niacinamide has been researched along with Chemical and Drug Induced Liver Injury in 35 studies
nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sorafenib was approved for treatment of unresectable hepatocellular carcinoma (HCC) in Japan in 2009." | 7.83 | Safety and effectiveness of sorafenib in Japanese patients with hepatocellular carcinoma in daily medical practice: interim analysis of a prospective postmarketing all-patient surveillance study. ( Furuse, J; Ikeda, K; Inuyama, L; Ito, Y; Kaneko, S; Matsuzaki, Y; Minami, H; Okayama, Y; Okita, K; Sunaya, T, 2016) |
| " The aim of this work was to characterize the profile of release of endogenous MNA during the initiation and progression of murine hepatitis induced by Concanavalin A (ConA)." | 7.81 | Differential involvement of IL-6 in the early and late phase of 1-methylnicotinamide (MNA) release in Concanavalin A-induced hepatitis. ( Chlopicki, S; Czarnowska, E; Jakubowski, A; Jasztal, A; Kaminski, K; Sitek, B; Slominska, EM; Smolenski, RT; Sternak, M; Szafarz, M; Walczak, M; Wojcik, T, 2015) |
| " In this study, we demonstrated that IL-10-producing macrophages contribute to immune tolerance in the inflamed liver under intestinal barrier disruption in a murine tandem model of dextran sulfate sodium (DSS) colitis and concanavalin A (Con A) hepatitis." | 3.88 | Intestinal barrier regulates immune responses in the liver via IL-10-producing macrophages. ( Amiya, T; Chu, PS; Ebinuma, H; Fukuda, S; Kanai, T; Katayama, T; Mikami, Y; Miyake, R; Nakamoto, N; Shiba, S; Suzuki, T; Taniki, N; Teratani, T; Tsukimi, T; Yamaguchi, A, 2018) |
| "Sorafenib was approved for treatment of unresectable hepatocellular carcinoma (HCC) in Japan in 2009." | 3.83 | Safety and effectiveness of sorafenib in Japanese patients with hepatocellular carcinoma in daily medical practice: interim analysis of a prospective postmarketing all-patient surveillance study. ( Furuse, J; Ikeda, K; Inuyama, L; Ito, Y; Kaneko, S; Matsuzaki, Y; Minami, H; Okayama, Y; Okita, K; Sunaya, T, 2016) |
| " The aim of this work was to characterize the profile of release of endogenous MNA during the initiation and progression of murine hepatitis induced by Concanavalin A (ConA)." | 3.81 | Differential involvement of IL-6 in the early and late phase of 1-methylnicotinamide (MNA) release in Concanavalin A-induced hepatitis. ( Chlopicki, S; Czarnowska, E; Jakubowski, A; Jasztal, A; Kaminski, K; Sitek, B; Slominska, EM; Smolenski, RT; Sternak, M; Szafarz, M; Walczak, M; Wojcik, T, 2015) |
| "The use of topical nicotinamide in the treatment of acne vulgaris; melasma; atopic dermatitis; rosacea; and oral nicotinamide in preventing nonmelanoma skin cancer is discussed." | 2.50 | A review of nicotinamide: treatment of skin diseases and potential side effects. ( Rolfe, HM, 2014) |
| " High-dose nicotinamide should still, however, be considered as a drug with toxic potential at adult doses in excess of 3 gm/day and unsupervised use should be discouraged." | 2.41 | Safety of high-dose nicotinamide: a review. ( Bingley, PJ; Douek, IF; Gale, EA; Gillmor, HA; Knip, M; McLean, AE; Moore, WP, 2000) |
