niacinamide has been researched along with Neuroblastoma in 25 studies
nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mice with subcutaneous neuroblastoma xenografts or orthotopic adrenal tumors were treated with sorafenib, and tumor growth rates were measured." | 7.78 | Sorafenib inhibits neuroblastoma cell proliferation and signaling, blocks angiogenesis, and impairs tumor growth. ( Chlenski, A; Cohn, SL; Guerrero, LJ; Kakodkar, NC; Maitland, ML; Peddinti, RR; Salwen, HR; Tian, Y; Yang, Q, 2012) |
| "Metastatic neuroblastoma is an aggressive malignancy with a poor prognosis." | 5.43 | Sorafenib treatment in children with relapsed and refractory neuroblastoma: an experience of four cases. ( Fujisaki, H; Hara, J; Nakano, Y; Nitani, C; Okada, K; Yamasaki, K, 2016) |
| "Sorafenib is a multikinase inhibitor that is approved for use against renal cell and hepatocellular carcinoma." | 5.38 | Sorafenib-induced mitochondrial complex I inactivation and cell death in human neuroblastoma cells. ( Bull, VH; Rajalingam, K; Thiede, B, 2012) |
| "Neuroblastoma is the most common extracranial solid tumor in the pediatric population." | 5.38 | Sorafenib inhibits endogenous and IL-6/S1P induced JAK2-STAT3 signaling in human neuroblastoma, associated with growth suppression and apoptosis. ( Ara, T; Buettner, R; DeClerck, YA; Jove, R; Jove, V; Nam, S; Seeger, R; Wang, Y; Wu, J; Xin, H; Xu, Y; Yang, F; Yu, H, 2012) |
| "Neuroblastoma is an extracranial, solid, and heterogeneous malignancy in children." | 5.36 | Synergistic efficacy of sorafenib and genistein in growth inhibition by down regulating angiogenic and survival factors and increasing apoptosis through upregulation of p53 and p21 in malignant neuroblastoma cells having N-Myc amplification or non-amplifi ( Banik, NL; Karmakar, S; Ray, SK; Roy Choudhury, S, 2010) |
| "Sorafenib is a multikinase inhibitor that also inhibits STAT3 signaling and induces apoptosis." | 5.36 | Sorafenib downregulates ERK/Akt and STAT3 survival pathways and induces apoptosis in a human neuroblastoma cell line. ( Brown, RE; Chai, H; Luo, AZ; Weerasinghe, P, 2010) |
| "Mice with subcutaneous neuroblastoma xenografts or orthotopic adrenal tumors were treated with sorafenib, and tumor growth rates were measured." | 3.78 | Sorafenib inhibits neuroblastoma cell proliferation and signaling, blocks angiogenesis, and impairs tumor growth. ( Chlenski, A; Cohn, SL; Guerrero, LJ; Kakodkar, NC; Maitland, ML; Peddinti, RR; Salwen, HR; Tian, Y; Yang, Q, 2012) |
| "NG108-15 neuroblastoma x glioma somatic hybrid cells were permeabilized in the presence of [32P]NAD+ and then cultured for 18 h." | 3.68 | Gs alpha is a substrate for mono(ADP-ribosyl)transferase of NG108-15 cells. ADP-ribosylation regulates Gs alpha activity and abundance. ( Boyd, RS; Donnelly, LE; MacDermot, J, 1992) |
| "Metastatic neuroblastoma is an aggressive malignancy with a poor prognosis." | 1.43 | Sorafenib treatment in children with relapsed and refractory neuroblastoma: an experience of four cases. ( Fujisaki, H; Hara, J; Nakano, Y; Nitani, C; Okada, K; Yamasaki, K, 2016) |
