niacinamide has been researched along with Muscle Relaxation in 42 studies
nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.
Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The dosage of 230 mg/kg of nicotinamide given intraperitoneally 15 min before STZ administration (65 mg/kg i." | 1.32 | Alterations in vascular endothelial function in the aorta and mesenteric artery in type II diabetic rats. ( Kamata, K; Kobayashi, T; Matsumoto, T; Wakabayashi, K, 2004) |
| "Pretreatment with methylene blue (10(-5) M) did not significantly influence the regional difference in the action of nicorandil." | 1.30 | Regional differences in the vasorelaxant effects of nicorandil and amlodipine on isolated porcine coronary arteries. ( Bagger, JP; Frøbert, O; Mikkelsen, EO; Tankó, LB, 1998) |
| " Nicorandil (3 mg/kg) given orally was rapidly absorbed, reaching the maximal plasma (approximately 2,600 ng/ml) and vascular concentrations (approximately 176 ng/g) at 15 min after the dosing and thereafter decreased rapidly." | 1.30 | Vascular levels and cGMP-increasing effects of nicorandil administered orally to rats. ( Akima, M; Kamachi, S; Kitajima, S; Moriyasu, M; Sakai, K; Tanikawa, M, 1998) |
| "Pretreatment with nicorandil 3 x 10(-7) and 3 x 10(-6) M potentiated the relaxation induced by ISO." | 1.29 | Potentiating effect of nicorandil, an antianginal agent, on relaxation induced by isoproterenol in isolated rat aorta: involvement of cyclic GMP-inhibitable cyclic AMP phosphodiesterase. ( Inoue, M; Morikawa, M; Satake, N; Shibata, S; Zhou, Q, 1995) |
| "Carbachol and SG75 were more effective in inhibiting phasic than tonic tension induced by noradrenaline in GPSMA, but substance P was more effective against tonic tension." | 1.27 | Endothelial-dependent relaxant actions of carbachol and substance P in arterial smooth muscle. ( Bolton, TB; Clapp, LH, 1986) |
| "Nicorandil is thought to be a K+ channel opening agent." | 1.27 | Studies on the mechanism of the vasodilator action of nicorandil. ( Lefer, AM; Lefer, DJ, 1988) |
| "Hydralazine was effective at similar concentrations on these three types of contraction." | 1.27 | Relaxant effects of pinacidil, nicorandil, hydralazine and nifedipine as studied in the porcine coronary artery and guinea-pig taenia coli. ( Imai, S; Matsui, K; Ogawa, Y, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (38.10) | 18.7374 |
| 1990's | 24 (57.14) | 18.2507 |
| 2000's | 2 (4.76) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Matsumoto, T | 2 |
| Wakabayashi, K | 1 |
| Kobayashi, T | 1 |
| Kamata, K | 3 |
| Ozyazgan, S | 1 |
| Kutluata, N | 1 |
| Afşar, S | 1 |
| Ozdaş, SB | 1 |
| Akkan, AG | 1 |
| Skolnick, P | 1 |
| Paul, SM | 1 |
| Sakanashi, M | 2 |
| Rokutanda, M | 1 |
| Takeo, S | 2 |
| Higuchi, M | 2 |
| Miyamoto, Y | 1 |
| Aniya, Y | 1 |
| Nakamura, Y | 1 |
| Shiraki, Y | 1 |
| Nabata, H | 1 |
| Sakai, K | 2 |
| Shibata, S | 3 |
| Satake, N | 3 |
| Takagi, T | 1 |
| Kerfoot, F | 1 |
| Suh, TK | 1 |
| Zhou, Q | 2 |
| Morikawa, M | 1 |
| Inoue, M | 1 |
| Yamashita, T | 2 |
| Masuda, Y | 2 |
| Tanaka, S | 2 |
| Atwal, KS | 1 |
| Kasai, H | 2 |
| Fukata, Y | 2 |
| Harada, K | 1 |
| Fukushima, H | 3 |
| Ogawa, N | 3 |
| Kaneta, S | 2 |
| Okada, Y | 2 |
| Yokoyama, T | 1 |
| Jinno, Y | 2 |
