niacinamide has been researched along with Cerebral Ischemia in 50 studies
nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The results provide, to our knowledge, the first evidence that nicaraven is effective against ischemia-reperfusion injury in the brain and demonstrate that oxygen free radicals generated during reperfusion are important triggers of ischemic brain damage." | 7.69 | Attenuation of ischemia-reperfusion injury in the rat neocortex by the hydroxyl radical scavenger nicaraven. ( Kassell, NF; Lee, KS; Toyoda, T, 1997) |
| " These data suggest that administration of NMN at a proper dosage has a strong protective effect against ischemic brain injury." | 5.43 | Nicotinamide mononucleotide inhibits post-ischemic NAD(+) degradation and dramatically ameliorates brain damage following global cerebral ischemia. ( Kristian, T; Long, A; Owens, K; Park, JH, 2016) |
| " The results provide, to our knowledge, the first evidence that nicaraven is effective against ischemia-reperfusion injury in the brain and demonstrate that oxygen free radicals generated during reperfusion are important triggers of ischemic brain damage." | 3.69 | Attenuation of ischemia-reperfusion injury in the rat neocortex by the hydroxyl radical scavenger nicaraven. ( Kassell, NF; Lee, KS; Toyoda, T, 1997) |
| "Ischemic stroke is one of the leading causes of human death and disability." | 1.72 | Acutely Inhibiting AQP4 With TGN-020 Improves Functional Outcome by Attenuating Edema and Peri-Infarct Astrogliosis After Cerebral Ischemia. ( Hao, X; Li, C; Lin, L; Ren, Y; Sun, C; Tian, J; Yang, Y; Yin, L; Zhang, X, 2022) |
| "TGN-020 significantly reduced oedema, glial scar, albumin effusion, and apoptosis, at both 3 and 7 days after MCAO." | 1.46 | Inhibition of Aquaporin-4 Improves the Outcome of Ischaemic Stroke and Modulates Brain Paravascular Drainage Pathways. ( Balsanu, TA; Bogdan, C; Carare, RO; Divan, T; Margaritescu, C; Mogoanta, L; Muresanu, DF; Pirici, D; Pirici, I; Vitalie, V, 2017) |
| " These data suggest that administration of NMN at a proper dosage has a strong protective effect against ischemic brain injury." | 1.43 | Nicotinamide mononucleotide inhibits post-ischemic NAD(+) degradation and dramatically ameliorates brain damage following global cerebral ischemia. ( Kristian, T; Long, A; Owens, K; Park, JH, 2016) |
| "Zinc neurotoxicity has been demonstrated in ischemic, seizure, hypoglycemic, and trauma-induced neuronal death where Zn(2+) is thought to be synaptically released and taken up in neighbouring neurons, reaching toxic concentrations." | 1.33 | Zinc neurotoxicity is dependent on intracellular NAD levels and the sirtuin pathway. ( Cai, AL; Sheline, CT; Zipfel, GJ, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (6.00) | 18.7374 |
| 1990's | 5 (10.00) | 18.2507 |
| 2000's | 15 (30.00) | 29.6817 |
| 2010's | 23 (46.00) | 24.3611 |
