niacinamide has been researched along with Diabetes Mellitus, Type 2 in 118 studies
nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.
Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In 2015, we published a study on a small series of patients with hepatocellular carcinoma (HCC) treated chronically with metformin for type II diabetes mellitus (DM2) who showed a poorer response to sorafenib." | 7.85 | Metformin and insulin impact on clinical outcome in patients with advanced hepatocellular carcinoma receiving sorafenib: Validation study and biological rationale. ( Aprile, G; Brunetti, O; Casadei Gardini, A; Cascinu, S; De Matteis, S; Ercolani, G; Faloppi, L; Foschi, FG; Frassineti, GL; Granato, AM; Marisi, G; Negrini, G; Palmieri, V; Passardi, A; Perrone, G; Santini, D; Scartozzi, M; Silvestris, N; Tamburini, E; Tovoli, F; Valgiusti, M; Vespasiani-Gentilucci, U, 2017) |
| "The presence of overweight/obesity, type 2 diabetes mellitus, hypertension, dyslipidemia, and of the MS itself did not impair the median OS." | 5.48 | Impact of Individual Components of the Metabolic Syndrome on the Outcome of Patients with Advanced Hepatocellular Carcinoma Treated with Sorafenib. ( Galle, PR; Huber, Y; Koch, S; Labenz, C; Marquardt, JU; Prenosil, V; Schattenberg, JM; Weinmann, A; Wörns, MA, 2018) |
| "Diabetic-induced rats were treated with 14-deoxy, 11, 12-didehydro andrographolide concentrations between 10 and 500 mg/kg body weight." | 4.31 | Antihyperglycemic activity of 14-deoxy, 11, 12-didehydro andrographolide on streptozotocin-nicotinamide induced type 2 diabetic rats. ( Guru, A; Issac, PK; Kamaraj, N; Velumani, K, 2023) |
| "In 2015, we published a study on a small series of patients with hepatocellular carcinoma (HCC) treated chronically with metformin for type II diabetes mellitus (DM2) who showed a poorer response to sorafenib." | 3.85 | Metformin and insulin impact on clinical outcome in patients with advanced hepatocellular carcinoma receiving sorafenib: Validation study and biological rationale. ( Aprile, G; Brunetti, O; Casadei Gardini, A; Cascinu, S; De Matteis, S; Ercolani, G; Faloppi, L; Foschi, FG; Frassineti, GL; Granato, AM; Marisi, G; Negrini, G; Palmieri, V; Passardi, A; Perrone, G; Santini, D; Scartozzi, M; Silvestris, N; Tamburini, E; Tovoli, F; Valgiusti, M; Vespasiani-Gentilucci, U, 2017) |
| "Adults with type 2 diabetes mellitus without foot ulcers were administered 400 mg oral 11β-HSD1 inhibitor AZD4017 (n = 14) or placebo (n = 14) bi-daily for 35 days." | 3.11 | Oral 11β-HSD1 inhibitor AZD4017 improves wound healing and skin integrity in adults with type 2 diabetes mellitus: a pilot randomized controlled trial. ( Abbas, A; Ajjan, RA; Arlt, W; Del Galdo, F; Fairclough, RJ; Freeman, A; Hensor, EMA; Morgan, AW; Pegg, L; Russell, DA; Shams, K; Stewart, PM; Tahrani, AA; Taylor, AE; Tiganescu, A; Webber, L, 2022) |
| "Type 2 diabetes is more prevalent (90-95%) in adults than type 1." | 2.82 | Model of Streptozotocin-nicotinamide Induced Type 2 Diabetes: a Comparative Review. ( Ahmad, R; Bari, DG; Gaur, R; Gautam, GK; Parveen, K; Rais, N; Shukla, KS; Singh, AP; Ved, A, 2022) |
| "Patients with manifest type 2 diabetes have a significantly (approximately twofold) higher NNMT expression both in omental and subcutaneous WAT compared with controls." | 2.80 | Association of nicotinamide-N-methyltransferase mRNA expression in human adipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulin resistance. ( Blüher, M; Dietrich, A; Kannt, A; Klöting, N; Pfenninger, A; Schön, MR; Teichert, L; Tönjes, A, 2015) |
| "It is generally accepted that type 2 diabetes is the result of gene-environmental interaction." | 2.46 | [Chronic nicotinamide overload and type 2 diabetes]. ( Li, D; Liu, XX; Lun, YZ; Sun, WP; Zhou, SS; Zhou, YM, 2010) |
| "Mangiferin has potential to be used as an agent to promote wound healing in diabetic condition." | 1.62 | Topical administration of mangiferin promotes healing of the wound of streptozotocin-nicotinamide-induced type-2 diabetic male rats. ( Giribabu, N; Kilari, EK; Lwin, OM; Salleh, N, 2021) |
| "Experimental diabetes mellitus was induced by a single intraperitoneal injection of STZ (60 mg/kg body weight), 15 min after intraperitoneal injection of NA (120 mg/kg body weight)." | 1.62 | Musa paradisiaca L. leaf and fruit peel hydroethanolic extracts improved the lipid profile, glycemic index and oxidative stress in nicotinamide/streptozotocin-induced diabetic rats. ( Abd El-Twab, SM; Abdel Aziz, SM; Abdel-Gabbar, M; Adel Amin, K; Ahmed, OM; Al-Muzafar, HM, 2021) |
| "Zingerone-treated diabetic groups exhibited significant reduction in LPO levels and restoration of GSH contents." | 1.62 | Modulatory effect of zingerone against STZ-nicotinamide induced type-2 diabetes mellitus in rats. ( Alkarbi, ZA; Alshahrani, S; Anwer, T; Firoz Alam, M; Hassan Najmi, A; Khan, G; Siddiqui, R, 2021) |
| " The solubility, dissolution rate and bioavailability of gliclazide SGNCs were significantly improved compared to pure gliclazide." | 1.51 | Fabrication of Second Generation Smarter PLGA Based Nanocrystal Carriers for Improvement of Drug Delivery and Therapeutic Efficacy of Gliclazide in Type-2 Diabetes Rat Model. ( Bhattamisra, SK; Krishnamoorthy, R; Panda, BP; Patnaik, S; Seng, LB; Shivashekaregowda, NKH, 2019) |
| "Type 2 diabetes was induced using a single dose of streptozotocin and nicotinamide by intraperitoneal injection." | 1.51 | Resveratrol supplementation improves DNA integrity and sperm parameters in streptozotocin-nicotinamide-induced type 2 diabetic rats. ( Alizadeh, Z; Bahmanzadeh, M; Fathi, N; Goodarzi, MT; Rezaei Farimani, A, 2019) |
