strepetov, NN | 2 |
| Mochaĭlo, IuA | 1 |
| Pchelintsev, KE | 1 |
| Petrov, VI | 1 |
| Yang, YY | 1 |
| Huang, YT | 1 |
| Lee, TY | 1 |
| Chan, CC | 1 |
| Yeh, YC | 1 |
| Lee, KC | 1 |
| Lin, HC | 1 |
| Tiuriaeva, II | 1 |
| Kuranova, ML | 1 |
| Gonchar, IV | 1 |
| Rozanov, IuM | 1 |
| Yang, J | 2 |
| Klaidman, LK | 1 |
| Adams, JD | 2 |
| Bozlu, M | 1 |
| Eskandari, G | 1 |
| Cayan, S | 1 |
| Canpolat, B | 1 |
| Akbay, E | 1 |
| Atik, U | 1 |
| Gupta, S | 1 |
| Kaul, CL | 1 |
| Sharma, SS | 1 |
| Bul'on, VV | 1 |
| Krylova, IB | 1 |
| Evdokimova, NR | 1 |
| Kovalenko, AL | 1 |
| Alekseeva, LE | 1 |
| Sapronov, NS | 1 |
| Turan, NN | 1 |
| Demiryürek, AT | 1 |
| Iwamoto, T | 1 |
| Kita, S | 1 |
| Su, CF | 1 |
| Liu, DD | 1 |
| Kao, SJ | 1 |
| Chen, HI | 1 |
| Klein, HH | 1 |
| Pich, S | 1 |
| Lindert-Heimberg, S | 1 |
| Schade-Brittinger, C | 1 |
| Maisch, B | 1 |
| Nebendahl, K | 1 |
| Naito, A | 1 |
| Aniya, Y | 1 |
| Sakanashi, M | 1 |
| Yamashita, M | 1 |
| Schmid, RA | 1 |
| Fujino, S | 1 |
| Cooper, JD | 1 |
| Patterson, GA | 1 |
| Toyoda, T | 1 |
| Kassell, NF | 1 |
| Lee, KS | 1 |
| Masaki, Y | 1 |
| Kumano, K | 1 |
| Endo, T | 1 |
| Iwamura, M | 1 |
| Koshiba, K | 1 |
| Yokota, K | 1 |
| Okubo, M | 1 |
| Sun, AY | 1 |
| Cheng, JS | 1 |
| Hashimoto, H | 1 |
| Ohta, S | 1 |
| Utsunomiya, H | 1 |
| Kumon, Y | 1 |
| Sakaki, S | 1 |
| Matsuda, S | 1 |
| Sakanaka, M | 1 |
| Zingarelli, B | 1 |
| Scott, GS | 1 |
| Hake, P | 1 |
| Salzman, AL | 1 |
| Szabo, C | 1 |
| Frantseva, MV | 2 |
| Carlen, PL | 2 |
| Perez Velazquez, JL | 2 |
| Chatterjee, PK | 1 |
| Zacharowski, K | 1 |
| Cuzzocrea, S | 1 |
| Otto, M | 1 |
| Thiemermann, C | 2 |
| Yokota, R | 1 |
| Fukai, M | 1 |
| Shimamura, T | 1 |
| Suzuki, T | 1 |
| Watanabe, Y | 1 |
| Nagashima, K | 1 |
| Kishida, A | 1 |
| Furukawa, H | 1 |
| Hayashi, T | 1 |
| Todo, S | 1 |
| Chang, ML | 1 |
| Kem, S | 1 |
| Klaidman, L | 1 |
| Sugawara, T | 1 |
| Chan, PH | 1 |
| Hanaki, Y | 1 |
| Sugiyama, S | 1 |
| Ajioka, M | 1 |
| Kondo, T | 1 |
| Fukushima, A | 1 |
| Ozawa, T | 1 |
1 review available for niacinamide and Reperfusion Injury
| Article | Year |
|---|---|
Medicinal chemistry of nicotinamide in the treatment of ischemia and reperfusion.
Topics: Animals; Humans; Ischemia; MELAS Syndrome; NAD; Niacinamide; Oxidative Stress; Poly(ADP-ribose) Poly | 2002 |
33 other studies available for niacinamide and Reperfusion Injury
| Article | Year |
|---|---|
Nicaraven Attenuates Postoperative Systemic Inflammatory Responses-Induced Tumor Metastasis.