| "Sorafenib is a multikinase inhibitor that is approved for use against renal cell and hepatocellular carcinoma." | 1.38 | Sorafenib-induced mitochondrial complex I inactivation and cell death in human neuroblastoma cells. ( Bull, VH; Rajalingam, K; Thiede, B, 2012) |
| "Neuroblastoma is the most common extracranial solid tumor in the pediatric population." | 1.38 | Sorafenib inhibits endogenous and IL-6/S1P induced JAK2-STAT3 signaling in human neuroblastoma, associated with growth suppression and apoptosis. ( Ara, T; Buettner, R; DeClerck, YA; Jove, R; Jove, V; Nam, S; Seeger, R; Wang, Y; Wu, J; Xin, H; Xu, Y; Yang, F; Yu, H, 2012) |
| "Neuroblastoma is an extracranial, solid, and heterogeneous malignancy in children." | 1.36 | Synergistic efficacy of sorafenib and genistein in growth inhibition by down regulating angiogenic and survival factors and increasing apoptosis through upregulation of p53 and p21 in malignant neuroblastoma cells having N-Myc amplification or non-amplifi ( Banik, NL; Karmakar, S; Ray, SK; Roy Choudhury, S, 2010) |
| "Sorafenib is a multikinase inhibitor that also inhibits STAT3 signaling and induces apoptosis." | 1.36 | Sorafenib downregulates ERK/Akt and STAT3 survival pathways and induces apoptosis in a human neuroblastoma cell line. ( Brown, RE; Chai, H; Luo, AZ; Weerasinghe, P, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (12.00) | 18.7374 |
| 1990's | 6 (24.00) | 18.2507 |
| 2000's | 2 (8.00) | 29.6817 |
| 2010's | 13 (52.00) | 24.3611 |
| 2020's | 1 (4.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zandona, A | 1 |
| Lihtar, G | 1 |
| Maraković, N | 1 |
| Miš, K | 1 |
| Bušić, V | 1 |
| Gašo-Sokač, D | 1 |
| Pirkmajer, S | 1 |
| Katalinić, M | 1 |
| Song, HY | 1 |
| Rellinger, EJ | 1 |
| Park, SH | 2 |
| Paul, P | 1 |
| Qiao, J | 1 |
| Vasilopoulos, A | 1 |
| Ozden, O | 1 |
| Gius, D | 1 |
| Chung, DH | 1 |
| Buonvicino, D | 1 |
| Mazzola, F | 1 |
| Zamporlini, F | 1 |
| Resta, F | 1 |
| Ranieri, G | 1 |
| Camaioni, E | 1 |
| Muzzi, M | 1 |
| Zecchi, R | 1 |
| Pieraccini, G | 1 |
| Dölle, C | 1 |
| Calamante, M | 1 |
| Bartolucci, G | 1 |
| Ziegler, M | 1 |
| Stecca, B | 1 |
| Raffaelli, N | 1 |
| Chiarugi, A | 1 |
| Milani, ZH | 1 |
| Ramsden, DB | 2 |
| Parsons, RB | 2 |
| Thompson, PA | 1 |
| Drissi, R | 1 |
| Muscal, JA | 1 |
| Panditharatna, E | 1 |
| Fouladi, M | 1 |
| Ingle, AM | 1 |
| Ahern, CH | 1 |
| Reid, JM | 1 |
| Lin, T | 1 |
| Weigel, BJ | 1 |
| Blaney, SM | 1 |
| Okada, K | 1 |
| Nakano, Y | 1 |
| Yamasaki, K | 1 |
| Nitani, C | 1 |
| Fujisaki, H | 1 |
| Hara, J | 1 |
| Kim, MJ | 1 |
| Ahn, K | 1 |
| Kang, HJ | 1 |
| Jang, BG | 1 |
| Oh, SJ | 1 |
| Oh, SM | 1 |
| Jeong, YJ | 1 |
| Heo, JI | 1 |
| Suh, JG | 1 |
| Lim, SS | 1 |
| Ko, YJ | 1 |
| Huh, SO | 1 |
| Kim, SC | 1 |
| Park, JB | 1 |
| Kim, J | 1 |
| Kim, JI | 1 |
| Jo, SA | 1 |
| Lee, JY | 1 |
| Roy Choudhury, S | 1 |
| Karmakar, S | 1 |
| Banik, NL | 1 |
| Ray, SK | 1 |
| Chai, H | 1 |
| Luo, AZ | 1 |
| Weerasinghe, P | 1 |
| Brown, RE | 1 |
| Pizarro, JG | 1 |
| Verdaguer, E | 1 |
| Ancrenaz, V | 1 |
| Junyent, F | 1 |
| Sureda, F | 1 |
| Pallàs, M | 1 |
| Folch, J | 1 |
| Camins, A | 1 |
| Aravindan, S | 1 |
| Kadampeswaran, A | 1 |
| Evans, EA | 1 |
| Sandhu, KK | 1 |
| Levy, ER | 1 |
| Thomas, MG | 1 |
| Austen, BM | 1 |
| Han, J | 1 |
| Shi, S | 1 |
| Min, L | 1 |
| Wu, T | 1 |
