niacinamide has been researched along with Experimental Neoplasms in 100 studies
nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Subcutaneous tumours and artificially induced pulmonary metastases of the rhabdomyosarcoma R1H of the rat were treated either with fractionated irradiation alone or in combination with nicotinamide and carbogen." | 3.69 | Combination of fractionated irradiation with nicotinamide and carbogen in R1H-tumours of the rat and its pulmonary metastases. ( Beck-Bornholdt, HP; Krüll, A; Raabe, A; Rett, M, 1997) |
| " administration of D-galactosamine, and it rather showed a decrease together with necrosis after carbon tetrachloride administration." | 3.68 | N1-methylnicotinamide level in the blood after nicotinamide loading as further evidence for malignant tumor burden. ( Fujimura, S; Kato, N; Miyazaki, M; Moriyama, Y; Nakagawa, K; Okui, K, 1991) |
| "Two human melanoma cell lines, MM96 and MM127, were found to be highly sensitive to the toxicity of adenosine (D50 100-150 micrograms/ml) compared with other melanoma lines." | 3.66 | Differential effects of NAD, nicotinamide and related compounds upon growth and nucleoside incorporation in human cells. ( Hayward, IP; Parsons, PG, 1983) |
| "Sorafenib is a kinase inhibitor approved for the treatment of primary kidney cancer, advanced primary liver cancer, and radioactive iodine resistant advanced thyroid carcinoma." | 1.48 | Adaptive immune cells are necessary for the enhanced therapeutic effect of sorafenib-loaded nanoparticles. ( Jiang, W; Li, L; Lian, ZX; Liu, QZ; Long, J; Wang, YC; Yan, K; Yang, JB; Zhao, YY; Zhao, ZB, 2018) |
| "Early diagnosis of malignant melanoma is important for patient survival." | 1.42 | Synthesis and evaluation of ¹²³/¹³¹I-Iochlonicotinamide as a novel SPECT probe for malignant melanoma. ( Chang, CC; Chang, CH; Chen, CL; Lin, MH; Liu, RS; Shen, CC; Wang, HE, 2015) |
| " We conducted studies using a TKI (sunitinib or sorafenib) in combination with recombinant vaccines in two murine tumor models: colon carcinoma (MC38-CEA) and breast cancer (4T1)." | 1.40 | Immune consequences of decreasing tumor vasculature with antiangiogenic tyrosine kinase inhibitors in combination with therapeutic vaccines. ( Coplin, MA; Donahue, RN; Farsaci, B; Grenga, I; Hodge, JW; Lepone, LM; Molinolo, AA, 2014) |
| "Quinolinic acid utilization was the most intense in the kidney of rats with Walker's carcinosarcoma while nicotinic acid and nicotinamide were mostly utilized in the kidney of rats with lymphosarcoma of Pliss." | 1.29 | [Basic and salvage pathways of NAD biosynthesis in organs of normal rats, tumor-bearing rats and in tumors]. ( Filov, VA; Ivin, BA; Kon'kov, SA; Krylova, IM; Reztsova, VV, 1994) |
| " The initial half-life increased significantly (P < 0." | 1.29 | Pharmacokinetics and biochemistry studies on nicotinamide in the mouse. ( Dennis, MF; Stratford, MR, 1994) |
| " The purpose in this paper is to investigate the possibility of selective radiosensitization of tumors by reduced dose rate irradiation in combination with carbogen inhalation." | 1.29 | Middle dose rate irradiation in combination with carbogen inhalation selectively and more markedly increases the responses of SCCVII tumors. ( Akaboshi, M; Akuta, K; Masunaga, S; Ono, K, 1994) |
| "In all hepatomas, with the exception of Morris hepatoma 5123tc, nicotinamide methylase activity was significantly decreased in comparison to normal adult rat liver." | 1.27 | Nicotinamide methylation. Tissue distribution, developmental and neoplastic changes. ( Hoshino, J; Kröger, H; Seifert, R, 1984) |
