niacinamide and Friedreich Ataxia
niacinamide has been researched along with Friedreich Ataxia in 6 studies
nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.
Friedreich Ataxia: An autosomal recessive disease, usually of childhood onset, characterized pathologically by degeneration of the spinocerebellar tracts, posterior columns, and to a lesser extent the corticospinal tracts. Clinical manifestations include GAIT ATAXIA, pes cavus, speech impairment, lateral curvature of spine, rhythmic head tremor, kyphoscoliosis, congestive heart failure (secondary to a cardiomyopathy), and lower extremity weakness. Most forms of this condition are associated with a mutation in a gene on chromosome 9, at band q13, which codes for the mitochondrial protein frataxin. (From Adams et al., Principles of Neurology, 6th ed, p1081; N Engl J Med 1996 Oct 17;335(16):1169-75) The severity of Friedreich ataxia associated with expansion of GAA repeats in the first intron of the frataxin gene correlates with the number of trinucleotide repeats. (From Durr et al, N Engl J Med 1996 Oct 17;335(16):1169-75)
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"Nicotinamide was generally well tolerated; the main adverse event was nausea, which in most cases was mild, dose-related, and resolved spontaneously or after dose reduction, use of antinausea drugs, or both." | 1.40 | Epigenetic and neurological effects and safety of high-dose nicotinamide in patients with Friedreich's ataxia: an exploratory, open-label, dose-escalation study. ( Athanasopoulos, S; Chan, PK; Festenstein, R; Giunti, P; Huson, L; Law, PP; Leiper, J; Libri, V; Loyse, N; Mauri, M; Mohammad, T; Natisvili, T; Parkinson, MH; Piper, S; Ramesh, A; Tam, KT; Yandim, C, 2014) |
Research
Studies (6)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 2 (33.33) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 4 (66.67) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors
Authors | Studies |
---|---|
Georges, P | 1 |
Boza-Moran, MG | 1 |
Gide, J | 1 |
Pêche, GA | 1 |
Forêt, B | 1 |
Bayot, A | 1 |
Rustin, P | 1 |
Peschanski, M | 1 |
Martinat, C | 1 |
Aubry, L | 1 |
Chan, PK | 2 |
Torres, R | 1 |
Yandim, C | 2 |
Law, PP | 2 |
Khadayate, S | 1 |
Mauri, M | 2 |
Grosan, C | 1 |
Chapman-Rothe, N | 1 |
Giunti, P | 2 |
Pook, M | 1 |
Festenstein, R | 2 |
Libri, V | 1 |
Athanasopoulos, S | 1 |
Loyse, N | 1 |
Natisvili, T | 1 |
Mohammad, T | 1 |
Tam, KT | 1 |
Leiper, J | 1 |
Piper, S | 1 |
Ramesh, A | 1 |
Parkinson, MH | 1 |
Huson, L | 1 |
Lynch, DR | 1 |
Fischbeck, KH | 1 |
DEMEULEMEESTER, F | 1 |
DELAEY, P | 1 |
HOOFT, C | 1 |
TIMMERMANS, J | 1 |
SNOECK, J | 1 |
Clinical Trials (1)
Trial Overview
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Pharmacodynamic Studies of a Histone Deacetylase Inhibitor in Friedreich's Ataxia[NCT01589809] | Phase 2 | 40 participants (Anticipated) | Interventional | 2012-06-30 | Active, not recruiting | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Other Studies
6 other studies available for niacinamide and Friedreich Ataxia
Article | Year |
---|---|
Induced pluripotent stem cells-derived neurons from patients with Friedreich ataxia exhibit differential sensitivity to resveratrol and nicotinamide.
Topics: Apoptosis; Cell Survival; Cells, Cultured; Drug Design; Fibroblasts; Frataxin; Friedreich Ataxia; Ge | 2019 |
Heterochromatinization induced by GAA-repeat hyperexpansion in Friedreich's ataxia can be reduced upon HDAC inhibition by vitamin B3.
Topics: Acetylation; Animals; Cell Line, Transformed; Chromatin; Deoxyribonuclease I; Epistasis, Genetic; Fr | 2013 |
Epigenetic and neurological effects and safety of high-dose nicotinamide in patients with Friedreich's ataxia: an exploratory, open-label, dose-escalation study.
Topics: Adult; Chromatin; Dose-Response Relationship, Drug; Epigenesis, Genetic; Female; Frataxin; Friedreic | 2014 |
Nicotinamide in Friedreich's ataxia: useful or not?
Topics: Female; Frataxin; Friedreich Ataxia; Humans; Iron-Binding Proteins; Male; Niacinamide; Vitamin B Com | 2014 |
[THE CLINICAL FORM OF HARTNUP'S DISEASE].
Topics: Diagnosis, Differential; Friedreich Ataxia; Hartnup Disease; Humans; Indican; Indoles; Infant; Metab | 1963 |
BIOCHEMICAL ASPECTS OF THE HARTNUP DISEASE. I. RESULTS OF INTRAVENOUS AND ORAL TRYPTOPHAN LOADING TESTS IN A CASE OF HARTNUP DISEASE.
Topics: Amino Acid Metabolism, Inborn Errors; Biomedical Research; Friedreich Ataxia; Genetics, Medical; Har | 1964 |