| Xia, W | 1 |
| Ying, W | 1 |
| Kakodkar, NC | 1 |
| Peddinti, RR | 1 |
| Tian, Y | 1 |
| Guerrero, LJ | 1 |
| Chlenski, A | 1 |
| Yang, Q | 1 |
| Salwen, HR | 1 |
| Maitland, ML | 1 |
| Cohn, SL | 1 |
| Bull, VH | 1 |
| Rajalingam, K | 1 |
| Thiede, B | 1 |
| Yang, F | 1 |
| Jove, V | 1 |
| Buettner, R | 1 |
| Xin, H | 1 |
| Wu, J | 1 |
| Wang, Y | 1 |
| Nam, S | 1 |
| Xu, Y | 1 |
| Ara, T | 1 |
| DeClerck, YA | 1 |
| Seeger, R | 1 |
| Yu, H | 1 |
| Jove, R | 1 |
| Jia, H | 1 |
| Li, X | 2 |
| Gao, H | 1 |
| Feng, Z | 1 |
| Zhao, L | 1 |
| Jia, X | 1 |
| Zhang, H | 1 |
| Liu, J | 1 |
| Donnelly, LE | 2 |
| Boyd, RS | 2 |
| Williams, RJ | 1 |
| Kelly, E | 1 |
| MacDermot, J | 2 |
| Willets, JM | 1 |
| Lunec, J | 1 |
| Williams, AC | 1 |
| Griffiths, HR | 1 |
| Cookson, MR | 1 |
| Ince, PG | 1 |
| Shaw, PJ | 1 |
| Fonti, R | 1 |
| Cheung, NK | 1 |
| Bridger, GJ | 1 |
| Guo, HF | 1 |
| Abrams, MJ | 1 |
| Larson, SM | 1 |
| Kolbe, H | 1 |
| Keller, K | 2 |
| Lange, K | 2 |
| Herken, H | 2 |
| Zeitz, M | 1 |
| Wintzerith, M | 1 |
| Dierich, A | 1 |
| Mandel, P | 1 |
| Roerig, SC | 1 |
| Loh, HH | 1 |
| Law, PY | 1 |
1 trial available for niacinamide and Neuroblastoma
| Article | Year |
|---|---|
A phase I trial of imetelstat in children with refractory or recurrent solid tumors: a Children's Oncology Group Phase I Consortium Study (ADVL1112).
Topics: Adolescent; Antineoplastic Agents; Area Under Curve; Bone Neoplasms; Child; Child, Preschool; Drug A | 2013 |
24 other studies available for niacinamide and Neuroblastoma
| Article | Year |
|---|---|
Vitamin B3-Based Biologically Active Compounds as Inhibitors of Human Cholinesterases.
Topics: Acetylcholinesterase; Butyrylcholinesterase; Catalytic Domain; Cell Proliferation; Cholinesterase In | 2020 |
Inhibition of Sirtuin 6 Induces Neuroblastoma Differentiation.
Topics: Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Gene K | 2018 |
Identification of the Nicotinamide Salvage Pathway as a New Toxification Route for Antimetabolites.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Survival; Glycolysis; Humans; Melan | 2018 |
Neuroprotective effects of nicotinamide N-methyltransferase and its metabolite 1-methylnicotinamide.
Topics: 2,4-Dinitrophenol; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Humans; Mitochondria; N | 2013 |
Sorafenib treatment in children with relapsed and refractory neuroblastoma: an experience of four cases.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Child, Preschool; Drug Resist | 2016 |
SIRT1 regulates tyrosine hydroxylase expression and differentiation of neuroblastoma cells via FOXO3a.
Topics: Antineoplastic Agents; Cell Differentiation; Cell Line, Tumor; Collagen Type XI; Forkhead Box Protei | 2009 |
Synergistic efficacy of sorafenib and genistein in growth inhibition by down regulating angiogenic and survival factors and increasing apoptosis through upregulation of p53 and p21 in malignant neuroblastoma cells having N-Myc amplification or non-amplifi
Topics: Angiogenesis Inducing Agents; Apoptosis; bcl-2-Associated X Protein; Benzenesulfonates; Caspase 3; C | 2010 |
Sorafenib downregulates ERK/Akt and STAT3 survival pathways and induces apoptosis in a human neuroblastoma cell line.