| "The presence of overweight/obesity, type 2 diabetes mellitus, hypertension, dyslipidemia, and of the MS itself did not impair the median OS." | 1.48 | Impact of Individual Components of the Metabolic Syndrome on the Outcome of Patients with Advanced Hepatocellular Carcinoma Treated with Sorafenib. ( Galle, PR; Huber, Y; Koch, S; Labenz, C; Marquardt, JU; Prenosil, V; Schattenberg, JM; Weinmann, A; Wörns, MA, 2018) |
| "However, the association of T2DM with liver cirrhosis and therapy response in HCC patients is not clear." | 1.48 | Association of liver cirrhosis severity with type 2 diabetes mellitus in hepatocellular carcinoma. ( Chakraborti, A; Chawla, YK; Dhiman, RK; Kalra, N; Kanthaje, S; Makol, A, 2018) |
| "Experimental type 2 diabetes was induced in male Sprague-Dawley rats by intraperitoneal injection of nicotinamide 15 min prior to intravenous injection of streptozotocin." | 1.46 | Hypoglycaemic activity of Mathurameha, a Thai traditional herbal formula aqueous extract, and its effect on biochemical profiles of streptozotocin-nicotinamide-induced diabetic rats. ( Chayarop, K; Chuakul, W; Peungvicha, P; Rojsanga, P; Temsiririrkkul, R; Wongkrajang, Y, 2017) |
| "Type 2 diabetes was induced by injection of streptozotocin and nicotinamide." | 1.43 | Effects of Nitrate Intake on Myocardial Ischemia-Reperfusion Injury in Diabetic Rats. ( Bageripour, F; Ghanbari, M; Ghasemi, A; Jeddi, S; Khalifi, S, 2016) |
| "augusta leaves (AA) against type 2 diabetes mellitus (T2DM) and its associated nephropathy and cardiomyopathy in experimental rats." | 1.42 | Abroma augusta L. (Malvaceae) leaf extract attenuates diabetes induced nephropathy and cardiomyopathy via inhibition of oxidative stress and inflammatory response. ( De Feo, V; Dewanjee, S; Gangopadhyay, M; K Dua, T; Khanra, R; Sahu, R; Zia-Ul-Haq, M, 2015) |
| "Metformin is a first-line therapeutic option for the treatment of type 2 diabetes, even though its underlying mechanisms of action are relatively unclear." | 1.42 | Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats. ( Côté, CD; Duca, FA; Filippi, BM; Lam, TK; Rasmussen, BA; Rutter, GA; Zadeh-Tahmasebi, M, 2015) |
| " The urinary glucose excretion was drastically elevated in the dapagliflozin group, but the combination with mitiglinide suppressed it about 50%." | 1.42 | Efficacy of Mitiglinide Combined with Dapagliflozin in Streptozotocin-nicotinamide-induced Type 2 Diabetic Rats and in Zucker Fatty Rats. ( Akahane, K; Inoue, T; Kiguchi, S; Kobayashi, M; Maruyama, K; Mori, Y; Ojima, K; Yaguchi, A; Yokoyama, A, 2015) |
| "In obesity and type 2 diabetes, Glut4 glucose transporter expression is decreased selectively in adipocytes." | 1.40 | Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. ( Alhonen, L; Asara, JM; Banks, AS; Bhanot, S; Cen, Y; Gong, F; Kahn, BB; Kong, D; Kraus, D; Monia, BP; Peroni, OD; Pirinen, E; Puigserver, P; Pulinilkunnil, TC; Rodgers, JT; Sauve, AA; Wang, YC; Yang, Q; Zhang, L, 2014) |
| "The purpose of this study is to investigate the effect of exenatide on glycemic control following two administration routes in a streptozotocin/nicotinamide (STZ/NA)-induced diabetic rat model, and to develop a pharmacodynamic model to better understand the disease progression and the action of exenatide in this experimental system." | 1.39 | Population pharmacodynamic modeling of exenatide after 2-week treatment in STZ/NA diabetic rats. ( Chen, T; Kagan, L; Mager, DE, 2013) |
| " Once-daily dosing of ipragliflozin (0." | 1.38 | Antidiabetic effects of SGLT2-selective inhibitor ipragliflozin in streptozotocin-nicotinamide-induced mildly diabetic mice. ( Hayashizaki, Y; Imamura, M; Kihara, R; Kobayashi, Y; Kurosaki, E; Noda, A; Qun, L; Sasamata, M; Shibasaki, M; Tahara, A; Takasu, T; Tomiyama, H; Yamajuku, D; Yokono, M, 2012) |
| " lamarckii at two dosage 250 and 500 mg/kg, p." | 1.37 | Antidiabetic activity of alcoholic leaves extract of Alangium lamarckii Thwaites on streptozotocin-nicotinamide induced type 2 diabetic rats. ( Hemalatha, S; Kumar, R; Pate, DK; Prasad, SK; Sairam, K, 2011) |
| "Since blood levels of ADN are low in type 2 diabetes mellitus (DM), this study was designed to investigate the therapeutic effectiveness of increasing the ADN level through injection of plasmid DNA encoding ADN in type 2 DM." | 1.36 | Construction of adiponectin-encoding plasmid DNA and gene therapy of non-obese type 2 diabetes mellitus. ( Myung, CS; Nan, MH; Park, JS, 2010) |
| " Together the present study clearly reflects that combined dosage of tetrahydrocurcumin and chlorogenic acid augments enzymic antioxidants with a concomitant decrease in lipid peroxidation and protects against streptozotocin-nicotinamide-induced type 2 diabetes in experimental rats." | 1.36 | Comparative and combined effect of chlorogenic acid and tetrahydrocurcumin on antioxidant disparities in chemical induced experimental diabetes. ( Karthikesan, K; Menon, VP; Pari, L, 2010) |
| " Long-term administration of guava leaf extracts increased the plasma insulin level and glucose utilization in diabetic rats." | 1.35 | Effect of guava (Psidium guajava Linn.) leaf soluble solids on glucose metabolism in type 2 diabetic rats. ( Cheng, FC; Shen, SC; Wu, NJ, 2008) |
| " Subsequently, the effects of a 1-week chronic daily dosing of DPP-IV inhibitors and sulfonylureas were investigated." | 1.35 | Antidiabetic effects of dipeptidyl peptidase-IV inhibitors and sulfonylureas in streptozotocin-nicotinamide-induced mildly diabetic mice. ( Hayakawa, M; Matsuyama-Yokono, A; Nakano, R; Shibasaki, M; Shiraki, K; Someya, Y; Tahara, A, 2009) |