| 2020's | 4 (8.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ferraris, D | 1 |
| Ko, YS | 1 |
| Pahutski, T | 1 |
| Ficco, RP | 1 |
| Serdyuk, L | 1 |
| Alemu, C | 1 |
| Bradford, C | 1 |
| Chiou, T | 1 |
| Hoover, R | 1 |
| Huang, S | 1 |
| Lautar, S | 1 |
| Liang, S | 1 |
| Lin, Q | 1 |
| Lu, MX | 1 |
| Mooney, M | 1 |
| Morgan, L | 1 |
| Qian, Y | 1 |
| Tran, S | 1 |
| Williams, LR | 1 |
| Wu, QY | 1 |
| Zhang, J | 1 |
| Zou, Y | 1 |
| Kalish, V | 1 |
| Sun, Y | 1 |
| Zhang, Y | 1 |
| Li, Y | 1 |
| Cheng, J | 1 |
| Chen, S | 1 |
| Xiao, Y | 1 |
| Ao, G | 1 |
| Sun, C | 1 |
| Lin, L | 1 |
| Yin, L | 1 |
| Hao, X | 1 |
| Tian, J | 1 |
| Zhang, X | 1 |
| Ren, Y | 1 |
| Li, C | 1 |
| Yang, Y | 1 |
| Kataeva, NG | 3 |
| Zamoshchina, TA | 3 |
| Svetlik, MV | 3 |
| Korotkova, EI | 3 |
| Voronova, OA | 3 |
| Poltavskaya, TS | 1 |
| Bazhenov, VA | 1 |
| Volojanin, AV | 1 |
| Belkin, AA | 1 |
| Leiderman, IN | 1 |
| Kovalenko, AL | 5 |
| Rizakhanova, OA | 1 |
| Parfenov, SA | 1 |
| Sapozhnikov, KV | 1 |
| Pirici, I | 1 |
| Balsanu, TA | 1 |
| Bogdan, C | 1 |
| Margaritescu, C | 1 |
| Divan, T | 1 |
| Vitalie, V | 1 |
| Mogoanta, L | 1 |
| Pirici, D | 1 |
| Carare, RO | 1 |
| Muresanu, DF | 1 |
| Krylov, VN | 2 |
| Deryugina, AV | 1 |
| Antipenko, EA | 4 |
| Savvina, IA | 1 |
| Cherebillo, VY | 1 |
| Zabrodskaya, YM | 1 |
| Petrova, AO | 1 |
| Sergeev, AV | 1 |
| Paltsev, AA | 1 |
| Rutkovskiy, RV | 1 |
| Malkhozova, AM | 1 |
| Siegel, CS | 1 |
| McCullough, LD | 1 |
| Deriugina, AV | 1 |
| Zakharova, OA | 1 |
| Madzhidova, EN | 3 |
| Khaĭdarova, DK | 1 |
| Khodzhaeva, DT | 1 |
| Rumyantseva, SA | 1 |
| Silina, EV | 3 |
| Chichanovskaya, LV | 1 |
| Nazarov, MV | 1 |
| Tsukurova, LA | 1 |
| Kabaeva, EN | 1 |
| Stupin, VA | 1 |
| Strukov, VI | 1 |
| Maksimova, MN | 1 |
| Kuptsova, TA | 1 |
| Lysev, SF | 1 |
| Shcherbakova, YG | 1 |
| Derugina, AV | 1 |
| Gustov, AV | 2 |
| Park, JH | 1 |
| Long, A | 1 |
| Owens, K | 1 |
| Kristian, T | 1 |
| Liu, D | 1 |
| Gharavi, R | 1 |
| Pitta, M | 1 |
| Gleichmann, M | 1 |
| Mattson, MP | 1 |
| Suslina, ZA | 2 |
| Klocheva, EG | 2 |
| Piradov, MA | 1 |
| Rumiantseva, SA | 3 |
| Romantsov, MG | 2 |
| Igarashi, H | 2 |
| Huber, VJ | 1 |
| Tsujita, M | 1 |
| Nakada, T | 1 |
| Degtiareva, EA | 1 |
| Zhdanova, OI | 1 |
| Mikheeva, AA | 1 |
| Avakian, AA | 1 |
| Tanashian, MM | 1 |
| Skoromets, AA | 1 |
| Fedin, AI | 1 |
| Sholomov, II | 1 |
| Shestakov, VV | 1 |
| Kosenkova, NV | 1 |
| Kichigina, EV | 1 |
| Larikova, TN | 1 |
| Starikova, NL | 1 |
| Sung, JH | 1 |
| Kim, MO | 1 |
| Koh, PO | 3 |
| Usmanova, DD | 2 |
| Baĭtursunova, ZhM | 2 |
| Bolevich, SB | 1 |
| Men'shova, NI | 1 |
| Leker, RR | 1 |
| Sadanaga-Akiyoshi, F | 2 |
| Yao, H | 2 |
| Tanuma, S | 1 |
| Nakahara, T | 1 |
| Hong, JS | 1 |
| Ibayashi, S | 2 |
| Uchimura, H | 1 |
| Fujishima, M | 1 |
| Klaidman, L | 2 |
| Morales, M | 1 |
| Kem, S | 2 |
| Yang, J | 2 |
| Chang, ML | 2 |