| "Pancreatic islet cell tumors were induced in 38 of 44 male Wistar rats (86%), which survived 9 to 14 months following the various treatment schedules." | 1.26 | Tumorigenic action of streptozotocin on the pancreas and kidney in male Wistar rats. ( Baba, S; Fujii, S; Kazumi, T; Yoshino, G, 1978) |
| "At that time pancreatic islet cell tumors were demonstrated in all of the rats in this experiment." | 1.26 | Glucagon secretion during the development of insulin-secreting tumors induced by streptozotocin and nicotinamide. ( Baba, S; Kazumi, T; Kobayashi, N; Morita, S; Terashi, K; Yoshino, G, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 54 (54.00) | 18.7374 |
| 1990's | 32 (32.00) | 18.2507 |
| 2000's | 3 (3.00) | 29.6817 |
| 2010's | 11 (11.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhu, Q | 1 |
| Wang, X | 2 |
| Chu, Z | 1 |
| He, G | 1 |
| Dong, G | 1 |
| Xu, Y | 1 |
| Zhao, ZB | 1 |
| Long, J | 1 |
| Zhao, YY | 1 |
| Yang, JB | 1 |
| Jiang, W | 1 |
| Liu, QZ | 1 |
| Yan, K | 1 |
| Li, L | 1 |
| Wang, YC | 1 |
| Lian, ZX | 1 |
| Keegan, K | 1 |
| Li, C | 1 |
| Li, Z | 1 |
| Ma, J | 1 |
| Ragains, M | 1 |
| Coberly, S | 1 |
| Hollenback, D | 1 |
| Eksterowicz, J | 1 |
| Liang, L | 1 |
| Weidner, M | 1 |
| Huard, J | 1 |
| Alba, G | 1 |
| Orf, J | 1 |
| Lo, MC | 1 |
| Zhao, S | 1 |
| Ngo, R | 1 |
| Chen, A | 1 |
| Liu, L | 1 |
| Carlson, T | 1 |
| Quéva, C | 1 |
| McGee, LR | 1 |
| Medina, J | 1 |
| Kamb, A | 1 |
| Wickramasinghe, D | 1 |
| Dai, K | 1 |
| Farsaci, B | 1 |
| Donahue, RN | 1 |
| Coplin, MA | 1 |
| Grenga, I | 1 |
| Lepone, LM | 1 |
| Molinolo, AA | 1 |
| Hodge, JW | 1 |
| Jiao, Y | 1 |
| Xin, BT | 1 |
| Zhang, Y | 1 |
| Wu, J | 1 |
| Lu, X | 1 |
| Zheng, Y | 1 |
| Tang, W | 1 |
| Zhou, X | 1 |
| Chang, CC | 1 |
| Chang, CH | 1 |
| Shen, CC | 1 |
| Chen, CL | 1 |
| Liu, RS | 1 |
| Lin, MH | 1 |
| Wang, HE | 1 |
| Yamamoto, Y | 1 |
| De Velasco, MA | 1 |
| Kura, Y | 1 |
| Nozawa, M | 1 |
| Hatanaka, Y | 1 |
| Oki, T | 1 |
| Ozeki, T | 1 |
| Shimizu, N | 1 |
| Minami, T | 1 |
| Yoshimura, K | 1 |
| Yoshikawa, K | 1 |
| Nishio, K | 1 |
| Uemura, H | 1 |
| Gao, M | 1 |
| Kong, Q | 1 |
| Hua, H | 1 |
| Yin, Y | 1 |
| Wang, J | 1 |
| Luo, T | 1 |
| Jiang, Y | 1 |
| Booth, L | 1 |
| Roberts, JL | 1 |
| Poklepovic, A | 1 |
| Dent, P | 1 |
| Sui, J | 1 |
| Cui, Y | 1 |
| Cai, H | 1 |
| Bian, S | 1 |
| Xu, Z | 1 |
| Zhou, L | 1 |
| Sun, Y | 1 |
| Liang, J | 1 |
| Fan, Y | 1 |
| Zhang, X | 1 |
| Lee, N | 1 |
| Woodrum, CL | 1 |
| Nobil, AM | 1 |
| Rauktys, AE | 1 |
| Messina, MP | 1 |
| Dabora, SL | 1 |
| Karroum, O | 1 |
| Kengen, J | 1 |
| Danhier, P | 1 |
| Magat, J | 1 |
| Mignion, L | 1 |
| Bouzin, C | 1 |
| Verrax, J | 1 |
| Charette, N | 1 |
| Starkel, P | 1 |
| Calderon, PB | 1 |
| Sonveaux, P | 1 |
| Feron, O | 1 |
| Grégoire, V | 1 |
| Gallez, B | 1 |
| Jordan, BF | 1 |
| Hori, Y | 1 |
| Rulifson, IC | 1 |
| Tsai, BC | 1 |
| Heit, JJ | 1 |
| Cahoy, JD | 1 |
| Kim, SK | 1 |
| ROSS, V | 1 |
| MATUYAMA, M | 1 |
| NAGAYO, T | 1 |
| HILZ, H | 3 |
| OLDEKOP, M | 1 |
| SCHOLZ, M | 1 |
| DIETRICH, LS | 2 |
| AHUJA, JN | 1 |
| WOODS, M | 1 |
| BURK, D | 1 |
| DEWEY, DL | 1 |
| HAWES, C | 1 |
| MANDEL, P | 1 |
| WEITZEL, G | 1 |
| SCHNEIDER, F | 1 |
| FRETZDORFF, AM | 1 |
| SEYNSCHE, K | 1 |
| FINGER, H | 1 |
| CLARK, JB | 1 |
| GREENBAUM, AL | 1 |
| MCLEAN, P | 2 |
| REID, E | 1 |
| BERNDT, H | 1 |