| Quast, U | 1 |
| Miyata, N | 3 |
| Yamaura, H | 2 |
| Tanaka, M | 1 |
| Takahashi, K | 2 |
| Tsuchida, K | 2 |
| Otomo, S | 2 |
| Miwa, A | 1 |
| Motoki, K | 1 |
| O'Rourke, ST | 1 |
| Fujiwara, T | 1 |
| Angus, JA | 1 |
| Takahashi, M | 1 |
| Omura, T | 1 |
| Takaoka, A | 1 |
| Liu, Q | 1 |
| Nakae, I | 1 |
| Kinoshita, M | 1 |
| Kita, Y | 1 |
| Hirasawa, Y | 1 |
| Kato, Y | 1 |
| Ohkubo, K | 1 |
| Ohno, M | 1 |
| Nishino, S | 1 |
| Kato, M | 1 |
| Fukuyama, S | 1 |
| Noguchi, K | 1 |
| Araki, H | 1 |
| Higuchi, S | 1 |
| Tankó, LB | 1 |
| Mikkelsen, EO | 1 |
| Frøbert, O | 1 |
| Bagger, JP | 1 |
| Moriyasu, M | 1 |
| Kitajima, S | 1 |
| Akima, M | 1 |
| Kamachi, S | 1 |
| Tanikawa, M | 1 |
| Kasuya, Y | 3 |
| Holzmann, S | 2 |
| Kukovetz, WR | 2 |
| Braida, C | 2 |
| Pöch, G | 2 |
| Greenberg, SS | 1 |
| Cantor, E | 1 |
| Ho, E | 1 |
| Walega, M | 1 |
| Borg, C | 1 |
| Mondot, S | 1 |
| Mestre, M | 1 |
| Cavero, I | 1 |
| Henry, PJ | 1 |
| Horowitz, JD | 1 |
| Louis, WJ | 1 |
| Arakawa, C | 1 |
| Miyajima, M | 1 |
| Shigenobu, K | 1 |
| Yanagisawa, T | 1 |
| Teshigawara, T | 1 |
| Taira, N | 1 |
| Allen, SL | 1 |
| Foster, RW | 1 |
| Morgan, GP | 1 |
| Small, RC | 1 |
| Bolton, TB | 1 |
| Clapp, LH | 1 |
| Lefer, DJ | 1 |
| Lefer, AM | 1 |
| Eltze, M | 1 |
| Wilson, C | 1 |
| Coldwell, MC | 1 |
| Howlett, DR | 1 |
| Cooper, SM | 1 |
| Hamilton, TC | 1 |
| Matsui, K | 1 |
| Ogawa, Y | 1 |
| Imai, S | 1 |
| Nakao, K | 1 |
| Okabe, K | 1 |
| Kitamura, K | 1 |
| Kuriyama, H | 1 |
| Weston, AH | 1 |
| Suzuki, K | 1 |
| Takagi, K | 1 |
| Satake, T | 2 |
| Sugiyama, S | 2 |
| Ozawa, T | 2 |
| Uchida, Y | 1 |
| Miyazaki, Y | 1 |
| Ogawa, K | 1 |
3 reviews available for niacinamide and Muscle Relaxation
| Article | Year |
|---|---|
The mechanism(s) of action of the benzodiazepines.
Topics: Adenosine; Animals; Anti-Anxiety Agents; Anxiety Disorders; Benzodiazepines; Caffeine; Carbolines; C | 1981 |
Pharmacology and structure-activity relationships for KATP modulators: tissue-selective KATP openers.
Topics: Action Potentials; Adenosine Triphosphate; Animals; Antihypertensive Agents; Benzopyrans; Cardiovasc | 1994 |
Do the K+ channel openers relax smooth muscle by opening K+ channels?
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Cromakalim; Humans; Inositol 1,4,5-Trisphosph | 1993 |
39 other studies available for niacinamide and Muscle Relaxation
| Article | Year |
|---|---|
Alterations in vascular endothelial function in the aorta and mesenteric artery in type II diabetic rats.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Biological Factors; Chlorides; Diabetes Mellitus, Experimen | 2004 |
Effect of glucagon-like peptide-1(7-36) and exendin-4 on the vascular reactivity in streptozotocin/nicotinamide-induced diabetic rats.
Topics: Animals; Aorta, Thoracic; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship | 2005 |
Effects of 4-aminopyridine and tetraethylammonium on relaxant responses of isolated dog coronary arteries to 2-nicotinamidoethyl nitrate (SG-75).
Topics: 4-Aminopyridine; Aminopyridines; Animals; Coronary Vessels; Dinoprost; Dogs; Female; In Vitro Techni | 1982 |
Effects of 2-nicotinamidoethyl nitrate (SG-75, nicorandil) on indomethacin-induced contractions of isolated dog coronary arteries.
