niacinamide has been researched along with Nerve Degeneration in 19 studies
nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.
Nerve Degeneration: Loss of functional activity and trophic degeneration of nerve axons and their terminal arborizations following the destruction of their cells of origin or interruption of their continuity with these cells. The pathology is characteristic of neurodegenerative diseases. Often the process of nerve degeneration is studied in research on neuroanatomical localization and correlation of the neurophysiology of neural pathways.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neuroinflammation is initiated by activation of the brain's innate immune system in response to an inflammatory challenge." | 5.62 | Inhibition of CD38 and supplementation of nicotinamide riboside ameliorate lipopolysaccharide-induced microglial and astrocytic neuroinflammation by increasing NAD ( Brenner, C; Hattori, T; Heer, CD; Higashida, H; Hori, O; Ishii, H; Nguyen, DT; O'Meally, D; Okamoto, H; Roboon, J; Takarada-Iemata, M; Yamamoto, Y, 2021) |
| "Clinical studies have reported that the nicotinic receptor agonist varenicline improves balance and coordination in patients with several types of ataxia, but confirmation in an animal model has not been demonstrated." | 3.79 | Neuronal nicotinic receptor agonists improve gait and balance in olivocerebellar ataxia. ( Antilla, JC; Bickford, PC; Engberg, ME; Hudson, CE; Kang, CW; Lambert, CS; Philpot, RM; Rowell, PP; Wecker, L; Zesiewicz, TA, 2013) |
| "Neuroinflammation is initiated by activation of the brain's innate immune system in response to an inflammatory challenge." | 1.62 | Inhibition of CD38 and supplementation of nicotinamide riboside ameliorate lipopolysaccharide-induced microglial and astrocytic neuroinflammation by increasing NAD ( Brenner, C; Hattori, T; Heer, CD; Higashida, H; Hori, O; Ishii, H; Nguyen, DT; O'Meally, D; Okamoto, H; Roboon, J; Takarada-Iemata, M; Yamamoto, Y, 2021) |
| "Familial forms of Alzheimer's disease associated with the accumulation of a toxic form of amyloid-β (Aβ) peptides are linked to mitochondrial impairment." | 1.62 | Parp mutations protect from mitochondrial toxicity in Alzheimer's disease. ( Celardo, I; Fedele, G; Loh, SHY; Martins, LM; Yu, Y, 2021) |
| " That a lesion of the inferior olive almost completely prevents the neurotoxicity demonstrates that ibogaine is not directly toxic to Purkinje cells, but that the toxicity is indirect and dependent on integrity of the olivocerebellar projection." | 1.30 | The olivocerebellar projection mediates ibogaine-induced degeneration of Purkinje cells: a model of indirect, trans-synaptic excitotoxicity. ( Molliver, ME; O'Hearn, E, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (15.79) | 18.7374 |
| 1990's | 3 (15.79) | 18.2507 |
| 2000's | 4 (21.05) | 29.6817 |
| 2010's | 5 (26.32) | 24.3611 |
| 2020's | 4 (21.05) | 2.80 |
| Authors | Studies |
|---|---|
| Kitaoka, Y | 1 |
| Sase, K | 1 |
| Tsukahara, C | 1 |
| Fujita, N | 1 |
| Arizono, I | 1 |
| Takagi, H | 1 |
| Obrador, E | 1 |
| Salvador, R | 1 |
| Marchio, P | 1 |
| López-Blanch, R | 1 |
| Jihad-Jebbar, A | 1 |
| Rivera, P | 1 |
| Vallés, SL | 1 |
| Banacloche, S | 1 |
| Alcácer, J | 1 |
| Colomer, N | 1 |
| Coronado, JA | 1 |
| Alandes, S | 1 |
| Drehmer, E | 1 |
| Benlloch, M | 1 |
| Estrela, JM | 1 |
| Roboon, J | 1 |
| Hattori, T | 1 |
| Ishii, H | 1 |
| Takarada-Iemata, M | 1 |
| Nguyen, DT | 1 |
| Heer, CD | 1 |
| O'Meally, D | 1 |
| Brenner, C | 2 |
| Yamamoto, Y | 1 |
| Okamoto, H | 1 |
| Higashida, H | 1 |
| Hori, O | 1 |
| Yu, Y | 1 |
| Fedele, G | 1 |
| Celardo, I | 1 |
| Loh, SHY | 1 |
| Martins, LM | 1 |
| Liu, HW | 1 |
| Smith, CB | 1 |
| Schmidt, MS | 1 |
| Cambronne, XA | 1 |
| Cohen, MS | 1 |
| Migaud, ME | 1 |
| Goodman, RH | 1 |
| Harrison, IF | 1 |
| Powell, NM | 1 |
| Dexter, DT | 1 |
| Wecker, L | 1 |
| Engberg, ME | 1 |
| Philpot, RM | 1 |
| Lambert, CS | 1 |
| Kang, CW | 1 |
| Antilla, JC | 1 |
| Bickford, PC | 1 |
| Hudson, CE | 1 |
| Zesiewicz, TA | 1 |
| Rowell, PP | 1 |
| Ullah, N | 1 |
| Ullah, I | 1 |
| Lee, HY | 1 |
| Naseer, MI | 1 |
| Seok, PM | 1 |
| Ahmed, J | 1 |
| Kim, MO | 1 |
| Wang, HL | 1 |
| Hu, SH | 1 |
| Chou, AH | 1 |
| Wang, SS | 1 |
| Weng, YH | 1 |
| Yeh, TH | 1 |
| Chong, ZZ | 1 |
| Lin, SH | 1 |
| Li, F | 1 |
| Maiese, K | 1 |
| Anderson, DW | 1 |
| Bradbury, KA | 1 |
| Schneider, JS | 1 |
| Holland, MA | 1 |
| Tan, AA | 1 |
| Smith, DC | 1 |
| Hoane, MR | 1 |
| Sotelo, C | 1 |
| Rio, JP | 1 |
| Klaidman, LK | 1 |
| Mukherjee, SK | 1 |
| Hutchin, TP | 1 |
| Adams, JD | 1 |
| Fallon, J | 1 |
| Matthews, RT | 1 |
| Hyman, BT | 1 |
| Beal, MF | 1 |
| O'Hearn, E | 1 |
| Molliver, ME | 1 |
| Tolbert, DL | 1 |
| Clark, BR | 1 |
| Politis, MJ | 1 |
| Meyer-König, E | 1 |
19 other studies available for niacinamide and Nerve Degeneration
| Article | Year |
|---|---|
Axonal Protection by Nicotinamide Riboside via SIRT1-Autophagy Pathway in TNF-Induced Optic Nerve Degeneration.