| NOGUCHI, S | 1 |
| NAKATA, Y | 1 |
| JINNAI, D | 1 |
| SAKAMOTO, Y | 1 |
| ALTENBRUNN, HJ | 1 |
| STEENBECK, L | 1 |
| EHRHARDT, E | 1 |
| SCHMAGLOWSKI, S | 1 |
| KLEMPIEN, EJ | 1 |
| KOCH, R | 1 |
| KLEMM, S | 1 |
| MIELSCH, M | 1 |
| GRIMBERG, H | 1 |
| DOLD, U | 1 |
| HOLZER, H | 1 |
| Brown, DM | 2 |
| Horsman, MR | 13 |
| Hirst, DG | 1 |
| Brown, JM | 8 |
| Pamukcu, AM | 1 |
| Milli, U | 1 |
| Bryan, GT | 2 |
| Toth, B | 1 |
| Parsons, PG | 1 |
| Hayward, IP | 1 |
| Seifert, R | 1 |
| Hoshino, J | 1 |
| Kröger, H | 1 |
| Chick, WL | 1 |
| Appel, MC | 1 |
| Weir, GC | 1 |
| Like, AA | 1 |
| Lauris, V | 1 |
| Porter, JG | 1 |
| Chute, RN | 1 |
| Frigo, I | 1 |
| Younoszai, R | 1 |
| Dixit, PK | 4 |
| Matta, SG | 1 |
| Bauer, GE | 4 |
| Yamamoto, H | 1 |
| Okamoto, H | 1 |
| Johnson, DE | 2 |
| Williams, FG | 2 |
| Reztsova, VV | 1 |
| Filov, VA | 1 |
| Ivin, BA | 1 |
| Kon'kov, SA | 1 |
| Krylova, IM | 1 |
| Honess, DJ | 2 |
| Bleehen, NM | 2 |
| Stratford, MR | 1 |
| Dennis, MF | 1 |
| Ono, K | 1 |
| Masunaga, S | 1 |
| Akuta, K | 1 |
| Akaboshi, M | 1 |
| Simon, JM | 1 |
| Lartigau, E | 1 |
| Guichard, M | 1 |
| Dorie, MJ | 1 |
| Menke, D | 1 |
| Chaplin, DJ | 9 |
| Siemann, DW | 2 |
| Bhujwalla, ZM | 1 |
| Shungu, DC | 1 |
| Glickson, JD | 1 |
| Denekamp, J | 3 |
| Waites, A | 1 |
| Rojas, A | 3 |
| Brizel, DM | 1 |
| Hage, WD | 1 |
| Dodge, RK | 1 |
| Munley, MT | 1 |
| Piantadosi, CA | 1 |
| Dewhirst, MW | 1 |
| Ohizumi, Y | 1 |
| Lam, GK | 1 |
| Pickles, T | 1 |
| Fowler, JF | 1 |
| Hartmann, KA | 1 |
| Van der Kleij, AJ | 1 |
| Schneider, CJ | 1 |
| Sminia, P | 1 |
| Overgaard, J | 4 |
| Raabe, A | 1 |
| Rett, M | 1 |
| Krüll, A | 1 |
| Beck-Bornholdt, HP | 1 |
| Pero, RW | 1 |
| Olsson, A | 1 |
| Amiri, A | 1 |
| Chaplin, D | 1 |
| Boyonoski, AC | 1 |
| Spronck, JC | 1 |
| Jacobs, RM | 1 |
| Shah, GM | 1 |
| Poirier, GG | 1 |
| Kirkland, JB | 1 |
| Sanderson, CJ | 1 |
| Thomas, JA | 1 |
| Wikstrand, CJ | 1 |
| Mahaley, MS | 1 |
| Bigner, DD | 1 |
| Martz, E | 1 |
| Schoental, R | 3 |
| Rakieten, N | 1 |
| Gordon, BS | 1 |
| Beaty, A | 1 |
| Cooney, DA | 1 |
| Schein, PS | 1 |
| Dixon, RL | 1 |
| Korec, R | 1 |
| Kazumi, T | 4 |
| Yoshino, G | 3 |
| Fujii, S | 2 |
| Baba, S | 3 |
| Yoshida, Y | 1 |
| Taniguchi, H | 1 |
| Morita, S | 2 |
| Kobayashi, N | 1 |
| Terashi, K | 1 |
| Joiner, MC | 2 |
| Lee, I | 2 |
| Song, CW | 1 |
| Boucher, Y | 1 |
| Jain, RK | 1 |
| Hurd, RE | 1 |
| Freeman, D | 1 |
| Lemmon, MJ | 3 |
| Lee, WW | 2 |
| Peters, CE | 1 |
| Trotter, MJ | 2 |
| Kjellen, E | 1 |
| Collier, JM | 1 |
| Johns, H | 1 |
| Nakagawa, K | 1 |
| Miyazaki, M | 1 |
| Okui, K | 1 |
| Kato, N | 1 |
| Moriyama, Y | 1 |
| Fujimura, S | 1 |
| Aoki, DS | 1 |
| Wood, PJ | 2 |
| Skov, KA | 1 |
| Kamat, JP | 1 |
| Narurkar, LM | 1 |
| Narurkar, MV | 1 |
| Nikonova, TV | 1 |
| Draudin-Krylenko, VA | 1 |
| Bukin, IuV | 1 |
| Turusov, VS | 1 |
| Hirst, VK | 1 |
| Dunphy, EP | 1 |
| Kuroki, T | 1 |
| Carruthers, C | 1 |
| Lewis, LR | 1 |
| Cheng, CC | 1 |
| Schmähl, D | 1 |
| Stackelberg, S | 1 |
| Calcutt, G | 1 |
| Ting, SM | 1 |
| Preece, AV | 1 |
| Hayashi, Y | 1 |
| Volk, BW | 1 |
| Wellmann, KF | 1 |
| Brancato, P | 1 |
| Maksimovich, IaB | 1 |
| Kalashnikov, AP | 1 |
| Tsybul'skaia, OV | 1 |
| Muniz, O | 1 |
| Powanda, M | 1 |
| Gumaa, KA | 1 |
4 reviews available for niacinamide and Experimental Neoplasms
| Article | Year |
|---|---|
ARCON--current status: summary of a workshop on preclinical and clinical studies.