| "After induction of type 2 diabetes, rats received daily injections of AG (50 mg kg(-1), i." | 1.35 | Aminoguanidine prevents the impairment of cardiac pumping mechanics in rats with streptozotocin and nicotinamide-induced type 2 diabetes. ( Chang, KC; Liang, JT; Lin, YD; Tseng, YZ; Wu, ET; Wu, MS, 2008) |
| "Type 2 diabetes mellitus is the result of a combination of impaired insulin secretion with reduced insulin sensitivity of target tissues." | 1.34 | A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human. ( Bentley, E; Cheeseman, M; Connor, SC; Cox, RD; Griffin, JL; Haselden, JN; Hough, T; Maguire, ML; Nunez, D; Rubtsov, DV; Salek, RM; Sweatman, BC, 2007) |
| " The dosage of 230 mg/kg of nicotinamide given intraperitoneally 15 min before STZ administration (65 mg/kg i." | 1.32 | Alterations in vascular endothelial function in the aorta and mesenteric artery in type II diabetic rats. ( Kamata, K; Kobayashi, T; Matsumoto, T; Wakabayashi, K, 2004) |
| " Among the various dosages of nicotinamide tested in 3-month-old Wistar rats (100-350 mg/kg body wt), the dosage of 230 mg/kg, given intraperitoneally 15 min before STZ administration (65 mg/kg i." | 1.30 | Experimental NIDDM: development of a new model in adult rats administered streptozotocin and nicotinamide. ( Broca, C; Gross, R; Hillaire-Buys, D; Manteghetti, M; Masiello, P; Novelli, M; Ribes, G; Roye, M, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (8.47) | 18.2507 |
| 2000's | 22 (18.64) | 29.6817 |
| 2010's | 64 (54.24) | 24.3611 |
| 2020's | 22 (18.64) | 2.80 |
| Authors | Studies |
|---|---|
| Rais, N | 1 |
| Ved, A | 1 |
| Ahmad, R | 1 |
| Parveen, K | 1 |
| Gautam, GK | 1 |
| Bari, DG | 1 |
| Shukla, KS | 1 |
| Gaur, R | 1 |
| Singh, AP | 1 |
| Parsa, H | 1 |
| Moradi-Khaligh, Z | 1 |
| Rajabi, S | 1 |
| Ranjbar, K | 1 |
| Komaki, A | 1 |
| Yadav, Y | 1 |
| Dunagan, K | 1 |
| Khot, R | 1 |
| Venkatesh, SK | 1 |
| Port, J | 1 |
| Galderisi, A | 1 |
| Cobelli, C | 1 |
| Wegner, C | 1 |
| Basu, A | 1 |
| Carter, R | 1 |
| Basu, R | 1 |
| Ajjan, RA | 1 |
| Hensor, EMA | 1 |
| Del Galdo, F | 1 |
| Shams, K | 1 |
| Abbas, A | 1 |
| Fairclough, RJ | 1 |
| Webber, L | 1 |
| Pegg, L | 1 |
| Freeman, A | 1 |
| Taylor, AE | 1 |
| Arlt, W | 1 |
| Morgan, AW | 1 |
| Tahrani, AA | 1 |
| Stewart, PM | 1 |
| Russell, DA | 1 |
| Tiganescu, A | 1 |
| Omoaghe, A | 1 |
| Oyesola, O | 1 |
| Ezike, T | 1 |
| Omizu, B | 1 |
| Boone, K | 1 |
| Heidari, H | 1 |
| Khalaj, A | 1 |
| Khani, S | 2 |
| Abdollahi, M | 1 |
| Farahani, H | 1 |
| Kharitonova, T | 2 |
| Shvarts, YG | 1 |
| Verbovoy, AF | 1 |
| Orlova, NS | 1 |
| Puzyreva, VP | 1 |
| Strokov, IA | 2 |
| Yan, LJ | 1 |
| Cercillieux, A | 1 |
| Ratajczak, J | 1 |
| Joffraud, M | 1 |
| Sanchez-Garcia, JL | 1 |
| Jacot, G | 1 |
| Zollinger, A | 1 |
| Métairon, S | 1 |
| Giroud-Gerbetant, J | 1 |
| Rumpler, M | 1 |
| Ciarlo, E | 1 |
| Valera-Alberni, M | 1 |
| Sambeat, A | 1 |
| Canto, C | 1 |
| Razliqi, RN | 1 |
| Ahangarpour, A | 1 |
| Mard, SA | 1 |
| Khorsandi, L | 1 |
| Trakhtenberg, YA | 1 |
| Kovalenko, AL | 2 |
| Madeswaran, A | 1 |
| Mohan, S | 1 |
| Wu, S | 1 |
| Ai, W | 1 |
| Nie, L | 1 |
| Lu, X | 1 |
| Kamaraj, N | 1 |
| Velumani, K | 1 |
| Guru, A | 1 |
| Issac, PK | 1 |
| Panda, BP | 1 |
| Krishnamoorthy, R | 1 |
| Bhattamisra, SK | 1 |
| Shivashekaregowda, NKH | 1 |
| Seng, LB | 1 |
| Patnaik, S | 1 |
| Lwin, OM | 1 |
| Giribabu, N | 2 |
| Kilari, EK | 2 |
| Salleh, N | 2 |
| Zhang, J | 2 |
| Chen, Y | 2 |
| Liu, C | 2 |
| Li, L | 3 |
| Li, P | 2 |
| Neyshaburinezhad, N | 1 |
| Seidabadi, M | 1 |
| Rouini, M | 1 |
| Lavasani, H | 1 |
| Foroumadi, A | 1 |
| Ardakani, YH | 1 |
| Bathina, S | 1 |
| Gundala, NKV | 1 |
| Rhenghachar, P | 1 |
| Polavarapu, S | 1 |
| Hari, AD | 1 |
| Sadananda, M | 1 |
| Das, UN | 1 |
| Ahmed, OM | 1 |
| Abd El-Twab, SM | 1 |
| Al-Muzafar, HM | 1 |
| Adel Amin, K | 1 |
| Abdel Aziz, SM | 1 |
| Abdel-Gabbar, M | 1 |
| Hallakou-Bozec, S | 1 |
| Kergoat, M | 1 |
| Fouqueray, P | 1 |
| Bolze, S | 1 |
| Moller, DE | 1 |
| Alaca, N | 1 |
| Uslu, S | 1 |
| Gulec Suyen, G | 1 |
| Ince, U | 1 |
| Serteser, M | 1 |
| Kurtel, H | 1 |
| Skrypko, V | 1 |
| Kovalenko, A | 1 |
| Zaplutanov, V | 1 |
| Myhaloyko, I | 1 |
| Rani, R | 1 |
| Dahiya, S | 1 |
| Dhingra, D | 1 |
| Dilbaghi, N | 1 |
| Kim, KH | 1 |
| Kumar, S | 1 |
| Chayarop, K | 1 |
| Peungvicha, P | 1 |
| Temsiririrkkul, R | 1 |
| Wongkrajang, Y | 1 |
| Chuakul, W | 1 |
| Rojsanga, P | 1 |
| Karim, K | 1 |
| Kassim, NM | 1 |
| Labenz, C | 1 |
| Prenosil, V | 1 |
| Koch, S | 1 |
| Huber, Y | 1 |
| Marquardt, JU | 1 |
| Schattenberg, JM | 1 |
| Galle, PR | 1 |
| Weinmann, A | 1 |
| Wörns, MA | 1 |
| Abdellatief, SA | 1 |
| Beheiry, RR | 1 |
| El-Mandrawy, SAM | 1 |
| Casadei Gardini, A | 2 |
| Faloppi, L | 2 |
| De Matteis, S | 1 |
| Foschi, FG | 2 |
| Silvestris, N | 2 |
| Tovoli, F | 1 |
| Palmieri, V | 1 |
| Marisi, G | 2 |
| Brunetti, O | 2 |
| Vespasiani-Gentilucci, U | 1 |
| Perrone, G | 1 |
| Valgiusti, M | 1 |
| Granato, AM | 1 |
| Ercolani, G | 1 |
| Negrini, G | 1 |
| Tamburini, E | 2 |
| Aprile, G | 1 |
| Passardi, A | 1 |
| Santini, D | 1 |
| Cascinu, S | 2 |
| Frassineti, GL | 2 |
| Scartozzi, M | 2 |
| Gumuslu, E | 1 |
| Cine, N | 1 |
| Ertan, M | 1 |
| Mutlu, O | 1 |
| Komsuoglu Celikyurt, I | 1 |
| Ulak, G | 1 |
| Makol, A | 1 |
| Kanthaje, S | 1 |
| Dhiman, RK | 1 |
| Kalra, N | 1 |
| Chawla, YK | 1 |
| Chakraborti, A | 1 |
| Ueno, H | 1 |
| Shimizu, R | 1 |
| Okuno, T | 1 |
| Ogino, H | 1 |
| Arakawa, T | 1 |
| Murano, K | 1 |