| "The major adverse effect associated with systemic administration of Fluconazole (FLZ), is hepatic toxicity." | 1.51 | Vitamin B combination reduces fluconazole toxicity in Wistar rats. ( Al-Abbasi, FA; Anwar, F; Mushtaq, G; Sadath, S, 2019) |
| "Thirty-six albino rats were divided into six groups: Control group; TAA group (IP injection with TAA at a dosage of 200 mg/Kg three times a week for two months); TAA + NA group (rats administered with NA at a dosage of 200 mg/kg daily besides TAA as in the control); TAA + VB2 group (rats administered with vitamin B2 at a dosage of 30 mg/kg daily besides injection with TAA); TAA + VC group (rats administered with vitamin C at a dosage of 200 mg/kg daily along with injection of TAA)." | 1.48 | Potential effects of the combination of nicotinamide, vitamin B2 and vitamin C on oxidative-mediated hepatotoxicity induced by thioacetamide. ( Abdelmottaleb Moussa, SA; Al Tamimi, J; Alaamer, A; Alhazza, IM; Bashandy, SAE; Ebaid, H; Hassan, I, 2018) |
| " We have developed a mouse model to demonstrate the toxic effects of methotrexate: mice were given 50 mg/kg acetaminophen, which itself has no effect on the liver." | 1.30 | Nicotinamide and methionine reduce the liver toxic effect of methotrexate. ( Bache, K; Hauschild, A; Kröger, H; Krüger, D; Ohde, M; Thefeldt, W; Voigt, WP, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (40.00) | 18.7374 |
| 1990's | 2 (5.71) | 18.2507 |
| 2000's | 2 (5.71) | 29.6817 |
| 2010's | 15 (42.86) | 24.3611 |
| 2020's | 2 (5.71) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Wang, Y | 2 |
| Cheng, W | 1 |
| Wang, X | 1 |
| He, T | 1 |
| Liu, J | 1 |
| Chen, S | 1 |
| Zhang, J | 1 |
| Brewer, CT | 1 |
| Kodali, K | 1 |
| Wu, J | 1 |
| Shaw, TI | 1 |
| Peng, J | 1 |
| Chen, T | 1 |
| Bashandy, SAE | 1 |
| Ebaid, H | 1 |
| Abdelmottaleb Moussa, SA | 1 |
| Alhazza, IM | 1 |
| Hassan, I | 1 |
| Alaamer, A | 1 |
| Al Tamimi, J | 1 |
| Wang, S | 1 |
| Wan, T | 1 |
| Ye, M | 1 |
| Qiu, Y | 1 |
| Pei, L | 1 |
| Jiang, R | 3 |
| Pang, N | 1 |
| Huang, Y | 1 |
| Liang, B | 1 |
| Ling, W | 1 |
| Lin, X | 1 |
| Zhang, Z | 1 |
| Yang, L | 1 |
| Taniki, N | 1 |
| Nakamoto, N | 1 |
| Chu, PS | 1 |
| Mikami, Y | 1 |
| Amiya, T | 1 |
| Teratani, T | 1 |
| Suzuki, T | 1 |
| Tsukimi, T | 1 |
| Fukuda, S | 1 |
| Yamaguchi, A | 1 |
| Shiba, S | 1 |
| Miyake, R | 1 |
| Katayama, T | 1 |
| Ebinuma, H | 1 |
| Kanai, T | 1 |
| Al-Abbasi, FA | 1 |
| Sadath, S | 1 |
| Mushtaq, G | 1 |
| Anwar, F | 1 |
| Mancuso, A | 1 |
| Zavaglia, C | 1 |
| Bai, F | 1 |
| Puoti, M | 1 |
| Belli, LS | 1 |
| Rolfe, HM | 1 |
| Sternak, M | 2 |
| Jakubowski, A | 2 |
| Czarnowska, E | 1 |
| Slominska, EM | 1 |
| Smolenski, RT | 1 |
| Szafarz, M | 1 |
| Walczak, M | 1 |
| Sitek, B | 1 |
| Wojcik, T | 1 |
| Jasztal, A | 1 |
| Kaminski, K | 1 |
| Chlopicki, S | 2 |
| Jablonski, K | 1 |