Topics: Animals; Carbon Dioxide; Cell Division; Cell Hypoxia; Head and Neck Neoplasms; Humans; Neoplasm Recu | 1997 |
The use of blood flow modifiers to improve the treatment response of solid tumors.
Topics: Animals; Combined Modality Therapy; Hydralazine; Mice; Neoplasms, Experimental; Niacinamide; Pyrazin | 1991 |
A therapeutic benefit from combining normobaric carbogen or oxygen with nicotinamide in fractionated X-ray treatments.
Topics: Adenocarcinoma; Animals; Carbon; Disease Models, Animal; Dose-Response Relationship, Radiation; In V | 1991 |
[Chemical carcinogenesis in vitro. 2].
Topics: Animals; Carcinogens; Cell Transformation, Neoplastic; Culture Techniques; Dactinomycin; DNA; Genes; | 1970 |
96 other studies available for niacinamide and Experimental Neoplasms
| Article | Year |
|---|---|
Design, synthesis and biological evaluation of novel imidazo[4,5-c]pyridinecarboxamide derivatives as PARP-1 inhibitors.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Cell Proliferation; Dose- | 2013 |
Adaptive immune cells are necessary for the enhanced therapeutic effect of sorafenib-loaded nanoparticles.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Homeodomain Proteins; Immunity, Cellular; Lymphocy | 2018 |
Preclinical evaluation of AMG 925, a FLT3/CDK4 dual kinase inhibitor for treating acute myeloid leukemia.
Topics: Animals; Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase 4; Dos | 2014 |
Immune consequences of decreasing tumor vasculature with antiangiogenic tyrosine kinase inhibitors in combination with therapeutic vaccines.
Topics: Angiogenesis Inhibitors; Animals; Cancer Vaccines; Cell Line, Tumor; Combined Modality Therapy; Fema | 2014 |
Design, synthesis and evaluation of novel 2-(1H-imidazol-2-yl) pyridine Sorafenib derivatives as potential BRAF inhibitors and anti-tumor agents.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Disease Models, Animal; Dose-R | 2015 |
Synthesis and evaluation of ¹²³/¹³¹I-Iochlonicotinamide as a novel SPECT probe for malignant melanoma.
Topics: Animals; Cell Line, Tumor; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Iodine | 2015 |
Evaluation of in vivo responses of sorafenib therapy in a preclinical mouse model of PTEN-deficient of prostate cancer.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Proliferation; Disease Mode | 2015 |
AMPK-mediated up-regulation of mTORC2 and MCL-1 compromises the anti-cancer effects of aspirin.
Topics: AMP-Activated Protein Kinases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Ag | 2016 |
PDE5 inhibitors enhance the lethality of [pemetrexed + sorafenib].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Autophagy; Cell Line, Tumor; Dru | 2017 |
Synergistic chemotherapeutic effect of sorafenib-loaded pullulan-Dox conjugate nanoparticles against murine breast carcinoma.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Doxorubicin; Drug Delivery Syste | 2017 |
Rapamycin weekly maintenance dosing and the potential efficacy of combination sorafenib plus rapamycin but not atorvastatin or doxycycline in tuberous sclerosis preclinical models.
Topics: Animals; Atorvastatin; Benzenesulfonates; Cystadenoma; Disease Models, Animal; Doxycycline; Drug Eva | 2009 |
Tumor reoxygenation following administration of Mitogen-Activated Protein Kinase inhibitors: a rationale for combination with radiation therapy.
Topics: Angiogenesis Inducing Agents; Animals; Apoptosis; Benzamides; Blotting, Western; Diphenylamine; Elec | 2012 |
Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells.
Topics: Androstadienes; Animals; Biomarkers; Cell Aggregation; Cell Differentiation; Cell Line; Diabetes Mel | 2002 |
Nicotinamide in adenocarcinoma 755 and in the milk of mice carrying the agent of spontaneous mammary tumor.
Topics: Adenocarcinoma; Animals; Breast Neoplasms; Humans; Mammary Neoplasms, Animal; Mice; Milk; Neoplasms, | 1957 |
The influence of nicotinamide and diphosphopyridine nucleotide on azo dye and methyl-cholanthrene carcinogenesis.
Topics: Animals; Azo Compounds; Benz(a)Anthracenes; Carcinogenesis; Coloring Agents; Methylcholanthrene; NAD | 1960 |
Effects of x-ray irradiation in ascites tumor cells: partial restoration of DPN content and DNA synthesis by nicotinamide.
Topics: Animals; Ascites; Coenzymes; DNA; DNA Replication; NAD; Neoplasms, Experimental; Niacin; Niacinamide | 1961 |
Uptake of nicotinic acid-C-14 and nicotinamide-C-14 by ascites cells in vitro.