| Adams, JD | 2 |
| Gupta, S | 1 |
| Kaul, CL | 1 |
| Sharma, SS | 1 |
| Pellicciari, R | 1 |
| Camaioni, E | 1 |
| Costantino, G | 1 |
| Macleod, MR | 1 |
| O'Collins, T | 1 |
| Howells, DW | 1 |
| Donnan, GA | 1 |
| Katayama, Y | 1 |
| Bul'on, VV | 1 |
| Krylova, IB | 1 |
| Evdokimova, NR | 1 |
| Alekseeva, LE | 1 |
| Sapronov, NS | 1 |
| Iida, M | 1 |
| Cai, AL | 1 |
| Zipfel, GJ | 1 |
| Sheline, CT | 1 |
| Asano, T | 2 |
| Johshita, H | 2 |
| Koide, T | 2 |
| Takakura, K | 2 |
| Yoshimura, N | 1 |
| Okada, M | 1 |
| Ota, T | 1 |
| Nohara, H | 1 |
| Heurteaux, C | 1 |
| Bertaina, V | 1 |
| Widmann, C | 1 |
| Lazdunski, M | 1 |
| Toyoda, T | 1 |
| Kassell, NF | 1 |
| Lee, KS | 1 |
| Germanò, A | 1 |
| Imperatore, C | 1 |
| d'Avella, D | 1 |
| Costa, G | 1 |
| Tomasello, F | 1 |
| Ayoub, IA | 2 |
| Lee, EJ | 1 |
| Ogilvy, CS | 2 |
| Beal, MF | 1 |
| Maynard, KI | 2 |
| Frantseva, MV | 1 |
| Carlen, PL | 1 |
| Perez Velazquez, JL | 1 |
| Sakakibara, Y | 1 |
| Mitha, AP | 1 |
| Sugawara, T | 1 |
| Chan, PH | 1 |
| Shevata, VN | 1 |
| Geviak, OM | 1 |
| Gotoh, O | 1 |
| Usui, M | 1 |
| Shigeno, T | 1 |
4 reviews available for niacinamide and Cerebral Ischemia
| Article | Year |
|---|---|
Nicaraven Chugai.
Topics: Animals; Antioxidants; Brain Edema; Brain Ischemia; Cerebral Hemorrhage; Clinical Trials, Phase I as | 2003 |
3. Life or death decisions: the cast of poly(ADP-ribose)polymerase (PARP) as a therapeutic target for brain ischaemia.
Topics: Animals; Brain; Brain Ischemia; Enzyme Inhibitors; Humans; Niacinamide; Poly (ADP-Ribose) Polymerase | 2004 |
Pooling of animal experimental data reveals influence of study design and publication bias.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Humans; Meta-Analysis as Topic; Neuroprotective Age | 2004 |
[Advances in the diagnosis and treatment of cerebral ischemia during the acute phase].
Topics: Acute-Phase Reaction; Antipyrine; Brain Ischemia; Cerebrovascular Circulation; Drug Design; Drug The | 2003 |
8 trials available for niacinamide and Cerebral Ischemia
| Article | Year |
|---|---|
[The efficacy of metabolic treatment in the early recovery period of patients with ischemic stroke].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Pressure; Brain Ischemia; Cognition; Drug Combinat | 2020 |
[Event-related potentials in moderate cognitive impairment in patients with chronic cerebral ischemia treated with cytoflavin].
Topics: Acoustic Stimulation; Brain Ischemia; Cognition; Cognitive Dysfunction; Drug Combinations; Evoked Po | 2013 |
[Efficacy of antioxidant energocorreсtion in brain infarction (results of a multicenter randomized trial)].
Topics: Adult; Aged; Antioxidants; Ascorbic Acid; Brain Infarction; Brain Ischemia; Drug Combinations; Femal | 2014 |
[Efficacy of cytoflavin in the treatment of hypoxic-ischemic lesions of the nervous system in 1-month old children with transient neonatal hypothyroidism].