| Nakamuro, K | 1 |
| Kheiripour, N | 1 |
| Karimi, J | 1 |
| Khodadadi, I | 1 |
| Tavilani, H | 1 |
| Goodarzi, MT | 2 |
| Hashemnia, M | 1 |
| Kazemi, F | 1 |
| Zahediasl, S | 1 |
| Hamza, AA | 1 |
| Fikry, EM | 1 |
| Abdallah, W | 1 |
| Amin, A | 1 |
| Abdullah, KM | 1 |
| Alam, MM | 1 |
| Iqbal, Z | 1 |
| Naseem, I | 1 |
| El-Beih, NM | 1 |
| Ramadan, G | 1 |
| El-Husseiny, EA | 1 |
| Hussein, AM | 1 |
| Bahmanzadeh, M | 1 |
| Rezaei Farimani, A | 1 |
| Fathi, N | 1 |
| Alizadeh, Z | 1 |
| Anwer, T | 1 |
| Alkarbi, ZA | 1 |
| Hassan Najmi, A | 1 |
| Alshahrani, S | 1 |
| Siddiqui, R | 1 |
| Khan, G | 1 |
| Firoz Alam, M | 1 |
| Agrawal, R | 1 |
| Sethiya, NK | 1 |
| Mishra, SH | 1 |
| Jangale, NM | 1 |
| Devarshi, PP | 1 |
| Dubal, AA | 1 |
| Ghule, AE | 1 |
| Koppikar, SJ | 1 |
| Bodhankar, SL | 2 |
| Chougale, AD | 1 |
| Kulkarni, MJ | 1 |
| Harsulkar, AM | 1 |
| Holstein, A | 1 |
| Kovacs, P | 1 |
| Beil, W | 1 |
| Chen, T | 1 |
| Kagan, L | 1 |
| Mager, DE | 1 |
| Rathinavelusamy, P | 1 |
| Mazumder, PM | 1 |
| Sasmal, D | 1 |
| Jayaprakash, V | 1 |
| Yang, SJ | 2 |
| Choi, JM | 1 |
| Kim, L | 1 |
| Park, SE | 1 |
| Rhee, EJ | 1 |
| Lee, WY | 1 |
| Oh, KW | 1 |
| Park, SW | 1 |
| Park, CY | 1 |
| Taha, H | 2 |
| Arya, A | 2 |
| Paydar, M | 1 |
| Looi, CY | 2 |
| Wong, WF | 1 |
| Vasudeva Murthy, CR | 1 |
| Noordin, MI | 1 |
| Ali, HM | 1 |
| Mustafa, AM | 1 |
| Hadi, AH | 1 |
| Weng, Y | 1 |
| Yu, L | 1 |
| Cui, J | 1 |
| Zhu, YR | 1 |
| Guo, C | 1 |
| Wei, G | 1 |
| Duan, JL | 1 |
| Yin, Y | 1 |
| Guan, Y | 1 |
| Wang, YH | 1 |
| Yang, ZF | 1 |
| Xi, MM | 1 |
| Wen, AD | 1 |
| Kraus, D | 1 |
| Yang, Q | 3 |
| Kong, D | 1 |
| Banks, AS | 1 |
| Zhang, L | 1 |
| Rodgers, JT | 1 |
| Pirinen, E | 1 |
| Pulinilkunnil, TC | 1 |
| Gong, F | 1 |
| Wang, YC | 1 |
| Cen, Y | 1 |
| Sauve, AA | 1 |
| Asara, JM | 1 |
| Peroni, OD | 1 |
| Monia, BP | 1 |
| Bhanot, S | 1 |
| Alhonen, L | 1 |
| Puigserver, P | 1 |
| Kahn, BB | 1 |
| Akahane, K | 1 |
| Inoue, T | 1 |
| Yokoyama, A | 1 |
| Yaguchi, A | 1 |
| Ojima, K | 1 |
| Kiguchi, S | 1 |
| Maruyama, K | 1 |
| Kobayashi, M | 1 |
| Mori, Y | 1 |
| Ghasemi, A | 2 |
| Khalifi, S | 2 |
| Jedi, S | 1 |
| Nayak, Y | 1 |
| Hillemane, V | 1 |
| Daroji, VK | 1 |
| Jayashree, BS | 1 |
| Unnikrishnan, MK | 1 |
| Mikhaloĭko, IIa | 1 |
| Sabadosh, RV | 1 |
| Skripko, VD | 1 |
| Khanra, R | 1 |
| Dewanjee, S | 1 |
| K Dua, T | 1 |
| Sahu, R | 1 |
| Gangopadhyay, M | 1 |
| De Feo, V | 1 |
| Zia-Ul-Haq, M | 1 |
| Kannt, A | 2 |
| Pfenninger, A | 2 |
| Teichert, L | 1 |
| Tönjes, A | 2 |
| Dietrich, A | 1 |
| Schön, MR | 1 |
| Klöting, N | 1 |
| Blüher, M | 2 |
| Duca, FA | 1 |
| Côté, CD | 1 |
| Rasmussen, BA | 1 |
| Zadeh-Tahmasebi, M | 1 |
| Rutter, GA | 1 |
| Filippi, BM | 1 |
| Lam, TK | 1 |
| Lee, HJ | 1 |
| Hong, YS | 1 |
| Jun, W | 1 |
| Liu, M | 2 |
| Chu, J | 1 |
| Zhu, B | 1 |
| Zhang, Q | 1 |
| Yin, X | 1 |
| Jiang, W | 1 |
| Dai, G | 1 |
| Ju, W | 1 |
| Wang, Z | 1 |
| Fang, Z | 1 |
| Zhou, SS | 4 |
| Li, D | 4 |
| Zhou, Y | 2 |
| Furman, BL | 1 |
| Fang, ZY | 1 |
| Vattam, KK | 1 |
| Raghavendran, H | 1 |
| Murali, MR | 1 |
| Savatey, H | 1 |
| Kamarul, T | 1 |
| Tahara, A | 5 |
| Takasu, T | 2 |
| Yokono, M | 2 |
| Imamura, M | 2 |
| Kurosaki, E | 2 |
| Scarpi, E | 1 |
| Masi, G | 1 |
| Vivaldi, C | 1 |
| Tamberi, S | 1 |
| Tenti, E | 1 |
| Ricca Rosellini, S | 1 |
| Ulivi, P | 1 |
| Nanni, O | 1 |
| Gatskikh, IV | 1 |
| Veselova, OF | 1 |
| Brikman, IN | 1 |
| Shalda, TP | 1 |
| Varygina, EL | 1 |
| Kuznetsov, MN | 1 |
| Shul'min, AV | 1 |
| Petrova, MM | 1 |
| Wang, P | 1 |
| Yang, X | 1 |
| Zhang, Z | 1 |
| Song, J | 1 |
| Guan, YF | 1 |
| Zou, DJ | 1 |
| Miao, CY | 1 |
| Chandran, R | 1 |
| Parimelazhagan, T | 1 |
| Shanmugam, S | 1 |
| Thankarajan, S | 1 |
| Manoka, S | 1 |
| Sungthong, B | 1 |
| Sato, H | 1 |
| Sugiyama, E | 1 |
| Sato, VH | 1 |
| Jeddi, S | 1 |
| Ghanbari, M | 1 |
| Bageripour, F | 1 |
| Taheri Rouhi, SZ | 1 |
| Sarker, MMR | 1 |
| Rahmat, A | 1 |
| Alkahtani, SA | 1 |
| Othman, F | 1 |
| Shen, SC | 1 |
| Cheng, FC | 1 |
| Wu, NJ | 1 |
| Matsuyama-Yokono, A | 3 |
| Nakano, R | 2 |
| Someya, Y | 2 |
| Hayakawa, M | 2 |
| Shibasaki, M | 4 |
| Shiraki, K | 1 |
| Nan, MH | 1 |
| Park, JS | 1 |
| Myung, CS | 1 |
| Sun, WP | 2 |
| Guo, M | 1 |
| Lun, YZ | 2 |
| Zhou, YM | 2 |
| Xiao, FC | 1 |
| Jing, LX | 1 |
| Sun, SX | 1 |
| Zhang, LB | 1 |
| Luo, N | 1 |
| Bian, FN | 1 |
| Zou, W | 1 |
| Dong, LB | 1 |
| Zhao, ZG | 1 |
| Li, SF | 1 |
| Gong, XJ | 1 |
| Yu, ZG | 1 |
| Sun, CB | 1 |
| Zheng, CL | 1 |
| Jiang, DJ | 1 |
| Li, ZN | 1 |
| Liu, XX | 1 |
| Pari, L | 6 |
| Karthikesan, K | 1 |
| Menon, VP | 1 |
| Rabbani, SI | 1 |
| Devi, K | 1 |
| Khanam, S | 1 |
| Wallach, I | 1 |
| Jaitly, N | 1 |
| Lilien, R | 1 |
| Gupta, LH | 1 |
| Badole, SL | 1 |
| Sabharwal, SG | 1 |
| Zhang, LN | 1 |
| Vincelette, J | 1 |
| Chen, D | 1 |
| Gless, RD | 1 |
| Anandan, SK | 1 |
| Rubanyi, GM | 1 |
| Webb, HK | 1 |
| MacIntyre, DE | 1 |
| Wang, YX | 1 |
| Kumar, R | 1 |
| Pate, DK | 1 |
| Prasad, SK | 1 |
| Sairam, K | 1 |
| Hemalatha, S | 1 |
| Islam, MS | 2 |
| Wilson, RD | 1 |
| Cheah, SC | 1 |
| Mustafa, MR | 1 |
| Mohd, MA | 1 |
| Yamajuku, D | 1 |
| Kihara, R | 1 |
| Hayashizaki, Y | 1 |
| Qun, L | 1 |
| Tomiyama, H | 1 |
| Kobayashi, Y | 1 |
| Noda, A | 1 |
| Sasamata, M | 1 |
| Perez-Gutierrez, RM | 1 |
| Damian-Guzman, M | 1 |
| Pierre, W | 1 |
| Gildas, AJ | 1 |
| Ulrich, MC | 1 |
| Modeste, WN | 1 |
| Benoît, NT | 1 |
| Albert, K | 1 |
| Fararh, KM | 1 |
| Atoji, Y | 1 |
| Shimizu, Y | 1 |
| Takewaki, T | 1 |
| Matsumoto, T | 1 |
| Wakabayashi, K | 1 |