Topics: Ascites; In Vitro Techniques; NAD; Neoplasms; Neoplasms, Experimental; Niacin; Niacinamide; Nicotini | 1963 |
INHIBITION OF TUMOR CELL GLYCOLYSIS BY DPNH2, AND REVERSAL OF THE INHIBITION BY DPN, PYRUVATE OR METHYLENE BLUE.
Topics: Animals; Carbohydrate Metabolism; Carcinoma, Ehrlich Tumor; Carcinoma, Krebs 2; Glycolysis; Melanoma | 1963 |
6-AMINONICOTINAMIDE AND THE RADIOSENSITIVITY OF HUMAN LIVER CELLS IN CULTURE.
Topics: 6-Aminonicotinamide; Animals; Carcinoma, Ehrlich Tumor; Chromosomes; Fetus; Liver; Mice; Neoplasms; | 1963 |
[SOME ASPECTS OF THE REGULATION OF RIBONUCLEIC ACID BIOSYNTHESES IN HIGHER ANIMALS].
Topics: Carcinoma, Hepatocellular; Chromatography; Leucine; Liver; Liver Neoplasms; Metabolism; NAD; Neoplas | 1964 |
[ADDITIONAL CLASSES OF COMPOUNDS INHIBITING TUMORS. I. CYTOSTATIC EFFECTS OF N- AND S-HYDROXYMETHYL COMPOUNDS].
Topics: Amides; Animals; Antineoplastic Agents; Benzimidazoles; Carbohydrate Metabolism; Carcinoma, Ehrlich | 1963 |
CONCENTRATIONS AND RATES OF SYNTHESIS OF NICOTINAMIDE-ADENINE-DINUCLEODIDE PHOSPHATE IN PRECANCEROUS LIVERS AND HEPATOMAS INDUCED BY AZO-DYE FEEDING.
Topics: Adenine; Carcinogens; Carcinoma, Hepatocellular; Liver; Liver Neoplasms; NADP; Neoplasms; Neoplasms, | 1964 |
[THE PROTECTIVE EFFECT OF NICOTINAMIDE ON RADIATION-INDUCED INJURY OF DNA SYNTHESIS AS A CELL POPULATION PROBLEM].
Topics: Animals; Carbohydrate Metabolism; Carcinoma, Ehrlich Tumor; DNA; DNA, Neoplasm; NAD; Neoplasm Protei | 1964 |
[STUDIES ON NICOTINAMIDE METHYLPHERASE ACTIVITY IN THE LIVER OF TUMOR-BEARING RAT].
Topics: Adrenalectomy; Adrenocorticotropic Hormone; Carcinoma, Hepatocellular; Cortisone; Endotoxins; Fluoro | 1964 |
[INVESTIGATION ON THE DECREASE IN CONCENTRATION OF NAD IN LYMPHOSARCOMA ASCITES CELLS FOLLOWING X-IRRADIATION].
Topics: Ascites; Chromatography; Lymphoma; Lymphoma, Non-Hodgkin; Metabolism; NAD; Neoplasms; Neoplasms, Exp | 1965 |
[On the effect of cytostatic compounds and nicotinic acid amide on ascites tumor ribonuclease (n)].
Topics: Amides; Animals; Antineoplastic Agents; Ascites; Carcinoma, Ehrlich Tumor; Humans; Neoplasms, Experi | 1959 |
[On the mechanism of the radiation protection effect of nicotinamide on Ehrlich ascites tumor].
Topics: Animals; Carcinoma, Ehrlich Tumor; Neoplasms, Experimental; Niacin; Niacinamide; Nicotinic Acids; Ra | 1962 |
[Influence of nicotinamide on the DPN-content, glycolysis and viability of ascites tumor cells after treatment with carcinostatic ethyleneimine compounds].
Topics: Animals; Antineoplastic Agents; Ascites; Aziridines; Coenzymes; Glycolysis; Humans; NAD; Neoplasms, | 1962 |
Enhancement of melphalan cytotoxicity in vivo and in vitro by inhibitors of poly (ADP-ribose) polymerase.
Topics: Animals; Benzamides; Caffeine; Cell Line; Cell Survival; Cricetinae; Cricetulus; Dose-Response Relat | 1984 |
Protective effect of nicotinamide on bracken fern induced carcinogenicity in rats.
Topics: Animals; Body Weight; Female; Intestinal Neoplasms; Male; NAD; Neoplasms, Experimental; Niacinamide; | 1981 |
Lack of carcinogenicity of nicotinamide and isonicotinamide following lifelong administration to mice.
Topics: Animals; Diet; Female; Male; Mice; Neoplasms, Experimental; Niacinamide; Structure-Activity Relation | 1983 |
Differential effects of NAD, nicotinamide and related compounds upon growth and nucleoside incorporation in human cells.
Topics: Adenosine; Cell Division; Cell Line; DNA Repair; DNA, Neoplasm; Fibroblasts; Humans; Melanoma; NAD; | 1983 |
Nicotinamide methylation. Tissue distribution, developmental and neoplastic changes.
Topics: Aging; Animals; Brain; Carcinoma, Ehrlich Tumor; Cell Line; Female; Kidney; Liver; Liver Neoplasms, | 1984 |
Serially transplantable chemically induced rat islet cell tumor.