Topics: Antioxidants; Brain Ischemia; Congenital Hypothyroidism; Drug Combinations; Female; Flavin Mononucle | 2015 |
[An effect of cytoprotective therapy on stress resistance and compensatory abilities of patients with chronic cerebral ischemia].
Topics: Adult; Antioxidants; Brain Ischemia; Chronic Disease; Drug Combinations; Female; Flavin Mononucleoti | 2015 |
[The complex energy correction of chronic brain ischemia].
Topics: Antioxidants; Brain Ischemia; Cognition; Drug Combinations; Female; Flavin Mononucleotide; Humans; I | 2011 |
[Pharmacotherapy of basic clinical presentations of chronic brain ischemia].
Topics: Antioxidants; Brain Ischemia; Chronic Disease; Drug Combinations; Flavin Mononucleotide; Humans; Ino | 2011 |
[Dynamics of the symptoms of chronic ischemia during the treatment with cytoflavin].
Topics: Brain; Brain Ischemia; Chronic Disease; Drug Combinations; Female; Flavin Mononucleotide; Hemodynami | 2012 |
38 other studies available for niacinamide and Cerebral Ischemia
| Article | Year |
|---|---|
Design and synthesis of poly ADP-ribose polymerase-1 inhibitors. 2. Biological evaluation of aza-5[H]-phenanthridin-6-ones as potent, aqueous-soluble compounds for the treatment of ischemic injuries.
Topics: Animals; Aza Compounds; Brain Ischemia; Dogs; Enzyme Inhibitors; Haplorhini; Humans; In Vitro Techni | 2003 |
Synthesis and biological evaluation of novel hydrogen sulfide releasing nicotinic acid derivatives.
Topics: Animals; Brain Ischemia; Cell Line; Cell Survival; Disease Models, Animal; Dose-Response Relationshi | 2016 |
Acutely Inhibiting AQP4 With TGN-020 Improves Functional Outcome by Attenuating Edema and Peri-Infarct Astrogliosis After Cerebral Ischemia.
Topics: Animals; Aquaporin 4; Brain Edema; Brain Ischemia; Gliosis; Infarction, Middle Cerebral Artery; Magn | 2022 |
[Comparison of neurotropic and antioxidant activity of Cytoflavin and etilmetilgydroxypiridine succinat in patients with chronic brain ischemia].
Topics: Antioxidants; Brain Ischemia; Female; Humans; Inosine Diphosphate; Niacinamide | 2022 |
[Comparison of neurotropic and antioxidant activity of Cytoflavin and etilmetilgydroxypiridine succinat in patients with chronic brain ischemia].
Topics: Antioxidants; Brain Ischemia; Female; Humans; Inosine Diphosphate; Niacinamide | 2022 |
[Comparison of neurotropic and antioxidant activity of Cytoflavin and etilmetilgydroxypiridine succinat in patients with chronic brain ischemia].
Topics: Antioxidants; Brain Ischemia; Female; Humans; Inosine Diphosphate; Niacinamide | 2022 |
[Comparison of neurotropic and antioxidant activity of Cytoflavin and etilmetilgydroxypiridine succinat in patients with chronic brain ischemia].
Topics: Antioxidants; Brain Ischemia; Female; Humans; Inosine Diphosphate; Niacinamide | 2022 |
[Cytoflavin as a modulator of rehabilitation treatment of patients with ischemic stroke complicated by post-intensive care syndrome].
Topics: Brain Ischemia; Critical Care; Drug Combinations; Flavin Mononucleotide; Humans; Inosine Diphosphate | 2020 |
Inhibition of Aquaporin-4 Improves the Outcome of Ischaemic Stroke and Modulates Brain Paravascular Drainage Pathways.
Topics: Albumins; Animals; Apoptosis; Aquaporin 4; Arteries; Brain; Brain Ischemia; Caspase 3; Disease Model | 2017 |
[STRESS-PROTECTIVE EFFECT OF CYTOFLAVIN ON CHRONIC CEREBRAL ISCHEMIA IN RATS.]