| Ciszek-Lenda, M | 1 |
| Marcinkiewicz, J | 1 |
| Kaneko, S | 1 |
| Ikeda, K | 1 |
| Matsuzaki, Y | 1 |
| Furuse, J | 1 |
| Minami, H | 1 |
| Okayama, Y | 1 |
| Sunaya, T | 1 |
| Ito, Y | 1 |
| Inuyama, L | 1 |
| Okita, K | 1 |
| Shantakumar, S | 1 |
| Nordstrom, BL | 1 |
| Djousse, L | 1 |
| Hall, SA | 1 |
| Gagnon, DR | 1 |
| Fraeman, KH | 1 |
| van Herk-Sukel, M | 1 |
| Chagin, K | 1 |
| Nelson, J | 1 |
| Llanos, L | 1 |
| Bellot, P | 1 |
| Zapater, P | 1 |
| Pérez-Mateo, M | 1 |
| Such, J | 1 |
| Herden, U | 1 |
| Fischer, L | 1 |
| Schäfer, H | 1 |
| Nashan, B | 1 |
| von Baehr, V | 1 |
| Sterneck, M | 1 |
| Xie, J | 1 |
| Wan, J | 1 |
| Lu, H | 1 |
| Peng, X | 1 |
| Zhang, L | 2 |
| Shi, Y | 1 |
| Chen, W | 1 |
| Zheng, W | 1 |
| Chen, L | 1 |
| Tang, L | 1 |
| Li, L | 2 |
| Tang, W | 1 |
| Yu, Y | 1 |
| Westgeest, HM | 1 |
| van Erp, NP | 1 |
| Honeywell, RJ | 1 |
| Hoekstra, R | 1 |
| Peters, GJ | 1 |
| Verheul, HM | 1 |
| OJI, N | 1 |
| Kröger, H | 4 |
| Grätz, R | 2 |
| Grahn, H | 1 |
| Museteanu, C | 1 |
| Haase, J | 1 |
| Dietrich, A | 1 |
| Ohde, M | 2 |
| Lange, R | 1 |
| Ehrlich, W | 1 |
| Kurpisz, M | 1 |
| Hauschild, A | 1 |
| Bache, K | 1 |
| Voigt, WP | 1 |
| Thefeldt, W | 1 |
| Krüger, D | 1 |
| Knip, M | 1 |
| Douek, IF | 1 |
| Moore, WP | 1 |
| Gillmor, HA | 1 |
| McLean, AE | 1 |
| Bingley, PJ | 1 |
| Gale, EA | 1 |
| Schoental, R | 2 |
| Chow, AY | 1 |
| Hirsch, GH | 1 |
| Buttar, HS | 1 |
| Jaus, H | 1 |
| Sturm, G | 1 |
| Grässle, B | 1 |
| Romen, W | 1 |
| Siebert, G | 1 |
| Gai, V | 1 |
| Gastaldi, L | 1 |
| Nattero, G | 1 |
| De Flora, A | 2 |
| Calabria, GA | 2 |
| Lorenzoni, I | 2 |
| Brenner, G | 1 |
| Trautmann, H | 1 |
| Simon, E | 1 |
| Veres, E | 1 |
| Bánki, G | 1 |
| Winter, SL | 1 |
| Boyer, JL | 1 |
| Gibb, JW | 1 |
| Brody, TM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Special Drug Use Investigation of Nexavar (Unresectable Hepatocellular Carcinoma)[NCT01411436] | 1,637 participants (Actual) | Observational | 2009-05-31 | Completed | |||
| Three-Day Dosing NAD + Study[NCT03707652] | 8 participants (Actual) | Interventional | 2018-03-12 | Completed | |||
| Randomized Double-blinded Comparative Trial to Study the Add-on Activity of Combination Treatment of Nicotinamide on Progression Free Survival for EGFR Mutated Lung Cancer Terminal Stage Patients Being Treated With Gefitinib or Erlotinib[NCT02416739] | Phase 2/Phase 3 | 110 participants (Actual) | Interventional | 2015-03-31 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for niacinamide and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
A review of nicotinamide: treatment of skin diseases and potential side effects.
Topics: Acne Vulgaris; Administration, Cutaneous; Administration, Oral; Chemical and Drug Induced Liver Inju | 2014 |
Protective effects of nicotinamide against acetaminophen-induced acute liver injury.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Niacinamid | 2012 |
Safety of high-dose nicotinamide: a review.