Topics: Adenoma, Islet Cell; Animals; Female; Male; Neoplasm Transplantation; Neoplasms, Experimental; Niaci | 1980 |
Insulin release in vitro from islet tissues and adenomas of rats treated with nicotinamide and streptozotocin. The effects of glucose.
Topics: Adenoma; Animals; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Male; Microbial Collage | 1981 |
Poly(ADP-ribose) synthetase inhibitors enhance streptozotocin-induced killing of insulinoma cells by inhibiting the repair of DNA strand breaks.
Topics: Adenoma, Islet Cell; Animals; Benzamides; Cell Line; Cell Survival; Cricetinae; DNA Repair; Insulino | 1982 |
The effect of glucose on insulin and proinsulin synthesis in the streptozotocin-nicotinamide--induced rat islet adenoma.
Topics: Adenoma; Adenoma, Islet Cell; Animals; Electrophoresis, Polyacrylamide Gel; Glucose; Insulin; Male; | 1984 |
The synthesis of insulin and proinsulin in a cell-free system derived from the streptozotocin-nicotinamide--induced rat islet adenoma.
Topics: Adenoma; Adenoma, Islet Cell; Animals; Carps; Cell-Free System; Heparin; Insulin; Liver; Male; Neopl | 1984 |
[Basic and salvage pathways of NAD biosynthesis in organs of normal rats, tumor-bearing rats and in tumors].
Topics: Animals; Carcinoma 256, Walker; Enzyme Precursors; Kidney; Liver; Lymphoma, Non-Hodgkin; NAD; Neopla | 1994 |
Perfusion changes in the RIF-1 tumour and normal tissues after carbogen and nicotinamide, individually and combined.
Topics: Administration, Inhalation; Animals; Body Temperature; Carbon Dioxide; Cell Hypoxia; Drug Interactio | 1995 |
Pharmacokinetics and biochemistry studies on nicotinamide in the mouse.
Topics: Animals; Biological Availability; Chromatography, High Pressure Liquid; Dose-Response Relationship, | 1994 |
Middle dose rate irradiation in combination with carbogen inhalation selectively and more markedly increases the responses of SCCVII tumors.
Topics: Animals; Bone Marrow; Carbon Dioxide; Cell Survival; DNA Damage; Intestines; Male; Mice; Mice, Inbre | 1994 |
Nicotinamide and carbogen: major effect on the radiosensitivity of EMT6 and HRT18 tumours.
Topics: Animals; Carbon Dioxide; Cell Survival; Female; Humans; Mice; Mice, Nude; Neoplasm Transplantation; | 1993 |
Comparison of the enhancement of tumor responses to fractionated irradiation by SR 4233 (tirapazamine) and by nicotinamide with carbogen.
Topics: Animals; Antineoplastic Agents; Carbon Dioxide; Combined Modality Therapy; Drug Combinations; Mice; | 1994 |
Further evaluation of nicotinamide and carbogen as a strategy to reoxygenate hypoxic cells in vivo: importance of nicotinamide dose and pre-irradiation breathing time.
Topics: Administration, Inhalation; Animals; Carbon Dioxide; Cell Hypoxia; Dose-Response Relationship, Drug; | 1993 |
Effects of the radiosensitising agent nicotinamide on relative tissue perfusion and kidney function in C3H mice.
Topics: Animals; Blood Circulation; Female; Glomerular Filtration Rate; Kidney; Liver Circulation; Mice; Mic | 1993 |
Effects of blood flow modifiers on tumor metabolism observed in vivo by proton magnetic resonance spectroscopic imaging.
Topics: Animals; Antihypertensive Agents; Glycerylphosphorylcholine; Hydralazine; Magnetic Resonance Spectro | 1996 |
The potential for improving radiotherapy outcome by improving the oxygen supply to solid tumours.
Topics: Animals; Carbon Dioxide; Cell Hypoxia; Cells, Cultured; Humans; Mice; Neoplasms; Neoplasms, Experime | 1996 |
ARCON.
Topics: Animals; Carbon Dioxide; Cell Hypoxia; Humans; Mice; Neoplasms; Neoplasms, Experimental; Niacinamide | 1996 |
Hyperbaric oxygen improves tumor radiation response significantly more than carbogen/nicotinamide.
Topics: Animals; Carbon Dioxide; Female; Hyperbaric Oxygenation; Neoplasms, Experimental; Niacinamide; Oxyge | 1997 |
Early skin response to fractionated doses of pions for determining therapeutic gain factors.
Topics: Animals; Carbon Dioxide; Cell Hypoxia; Combined Modality Therapy; Dose-Response Relationship, Radiat | 1996 |
Is hyperbaric oxygen more effective than carbogen/nicotinamide in tumor radiation response?
Topics: Animals; Carbon Dioxide; Hyperbaric Oxygenation; Hypoxia; Neoplasms, Experimental; Niacinamide; Oxyg | 1997 |
Nicotinamide as a radiosensitizer in tumours and normal tissues: the importance of drug dose and timing.
Topics: Animals; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Drug Administration | 1997 |
Combination of fractionated irradiation with nicotinamide and carbogen in R1H-tumours of the rat and its pulmonary metastases.
Topics: Animals; Carbon Dioxide; Combined Modality Therapy; Disease Models, Animal; Dose Fractionation, Radi | 1997 |
Multiple mechanisms of action of the benzamides and nicotinamides as sensitizers of radiotherapy: opportunities for drug design.