Topics: Animals; Autophagy; Axons; Male; Microtubule-Associated Proteins; Nerve Degeneration; Neuroprotectio | 2020 |
Nicotinamide Riboside and Pterostilbene Cooperatively Delay Motor Neuron Failure in ALS SOD1
Topics: Acetylcysteine; Amyotrophic Lateral Sclerosis; Animals; Antioxidants; Apoptosis; Cytokines; Female; | 2021 |
Inhibition of CD38 and supplementation of nicotinamide riboside ameliorate lipopolysaccharide-induced microglial and astrocytic neuroinflammation by increasing NAD
Topics: ADP-ribosyl Cyclase 1; Animals; Apigenin; Astrocytes; Chemokines; Cytokines; Gene Deletion; Hippocam | 2021 |
Parp mutations protect from mitochondrial toxicity in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Behavior, Animal; | 2021 |
Pharmacological bypass of NAD
Topics: Acrylamides; Animals; Antineoplastic Agents, Phytogenic; Drug Combinations; Francisella tularensis; | 2018 |
The histone deacetylase inhibitor nicotinamide exacerbates neurodegeneration in the lactacystin rat model of Parkinson's disease.
Topics: Acetylation; Acetylcysteine; Animals; Cell Death; Disease Models, Animal; Dopaminergic Neurons; Hist | 2019 |
Neuronal nicotinic receptor agonists improve gait and balance in olivocerebellar ataxia.
Topics: Animals; Ataxia; Benzazepines; Cerebellum; Dose-Response Relationship, Drug; Gait; Male; Mecamylamin | 2013 |
Protective function of nicotinamide against ketamine-induced apoptotic neurodegeneration in the infant rat brain.
Topics: Anesthetics, Dissociative; Animals; Animals, Newborn; Apoptosis; Ketamine; Nerve Degeneration; Neuro | 2012 |
H1152 promotes the degradation of polyglutamine-expanded ataxin-3 or ataxin-7 independently of its ROCK-inhibiting effect and ameliorates mutant ataxin-3-induced neurodegeneration in the SCA3 transgenic mouse.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Ataxin-3; Ataxin-7; Brain; Dose-Resp | 2013 |
The sirtuin inhibitor nicotinamide enhances neuronal cell survival during acute anoxic injury through AKT, BAD, PARP, and mitochondrial associated "anti-apoptotic" pathways.
Topics: Animals; Apoptosis; bcl-Associated Death Protein; Caspases; Cell Survival; Cells, Cultured; DNA Frag | 2005 |
Neuroprotection in Parkinson models varies with toxin administration protocol.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Antigens, Nuclear; Axons; Benzothiazoles; Bio | 2006 |
Nicotinamide treatment provides acute neuroprotection and GFAP regulation following fluid percussion injury.
Topics: Animals; Astrocytes; Behavior, Animal; Brain Chemistry; Brain Injuries; Cell Count; Cerebral Cortex; | 2008 |
Cerebellar malformation obtained in rats by early postnatal treatment with 6-aminonicotinamide. Role of neuron-glia interactions in cerebellar development.
Topics: 6-Aminonicotinamide; Animals; Cell Movement; Cerebellar Cortex; Cerebellum; Dendrites; Female; Micro | 1980 |
Nicotinamide as a precursor for NAD+ prevents apoptosis in the mouse brain induced by tertiary-butylhydroperoxide.
Topics: Animals; Apoptosis; Brain; DNA; DNA Repair; Immunohistochemistry; Injections, Intraventricular; Mice | 1996 |
MPP+ produces progressive neuronal degeneration which is mediated by oxidative stress.
Topics: 1-Methyl-4-phenylpyridinium; Animals; Coenzymes; Cyclic N-Oxides; Dopamine Agents; Drug Combinations | 1997 |
The olivocerebellar projection mediates ibogaine-induced degeneration of Purkinje cells: a model of indirect, trans-synaptic excitotoxicity.
Topics: Aminopyridines; Animals; Behavior, Animal; Cell Death; Cerebellar Cortex; Hallucinogens; Harmaline; | 1997 |
Olivocerebellar projections modify hereditary Purkinje cell degeneration.
Topics: Animals; Behavior, Animal; Calbindins; Cell Survival; Cerebellar Cortex; Denervation; Disease Models | 2000 |
6-Aminonicotinamide selectively causes necrosis in reactive astroglia cells in vivo. Preliminary morphological observations.
Topics: 6-Aminonicotinamide; Animals; Astrocytes; Cell Nucleus; Male; Necrosis; Nerve Degeneration; Niacinam | 1989 |
[Ultrastructure of glial and axonal changes in the optic nerve of the rat induced by 6-aminonicotinamide (author's transl)].
Topics: Animals; Axons; Brain Edema; Endoplasmic Reticulum; Microscopy, Electron; Nerve Degeneration; Neurog | 1973 |