Topics: Animals; Cytokines; Inflammation; Lung; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; Neoplasm Met | 2020 |
Differential role of nicotinamide adenine dinucleotide deficiency in acute and chronic kidney disease.
Topics: Acute Kidney Injury; Animals; Antineoplastic Agents; Cisplatin; Disease Models, Animal; Disease Prog | 2021 |
Effect of NAD+ boosting on kidney ischemia-reperfusion injury.
Topics: Acute Kidney Injury; Animals; Autophagy; Disease Progression; Fibrosis; Glucuronidase; Kidney; Kloth | 2021 |
Sorafenib tosylate inhibits directly necrosome complex formation and protects in mouse models of inflammation and tissue injury.
Topics: Animals; Apoptosis; Cell Death; Disease Models, Animal; Humans; Inflammation; Mice; Necrosis; Niacin | 2017 |
Nicotinamide riboside has protective effects in a rat model of mesenteric ischaemia-reperfusion.
Topics: Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Endothelium, Vascular; Intestine, Sma | 2018 |
Sirtuin 1-mediated inhibition of p66shc expression alleviates liver ischemia/reperfusion injury.
Topics: Abietanes; Analysis of Variance; Animals; Caspases; Enzyme Inhibitors; Hep G2 Cells; Humans; In Situ | 2014 |
[Correction of a reperfusion dysfunction in acute intestinal obstruction].
Topics: Acute Disease; Animals; Digestive System Surgical Procedures; Disease Models, Animal; Dogs; Drug Com | 2008 |
[Effect of 1-methylnicotinamide on prooxidant-antioxidant balance parameters in rats during hepatic ischemia-reperfusion].
Topics: Animals; Antioxidants; Liver; Liver Diseases; Male; Niacinamide; Rats; Rats, Wistar; Reperfusion Inj | 2010 |
[Pharmacologic neuroprotection of the brain in carotid artery surgeries].
Topics: Aged; Brain; Carotid Arteries; Carotid Stenosis; Drug Combinations; Endarterectomy, Carotid; Female; | 2011 |
[Pharmacological neuroprotection against brain damage in ischemiai/reperfusion experiment].
Topics: Animals; Brain; Drug Combinations; Drug Evaluation, Preclinical; Eosine Yellowish-(YS); Flavin Monon | 2011 |
Rho-kinase-dependent pathway mediates the hepatoprotective effects of sorafenib against ischemia/reperfusion liver injury in rats with nonalcoholic steatohepatitis.
Topics: Animals; Apoptosis; Disease Models, Animal; Fatty Liver; Gene Expression Regulation, Enzymologic; He | 2012 |
[Energy corrective and antioxidative actions of cytoflavin during postischemic period of human dermal fibroblasts in vitro].
Topics: Adenosine Triphosphate; Antioxidants; Blotting, Western; Cell Culture Techniques; Cell Cycle; Cell P | 2012 |
The effect of poly (adenosine diphosphate-ribose) polymerase inhibitors on biochemical changes in testicular ischemia-reperfusion injury.
Topics: 1-Naphthylamine; Animals; Benzamides; Isoquinolines; Male; Naphthalimides; Niacinamide; Poly(ADP-rib | 2003 |
Neuroprotective effect of combination of poly (ADP-ribose) polymerase inhibitor and antioxidant in middle cerebral artery occlusion induced focal ischemia in rats.
Topics: Animals; Antioxidants; Benzamides; Brain Ischemia; Disease Models, Animal; Drug Combinations; Drug T | 2004 |
Effects of cytoflavin and neuronol on morphological changes in the brain and survival of rats with ischemic disturbances in cerebral blood flow.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Drug Combinations; Flavin Mononucleotid | 2004 |
Preconditioning effects of peroxynitrite in the rat lung.
Topics: Animals; Benzamides; Enzyme Inhibitors; In Vitro Techniques; Ischemic Preconditioning; Lung; Male; M | 2006 |
YM-244769, a novel Na+/Ca2+ exchange inhibitor that preferentially inhibits NCX3, efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage.