| Kobayashi, T | 1 |
| Kamata, K | 1 |
| Kuntz, E | 1 |
| Pinget, M | 1 |
| Damgé, P | 1 |
| Lo, HC | 1 |
| Tsai, FA | 1 |
| Wasser, SP | 1 |
| Yang, JG | 1 |
| Huang, BM | 1 |
| Nakamura, T | 1 |
| Terajima, T | 1 |
| Ogata, T | 1 |
| Ueno, K | 1 |
| Hashimoto, N | 1 |
| Ono, K | 1 |
| Yano, S | 1 |
| Saravanan, R | 3 |
| Salek, RM | 1 |
| Maguire, ML | 1 |
| Bentley, E | 1 |
| Rubtsov, DV | 1 |
| Hough, T | 1 |
| Cheeseman, M | 1 |
| Nunez, D | 1 |
| Sweatman, BC | 1 |
| Haselden, JN | 1 |
| Cox, RD | 1 |
| Connor, SC | 1 |
| Griffin, JL | 1 |
| Choi, H | 1 |
| Murugan, P | 2 |
| L'Abbate, A | 1 |
| Neglia, D | 1 |
| Vecoli, C | 1 |
| Novelli, M | 5 |
| Ottaviano, V | 1 |
| Baldi, S | 1 |
| Barsacchi, R | 1 |
| Paolicchi, A | 1 |
| Masiello, P | 5 |
| Drummond, GS | 1 |
| McClung, JA | 1 |
| Abraham, NG | 1 |
| D'Aleo, V | 1 |
| Lupi, R | 1 |
| Paolini, M | 1 |
| Soleti, A | 1 |
| Marchetti, P | 1 |
| Wu, MS | 1 |
| Liang, JT | 1 |
| Lin, YD | 1 |
| Wu, ET | 1 |
| Tseng, YZ | 1 |
| Chang, KC | 1 |
| Unger, RH | 2 |
| Zhu, M | 4 |
| Noma, Y | 2 |
| Mizuno, A | 2 |
| Sano, T | 2 |
| Shima, K | 4 |
| Shimabukuro, M | 1 |
| Ohneda, M | 1 |
| Lee, Y | 1 |
| Broca, C | 2 |
| Gross, R | 2 |
| Roye, M | 1 |
| Manteghetti, M | 2 |
| Hillaire-Buys, D | 1 |
| Ribes, G | 2 |
| Polo, V | 1 |
| Saibene, A | 1 |
| Pontiroli, AE | 1 |
| Kuwajima, M | 2 |
| Ogino, T | 1 |
| Murakami, T | 1 |
| Petit, P | 1 |
| Sauvaire, Y | 1 |
| Tournier, M | 1 |
| Gomis, R | 2 |
| Piercy, V | 1 |
| Toseland, CD | 1 |
| Turner, NC | 1 |
| Fabregat, ME | 1 |
| Fernandez-Alvarez, J | 1 |
| Reddy, S | 1 |
| Young, M | 1 |
| Ginn, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Multicenter, Double-blind, Placebo-controlled Randomized Clinical Trial of Efficacy and Safety of the Drug Cytoflavin®, Administered Intravenously Followed by Oral Intake, in Patients With Diabetic Polyneuropathy[NCT04649203] | Phase 3 | 216 participants (Actual) | Interventional | 2020-11-25 | Completed | ||
| Pilot Study of the Effect of Fenugreek on Blood Sugar and Insulin in Diabetic Humans[NCT00597350] | 8 participants (Actual) | Observational | 2007-11-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for niacinamide and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Model of Streptozotocin-nicotinamide Induced Type 2 Diabetes: a Comparative Review.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Humans; NAD; Niacinami | 2022 |
The Nicotinamide/Streptozotocin Rodent Model of Type 2 Diabetes: Renal Pathophysiology and Redox Imbalance Features.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Glucose | 2022 |
Streptozotocin-nicotinamide-induced rat model of type 2 diabetes (review).
Topics: Animals; Blood Glucose; Diabetes Mellitus, Type 2; Humans; Insulin; Insulin-Secreting Cells; Niacina | 2014 |
[Chronic nicotinamide overload and type 2 diabetes].
Topics: Diabetes Mellitus, Type 2; Diet; Food, Fortified; Humans; Niacin; Niacinamide | 2010 |
Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications.
Topics: Acyl Coenzyme A; Adipocytes; Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Type 2; F | 1995 |
9 trials available for niacinamide and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Inhibition of 11β-Hydroxysteroid dehydrogenase-1 with AZD4017 in patients with nonalcoholic steatohepatitis or nonalcoholic fatty liver disease: A randomized, double-blind, placebo-controlled, phase II study.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Diabetes Mellitus, Type 2; Double-Blind Method; Humans; | 2022 |
Oral 11β-HSD1 inhibitor AZD4017 improves wound healing and skin integrity in adults with type 2 diabetes mellitus: a pilot randomized controlled trial.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Adult; Aged; Aged, 80 and over; Diabetes Mellitus, Type | 2022 |
Efficacy and safety of the combined metabolic medication, containing inosine, nicotinamide, riboflavin and succinic acid, for the treatment of diabetic neuropathy: a multicenter randomized, double-blind, placebo-controlled parallel group clinical trial (C
Topics: Antioxidants; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Female; Humans; Inosine; Male; Niaci | 2022 |
[Efficacy and safety of Cytoflavin in the treatment of diabetic polyneuropathy: results of a multicenter, double-blind, placebo-controlled, randomized CYLINDER study].
Topics: Diabetes Mellitus, Type 2; Diabetic Neuropathies; Humans; Inosine Diphosphate; Niacinamide | 2023 |
[EFFICACY OF CYTOFLAVIN IN COMPLEX TREATMENT OF DIABETIC FOOT SYNDROME].
Topics: Antioxidants; Combined Modality Therapy; Diabetes Mellitus, Type 2; Diabetic Foot; Drug Combinations | 2017 |
[Rationale of application of the drug Cytoflavin in complex treatment of patients with diabetic foot syndrome with mediacalcification arteries].
Topics: Aged; Anti-Bacterial Agents; Antioxidants; Arteries; Combined Modality Therapy; Debridement; Diabete | 2014 |
Association of nicotinamide-N-methyltransferase mRNA expression in human adipose tissue and the plasma concentration of its product, 1-methylnicotinamide, with insulin resistance.
Topics: Adult; Aged; Bariatric Surgery; Biomarkers; Case-Control Studies; Cross-Sectional Studies; Diabetes | 2015 |
[EFFECTIVENESS OF CYTOFLAVIN FOR THE CORRECTION OF COGNITIVE IMPAIRMENTS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS].
Topics: Adult; Aged; Cognition Disorders; Diabetes Complications; Diabetes Mellitus, Type 2; Drug Combinatio | 2015 |
Nicotinamide improves insulin secretion and metabolic control in lean type 2 diabetic patients with secondary failure to sulphonylureas.
