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niacinamide and Kidney Diseases

niacinamide has been researched along with Kidney Diseases in 20 studies

nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.

Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.

Research Excerpts

ExcerptRelevanceReference
"Eight-week-old rats were subjected to unilateral ureteral obstruction (UUO) and were intragastrically administered sorafenib, while control and sham groups were administered vehicle for 14 or 21 days."7.81Sorafenib ameliorates renal fibrosis through inhibition of TGF-β-induced epithelial-mesenchymal transition. ( Chen, Z; Duan, Z; Fu, R; Ge, H; Gui, B; Han, J; Jia, L; Ma, X; Ou, Y; Tian, L; Wang, L, 2015)
"Eight-week-old rats were subjected to unilateral ureteral obstruction (UUO) and were intragastrically administered sorafenib, while control and sham groups were administered vehicle for 14 or 21 days."3.81Sorafenib ameliorates renal fibrosis through inhibition of TGF-β-induced epithelial-mesenchymal transition. ( Chen, Z; Duan, Z; Fu, R; Ge, H; Gui, B; Han, J; Jia, L; Ma, X; Ou, Y; Tian, L; Wang, L, 2015)
"Recently, cancer therapies have been supplemented by vascular endothelial growth factor (VEGF) inhibitors as anti-angiogenic agents."2.50Clinicopathological spectrum of kidney diseases in cancer patients treated with vascular endothelial growth factor inhibitors: a report of 5 cases and review of literature. ( Chandran, CB; Flombaum, CD; Glezerman, IG; Salvatore, SP; Seshan, SV; Usui, J, 2014)
" With expanded clinical experience with this class of agents has come the increasing recognition of the diverse adverse effects related to disturbance of VEGF-dependent physiological functions and homeostasis in the cardiovascular and renal systems, as well as wound healing and tissue repair."2.45Adverse effects of anticancer agents that target the VEGF pathway. ( Chen, HX; Cleck, JN, 2009)
"Renal interstitial fibrosis is a common pathological feature in progressive kidney diseases currently lacking effective treatment."1.51Nicotinamide reduces renal interstitial fibrosis by suppressing tubular injury and inflammation. ( Cai, J; Dong, Z; Liu, Z; Shu, S; Tang, C; Wang, Y; Zheng, M, 2019)
" Dose recommendations for these patients are not available because pharmacokinetic data are missing."1.37Pharmacokinetics and dose recommendations of Niaspan® in chronic kidney disease and dialysis patients. ( Bode-Böger, SM; Luley, C; Martens-Lobenhoffer, J; Reiche, I; Tröger, U; Westphal, S, 2011)
" No significant difference was noted in any of the other pharmacokinetic parameters examined in the three groups, not even on comparing values obtained on the first and last days of treatment."1.28Pharmacokinetics of nicorandil in patients with normal and impaired renal function. ( Molinaro, M; Regazzi, MB; Rondanelli, R; Salvadeo, A; Sartirana, E; Segagni, S; Villa, G, 1992)

