Page last updated: 2024-10-19

niacinamide and Hemorrhage, Subarachnoid

niacinamide has been researched along with Hemorrhage, Subarachnoid in 10 studies

nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.

Research Excerpts

ExcerptRelevanceReference
"Cerebral vasospasm is a complication of subarachnoid haemorrhage and can cause cerebral ischaemia."2.41Nicaraven for the treatment of cerebral vasospasm in subarachnoid haemorrhage. ( Jain, KK, 2000)
" We evaluated the effects of hydroxyl radical scavenger AVS [(+/-)-N,N'-propylenedinicotinamide; Nicaraven] after experimental SAH on rodent behavioral deficits (employing a battery of well-characterized assessment tasks over a 2-day observation period) and blood-brain barrier (BBB) permeability changes two days after SAH (quantifying the microvascular alterations according to the extravasation of protein-bound Evans Blue using a spectrophotofluorimetric technique) in dose-response and time-window experiments."1.31Effects of the radical scavenger AVS on behavioral and BBB changes after experimental subarachnoid hemorrhage. ( Costa, G; d'Avella, D; Germanò, A; Imperatore, C; Tomasello, F, 2000)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19901 (10.00)18.7374
1990's3 (30.00)18.2507
2000's5 (50.00)29.6817
2010's1 (10.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Zhang, J1
Xu, X1
Zhou, D1
Li, H1
You, W1
Wang, Z1
Chen, G1
Shimada, Y1
Tsunoda, H1
Zang, L1
Hirano, M1
Oka, T1
Tanaka, T1
Longo, M1
Blandino, A1
Ascenti, G1
Ricciardi, GK1
Granata, F1
Vinci, S1
Matsui, T1
Nagafuji, T1
Tsutsumi, K1
Uchida, H1
Miyauchi, T1
Asano, T2
Takakura, K1
Sano, K1
Kikuchi, H1
Nagai, H1
Saito, I1
Tamura, A1
Ochiai, C1
Sasaki, T1
Germanò, A2
Imperatore, C2
d'Avella, D2
Costa, G2
Tomasello, F2
Yamamoto, S1
Teng, W1
Nishizawa, S1
Kakiuchi, T1
Tsukada, H1
Jain, KK1
Harder, DR1
Dernbach, P1
Waters, A1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Neuroprotective Effect of Dapsone in Patients With Aneurysmal Subarachnoid Hemorrhage: Prospective, Randomized, Double-Blinded, Placebo-Controlled, Clinical Trial[NCT05131295]Phase 349 participants (Actual)Interventional2007-09-05Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for niacinamide and Hemorrhage, Subarachnoid

ArticleYear
Nicaraven for the treatment of cerebral vasospasm in subarachnoid haemorrhage.
    Expert opinion on investigational drugs, 2000, Volume: 9, Issue:4

    Topics: Animals; Antioxidants; Clinical Trials as Topic; Humans; Niacinamide; Subarachnoid Hemorrhage; Vasos

2000

Trials

1 trial available for niacinamide and Hemorrhage, Subarachnoid

ArticleYear
Effects of a hydroxyl radical scavenger on delayed ischemic neurological deficits following aneurysmal subarachnoid hemorrhage: results of a multicenter, placebo-controlled double-blind trial.
    Journal of neurosurgery, 1996, Volume: 84, Issue:5

    Topics: Adult; Aged; Double-Blind Method; Female; Free Radical Scavengers; Humans; Hydroxyl Radical; Intracr

1996

Other Studies

8 other studies available for niacinamide and Hemorrhage, Subarachnoid

ArticleYear
Possible Role of Raf-1 Kinase in the Development of Cerebral Vasospasm and Early Brain Injury After Experimental Subarachnoid Hemorrhage in Rats.
    Molecular neurobiology, 2015, Volume: 52, Issue:3

    Topics: Animals; Basilar Artery; Blood-Brain Barrier; Brain Damage, Chronic; Brain Edema; Cyclooxygenase 2;

2015
Synergistic induction of heme oxygenase-1 by nicaraven after subarachnoid hemorrhage to prevent delayed cerebral vasospasm.
    European journal of pharmacology, 2009, Oct-12, Volume: 620, Issue:1-3

    Topics: Animals; Basilar Artery; Cerebral Angiography; Cyclic GMP; Enzyme Induction; Gene Expression Regulat

2009
Cerebral angiography in the rat with mammographic equipment: a simple, cost-effective method for assessing vasospasm in experimental subarachnoid haemorrhage.
    Neuroradiology, 2002, Volume: 44, Issue:8

    Topics: Animals; Cerebral Angiography; Cost-Benefit Analysis; Free Radical Scavengers; Male; Mammography; Ni

2002
The effect of Nicorandil on chronic cerebral vasospasm.
    Acta neurochirurgica, 1994, Volume: 126, Issue:2-4

    Topics: Animals; Basilar Artery; Chronic Disease; Dogs; Female; Ischemic Attack, Transient; Male; Niacinamid

1994
Antivasospastic and brain-protective effects of a hydroxyl radical scavenger (AVS) after experimental subarachnoid hemorrhage.
    Journal of neurosurgery, 1998, Volume: 88, Issue:6

    Topics: Animals; Antioxidants; Basilar Artery; Behavior, Animal; Blood-Brain Barrier; Body Weight; Brain; Br

1998
Effects of the radical scavenger AVS on behavioral and BBB changes after experimental subarachnoid hemorrhage.
    Life sciences, 2000, Jan-21, Volume: 66, Issue:9

    Topics: Animals; Behavior, Animal; Blood-Brain Barrier; Dose-Response Relationship, Drug; Free Radical Scave

2000
Improvement in cerebral blood flow and metabolism following subarachnoid hemorrhage in response to prophylactic administration of the hydroxyl radical scavenger, AVS, (+/-)-N,N'-propylenedinicotinamide: a positron emission tomography study in rats.
    Journal of neurosurgery, 2000, Volume: 92, Issue:6

    Topics: Animals; Brain; Cerebrovascular Circulation; Free Radical Scavengers; Glucose; Male; Niacinamide; Po

2000
Possible cellular mechanism for cerebral vasospasm after experimental subarachnoid hemorrhage in the dog.
    The Journal of clinical investigation, 1987, Volume: 80, Issue:3

    Topics: Action Potentials; Animals; Biomechanical Phenomena; Cerebral Angiography; Dogs; Homeostasis; Ischem

1987