Topics: Animals; Brain Ischemia; Chronic Disease; Drug Combinations; Erythrocytes; Flavin Mononucleotide; In | 2016 |
[The intraoperative prophylaxis of local ischemical brain damage in neurosurgical patients with cerebral aneurysm].
Topics: Brain; Brain Injuries; Brain Ischemia; Drug Combinations; Flavin Mononucleotide; Humans; Inosine Dip | 2019 |
NAD+ and nicotinamide: sex differences in cerebral ischemia.
Topics: Analysis of Variance; Animals; Brain Ischemia; Caspase 3; Disease Models, Animal; Female; Male; Mice | 2013 |
[The diagnostics of adaptive reactions of blood on application the stress-modulating therapy in patients with brain chronic ischemia].
Topics: Adult; Brain Ischemia; Chronic Disease; Delta Sleep-Inducing Peptide; Drug Combinations; Erythrocyte | 2012 |
Nicotinamide mononucleotide inhibits post-ischemic NAD(+) degradation and dramatically ameliorates brain damage following global cerebral ischemia.
Topics: Animals; Brain Injuries; Brain Ischemia; Cell Death; Disease Models, Animal; Hippocampus; Male; Mice | 2016 |
Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons.
Topics: Animals; Antioxidants; Brain Ischemia; Cell Death; Cells, Cultured; Male; Mice; Mice, Inbred C57BL; | 2009 |
[Efficacy of cytoflavin in the treatment of chronic cerebral ischemia].
Topics: Asthenia; Brain Ischemia; Chronic Disease; Drug Combinations; Flavin Mononucleotide; Humans; Inosine | 2010 |
Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema.
Topics: Analysis of Variance; Animals; Aquaporin 4; Brain Edema; Brain Ischemia; Cerebrovascular Circulation | 2011 |
[Correcting posthypoxic damage of myocardium in newborns with cerebral ischemia].
Topics: Brain Ischemia; Drug Combinations; Female; Flavin Mononucleotide; Follow-Up Studies; Heart; Humans; | 2010 |
[Antioxidant therapy in discirculatory encephalopathy].
Topics: Antioxidants; Brain Ischemia; Drug Combinations; Female; Flavin Mononucleotide; Humans; Inosine Diph | 2010 |
[Clinical efficacy of cytoflavin in the combined treatment of patients during acute phase of ischemic stroke].
Topics: Acute Disease; Adult; Aged; Brain Ischemia; Drug Combinations; Electroencephalography; Flavin Mononu | 2011 |
Nicotinamide prevents the down-regulation of MEK/ERK/p90RSK signaling cascade in brain ischemic injury.
Topics: Animals; Brain Injuries; Brain Ischemia; Cerebral Infarction; Down-Regulation; Extracellular Signal- | 2012 |
Nicotinamide attenuates the decrease of astrocytic phosphoprotein PEA-15 in focal cerebral ischemic injury.
Topics: Animals; Apoptosis Regulatory Proteins; Astrocytes; Brain Ischemia; Gene Expression Regulation; Male | 2012 |
[Course of free radical processes and prognosis of ischemic and hemorrhagic stroke].
Topics: Aged; Antioxidants; Biomarkers; Brain Ischemia; Drug Combinations; Female; Flavin Mononucleotide; Fr | 2011 |
Nicotinamide restores the reduction of parvalbumin in cerebral ischemic injury.
Topics: Animals; Brain Ischemia; Calcium; Cell Line; Cerebral Cortex; Glutamic Acid; Hippocampus; Mice; Niac | 2013 |
Nicotinamide attenuates focal ischemic brain injury in rats: with special reference to changes in nicotinamide and NAD+ levels in ischemic core and penumbra.
Topics: Animals; Brain; Brain Ischemia; Chromatography, High Pressure Liquid; Male; NAD; Niacinamide; Rats; | 2003 |
Nicotinamide offers multiple protective mechanisms in stroke as a precursor for NAD+, as a PARP inhibitor and by partial restoration of mitochondrial function.