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19905 (25.00)18.7374
1990's4 (20.00)18.2507
2000's3 (15.00)29.6817
2010's8 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zheng, M1
Cai, J1
Liu, Z1
Shu, S1
Wang, Y1
Tang, C1
Dong, Z1
Izzedine, H1
Mangier, M1
Ory, V1
Zhang, SY1
Sendeyo, K1
Bouachi, K1
Audard, V1
Péchoux, C1
Soria, JC1
Massard, C1
Bahleda, R1
Bourry, E1
Khayat, D1
Baumelou, A1
Lang, P1
Ollero, M1
Pawlak, A1
Sahali, D1
Usui, J1
Glezerman, IG1
Salvatore, SP1
Chandran, CB1
Flombaum, CD1
Seshan, SV1
Jia, L1
Ma, X1
Gui, B1
Ge, H1
Wang, L1
Ou, Y1
Tian, L1
Chen, Z1
Duan, Z1
Han, J1
Fu, R1
Nouhaud, FX1
Pfister, C1
Defortescu, G1
Giwerc, A1
Charbit, D1
Gouerant, S1
Sabourin, JC1
Di Fiore, F1
Hsieh, JJ1
Purdue, MP1
Signoretti, S1
Swanton, C1
Albiges, L1
Schmidinger, M1
Heng, DY1
Larkin, J1
Ficarra, V1
MESSINA, R1
Hilger, RA1
Richly, H1
Grubert, M1
Kredtke, S1
Thyssen, D1
Eberhardt, W1
Hense, J1
Schuler, M1
Scheulen, ME1
Chen, HX1
Cleck, JN1
Reiche, I1
Westphal, S1
Martens-Lobenhoffer, J1
Tröger, U1
Luley, C1
Bode-Böger, SM1
Karpishchenko, SN1
Zheregelia, SN1
Glushkov, SI1
Cheng, SC1
Young, DO1
Huang, Y1
Delmez, JA1
Coyne, DW1
McDonald, MC1
Filipe, HM1
Thiemermann, C1
Stroo, WE1
Hook, JB1
Chow, AY1
Hirsch, GH1
Buttar, HS1
Wold, JS1
Turnipseed, SA1
Miller, BL1
Lock, EA1
Ishmael, J1
Maïza, A1
Waldek, S1
Ballardie, FW1
Daley-Yates, PT1
Molinaro, M1
Villa, G1
Regazzi, MB1
Salvadeo, A1
Segagni, S1
Rondanelli, R1
Sartirana, E1
Somogyi, A1
Siebert, D1
Bochner, F1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effect of Oral Niacinamide on Serum Phosphorus Levels in Hemodialysis Patients[NCT00316472]Phase 140 participants Interventional2006-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for niacinamide and Kidney Diseases

ArticleYear
Clinicopathological spectrum of kidney diseases in cancer patients treated with vascular endothelial growth factor inhibitors: a report of 5 cases and review of literature.
    Human pathology, 2014, Volume: 45, Issue:9

    Topics: Acute Kidney Injury; Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplasti

2014
Renal cell carcinoma.
    Nature reviews. Disease primers, 2017, Mar-09, Volume: 3

    Topics: Axitinib; Bevacizumab; Carcinoma, Renal Cell; Humans; Imidazoles; Indazoles; Indoles; Kidney; Kidney

2017
Adverse effects of anticancer agents that target the VEGF pathway.
    Nature reviews. Clinical oncology, 2009, Volume: 6, Issue:8

    Topics: Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic A

2009

Trials

1 trial available for niacinamide and Kidney Diseases

ArticleYear
A randomized, double-blind, placebo-controlled trial of niacinamide for reduction of phosphorus in hemodialysis patients.
    Clinical journal of the American Society of Nephrology : CJASN, 2008, Volume: 3, Issue:4

    Topics: Administration, Oral; Biomarkers; Chelating Agents; Cross-Over Studies; Double-Blind Method; Down-Re

2008

Other Studies

16 other studies available for niacinamide and Kidney Diseases

ArticleYear
Nicotinamide reduces renal interstitial fibrosis by suppressing tubular injury and inflammation.
    Journal of cellular and molecular medicine, 2019, Volume: 23, Issue:6

    Topics: Animals; Apoptosis; Cell Line; Chemokine CCL2; Disease Models, Animal; Fibrosis; Inflammation; Inter

2019
Expression patterns of RelA and c-mip are associated with different glomerular diseases following anti-VEGF therapy.
    Kidney international, 2014, Volume: 85, Issue:2

    Topics: Adaptor Proteins, Signal Transducing; Adult; Aged; Angiogenesis Inhibitors; Animals; Base Sequence;

2014
Sorafenib ameliorates renal fibrosis through inhibition of TGF-β-induced epithelial-mesenchymal transition.
    PloS one, 2015, Volume: 10, Issue:2

