Page last updated: 2024-10-19

niacinamide and Libman-Sacks Disease

niacinamide has been researched along with Libman-Sacks Disease in 8 studies

nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.

Research Excerpts

ExcerptRelevanceReference
"Activation of B cells is a hallmark of systemic lupus erythematosus (SLE)."1.42Increased Syk phosphorylation leads to overexpression of TRAF6 in peripheral B cells of patients with systemic lupus erythematosus. ( Akashi, K; Iwata, S; Jabbarzadeh-Tabrizi, S; Kondo, M; Niiro, H; Tanaka, Y; Wang, SP; Yamaoka, K; Yoshikawa, M, 2015)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19904 (50.00)18.7374
1990's0 (0.00)18.2507
2000's1 (12.50)29.6817
2010's2 (25.00)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
Wu, J1
Singh, K1
Lin, A1
Meadows, AM1
Wu, K1
Shing, V1
Bley, M1
Hassanzadeh, S1
Huffstutler, RD1
Schmidt, MS1
Blanco, LP1
Tian, R1
Brenner, C1
Pirooznia, M1
Kaplan, MJ1
Sack, MN1
Imaruoka, K1
Oe, Y1
Fushima, T1
Sato, E1
Sekimoto, A1
Sato, H1
Sugawara, J1
Ito, S1
Takahashi, N1
Iwata, S1
Yamaoka, K1
Niiro, H1
Jabbarzadeh-Tabrizi, S1
Wang, SP1
Kondo, M1
Yoshikawa, M1
Akashi, K1
Tanaka, Y1
Tutrone, WD1
Spann, CT1
Scheinfeld, N1
Deleo, VA1
RUGGIERO, N1
BETTLEY, FR1
Takeuchi, F1
Otsuka, F1
Enomoto, T1
Hanaoka, F1
Yamada, M1
Kamatani, N1
Nakano, K1
Matsuta, K1
Tanimoto, K1
Morita, T1
Goldstein, BD1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Study to Evaluate the Effect of Nicotinamide Riboside on Immunity[NCT02812238]38 participants (Actual)Interventional2016-06-23Completed
Studies of the Pathogenesis and Natural History of Systemic Lupus Erythematosus (SLE)[NCT00001372]2,250 participants (Anticipated)Observational1994-02-10Recruiting
Collection and Distribution of Blood Components From Healthy Donors for In Vitro Research Use[NCT00001846]5,000 participants (Anticipated)Observational2001-01-11Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Mean IL-1 Beta Release From Peripheral Blood Mononuclear Cells During Refeeding After 24 Hour Fast

The IL- 1beta secretion is measured in response to fasting, refeeding and administration of Nicotinamide Riboside (or placebo). Nicotinamide riboside acts as a fasting mimetic, and is supposed to maintain the reduction of IL-1 beta secretion (indicating NLRP3 inflammasome activation) induced by fasting. 1000 mg of Nicotinamide riboside on a daily basis is given to the subjects for a period of 7-10 days. (NCT02812238)
Timeframe: 4 weeks

Interventionmg/dL (Mean)
Nicotinamide Riboside582
Placebo794

Reviews

1 review available for niacinamide and Libman-Sacks Disease

ArticleYear
Polymorphic light eruption.
    Dermatologic therapy, 2003, Volume: 16, Issue:1

    Topics: Arachidonic Acid; Comorbidity; Dermatologic Agents; Humans; Hydroxychloroquine; Lupus Erythematosus,

2003

Other Studies

7 other studies available for niacinamide and Libman-Sacks Disease

ArticleYear
Boosting NAD+ blunts TLR4-induced type I IFN in control and systemic lupus erythematosus monocytes.
    The Journal of clinical investigation, 2022, 03-01, Volume: 132, Issue:5

    Topics: Clinical Studies as Topic; Humans; Inosine; Interferon-beta; Lipopolysaccharides; Lupus Erythematosu

2022
Boosting NAD+ blunts TLR4-induced type I IFN in control and systemic lupus erythematosus monocytes.
    The Journal of clinical investigation, 2022, 03-01, Volume: 132, Issue:5

    Topics: Clinical Studies as Topic; Humans; Inosine; Interferon-beta; Lipopolysaccharides; Lupus Erythematosu

2022
Boosting NAD+ blunts TLR4-induced type I IFN in control and systemic lupus erythematosus monocytes.
    The Journal of clinical investigation, 2022, 03-01, Volume: 132, Issue:5