Topics: Adult; C-Peptide; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Insulin; Insulin S | 1998 |
104 other studies available for niacinamide and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Swimming training and Plantago psyllium ameliorate cognitive impairment and glucose tolerance in streptozotocin-nicotinamide-induced type 2 diabetic rats.
Topics: Animals; Blood Glucose; Cognitive Dysfunction; Diabetes Mellitus, Experimental; Diabetes Mellitus, T | 2021 |
Effects of Combined
Topics: Animals; Aryldialkylphosphatase; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, | 2022 |
Hypoglycemic, hypolipidemic and hepatoprotective effects of
Topics: Alpinia; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glyburi | 2022 |
Nicotinamide riboside kinase 1 protects against diet and age-induced pancreatic β-cell failure.
Topics: Aging; Animals; Diabetes Mellitus, Type 2; Diet, High-Fat; Glucose; Insulin-Secreting Cells; Mice; M | 2022 |
Gentisic acid ameliorates type 2 diabetes induced by Nicotinamide-Streptozotocin in male mice by attenuating pancreatic oxidative stress and inflammation through modulation of Nrf2 and NF-кB pathways.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Inflammation; Kel | 2023 |
Neuroprotective effects of terpenoids against streptozotocin-nicotinamide-induced diabetic rats: An in silico, in vitro and in vivo study.
Topics: Acetylcholinesterase; Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetes Mellitus, Typ | 2023 |
Antidiabetic activity of eupafolin through peroxisome proliferator-activated receptor-gamma and PI3K/Akt signaling in Type 2 diabetic rats.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fl | 2023 |
Antihyperglycemic activity of 14-deoxy, 11, 12-didehydro andrographolide on streptozotocin-nicotinamide induced type 2 diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Hyp | 2023 |
Fabrication of Second Generation Smarter PLGA Based Nanocrystal Carriers for Improvement of Drug Delivery and Therapeutic Efficacy of Gliclazide in Type-2 Diabetes Rat Model.
Topics: Animals; Biological Availability; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Diab | 2019 |
Topical administration of mangiferin promotes healing of the wound of streptozotocin-nicotinamide-induced type-2 diabetic male rats.
Topics: Administration, Topical; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Male; | 2021 |
N
Topics: Acetylation; Animals; Blood Glucose; Cell Line; Diabetes Mellitus, Type 2; Forkhead Box Protein O1; | 2020 |
Evaluation of hepatic CYP2D1 activity and hepatic clearance in type I and type II diabetic rat models, before and after treatment with insulin and metformin.
Topics: Animals; Cytochrome P450 Family 2; Dextromethorphan; Diabetes Mellitus, Experimental; Diabetes Melli | 2020 |
Resolvin D1 Ameliorates Nicotinamide-streptozotocin-induced Type 2 Diabetes Mellitus by its Anti-inflammatory Action and Modulating PI3K/Akt/mTOR Pathway in the Brain.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Brain; Diabetes Mellitus, Experimental; Diabetes Melli | 2020 |
Musa paradisiaca L. leaf and fruit peel hydroethanolic extracts improved the lipid profile, glycemic index and oxidative stress in nicotinamide/streptozotocin-induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fruit; Glycemic Index; Hypoglyc | 2021 |
N1‑methylnicotinamide ameliorates insulin resistance in skeletal muscle of type 2 diabetic mice by activating the SIRT1/PGC‑1α signaling pathway.
Topics: Animals; Cell Line; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Insulin Receptor Sub | 2021 |
Imeglimin amplifies glucose-stimulated insulin release from diabetic islets via a distinct mechanism of action.
Topics: Adenosine Triphosphate; Animals; Calcium; Cyclic ADP-Ribose; Cytokines; Diabetes Mellitus, Type 2; G | 2021 |
Effects of different aerobic exercise frequencies on streptozotocin-nicotinamide-induced type 2 diabetic rats: Continuous versus short bouts and weekend warrior exercises.
Topics: Animals; Antibiotics, Antineoplastic; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Gl | 2018 |
Evaluation of anti-diabetic activity of glycyrrhizin-loaded nanoparticles in nicotinamide-streptozotocin-induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug Delivery Systems; Drug Lib | 2017 |
Hypoglycaemic activity of Mathurameha, a Thai traditional herbal formula aqueous extract, and its effect on biochemical profiles of streptozotocin-nicotinamide-induced diabetic rats.
Topics: Animals; Cholesterol; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Male; Niacinam | 2017 |
Anti-Inflammatory, Antiapoptotic and Proproliferative Effects of Vitis vinifera Seed Ethanolic Extract in the Liver of Streptozotocin-Nicotinamide-Induced Type 2 Diabetes in Male Rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Cell Proliferation; Diabetes Mellitus, E | 2018 |
Impact of Individual Components of the Metabolic Syndrome on the Outcome of Patients with Advanced Hepatocellular Carcinoma Treated with Sorafenib.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Hepatocellular; Diabetes Mellitus, | 2018 |
Peppermint essential oil alleviates hyperglycemia caused by streptozotocin- nicotinamide-induced type 2 diabetes in rats.
Topics: Administration, Oral; Animals; Antioxidants; Diabetes Mellitus, Type 2; Free Radical Scavengers; Gly | 2017 |
Metformin and insulin impact on clinical outcome in patients with advanced hepatocellular carcinoma receiving sorafenib: Validation study and biological rationale.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Hepatocellular; Databases, Factual | 2017 |
Exenatide upregulates gene expression of glucagon-like peptide-1 receptor and nerve growth factor in streptozotocin/nicotinamide-induced diabetic mice.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Exenatide; Glucagon-Like Peptid | 2018 |
Association of liver cirrhosis severity with type 2 diabetes mellitus in hepatocellular carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Hepatocellular; Diabetes Mellitus, | 2018 |
Effect of Seleno-L-methionine on Oxidative Stress in the Pancreatic Islets of a Short-Term Induced Diabetic Mouse Model in Insufficient Selenium Status.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose Tolerance Test; Glycate | 2018 |
Silymarin prevents lipid accumulation in the liver of rats with type 2 diabetes via sirtuin1 and SREBP-1c.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dose-Response Relationship, Dru | 2018 |
Effects of exercise training on adipose tissue apelin expression in streptozotocin-nicotinamide induced diabetic rats.
Topics: Adipose Tissue; Animals; Apelin; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabet | 2018 |
Mechanistic insights into the augmented effect of bone marrow mesenchymal stem cells and thiazolidinediones in streptozotocin-nicotinamide induced diabetic rats.
Topics: Animals; Antibiotics, Antineoplastic; Cells, Cultured; Combined Modality Therapy; Diabetes Mellitus, | 2018 |
Therapeutic effect of vitamin B
Topics: Alloxan; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, T | 2018 |
Effects of pomegranate aril juice and its punicalagin on some key regulators of insulin resistance and oxidative liver injury in streptozotocin-nicotinamide type 2 diabetic rats.
Topics: Animals; Antioxidants; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Hydrolyzable Tannins; | 2019 |
Resveratrol supplementation improves DNA integrity and sperm parameters in streptozotocin-nicotinamide-induced type 2 diabetic rats.
Topics: Animals; Antioxidants; Chromatin; Chromatin Assembly and Disassembly; Diabetes Mellitus, Experimenta | 2019 |
Modulatory effect of zingerone against STZ-nicotinamide induced type-2 diabetes mellitus in rats.
Topics: Animals; Antibiotics, Antineoplastic; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Melli | 2021 |
Antidiabetic activity of alkaloids of Aerva lanata roots on streptozotocin-nicotinamide induced type-II diabetes in rats.
Topics: Administration, Oral; Alkaloids; Amaranthaceae; Animals; Blood Glucose; Chromatography, Thin Layer; | 2013 |
Dietary flaxseed oil and fish oil modulates expression of antioxidant and inflammatory genes with alleviation of protein glycation status and inflammation in liver of streptozotocin-nicotinamide induced diabetic rats.