Topics: Animals; Apoptosis; Benzamides; Cell Division; DNA Damage; Drug Design; Enzyme Activation; HL-60 Cel | 1998 |
Pharmacological intakes of niacin increase bone marrow poly(ADP-ribose) and the latency of ethylnitrosourea-induced carcinogenesis in rats.
Topics: Alkylating Agents; Animals; Bone Marrow; Dietary Supplements; Dose-Response Relationship, Drug; Ethy | 2002 |
The mechanism of K cell (antibody-dependent) cell mediated cytotoxicity. I. The release of different cell components.
Topics: Animals; Cell Line; Chromium Radioisotopes; Cytotoxicity Tests, Immunologic; DNA, Neoplasm; Immunity | 1977 |
Surface antigenic characteristics of human glial brain tumor cells.
Topics: Antibodies, Neoplasm; Antibody Specificity; Antigens, Neoplasm; Brain Neoplasms; Cell Line; Cell Mem | 1977 |
Sizes of isotopically labeled molecules released during lysis of tumor cells labeled with 51Cr and [14C]nicotinamide.
Topics: Carbon Radioisotopes; Cells, Cultured; Chromium Radioisotopes; Cytotoxicity Tests, Immunologic; Mole | 1976 |
The role of nicotinamide and of certain other modifying factors in diethylnitrosamine carcinogenesis: fusaria mycotoxins and "spontaneous" tumors in animals and man.
Topics: Animals; Diethylnitrosamine; Female; Fusarium; Gastrointestinal Neoplasms; Genital Neoplasms, Female | 1977 |
Pancreatic islet-cell and other tumors in rats given heliotrine, a monoester pyrrolizidine alkaloid, and nicotinamide.
Topics: Adenoma; Adenoma, Islet Cell; Animals; Carcinoma, Hepatocellular; Hyperplasia; Liver Neoplasms; Male | 1975 |
Proceedings: Pancreatic islet cell and other tumours induced in rats by heliotrine- a mono-ester pyrrolizidine alkaloid; the effects of additional treatment with nicotinamide.
Topics: Adenoma, Islet Cell; Animals; Neoplasms, Experimental; Niacinamide; Pancreatic Neoplasms; Pyrrolizid | 1975 |
Modification of renal tumorigenic effect of streptozotocin by nicotinamide: spontaneous reversibility of streptozotocin diabetes.
Topics: Adenocarcinoma; Adenoma; Adenoma, Islet Cell; Animals; Diabetes Mellitus; Dose-Response Relationship | 1976 |
Studies on rats with islet beta cell tumors induced by nicotinamide and streptozotocin.
Topics: Adenoma; Adenoma, Islet Cell; Animals; Disease Models, Animal; Glucose Tolerance Test; Insulin; Neop | 1976 |
Experimental hypoglycemizing tumor of B-cells of Langerhans islets produced by the combined action of streptozotocin annd nicotinamide in the rat.
Topics: Adenoma, Islet Cell; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Hypoglycemia; | 1978 |
Tumorigenic action of streptozotocin on the pancreas and kidney in male Wistar rats.
Topics: Adenoma, Islet Cell; Animals; Carcinogens; Kidney Neoplasms; Liver; Male; Neoplasms, Experimental; N | 1978 |
[Biochemical studies on rats in the course of the induction of insulin-secreting islet cell tumors by streptozotocin (author's transl)].
Topics: Adenoma, Islet Cell; Animals; Blood Glucose; Carcinogens; Glucagon; Glucose Tolerance Test; Insulin; | 1978 |
Effect of calcium antagonist on glucose-induced insulin and glucagon secretion in rats with insulin-secreting tumors induced by streptozotocin and nicotinamide.
Topics: Adenoma, Islet Cell; Animals; Calcium; Diltiazem; Glucagon; Glucose; Glucose Tolerance Test; Insulin | 1979 |
Glucagon secretion during the development of insulin-secreting tumors induced by streptozotocin and nicotinamide.
Topics: Adenoma, Islet Cell; Animals; Blood Glucose; Glucagon; Glucose Tolerance Test; Insulin; Insulin Secr | 1979 |
Carbogen and nicotinamide: expectations too high? (response to J. Martin Brown)
Topics: Animals; Carbon Dioxide; Humans; Mice; Neoplasms; Neoplasms, Experimental; Niacinamide; Oxygen; Radi | 1992 |
Extrapolations from laboratory and preclinical studies for the use of carbogen and nicotinamide in radiotherapy.
Topics: Animals; Carbon Dioxide; Humans; Mice; Neoplasms; Neoplasms, Experimental; Niacinamide; Oxygen; Radi | 1992 |
Carbogen and nicotinamide: expectations too high?
Topics: Animals; Carbon Dioxide; Humans; Mice; Neoplasms; Neoplasms, Experimental; Niacinamide; Oxygen; Radi | 1992 |
The oxygenation of murine tumor isografts and human tumor xenografts by nicotinamide.
Topics: Animals; Blood Flow Velocity; Humans; Lasers; Mice; Mice, Inbred C3H; Neoplasm Transplantation; Neop | 1992 |
Nicotinamide can lower tumor interstitial fluid pressure: mechanistic and therapeutic implications.