    Topics: Clinical Studies as Topic; Humans; Inosine; Interferon-beta; Lipopolysaccharides; Lupus Erythematosu

2022
Boosting NAD+ blunts TLR4-induced type I IFN in control and systemic lupus erythematosus monocytes.
    The Journal of clinical investigation, 2022, 03-01, Volume: 132, Issue:5

    Topics: Clinical Studies as Topic; Humans; Inosine; Interferon-beta; Lipopolysaccharides; Lupus Erythematosu

2022
Boosting NAD+ blunts TLR4-induced type I IFN in control and systemic lupus erythematosus monocytes.
    The Journal of clinical investigation, 2022, 03-01, Volume: 132, Issue:5

    Topics: Clinical Studies as Topic; Humans; Inosine; Interferon-beta; Lipopolysaccharides; Lupus Erythematosu

2022
Boosting NAD+ blunts TLR4-induced type I IFN in control and systemic lupus erythematosus monocytes.
    The Journal of clinical investigation, 2022, 03-01, Volume: 132, Issue:5

    Topics: Clinical Studies as Topic; Humans; Inosine; Interferon-beta; Lipopolysaccharides; Lupus Erythematosu

2022
Boosting NAD+ blunts TLR4-induced type I IFN in control and systemic lupus erythematosus monocytes.
    The Journal of clinical investigation, 2022, 03-01, Volume: 132, Issue:5

    Topics: Clinical Studies as Topic; Humans; Inosine; Interferon-beta; Lipopolysaccharides; Lupus Erythematosu

2022
Boosting NAD+ blunts TLR4-induced type I IFN in control and systemic lupus erythematosus monocytes.
    The Journal of clinical investigation, 2022, 03-01, Volume: 132, Issue:5

    Topics: Clinical Studies as Topic; Humans; Inosine; Interferon-beta; Lipopolysaccharides; Lupus Erythematosu

2022
Boosting NAD+ blunts TLR4-induced type I IFN in control and systemic lupus erythematosus monocytes.
    The Journal of clinical investigation, 2022, 03-01, Volume: 132, Issue:5

    Topics: Clinical Studies as Topic; Humans; Inosine; Interferon-beta; Lipopolysaccharides; Lupus Erythematosu

2022
Nicotinamide alleviates kidney injury and pregnancy outcomes in lupus-prone MRL/lpr mice treated with lipopolysaccharide.
    Biochemical and biophysical research communications, 2019, 03-19, Volume: 510, Issue:4

    Topics: Animals; Disease Models, Animal; Female; Glomerulonephritis; Lipopolysaccharides; Lupus Erythematosu

2019
Increased Syk phosphorylation leads to overexpression of TRAF6 in peripheral B cells of patients with systemic lupus erythematosus.
    Lupus, 2015, Volume: 24, Issue:7

    Topics: Adolescent; Adult; Antigens, CD19; B-Lymphocytes; Case-Control Studies; Female; Flow Cytometry; Huma

2015
[Filatov tissue implants and nicotinic acid amide in lupus erythematosus].
    Rassegna medica, 1953, Volume: 30, Issue:5

    Topics: Amides; Cell- and Tissue-Based Therapy; Lupus Erythematosus, Systemic; Niacin; Niacinamide; Nicotini

1953
CHILBLAIN LUPUS ERYTHEMATOSUS.
    Proceedings of the Royal Society of Medicine, 1964, Volume: 57

    Topics: Chilblains; Chloroquine; Fluocinolone Acetonide; Frostbite; Humans; Hydroxychloroquine; Hypothyroidi

1964
Decrease in the reaction of DNA repair synthesis in response to nicotinamide or 3-aminobenzamide in ultraviolet irradiated systemic lupus erythematosus lymphocytes.
    The Journal of rheumatology, 1985, Volume: 12, Issue:3

    Topics: Benzamides; DNA Repair; Humans; In Vitro Techniques; Lupus Erythematosus, Systemic; Lymphocytes; Nia

1985
Exacerbation of dapsone-induced Heinz body hemolytic anemia following treatment with methylene blue.
    The American journal of the medical sciences, 1974, Volume: 267, Issue:5

    Topics: Anemia, Hemolytic; Dapsone; Erythrocytes; Female; Glutathione; Heinz Bodies; Humans; Lupus Erythemat

1974