Topics: Animals; Antioxidants; Aryldialkylphosphatase; Catalase; Cytokines; Diabetes Mellitus, Type 2; Disea | 2013 |
Severe hypoglycemia due to possible interaction between glibenclamide and sorafenib in a patient with hepatocellular carcinoma.
Topics: Aged; Antineoplastic Agents; Blood Glucose; Carcinoma, Hepatocellular; Diabetes Mellitus, Type 2; Dr | 2013 |
Population pharmacodynamic modeling of exenatide after 2-week treatment in STZ/NA diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Progress | 2013 |
Evaluation of in silico, in vitro α-amylase inhibition potential and antidiabetic activity of Pterospermum acerifolium bark.
Topics: Animals; Computer Simulation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dose-Respo | 2014 |
Nicotinamide improves glucose metabolism and affects the hepatic NAD-sirtuin pathway in a rodent model of obesity and type 2 diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, | 2014 |
Upregulation of insulin secretion and downregulation of pro-inflammatory cytokines, oxidative stress and hyperglycemia in STZ-nicotinamide-induced type 2 diabetic rats by Pseuduvaria monticola bark extract.
Topics: Animals; Annonaceae; Cytokines; Diabetes Mellitus, Type 2; Down-Regulation; Inflammation Mediators; | 2014 |
Antihyperglycemic, hypolipidemic and antioxidant activities of total saponins extracted from Aralia taibaiensis in experimental type 2 diabetic rats.
Topics: Animals; Antioxidants; Aralia; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Ty | 2014 |
Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.
Topics: Acetyltransferases; Adipocytes; Adipose Tissue; Adipose Tissue, White; Animals; Diabetes Mellitus, T | 2014 |
Efficacy of Mitiglinide Combined with Dapagliflozin in Streptozotocin-nicotinamide-induced Type 2 Diabetic Rats and in Zucker Fatty Rats.
Topics: Animals; Benzhydryl Compounds; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Ty | 2015 |
Antidiabetic activity of benzopyrone analogues in nicotinamide-streptozotocin induced type 2 diabetes in rats.
Topics: Animals; Biomarkers; Blood Glucose; Coumarins; Creatinine; Diabetes Mellitus, Experimental; Diabetes | 2014 |
Abroma augusta L. (Malvaceae) leaf extract attenuates diabetes induced nephropathy and cardiomyopathy via inhibition of oxidative stress and inflammatory response.
Topics: Adenosine Triphosphate; Animals; Biomarkers; Blood Glucose; Body Weight; Cardiomyopathies; Diabetes | 2015 |
Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats.
Topics: AMP-Activated Protein Kinases; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Duodenum; Gene Exp | 2015 |
Nicotinamide Riboside Ameliorates Hepatic Metaflammation by Modulating NLRP3 Inflammasome in a Rodent Model of Type 2 Diabetes.
Topics: Adiponectin; Animals; Anti-Inflammatory Agents; Apoptosis Regulatory Proteins; Blood Glucose; CARD S | 2015 |
Serum N(1)-Methylnicotinamide Is Associated With Obesity and Diabetes in Chinese.
Topics: Adult; Asian People; Body Mass Index; China; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Fem | 2015 |
Management of nicotinamide N-methyltransferase overexpression: inhibit the enzyme or reduce nicotinamide intake? Reply to Zhou S, Li D, Zhou Y [letter].
Topics: Diabetes Mellitus, Type 2; Female; Humans; Insulin Resistance; Male; Niacinamide; Nicotinamide N-Met | 2015 |
Management of nicotinamide N-methyltransferase overexpression: inhibit the enzyme or reduce nicotinamide intake?
Topics: Diabetes Mellitus, Type 2; Female; Humans; Insulin Resistance; Male; Niacinamide; Nicotinamide N-Met | 2015 |
Streptozotocin-Induced Diabetic Models in Mice and Rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diet | 2015 |
Letter to the Editor: High Serum N(1)-Methylnicotinamide in Obesity and Diabetes: A Consequence of Excess Nicotinamide?
Topics: Diabetes Mellitus, Type 2; Female; Humans; Male; Niacinamide; Obesity | 2015 |
Response to the Letter by Zhou, et al.
Topics: Diabetes Mellitus, Type 2; Female; Humans; Male; Niacinamide; Obesity | 2015 |
Coadministration of alloxan and nicotinamide in rats produces biochemical changes in blood and pathological alterations comparable to the changes in type II diabetes mellitus.
Topics: Adiponectin; Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Ty | 2016 |
Effects of the combination of SGLT2 selective inhibitor ipragliflozin and various antidiabetic drugs in type 2 diabetic mice.
Topics: Animals; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet | 2016 |
Effects of metformin on clinical outcome in diabetic patients with advanced HCC receiving sorafenib.
Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Diabetes Mellitus, Type 2; Drug Resistance, Neopla | 2015 |
Depletion of NAD pool contributes to impairment of endothelial progenitor cell mobilization in diabetes.
Topics: Animals; Chemokine CXCL12; Diabetes Mellitus, Type 2; Endothelial Progenitor Cells; Female; Hindlimb | 2016 |
Antidiabetic activity of Syzygium calophyllifolium in Streptozotocin-Nicotinamide induced Type-2 diabetic rats.
Topics: Animals; Antioxidants; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Hypo | 2016 |
Hypoglycemic and Antioxidant Activities of the Water Extract of Aquilaria crassna Leaves in Streptozotocin-Nicotinamide-Induced Type-2 Diabetic Mice.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Hu | 2016 |
Effects of Nitrate Intake on Myocardial Ischemia-Reperfusion Injury in Diabetic Rats.
Topics: Animals; Cardiotonic Agents; Coronary Vessels; Diabetes Mellitus, Experimental; Diabetes Mellitus, T | 2016 |
The effect of pomegranate fresh juice versus pomegranate seed powder on metabolic indices, lipid profile, inflammatory biomarkers, and the histopathology of pancreatic islets of Langerhans in streptozotocin-nicotinamide induced type 2 diabetic Sprague-Daw
Topics: Animals; Biomarkers; Cholesterol; Diabetes Mellitus, Type 2; Disease Models, Animal; Fruit and Veget | 2017 |
Effect of guava (Psidium guajava Linn.) leaf soluble solids on glucose metabolism in type 2 diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose Toleranc | 2008 |
Effects of the combination of dipeptidyl peptidase-IV inhibitor ASP8497 and antidiabetic drugs in streptozotocin-nicotinamide-induced mildly diabetic mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl-Pepti | 2009 |
Antidiabetic effects of dipeptidyl peptidase-IV inhibitors and sulfonylureas in streptozotocin-nicotinamide-induced mildly diabetic mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl-Pepti | 2009 |
Construction of adiponectin-encoding plasmid DNA and gene therapy of non-obese type 2 diabetes mellitus.
Topics: Adiponectin; Animals; Blood Glucose; Cell Line; Cell Line, Tumor; Diabetes Mellitus, Experimental; D | 2010 |
Nicotinamide overload may play a role in the development of type 2 diabetes.
Topics: Adult; Aged; Aldehyde Oxidase; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Erythrocytes; Fema | 2009 |
Comparative and combined effect of chlorogenic acid and tetrahydrocurcumin on antioxidant disparities in chemical induced experimental diabetes.
Topics: Animals; Antioxidants; Chlorogenic Acid; Curcumin; Diabetes Mellitus, Experimental; Diabetes Mellitu | 2010 |
Pioglitazone, a PPAR-gamma ligand inhibited the nicotinamide-streptozotocin induced sperm abnormalities in type-2 diabetic Wistar rats.
Topics: alpha-Tocopherol; Animals; Antioxidants; Diabetes Mellitus, Type 2; Glucose Tolerance Test; Hypoglyc | 2010 |
A structure-based approach for mapping adverse drug reactions to the perturbation of underlying biological pathways.
