Page last updated: 2024-10-19

niacinamide and Cancer of Skin

niacinamide has been researched along with Cancer of Skin in 142 studies

nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.

Research Excerpts

ExcerptRelevanceReference
" We assessed the association of somatic mutations with clinicopathologic features and clinical outcomes in patients with metastatic melanoma treated on E2603, comparing treatment with carboplatin, paclitaxel ± sorafenib (CP vs."9.19Correlation of somatic mutations and clinical outcome in melanoma patients treated with Carboplatin, Paclitaxel, and sorafenib. ( D'Andrea, K; Flaherty, KT; Kirkwood, JM; Kluger, HM; Lee, SJ; Letrero, R; Nathanson, KL; Rimm, DL; Schuchter, LM; Wilson, MA; Zhao, F, 2014)
"In a multicenter phase-II-DeCOG study (NCT00623402) in 10 dermato-oncology centers, 55 patients with metastatic melanoma received a combination of sorafenib (2 x 400 mg/day orally) and pegylated interferon alpha-2b (3 μg/kg body weight 1 x/week subcutaneously)."9.17Cutaneous side effects of combined therapy with sorafenib and pegylated interferon alpha-2b in metastatic melanoma (phase II DeCOG trial). ( Degen, A; Egberts, F; Garbe, C; Gutzmer, R; Hauschild, A; Kilian, K; Poppe, LM; Trefzer, U; Ugurel, S; Weichenthal, M, 2013)
"Isolated limb infusion with melphalan (ILI-M) corrected for ideal body weight (IBW) is a well-tolerated treatment for patients with in-transit extremity melanoma with an approximate 29 % complete response (CR) rate."9.16A phase I multi-institutional study of systemic sorafenib in conjunction with regional melphalan for in-transit melanoma of the extremity. ( Augustine, C; Beasley, GM; Brady, MS; Coleman, AP; Davies, MA; Peterson, BL; Raymond, A; Sanders, G; Selim, MA; Tyler, DS, 2012)
"The safety of oral sorafenib up to a maximum protocol-specified dose combined with dacarbazine in patients with metastatic, histologically confirmed melanoma was investigated in a phase I dose-escalation study and the activity of the combination was explored in an open-label phase II study."9.15Sorafenib and dacarbazine as first-line therapy for advanced melanoma: phase I and open-label phase II studies. ( Affolter, A; Ahmad, T; Chao, D; Chevreau, C; Corrie, P; Eisen, T; Gibbens, I; Gore, ME; Harries, M; James, MG; Jouary, T; Lorigan, P; Marais, R; Montegriffo, E; Nathan, PD; Negrier, S; Ottensmeier, C; Prendergast, S; Robert, C; Strauss, UP, 2011)
" Sorafenib, carboplatin, and paclitaxel (SCP) has antitumor activity in melanoma patients, but no association was found between response and activating B-Raf V600E mutations."9.14Expression of sorafenib targets in melanoma patients treated with carboplatin, paclitaxel and sorafenib. ( Camp, RL; Flaherty, KT; Jilaveanu, L; Kluger, HM; Lee, SJ; Nathanson, KL; Rimm, DL; Zito, C, 2009)
"These data suggest that there could be an association between sorafenib therapy and the development of cutaneous SCC and inflammation of AK."7.75Cutaneous squamous cell carcinoma and inflammation of actinic keratoses associated with sorafenib. ( Dubauskas, Z; Hwu, P; Jonasch, E; Kunishige, J; Prieto, VG; Tannir, NM, 2009)
"To report the development of keratoacanthoma (KA)-type squamous cell carcinomas (SCCs) in patients treated with the multikinase inhibitor sorafenib for the treatment of solid tumors, to present the possible mechanisms for induction of these SCCs, and to discuss the implications for discontinuation of therapy and possible cotherapies to decrease this side effect."7.75Eruptive keratoacanthoma-type squamous cell carcinomas in patients taking sorafenib for the treatment of solid tumors. ( Haley, H; Hamza, S; Skelton, HG; Smith, KJ, 2009)
"A 66-year-old man with malignant melanoma was treated with sorafenib, 2 yen 400 mg per day."7.75Multiple colon ulcerations, perforation and death during treatment of malignant melanoma with sorafenib. ( Frieling, T; Heise, J; Wassilew, SW, 2009)
"Sorafenib is an oral multikinase inhibitor that targets 2 classes of kinases which are known to be involved in both tumor proliferation and angiogenesis."6.44Metastatic melanoma: scientific rationale for sorafenib treatment and clinical results. ( Egberts, F; Hauschild, A; Kahler, KC; Livingstone, E, 2008)
"Sorafenib is a multikinase inhibitor that displays antiproliferative and antiangiogenic properties in the treatment of solid tumors."5.37Eruptive squamous cell carcinomas with keratoacanthoma-like features in a patient treated with sorafenib. ( Adams, DR; Lynch, MC; Straub, R, 2011)