Topics: Adenosine Triphosphate; Animals; Brain; Brain Ischemia; Disease Models, Animal; Mice; Mice, Inbred B | 2003 |
Neuroprotective effect of combination of poly (ADP-ribose) polymerase inhibitor and antioxidant in middle cerebral artery occlusion induced focal ischemia in rats.
Topics: Animals; Antioxidants; Benzamides; Brain Ischemia; Disease Models, Animal; Drug Combinations; Drug T | 2004 |
Effects of cytoflavin and neuronol on morphological changes in the brain and survival of rats with ischemic disturbances in cerebral blood flow.
Topics: Animals; Brain; Brain Ischemia; Cerebrovascular Circulation; Drug Combinations; Flavin Mononucleotid | 2004 |
Nicotinamide attenuates focal ischemic brain injury: meta-analysis or mechanism of protection.
Topics: Animals; Brain Ischemia; Cerebrovascular Circulation; Humans; Neuroprotective Agents; Niacinamide | 2004 |
Zinc neurotoxicity is dependent on intracellular NAD levels and the sirtuin pathway.
Topics: Aldehydes; Animals; Antioxidants; Brain Ischemia; Cells, Cultured; Flavonoids; Flavonols; Ion Channe | 2006 |
Amelioration of ischaemic cerebral oedema by a free radical scavenger, AVS: 1,2-bis(nicotinamido)-propane. An experimental study using a regional ischaemia model in cats.
Topics: Animals; Brain Edema; Brain Ischemia; Cats; Cerebral Cortex; Disease Models, Animal; Energy Metaboli | 1984 |
Pharmacologic intervention for ischemic brain edema after retrograde cerebral perfusion.
Topics: Animals; Aorta, Thoracic; Aortic Aneurysm, Thoracic; Brain; Brain Edema; Brain Ischemia; Cardiopulmo | 1995 |
K+ channel openers prevent global ischemia-induced expression of c-fos, c-jun, heat shock protein, and amyloid beta-protein precursor genes and neuronal death in rat hippocampus.
Topics: Alternative Splicing; Amyloid beta-Protein Precursor; Animals; Base Sequence; Benzopyrans; Brain Isc | 1993 |
Attenuation of ischemia-reperfusion injury in the rat neocortex by the hydroxyl radical scavenger nicaraven.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Cerebral Infarction; Free Radical Scavengers; Hydroxyl Rad | 1997 |
Antivasospastic and brain-protective effects of a hydroxyl radical scavenger (AVS) after experimental subarachnoid hemorrhage.
Topics: Animals; Antioxidants; Basilar Artery; Behavior, Animal; Blood-Brain Barrier; Body Weight; Brain; Br | 1998 |
Nicotinamide reduces infarction up to two hours after the onset of permanent focal cerebral ischemia in Wistar rats.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Dose-Response Relationship, Drug; Male; Niacinamide; R | 1999 |
Dynamics of intracellular calcium and free radical production during ischemia in pyramidal neurons.
Topics: Aniline Compounds; Animals; Brain Ischemia; Calcium; Calcium Channels; Calcium-Binding Proteins; Cul | 2001 |
Delayed treatment with nicotinamide (vitamin B3) reduces the infarct volume following focal cerebral ischemia in spontaneously hypertensive rats, diabetic and non-diabetic Fischer 344 rats.
Topics: Animals; Blood Gas Analysis; Brain Ischemia; Cerebral Infarction; Cerebrovascular Circulation; Diabe | 2002 |
Nicotinamide and ketamine reduce infarct volume and DNA fragmentation in rats after brain ischemia and reperfusion.
Topics: Animals; Brain Ischemia; Cerebral Infarction; DNA Fragmentation; Excitatory Amino Acid Antagonists; | 2002 |
[The vitamin B6, PP and C allowances of patients in the acute period of ischemic stroke].
Topics: Acute Disease; Adult; Aged; Ascorbic Acid; Brain Ischemia; Female; Humans; Male; Middle Aged; Niacin | 1989 |
[The pathomechanism underlying ischemic brain edema: the role of Na+, K+-ATPase of the brain microvessels].
Topics: Animals; Brain Chemistry; Brain Edema; Brain Ischemia; Cats; Cerebrovascular Circulation; Disease Mo | 1985 |