Topics: Breast Neoplasms; Computational Biology; Databases, Factual; Diabetes Mellitus, Type 2; Drug-Related | 2010 |
Antidiabetic potential of α-amylase inhibitor from the seeds of Macrotyloma uniflorum in streptozotocin-nicotinamide-induced diabetic mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Enzyme Inhibitor | 2011 |
Inhibition of soluble epoxide hydrolase attenuates endothelial dysfunction in animal models of diabetes, obesity and hypertension.
Topics: Adamantane; Administration, Oral; Animals; Aorta; Diabetes Mellitus, Experimental; Diabetes Mellitus | 2011 |
Effects of antidiabetic drugs in high-fat diet and streptozotocin-nicotinamide-induced type 2 diabetic mice.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dietary Fats; Drug Administrati | 2011 |
Antidiabetic activity of alcoholic leaves extract of Alangium lamarckii Thwaites on streptozotocin-nicotinamide induced type 2 diabetic rats.
Topics: Alangiaceae; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus | 2011 |
Experimentally induced rodent models of type 2 diabetes.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Fetal | 2012 |
The methanolic fraction of Centratherum anthelminticum seed downregulates pro-inflammatory cytokines, oxidative stress, and hyperglycemia in STZ-nicotinamide-induced type 2 diabetic rats.
Topics: Animals; Antioxidants; Asteraceae; Cells, Cultured; Cytokines; Diabetes Mellitus, Type 2; Hyperglyce | 2012 |
Antidiabetic effects of SGLT2-selective inhibitor ipragliflozin in streptozotocin-nicotinamide-induced mildly diabetic mice.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose; Glucose Tolerance Test | 2012 |
Meliacinolin: a potent α-glucosidase and α-amylase inhibitor isolated from Azadirachta indica leaves and in vivo antidiabetic property in streptozotocin-nicotinamide-induced type 2 diabetes in mice.
Topics: alpha-Amylases; Animals; Azadirachta; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Di | 2012 |
Hypoglycemic and hypolipidemic effects of Bersama engleriana leaves in nicotinamide/streptozotocin-induced type 2 diabetic rats.
Topics: Animals; Blood Glucose; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 2; Hyperlipidemi | 2012 |
Isulinotropic properties of Nigella sativa oil in Streptozotocin plus Nicotinamide diabetic hamster.
Topics: Animals; Blood Glucose; Cricetinae; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Immu | 2002 |
Alterations in vascular endothelial function in the aorta and mesenteric artery in type II diabetic rats.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Biological Factors; Chlorides; Diabetes Mellitus, Experimen | 2004 |
Cholecystokinin octapeptide: a potential growth factor for pancreatic beta cells in diabetic rats.
Topics: Animals; Blood Glucose; Cell Division; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; D | 2004 |
Effects of ingested fruiting bodies, submerged culture biomass, and acidic polysaccharide glucuronoxylomannan of Tremella mesenterica Retz.:Fr. on glycemic responses in normal and diabetic rats.
Topics: Agaricales; Animals; Biomass; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dia | 2006 |
Establishment and pathophysiological characterization of type 2 diabetic mouse model produced by streptozotocin and nicotinamide.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dietary Fats; Do | 2006 |
Succinic acid monoethyl ester prevents oxidative stress in streptozotocin-nicotinamide-induced type2 diabetic rats.
Topics: Animals; Antioxidants; Ascorbic Acid; Blood Glucose; Catalase; Diabetes Mellitus, Experimental; Diab | 2006 |
A metabolomic comparison of urinary changes in type 2 diabetes in mouse, rat, and human.
Topics: Animals; Diabetes Mellitus, Type 2; Female; Humans; Magnetic Resonance Spectroscopy; Male; Methylami | 2007 |
Nongenetic model of type 2 diabetes: a comparative study.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dietary Fats; Male; Niacinamide | 2007 |
Beneficial effect of succinic acid monoethyl ester on erythrocyte membrane bound enzymes and antioxidant status in streptozotocin-nicotinamide induced type 2 diabetes.
Topics: Adenosine Triphosphatases; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Di | 2007 |
Influence of tetrahydrocurcumin on hepatic and renal functional markers and protein levels in experimental type 2 diabetic rats.
Topics: Animals; Antioxidants; Biomarkers; Chemoprevention; Curcumin; Diabetes Mellitus, Experimental; Diabe | 2007 |
Beneficial effect of heme oxygenase-1 expression on myocardial ischemia-reperfusion involves an increase in adiponectin in mildly diabetic rats.
Topics: Adiponectin; Animals; bcl-X Protein; Cardiovascular Agents; Coronary Vessels; Diabetes Mellitus, Exp | 2007 |
Influence of tetrahydrocurcumin on tail tendon collagen contents and its properties in rats with streptozotocin-nicotinamide-induced type 2 diabetes.
Topics: Animals; Collagen; Curcumin; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Hydroxyprol | 2007 |
Reduction of oxidative stress by a new low-molecular-weight antioxidant improves metabolic alterations in a nonobese mouse diabetes model.
Topics: Animals; Antioxidants; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitu | 2007 |
Aminoguanidine prevents the impairment of cardiac pumping mechanics in rats with streptozotocin and nicotinamide-induced type 2 diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Enzyme | 2008 |
Effect of succinic acid monoethyl ester on hemoglobin glycation and tail tendon collagen properties in type 2 diabetic rats.
Topics: Animals; Blood Glucose; Collagen; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glycat | 2008 |
Poor capacity for proliferation of pancreatic beta-cells in Otsuka-Long-Evans-Tokushima Fatty rat: a model of spontaneous NIDDM.
Topics: Animals; Blood Glucose; Body Weight; Cell Division; Diabetes Mellitus; Diabetes Mellitus, Type 2; Fe | 1996 |
Pancreatic A-cell function in the partially pancreatectomized Otsuka Long-Evans Tokushima Fatty rat, a model of spontaneous non-insulin-dependent diabetes mellitus.
Topics: Animals; Arginine; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Disease Models, Animal; Gl | 1996 |
Role of nitric oxide in obesity-induced beta cell disease.
Topics: Animals; Blood Glucose; Cells, Cultured; Diabetes Mellitus; Diabetes Mellitus, Type 2; Fatty Acids, | 1997 |
Experimental NIDDM: development of a new model in adult rats administered streptozotocin and nicotinamide.
Topics: Animals; Arginine; Blood Glucose; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucose; Glucos | 1998 |
A role of nicotinamide-induced increase in pancreatic beta-cell mass on blood glucose control after discontinuation of the treatment in partially pancreatectomized OLETF rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Insulin; Islets | 1998 |
Report for the EASD-Bayer Travel Fellowship for Young Scientists 1997. European Association for the Study of Diabetes.
Topics: Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Europe; Fell | 1998 |
Effect of partial pancreatectomy on beta-cell mass in the remnant pancreas of Wistar fatty rats.
Topics: Animals; Blood Glucose; Cell Division; Diabetes Mellitus; Diabetes Mellitus, Type 2; Disease Models, | 1998 |
4-Hydroxyisoleucine: experimental evidence of its insulinotropic and antidiabetic properties.
Topics: Acids; Animals; Diabetes Mellitus, Type 2; Glucose Tolerance Test; Hypoglycemic Agents; Insulin; Ins | 1999 |
Acceleration of the development of diabetes in obese diabetic (db/db) mice by nicotinamide: a comparison with its antidiabetic effects in non-obese diabetic mice.
Topics: Animals; Diabetes Mellitus, Type 2; Disease Progression; Female; Glycosuria; Hyperglycemia; Insulin; | 2000 |
Metabolic and functional studies on isolated islets in a new rat model of type 2 diabetes.
Topics: Aminooxyacetic Acid; Animals; Diabetes Mellitus, Type 2; Disease Models, Animal; Glucose; Glycerolph | 2001 |
Immunoexpression of interleukin-1beta in pancreatic islets of NOD mice during cyclophosphamide-accelerated diabetes: co-localization in macrophages and endocrine cells and its attenuation with oral nicotinamide.
Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Cyclophosphamide; Diabetes Mellitus, Type 2; | 2001 |