Topics: Animals; Coronary Vessels; Depression, Chemical; Dogs; Epoprostenol; In Vitro Techniques; Indomethac | 1983 |
Comparative effects of nicorandil and nitroglycerin on tracheal and vascular smooth muscle in the dog, in vivo and in vitro.
Topics: Animals; Coronary Vessels; Dogs; Dose-Response Relationship, Drug; Female; Hemodynamics; In Vitro Te | 1984 |
Relaxing effect of nicorandil (N-2-(hydroxyethyl)-nicotinamide nitrate), a new anti-angina agent, on the isolated vascular smooth muscle.
Topics: Animals; Aorta, Thoracic; Basilar Artery; Calcium; Cats; Coronary Vessels; In Vitro Techniques; Male | 1984 |
The inhibitory mechanisms of nicorandil in isolated rat urinary bladder and femoral artery.
Topics: Acetylcholine; Animals; Benzopyrans; Cromakalim; Cyclic GMP; Electric Stimulation; Femoral Artery; G | 1995 |
Potentiating effect of nicorandil, an antianginal agent, on relaxation induced by isoproterenol in isolated rat aorta: involvement of cyclic GMP-inhibitable cyclic AMP phosphodiesterase.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Angina Pectoris; Animals; Aorta; Cyclic AMP; Cyclic GMP; Drug S | 1995 |
Potassium channel openers relax A23187-induced nifedipine-resistant contraction of rat aorta.
Topics: Animals; Aorta; Benzopyrans; Calcimycin; Cromakalim; In Vitro Techniques; Male; Muscle Relaxation; M | 1994 |
Dissimilarity in the mechanisms of action of KRN2391, nicorandil and cromakalim in canine renal artery.
Topics: Animals; Benzopyrans; Cromakalim; Dogs; Female; Glyburide; In Vitro Techniques; Male; Methylene Blue | 1993 |
Mechanism of action of KRN2391 in canine coronary vascular bed.
Topics: Animals; Antihypertensive Agents; Arteries; Benzopyrans; Coronary Circulation; Coronary Vessels; Cro | 1993 |
CD-832, a new dihydropyridine derivative with both nitrate-like and Ca2+ channel antagonist vasodilator activities.
Topics: Animals; Aorta, Thoracic; Brain Chemistry; Calcium Channel Blockers; Cyclic AMP; Cyclic GMP; In Vitr | 1993 |
Vasorelaxant mechanism of KRN2391 and nicorandil in porcine coronary arteries of different sizes.
Topics: Animals; Benzopyrans; Coronary Vessels; Cromakalim; Glyburide; In Vitro Techniques; Muscle Relaxatio | 1993 |
KATP channel activation mediates nicorandil-induced relaxation of nitrate-tolerant coronary arteries.
Topics: Animals; Coronary Vessels; Dose-Response Relationship, Drug; Drug Tolerance; Glyburide; In Vitro Tec | 1996 |
Analysis of relaxation and repolarization mechanisms of nicorandil in rat mesenteric artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzopyrans; Calcium Ch | 1996 |
Heterogeneity in the vasorelaxing effect of nicorandil on dog epicardial coronary arteries: comparison with other NO donors.
Topics: Animals; Atrial Natriuretic Factor; Benzopyrans; Coronary Vessels; Cromakalim; Cyclic GMP; Dogs; Fem | 1997 |
Comparison of hemodynamic effects of nitric oxide (NO) donors with different NO-releasing properties in rats.
Topics: Animals; Blood Pressure; Enzyme Inhibitors; Hematocrit; Hemodynamics; In Vitro Techniques; Isosorbid | 1997 |
Vasodilation profile of CD-832, a novel dihydropyridine derivative in rabbit aorta.
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Calcium Channel Blockers; In Vitro Techniques; | 1997 |
Regional differences in the vasorelaxant effects of nicorandil and amlodipine on isolated porcine coronary arteries.
Topics: Amlodipine; Animals; Calcium; Calcium Channel Blockers; Coronary Vessels; Enzyme Activation; Extrace | 1998 |
Vascular levels and cGMP-increasing effects of nicorandil administered orally to rats.
Topics: Administration, Oral; Animals; Aorta, Thoracic; Cyclic GMP; In Vitro Techniques; Male; Muscle Relaxa | 1998 |
Changes in responsiveness of the aorta to vasorelaxant agents in genetically diabetic rats: a study in WBN/Kob rats.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Colforsin; Cromakalim; Diabetes Mellitus, Experimental; Endot | 1992 |
Pharmacological interaction experiments differentiate between glibenclamide-sensitive K+ channels and cyclic GMP as components of vasodilation by nicorandil.