Topics: Abnormalities, Drug-Induced; Adenoma, Islet Cell; Animals; Chemical and Drug Induced Liver Injury; D | 2000 |
Safety of high-dose nicotinamide: a review.
Topics: Abnormalities, Drug-Induced; Adenoma, Islet Cell; Animals; Chemical and Drug Induced Liver Injury; D | 2000 |
Safety of high-dose nicotinamide: a review.
Topics: Abnormalities, Drug-Induced; Adenoma, Islet Cell; Animals; Chemical and Drug Induced Liver Injury; D | 2000 |
Safety of high-dose nicotinamide: a review.
Topics: Abnormalities, Drug-Induced; Adenoma, Islet Cell; Animals; Chemical and Drug Induced Liver Injury; D | 2000 |
32 other studies available for niacinamide and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Integrated metabolomics and network pharmacology revealing the mechanism of arsenic-induced hepatotoxicity in mice.
Topics: Animals; Arsenic; Chemical and Drug Induced Liver Injury; Drugs, Chinese Herbal; Humans; Metabolomic | 2023 |
Toxicoproteomic Profiling of
Topics: Animals; Antitubercular Agents; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Syst | 2020 |
Potential effects of the combination of nicotinamide, vitamin B2 and vitamin C on oxidative-mediated hepatotoxicity induced by thioacetamide.
Topics: Animals; Antioxidants; Ascorbic Acid; Chemical and Drug Induced Liver Injury; Drug Combinations; Hum | 2018 |
Nicotinamide riboside attenuates alcohol induced liver injuries via activation of SirT1/PGC-1α/mitochondrial biosynthesis pathway.
Topics: Animals; Chemical and Drug Induced Liver Injury; Ethanol; Gene Expression Regulation; Hep G2 Cells; | 2018 |
Intestinal barrier regulates immune responses in the liver via IL-10-producing macrophages.
Topics: Animals; Chemical and Drug Induced Liver Injury; Colitis; Concanavalin A; Dextran Sulfate; Disease M | 2018 |
Vitamin B combination reduces fluconazole toxicity in Wistar rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; | 2019 |
Letter: Sorafenib hepatotoxicity may be enhanced during treatment of advanced hepatocellular carcinoma in HIV-infected patients.
Topics: Adult; Antineoplastic Agents; Antiretroviral Therapy, Highly Active; Carcinoma, Hepatocellular; Chem | 2013 |
Differential involvement of IL-6 in the early and late phase of 1-methylnicotinamide (MNA) release in Concanavalin A-induced hepatitis.
Topics: Acute-Phase Reaction; Aldehyde Oxidase; Animals; Chemical and Drug Induced Liver Injury; Concanavali | 2015 |
1-Methylnicotinamide protects against liver injury induced by concanavalin A via a prostacyclin-dependent mechanism: A possible involvement of IL-4 and TNF-α.
Topics: Animals; Benzofurans; Cells, Cultured; Chemical and Drug Induced Liver Injury; Concanavalin A; Dexam | 2016 |
Safety and effectiveness of sorafenib in Japanese patients with hepatocellular carcinoma in daily medical practice: interim analysis of a prospective postmarketing all-patient surveillance study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Hepatocellular; Chemic | 2016 |
Occurrence of hepatotoxicity with pazopanib and other anti-VEGF treatments for renal cell carcinoma: an observational study utilizing a distributed database network.
Topics: Aged; Antineoplastic Agents; Bevacizumab; Carcinoma, Renal Cell; Chemical and Drug Induced Liver Inj | 2016 |
Acute hepatitis in a patient with cirrhosis and hepatocellular carcinoma treated with sorafenib.
Topics: Acute Disease; Aged; Antineoplastic Agents; Benzenesulfonates; Carcinoma, Hepatocellular; Chemical a | 2009 |
Sorafenib-induced severe acute hepatitis in a stable liver transplant recipient.
Topics: Acute Disease; Antineoplastic Agents; Benzenesulfonates; Bilirubin; Carcinoma, Hepatocellular; Chemi | 2010 |
Upregulation of Sirt1 in carbon-tetrachloride-induced acute liver injury.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Blotting, Western; Carbon Tetrachloride; | 2013 |
Successful treatment of renal cell carcinoma with sorafenib after effective but hepatotoxic sunitinib exposure.