Topics: Antineoplastic Agents; Apoptosis; Benzenesulfonates; Blotting, Western; Cell Line, Tumor; Cell Survi | 2010 |
Resveratrol inhibits proliferation and promotes apoptosis of neuroblastoma cells: role of sirtuin 1.
Topics: Animals; Antineoplastic Agents, Phytogenic; Apoptosis; Benzamides; Cell Cycle; Cell Line, Tumor; Cel | 2011 |
The expression of nicotinamide N-methyltransferase increases ATP synthesis and protects SH-SY5Y neuroblastoma cells against the toxicity of Complex I inhibitors.
Topics: 1-Methyl-4-phenylpyridinium; Adenosine Triphosphate; Cell Line, Tumor; Electron Transport Complex I; | 2011 |
NAD+ treatment induces delayed autophagy in Neuro2a cells partially by increasing oxidative stress.
Topics: Animals; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Cell Survival; Mice; Microtubule-Associ | 2011 |
Sorafenib inhibits neuroblastoma cell proliferation and signaling, blocks angiogenesis, and impairs tumor growth.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Benzenesulfonates; Cell Cycle; Cell Line, T | 2012 |
Sorafenib-induced mitochondrial complex I inactivation and cell death in human neuroblastoma cells.
Topics: Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Benzenesulfonates; Cell Line, Tumor | 2012 |
Sorafenib inhibits endogenous and IL-6/S1P induced JAK2-STAT3 signaling in human neuroblastoma, associated with growth suppression and apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Benzenesulfonates; Cell Li | 2012 |
High doses of nicotinamide prevent oxidative mitochondrial dysfunction in a cellular model and improve motor deficit in a Drosophila model of Parkinson's disease.
Topics: alpha-Synuclein; Animals; Animals, Genetically Modified; Cell Line, Tumor; Cell Survival; Disease Mo | 2008 |
Inhibition of ADP-ribosyltransferase increases synthesis of Gs alpha in neuroblastoma x glioma hybrid cells and reverses iloprost-dependent heterologous loss of fluoride-sensitive adenylate cyclase.
Topics: Adenylyl Cyclase Inhibitors; ADP Ribose Transferases; Blood Platelets; Fluorides; Glioma; GTP-Bindin | 1995 |
Neurotoxicity of nicotinamide derivatives: their role in the aetiology of Parkinson's disease.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Cell Survival; Humans; Isomerism; Kinetics; L-Lactate Dehydrog | 1993 |
Peroxynitrite and hydrogen peroxide induced cell death in the NSC34 neuroblastoma x spinal cord cell line: role of poly (ADP-ribose) polymerase.
Topics: Animals; Benzamides; Cell Death; Cell Survival; Dactinomycin; DNA Damage; Enzyme Inhibitors; Hybrid | 1998 |
99mTc-monoclonal antibody radiolabeled via hydrazino nicotinamide derivative for imaging disialoganglioside G(D2)-positive tumors.
Topics: Animals; Antibodies, Monoclonal; Gangliosides; Humans; Iodine Radioisotopes; Mice; Mice, Nude; Neuro | 1999 |
Metabolic consequences of drug-induced inhibition of the pentose phosphate pathway in neuroblastoma and glioma cells.
Topics: 6-Aminonicotinamide; Animals; Brain; Cell Line; Glioma; Gluconates; Glucose; Glucosephosphates; Lact | 1976 |
Effects of 6-aminonicotinamide on growth and acetylcholinesterase activity during differentiation of neuroblastoma cells in vitro.
Topics: 6-Aminonicotinamide; Acetylcholinesterase; Cell Differentiation; Cell Division; Cells, Cultured; Neo | 1978 |
Nicotinamide deamidase released by neuroblastoma cell cultures.
Topics: Amidohydrolases; Animals; Cell Line; Chromatography, Gas; Mass Spectrometry; Mice; Neuroblastoma; Ni | 1979 |
Gs alpha is a substrate for mono(ADP-ribosyl)transferase of NG108-15 cells. ADP-ribosylation regulates Gs alpha activity and abundance.
Topics: Adenosine Diphosphate Ribose; ADP Ribose Transferases; Blotting, Western; Cholera Toxin; Glioma; GTP | 1992 |
Requirement of ADP-ribosylation for the pertussis toxin-induced alteration in electrophoretic mobility of G-proteins.
Topics: Adenosine Diphosphate Ribose; Animals; Autoradiography; Cell Line; Electrophoresis, Polyacrylamide G | 1991 |