Page last updated: 2024-10-19

niacinamide and Friedreich Ataxia

niacinamide has been researched along with Friedreich Ataxia in 6 studies

nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.

Friedreich Ataxia: An autosomal recessive disease, usually of childhood onset, characterized pathologically by degeneration of the spinocerebellar tracts, posterior columns, and to a lesser extent the corticospinal tracts. Clinical manifestations include GAIT ATAXIA, pes cavus, speech impairment, lateral curvature of spine, rhythmic head tremor, kyphoscoliosis, congestive heart failure (secondary to a cardiomyopathy), and lower extremity weakness. Most forms of this condition are associated with a mutation in a gene on chromosome 9, at band q13, which codes for the mitochondrial protein frataxin. (From Adams et al., Principles of Neurology, 6th ed, p1081; N Engl J Med 1996 Oct 17;335(16):1169-75) The severity of Friedreich ataxia associated with expansion of GAA repeats in the first intron of the frataxin gene correlates with the number of trinucleotide repeats. (From Durr et al, N Engl J Med 1996 Oct 17;335(16):1169-75)

Research Excerpts

ExcerptRelevanceReference
"Nicotinamide was generally well tolerated; the main adverse event was nausea, which in most cases was mild, dose-related, and resolved spontaneously or after dose reduction, use of antinausea drugs, or both."1.40Epigenetic and neurological effects and safety of high-dose nicotinamide in patients with Friedreich's ataxia: an exploratory, open-label, dose-escalation study. ( Athanasopoulos, S; Chan, PK; Festenstein, R; Giunti, P; Huson, L; Law, PP; Leiper, J; Libri, V; Loyse, N; Mauri, M; Mohammad, T; Natisvili, T; Parkinson, MH; Piper, S; Ramesh, A; Tam, KT; Yandim, C, 2014)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19902 (33.33)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (66.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Georges, P1
Boza-Moran, MG1
Gide, J1
Pêche, GA1
Forêt, B1
Bayot, A1
Rustin, P1
Peschanski, M1
Martinat, C1
Aubry, L1
Chan, PK2
Torres, R1
Yandim, C2
Law, PP2
Khadayate, S1
Mauri, M2
Grosan, C1
Chapman-Rothe, N1
Giunti, P2
Pook, M1
Festenstein, R2
Libri, V1
Athanasopoulos, S1
Loyse, N1
Natisvili, T1
Mohammad, T1
Tam, KT1
Leiper, J1
Piper, S1
Ramesh, A1
Parkinson, MH1
Huson, L1
Lynch, DR1
Fischbeck, KH1
DEMEULEMEESTER, F1
DELAEY, P1
HOOFT, C1
TIMMERMANS, J1
SNOECK, J1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Pharmacodynamic Studies of a Histone Deacetylase Inhibitor in Friedreich's Ataxia[NCT01589809]Phase 240 participants (Anticipated)Interventional2012-06-30Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Other Studies

6 other studies available for niacinamide and Friedreich Ataxia

ArticleYear
Induced pluripotent stem cells-derived neurons from patients with Friedreich ataxia exhibit differential sensitivity to resveratrol and nicotinamide.
    Scientific reports, 2019, 10-10, Volume: 9, Issue:1

    Topics: Apoptosis; Cell Survival; Cells, Cultured; Drug Design; Fibroblasts; Frataxin; Friedreich Ataxia; Ge

2019
Heterochromatinization induced by GAA-repeat hyperexpansion in Friedreich's ataxia can be reduced upon HDAC inhibition by vitamin B3.
    Human molecular genetics, 2013, Jul-01, Volume: 22, Issue:13

    Topics: Acetylation; Animals; Cell Line, Transformed; Chromatin; Deoxyribonuclease I; Epistasis, Genetic; Fr

2013
Epigenetic and neurological effects and safety of high-dose nicotinamide in patients with Friedreich's ataxia: an exploratory, open-label, dose-escalation study.
    Lancet (London, England), 2014, Aug-09, Volume: 384, Issue:9942

    Topics: Adult; Chromatin; Dose-Response Relationship, Drug; Epigenesis, Genetic; Female; Frataxin; Friedreic

2014
Nicotinamide in Friedreich's ataxia: useful or not?
    Lancet (London, England), 2014, Aug-09, Volume: 384, Issue:9942

    Topics: Female; Frataxin; Friedreich Ataxia; Humans; Iron-Binding Proteins; Male; Niacinamide; Vitamin B Com

2014
[THE CLINICAL FORM OF HARTNUP'S DISEASE].
    Acta paediatrica Belgica, 1963, Volume: 17

    Topics: Diagnosis, Differential; Friedreich Ataxia; Hartnup Disease; Humans; Indican; Indoles; Infant; Metab

1963
BIOCHEMICAL ASPECTS OF THE HARTNUP DISEASE. I. RESULTS OF INTRAVENOUS AND ORAL TRYPTOPHAN LOADING TESTS IN A CASE OF HARTNUP DISEASE.
    Annales paediatrici. International review of pediatrics, 1964, Volume: 202

    Topics: Amino Acid Metabolism, Inborn Errors; Biomedical Research; Friedreich Ataxia; Genetics, Medical; Har

1964
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