Topics: Animals; Blood Pressure; Body Water; Female; Hematocrit; Mice; Mice, Inbred C3H; Neoplasms, Experime | 1992 |
Proton editing and imaging of lactate.
Topics: Animals; Hydralazine; Lactates; Lactic Acid; Magnetic Resonance Imaging; Magnetic Resonance Spectros | 1991 |
Structure-activity relationships for tumour radiosensitization by analogues of nicotinamide and benzamide.
Topics: Animals; Benzamides; Dose-Response Relationship, Radiation; Female; Mice; Mice, Inbred Strains; Neop | 1991 |
Drug induced perturbations in tumor blood flow: therapeutic potential and possible limitations.
Topics: Animals; Cell Hypoxia; Hydralazine; Mice; Neoplasms, Experimental; Niacinamide; Propranolol; Regiona | 1991 |
N1-methylnicotinamide level in the blood after nicotinamide loading as further evidence for malignant tumor burden.
Topics: Animals; Carbon Tetrachloride Poisoning; Cells, Cultured; DNA Replication; Galactosamine; Inflammati | 1991 |
Nicotinamide, Fluosol DA and Carbogen: a strategy to reoxygenate acutely and chronically hypoxic cells in vivo.
Topics: Animals; Carbon Dioxide; Carcinoma, Small Cell; Cell Hypoxia; Cell Survival; Dose-Response Relations | 1991 |
The potentiation of radiation damage by nicotinamide in the SCCVII tumour in vivo.
Topics: Animals; Cell Hypoxia; Dose-Response Relationship, Radiation; Female; Mice; Neoplasms, Experimental; | 1990 |
Modification of tumour radiation response in vivo by the benzamide analogue pyrazinamide.
Topics: Animals; Cell Survival; Cells, Cultured; Hypoxia; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Neopl | 1990 |
Preferential tumor radiosensitization by analogs of nicotinamide and benzamide.
Topics: Animals; Benzamides; Combined Modality Therapy; Mice; Neoplasms, Experimental; Niacinamide; Radiatio | 1986 |
Radiosensitization by nicotinamide in vivo: a greater enhancement of tumor damage compared to that of normal tissues.
Topics: Animals; Cell Survival; Dose-Response Relationship, Radiation; Female; Jejunum; Lethal Dose 50; Mice | 1987 |
The influence of niacin and nicotinamide on in vivo carcinogenesis.
Topics: Animals; Carcinogens; Neoplasms, Experimental; Niacin; Niacinamide | 1986 |
Effect of nicotinamide on hepatic microsomal drug metabolising system in tumour-bearing rats and mice.
Topics: Animals; Cytochrome P-450 Enzyme System; Dactinomycin; Female; Male; Mice; Mice, Inbred CBA; Microso | 1987 |
[Protective action of nicotinamide and pyridoxine on the initiation stage of carcinogenesis induced in mice by procarbazine].
Topics: Animals; Drug Evaluation, Preclinical; Female; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Neoplasms | 1988 |
Mechanism of action of the selective tumor radiosensitizer nicotinamide.
Topics: Animals; Cell Survival; Female; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Niacinamide; Radiat | 1988 |
Urocanic acid in epidermal carcinogenesis.
Topics: Animals; Carcinoma, Squamous Cell; Humans; Imidazoles; Methylcholanthrene; Mice; Neoplasms, Experime | 1968 |
Antineoplastic activity of 6-dimethylaminonicotinamide.
Topics: Antineoplastic Agents; Humans; Methylamines; Methyltransferases; Neoplasms, Experimental; Niacinamid | 1972 |
[The effect of lactoflavin, nicotinic acid amide or dipyridamol on the cancerogenic action of diethylnitrosamine in rats].
Topics: Animals; Carcinogens; Carcinoma, Hepatocellular; Dipyridamole; Female; Kidney; Liver; Liver Neoplasm | 1968 |
Tissue NAD levels and the response to irradiation of cytotoxic drugs.
Topics: Animals; beta-Aminoethyl Isothiourea; Cysteamine; Female; Lymphoma; Male; Mechlorethamine; Mice; NAD | 1970 |
[Experimental pancreatic tumor].
Topics: Adenoma, Islet Cell; Animals; Carcinogens; Cyclic N-Oxides; Dogs; Guinea Pigs; Methylation; Neoplasm | 1972 |
Fine structure of rat islet cell tumors induced by streptozotocin and nicotinamide.
Topics: Adenoma, Islet Cell; Animals; Blood Glucose; Drug Synergism; Insulin; Male; Microscopy, Electron; Ne | 1974 |
[Nicotinic acid and experimental tumor growth].
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cachexia; Depression, Chemical; NAD; NADP; Neoplasms | 1966 |
NAD synthesis in animal tissues.
Topics: Adenosine Triphosphate; Animals; Autoradiography; Brain; Carbon Isotopes; Carcinoma, Ehrlich Tumor; | 1968 |
Effect of oxamate, pyruvate, nicotinamide and streptozotocin on the pentose phosphate pathway intermediates in ascites tumour cells.
Topics: Animals; Antibiotics, Antineoplastic; Carbon Dioxide; Carbon Isotopes; Depression, Chemical; Glucose | 1969 |