    Topics: Actins; Animals; Apoptosis; Cadherins; Cell Line; Disease Models, Animal; Epithelial-Mesenchymal Tra

2015
Baseline chronic kidney disease is associated with toxicity and survival in patients treated with targeted therapies for metastatic renal cell carcinoma.
    Anti-cancer drugs, 2015, Volume: 26, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cel

2015
The influence of vitamin PP on the exchange of creatine and creatinine in some morbid conditions; behavior of creatine and nephrópatients
    Archivio per le scienze mediche, 1948, Volume: 86, Issue:6

    Topics: Creatine; Kidney Diseases; Niacinamide; Nutrition Therapy

1948
Pharmacokinetics of sorafenib in patients with renal impairment undergoing hemodialysis.
    International journal of clinical pharmacology and therapeutics, 2009, Volume: 47, Issue:1

    Topics: Antineoplastic Agents; Benzenesulfonates; Blood Specimen Collection; Clinical Trials as Topic; Dose-

2009
Pharmacokinetics and dose recommendations of Niaspan® in chronic kidney disease and dialysis patients.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2011, Volume: 26, Issue:1

    Topics: Aged; Chronic Disease; Cohort Studies; Dose-Response Relationship, Drug; Female; Follow-Up Studies;

2011
[Using cytoflavin for correcting x-ray contrasting agent-induced nephropathy].
    Eksperimental'naia i klinicheskaia farmakologiia, 2010, Volume: 73, Issue:10

    Topics: Animals; Contrast Media; Cytoprotection; Drug Combinations; Flavin Mononucleotide; Inosine Diphospha

2010
Effects of inhibitors of the activity of poly (ADP-ribose) synthetase on the organ injury and dysfunction caused by haemorrhagic shock.
    British journal of pharmacology, 1999, Volume: 128, Issue:6

    Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Benzamides; Blood Pressure; Creatine Kin

1999
Enzymes of renal origin in urine as indicators of nephrotoxicity.
    Toxicology and applied pharmacology, 1977, Volume: 39, Issue:3

    Topics: Alkaline Phosphatase; Animals; Blood Urea Nitrogen; Carbon Tetrachloride; Folic Acid; Glucosidases;

1977
Nephrotoxic and hepatotoxic effects of triclosan and chlorhexidine in rats.
    Toxicology and applied pharmacology, 1977, Volume: 42, Issue:1

    Topics: Age Factors; Animals; Biguanides; Chemical and Drug Induced Liver Injury; Chlorhexidine; Female; Kid

1977
The effect of renal cation transport inhibition on cephaloridine nephrotoxicity.
    Toxicology and applied pharmacology, 1979, Volume: 47, Issue:1

    Topics: Animals; Biological Transport; Blood Urea Nitrogen; Cations; Cephaloridine; Cyanides; Drug Interacti

1979
The acute toxic effects of paraquat and diquat on the rat kidney.
    Toxicology and applied pharmacology, 1979, Volume: 50, Issue:1

    Topics: Animals; Carbon Dioxide; Diquat; Fatty Acids; Glucose; Kidney Diseases; Male; Mercury; Niacinamide;

1979
Estimation of renal tubular secretion in man, in health and disease, using endogenous N-1-methylnicotinamide.
    Nephron, 1992, Volume: 60, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Creatine; Female; Glomerular Filtration Rate; Humans; Ki

1992
Pharmacokinetics of nicorandil in patients with normal and impaired renal function.
    European journal of clinical pharmacology, 1992, Volume: 42, Issue:2

    Topics: Administration, Oral; Adult; Aged; Antihypertensive Agents; Female; Half-Life; Humans; Kidney Diseas

1992
Determination of endogenous concentrations of N1-methylnicotinamide in human plasma and urine by high-performance liquid chromatography.
    Analytical biochemistry, 1990, May-15, Volume: 187, Issue:1

    Topics: Acetophenones; Adolescent; Adult; Aged; Aging; Chromatography, High Pressure Liquid; Female; Fluores

1990