Topics: Aged; Angiogenesis Inhibitors; Antineoplastic Agents; Carcinoma, Renal Cell; Chemical and Drug Induc | 2013 |
The inactivation of cortisol in experimental diabetic animals.
Topics: Anatomy; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Diabetes M | 1963 |
Influence of D-galactosamine upon the NAD-metabolism in rat liver.
Topics: Adrenalectomy; Animals; Chemical and Drug Induced Liver Injury; Galactosamine; Liver; Methionine; NA | 1983 |
The influence of nicotinamide, tryptophan, and methionine upon galactosamine-induced effects in the liver.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; | 1981 |
Protection from acetaminophen-induced liver damage by the synergistic action of low doses of the poly(ADP-ribose) polymerase-inhibitor nicotinamide and the antioxidant N-acetylcysteine or the amino acid L-methionine.
Topics: Acetaminophen; Acetylcysteine; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antioxidants | 1997 |
Nicotinamide and methionine reduce the liver toxic effect of methotrexate.
Topics: Acetaminophen; Alanine Transaminase; Analgesics, Non-Narcotic; Animals; Antirheumatic Agents; Aspart | 1999 |
Proceedings: Is alkylation of nicotinamide the cause of liver necrosis that follows large doses of hepatocarcinogens?
Topics: Carcinogens; Chemical and Drug Induced Liver Injury; Liver; Necrosis; Niacinamide | 1975 |
Nephrotoxic and hepatotoxic effects of triclosan and chlorhexidine in rats.
Topics: Age Factors; Animals; Biguanides; Chemical and Drug Induced Liver Injury; Chlorhexidine; Female; Kid | 1977 |
Biochemical basis of liver necrosis caused by pyrrolizidine alkaloids and certain other hepatotoxins.
Topics: Alkylation; Animals; Chemical and Drug Induced Liver Injury; NAD; Necrosis; Niacinamide; Pyridones; | 1975 |
Metabolic effects and liver damage after prolonged administration of high doses of nicotinamide to rats.
Topics: Animals; Chemical and Drug Induced Liver Injury; Female; Injections, Intraperitoneal; Liver; Male; N | 1977 |
[Evaluation of the therapeutic possibilities offered by the combination: substrates of the Krebs-Henseleit cycle and vitamins in hepatic toxicoses].
Topics: Adult; Aged; Arginine; Chemical and Drug Induced Liver Injury; Citrulline; Female; Folic Acid; Human | 1967 |
[Acute biochemical syndrome caused by high dosage of vitamin PP. I. Effect of adrenalectomy on the behavior of hepatic glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase].
Topics: Adrenal Glands; Adrenalectomy; Animals; Chemical and Drug Induced Liver Injury; Glucosephosphate Deh | 1966 |
[Acute biochemical syndrome caused by high doses of vitamin PP. II. Effect of adrenalectomy on the behavior of hepatic transketolase and transaldolase and on the heptose content of the liver].
Topics: Adrenalectomy; Animals; Chemical and Drug Induced Liver Injury; Heptoses; Liver; Niacinamide; Rats; | 1966 |
[Effect of xanthinol-nicotinate on detoxification processes in liver. Experimental studies on the model of hexobarbital-narcosis in rat].
Topics: Anesthesia, General; Animals; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical and Dru | 1969 |
Changes in SGOT activity during treatment with ethionamide.
Topics: Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Ethionamide; Female; Humans; Li | 1969 |
Hepatic toxicity from large doses of vitamin B3 (nicotinamide).
Topics: Adult; Alanine Transaminase; Aspartate Aminotransferases; Bilirubin; Biopsy; Chemical and Drug Induc | 1973 |
The protective effect of nicotinamide on carbon tetrachloride-induced hepatotoxicity.
Topics: Animals; Antidotes; Body Temperature; Carbon Tetrachloride; Carbon Tetrachloride Poisoning; Chemical | 1967 |