Topics: Animals; Benzopyrans; Cattle; Coronary Vessels; Cromakalim; Cyclic GMP; Drug Interactions; Glyburide | 1992 |
Comparison of nicorandil-induced relaxation, elevations of cyclic guanosine monophosphate and stimulation of guanylate cyclase with organic nitrate esters.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cyclic GMP; Dogs; Endothelium, Vascular; Enzyme Activa | 1991 |
Nicorandil: differential contribution of K+ channel opening and guanylate cyclase stimulation to its vasorelaxant effects on various endothelin-1-contracted arterial preparations. Comparison to aprikalim (RP 52891) and nitroglycerin.
Topics: Animals; Coronary Vessels; Endothelins; Endothelium, Vascular; Glyburide; Guanylate Cyclase; Heart; | 1991 |
Nitrate tolerance induced by nicorandil or nitroglycerin is associated with minimal loss of nicorandil vasodilator activity.
Topics: Animals; Arteries; Cattle; Coronary Vessels; Drug Tolerance; In Vitro Techniques; Isosorbide Dinitra | 1990 |
Dual mechanism of the relaxing effect of nicorandil by stimulation of cyclic GMP formation and by hyperpolarization.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Barium; Cattle; Coronar | 1991 |
Potassium channel opening properties of a novel compound, NIP-121, cromakalim and nicorandil in rat aorta and portal vein.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Benzopyrans; Cromakalim; Glyburide; In Vitro Tech | 1991 |
Cytoplasmic calcium and the relaxation of canine coronary arterial smooth muscle produced by cromakalim, pinacidil and nicorandil.
Topics: Adenosine Triphosphate; Animals; Benzopyrans; Calcium; Coronary Vessels; Cromakalim; Cytoplasm; Dogs | 1990 |
The relaxant action of nicorandil in guinea-pig isolated trachealis.
Topics: Aminophylline; Animals; Dose-Response Relationship, Drug; Female; Guinea Pigs; In Vitro Techniques; | 1986 |
Endothelial-dependent relaxant actions of carbachol and substance P in arterial smooth muscle.
Topics: Animals; Calcimycin; Carbachol; Endothelium; Female; Guinea Pigs; In Vitro Techniques; Indomethacin; | 1986 |
Studies on the mechanism of the vasodilator action of nicorandil.
Topics: Acetylcholine; Animals; Aorta; Arteriosclerosis; Endothelium, Vascular; Guanylate Cyclase; Ion Chann | 1988 |
Glibenclamide is a competitive antagonist of cromakalim, pinacidil and RP 49356 in guinea-pig pulmonary artery.
Topics: Animals; Benzopyrans; Cromakalim; Glyburide; Guanidines; Guinea Pigs; In Vitro Techniques; Male; Met | 1989 |
Functional changes in potassium channels in aortas from rats with streptozotocin-induced diabetes.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Blood Glucose; Cromakalim; Diabetes Mellitus, Experimental; I | 1989 |
Comparative effects of K+ channel blockade on the vasorelaxant activity of cromakalim, pinacidil and nicorandil.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Benzopyrans; Cardiovascular Agents; Cromakalim; Guanidines | 1988 |
Relaxant effects of pinacidil, nicorandil, hydralazine and nifedipine as studied in the porcine coronary artery and guinea-pig taenia coli.
Topics: Animals; Caffeine; Colon; Coronary Vessels; Female; Guanidines; Guinea Pigs; Hydralazine; In Vitro T | 1986 |
Characteristics of cromakalim-induced relaxations in the smooth muscle cells of guinea-pig mesenteric artery and vein.
Topics: Action Potentials; Animals; Antihypertensive Agents; Benzopyrans; Cromakalim; Female; Guinea Pigs; I | 1988 |
The relationship between tissue levels of cyclic GMP and tracheal smooth muscle relaxation in the guinea-pig.
Topics: Animals; Cyclic GMP; Dose-Response Relationship, Drug; Guinea Pigs; Male; Muscle Contraction; Muscle | 1986 |
Decreasing potassium conductance--a possible mechanism of phasic coronary vasospasm.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Calcium; Coronary Vasospasm; Coronary Vesse | 1985 |
Vasodilative effect of nicorandil on coronary artery.
Topics: Animals; Coronary Vessels; Dinoprost; Dogs; Female; Male; Muscle Relaxation; Niacinamide; Nicorandil | 1985 |