niacinamide has been researched along with Mitochondrial Diseases in 4 studies
nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.
Mitochondrial Diseases: Diseases caused by abnormal function of the MITOCHONDRIA. They may be caused by mutations, acquired or inherited, in mitochondrial DNA or in nuclear genes that code for mitochondrial components. They may also be the result of acquired mitochondria dysfunction due to adverse effects of drugs, infections, or other environmental causes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Mitochondrial disorders are highly heterogeneous conditions characterized by defects of the mitochondrial respiratory chain." | 1.40 | NAD(+)-dependent activation of Sirt1 corrects the phenotype in a mouse model of mitochondrial disease. ( Auwerx, J; Cerutti, R; Dantzer, F; Lamperti, C; Leoni, V; Li, W; Marchet, S; Pirinen, E; Sauve, AA; Schon, EA; Viscomi, C; Zeviani, M, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 2 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Orlandi, I | 1 |
| Vai, M | 1 |
| Zhao, N | 1 |
| Xia, J | 1 |
| Xu, B | 1 |
| Cerutti, R | 1 |
| Pirinen, E | 1 |
| Lamperti, C | 1 |
| Marchet, S | 1 |
| Sauve, AA | 1 |
| Li, W | 1 |
| Leoni, V | 1 |
| Schon, EA | 1 |
| Dantzer, F | 1 |
| Auwerx, J | 1 |
| Viscomi, C | 1 |
| Zeviani, M | 1 |
| Hathorn, T | 1 |
| Snyder-Keller, A | 1 |
| Messer, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Niacin Supplementation on Systemic Nicotinamide Adenine Dinucleotide (NAD+) Metabolism, Physiology and Muscle Performance in Healthy Controls and Mitochondrial Myopathy Patients[NCT03973203] | 15 participants (Actual) | Interventional | 2014-06-01 | Completed | |||
| NiaMIT (NiaMIT_0001) Continuation for Early-stage Mitochondrial Myopathy Patients to Investigate the Effect of Niacin Supplementation on Systemic Nicotinamide Adenine Dinucleotide (NAD+) Metabolism, Physiology and Muscle Performance[NCT04538521] | 3 participants (Actual) | Interventional | 2019-02-11 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 other studies available for niacinamide and Mitochondrial Diseases
| Article | Year |
|---|---|
Assays for Monitoring the Effects of Nicotinamide Supplementation on Mitochondrial Activity in Saccharomyces cerevisiae.
Topics: Aging; Cell Respiration; Dietary Supplements; Membrane Potential, Mitochondrial; Mitochondria; Mitoc | 2020 |
Physical exercise may exert its therapeutic influence on Alzheimer's disease through the reversal of mitochondrial dysfunction via SIRT1-FOXO1/3-PINK1-Parkin-mediated mitophagy.
Topics: Adenosine Triphosphate; Alzheimer Disease; Amyloid beta-Peptides; Brain-Derived Neurotrophic Factor; | 2021 |
NAD(+)-dependent activation of Sirt1 corrects the phenotype in a mouse model of mitochondrial disease.
Topics: Animals; Dietary Supplements; Disease Models, Animal; Electron Transport Complex IV; Energy Metaboli | 2014 |
NAD(+)-dependent activation of Sirt1 corrects the phenotype in a mouse model of mitochondrial disease.
Topics: Animals; Dietary Supplements; Disease Models, Animal; Electron Transport Complex IV; Energy Metaboli | 2014 |
NAD(+)-dependent activation of Sirt1 corrects the phenotype in a mouse model of mitochondrial disease.
Topics: Animals; Dietary Supplements; Disease Models, Animal; Electron Transport Complex IV; Energy Metaboli | 2014 |
NAD(+)-dependent activation of Sirt1 corrects the phenotype in a mouse model of mitochondrial disease.
Topics: Animals; Dietary Supplements; Disease Models, Animal; Electron Transport Complex IV; Energy Metaboli | 2014 |
Nicotinamide improves motor deficits and upregulates PGC-1α and BDNF gene expression in a mouse model of Huntington's disease.
Topics: Animals; Brain-Derived Neurotrophic Factor; Disease Models, Animal; Female; Humans; Huntington Disea | 2011 |