Topics: Animals; Base Sequence; Cell Hypoxia; Cell Line; Cell Line, Tumor; Cricetinae; DNA Primers; Humans; | 2006 |
Nicotinamide abrogates acute lung injury caused by ischaemia/reperfusion.
Topics: Adenosine Triphosphate; Analysis of Variance; Animals; Disease Models, Animal; Free Radicals; Interl | 2007 |
Comparative study on the effects of intracoronary nicorandil and nitroglycerin in ischaemic, reperfused porcine hearts.
Topics: Animals; Female; Hemodynamics; Injections, Intra-Arterial; Male; Niacinamide; Nicorandil; Nitroglyce | 1995 |
Antioxidative action of the nitrovasodilator nicorandil: inhibition of oxidative activation of liver microsomal glutathione S-transferase and lipid peroxidation.
Topics: Animals; Antioxidants; Dose-Response Relationship, Drug; Enzyme Activation; Glutathione Transferase; | 1994 |
Nicorandil, a potent adenosine triphosphate-sensitive potassium-channel opener, ameliorates lung allograft reperfusion injury.
Topics: Animals; Dogs; Hemodynamics; Lung; Lung Transplantation; Niacinamide; Nicorandil; Potassium Channels | 1996 |
Attenuation of ischemia-reperfusion injury in the rat neocortex by the hydroxyl radical scavenger nicaraven.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Cerebral Infarction; Free Radical Scavengers; Hydroxyl Rad | 1997 |
Protective effect of nicaraven against prolonged cold kidney preservation and reperfusion injury.
Topics: Adenosine; Allopurinol; Animals; Antioxidants; Cold Temperature; Creatinine; Diuresis; Dogs; Glutath | 1998 |
Neuroprotective effects of poly (ADP-ribose) polymerase inhibitors in transient focal cerebral ischemia of rats.
Topics: ADP Ribose Transferases; Animals; Benzamides; Brain; Enzyme Inhibitors; Ischemic Attack, Transient; | 1998 |
Changes in guanylate cyclase activity in arteriolar smooth muscle cells and hemodynamics after ischemia-reperfusion in rats.
Topics: Animals; Cerebrovascular Circulation; Enzyme Inhibitors; Free Radical Scavengers; Free Radicals; Gua | 1999 |
Effects of nicaraven on nitric oxide-related pathways and in shock and inflammation.
Topics: Animals; Antioxidants; Arthritis, Experimental; Carrageenan; Dose-Response Relationship, Drug; Edema | 2000 |
Molecular mechanisms of free radical production and protective efficacies of antioxidants in in vitro ischemia-reperfusion.
Topics: Animals; Antioxidants; Cyclosporine; Free Radicals; Glutathione; Hippocampus; Niacinamide; Organ Cul | 1999 |
Inhibitors of poly (ADP-ribose) synthetase reduce renal ischemia-reperfusion injury in the anesthetized rat in vivo.
Topics: Anesthesia; Animals; Benzamides; Creatinine; Enzyme Inhibitors; Glomerular Filtration Rate; Isoquino | 2000 |
A novel hydroxyl radical scavenger, nicaraven, protects the liver from warm ischemia and reperfusion injury.
Topics: Adenine Nucleotides; Animals; Dogs; Endothelin-1; Female; Free Radical Scavengers; Hemodynamics; Hum | 2000 |
Inhibition of the activity of poly (ADP-ribose) polymerase in ischemia-reperfusion injury.
Topics: Animals; DNA Damage; Drug Design; Energy Metabolism; Enzyme Inhibitors; Feedback; Humans; Ischemia; | 2000 |
Dynamics of intracellular calcium and free radical production during ischemia in pyramidal neurons.
Topics: Aniline Compounds; Animals; Brain Ischemia; Calcium; Calcium Channels; Calcium-Binding Proteins; Cul | 2001 |
Nicotinamide and ketamine reduce infarct volume and DNA fragmentation in rats after brain ischemia and reperfusion.
Topics: Animals; Brain Ischemia; Cerebral Infarction; DNA Fragmentation; Excitatory Amino Acid Antagonists; | 2002 |
Acceleration of recovery of mitochondrial function after coronary reperfusion by various coronary dilating drugs in canine hearts.
Topics: Animals; Blood Pressure; Coronary Circulation; Dilazep; Diltiazem; Dogs; Female; Heart Rate; Hemodyn | 1989 |