" We assessed the association of somatic mutations with clinicopathologic features and clinical outcomes in patients with metastatic melanoma treated on E2603, comparing treatment with carboplatin, paclitaxel ± sorafenib (CP vs."5.19Correlation of somatic mutations and clinical outcome in melanoma patients treated with Carboplatin, Paclitaxel, and sorafenib. ( D'Andrea, K; Flaherty, KT; Kirkwood, JM; Kluger, HM; Lee, SJ; Letrero, R; Nathanson, KL; Rimm, DL; Schuchter, LM; Wilson, MA; Zhao, F, 2014)
"In a multicenter phase-II-DeCOG study (NCT00623402) in 10 dermato-oncology centers, 55 patients with metastatic melanoma received a combination of sorafenib (2 x 400 mg/day orally) and pegylated interferon alpha-2b (3 μg/kg body weight 1 x/week subcutaneously)."5.17Cutaneous side effects of combined therapy with sorafenib and pegylated interferon alpha-2b in metastatic melanoma (phase II DeCOG trial). ( Degen, A; Egberts, F; Garbe, C; Gutzmer, R; Hauschild, A; Kilian, K; Poppe, LM; Trefzer, U; Ugurel, S; Weichenthal, M, 2013)
"Isolated limb infusion with melphalan (ILI-M) corrected for ideal body weight (IBW) is a well-tolerated treatment for patients with in-transit extremity melanoma with an approximate 29 % complete response (CR) rate."5.16A phase I multi-institutional study of systemic sorafenib in conjunction with regional melphalan for in-transit melanoma of the extremity. ( Augustine, C; Beasley, GM; Brady, MS; Coleman, AP; Davies, MA; Peterson, BL; Raymond, A; Sanders, G; Selim, MA; Tyler, DS, 2012)
"The safety of oral sorafenib up to a maximum protocol-specified dose combined with dacarbazine in patients with metastatic, histologically confirmed melanoma was investigated in a phase I dose-escalation study and the activity of the combination was explored in an open-label phase II study."5.15Sorafenib and dacarbazine as first-line therapy for advanced melanoma: phase I and open-label phase II studies. ( Affolter, A; Ahmad, T; Chao, D; Chevreau, C; Corrie, P; Eisen, T; Gibbens, I; Gore, ME; Harries, M; James, MG; Jouary, T; Lorigan, P; Marais, R; Montegriffo, E; Nathan, PD; Negrier, S; Ottensmeier, C; Prendergast, S; Robert, C; Strauss, UP, 2011)
" Sorafenib, carboplatin, and paclitaxel (SCP) has antitumor activity in melanoma patients, but no association was found between response and activating B-Raf V600E mutations."5.14Expression of sorafenib targets in melanoma patients treated with carboplatin, paclitaxel and sorafenib. ( Camp, RL; Flaherty, KT; Jilaveanu, L; Kluger, HM; Lee, SJ; Nathanson, KL; Rimm, DL; Zito, C, 2009)
"Autophagy was measured in tumor biopsies obtained from metastatic melanoma patients enrolled on a phase II trial of temozolomide and sorafenib and correlated to clinical outcome."3.77Measurements of tumor cell autophagy predict invasiveness, resistance to chemotherapy, and survival in melanoma. ( Amaravadi, RK; Li, LZ; Lum, JJ; Ma, XH; McAfee, QW; Nathanson, KL; Piao, S; Wang, D, 2011)
"To report the development of keratoacanthoma (KA)-type squamous cell carcinomas (SCCs) in patients treated with the multikinase inhibitor sorafenib for the treatment of solid tumors, to present the possible mechanisms for induction of these SCCs, and to discuss the implications for discontinuation of therapy and possible cotherapies to decrease this side effect."3.75Eruptive keratoacanthoma-type squamous cell carcinomas in patients taking sorafenib for the treatment of solid tumors. ( Haley, H; Hamza, S; Skelton, HG; Smith, KJ, 2009)
"A 66-year-old man with malignant melanoma was treated with sorafenib, 2 yen 400 mg per day."3.75Multiple colon ulcerations, perforation and death during treatment of malignant melanoma with sorafenib. ( Frieling, T; Heise, J; Wassilew, SW, 2009)
"These data suggest that there could be an association between sorafenib therapy and the development of cutaneous SCC and inflammation of AK."3.75Cutaneous squamous cell carcinoma and inflammation of actinic keratoses associated with sorafenib. ( Dubauskas, Z; Hwu, P; Jonasch, E; Kunishige, J; Prieto, VG; Tannir, NM, 2009)
"Subcutaneous tumours and artificially induced pulmonary metastases of the rhabdomyosarcoma R1H of the rat were treated either with fractionated irradiation alone or in combination with nicotinamide and carbogen."3.69Combination of fractionated irradiation with nicotinamide and carbogen in R1H-tumours of the rat and its pulmonary metastases. ( Beck-Bornholdt, HP; Krüll, A; Raabe, A; Rett, M, 1997)
"Phorbol ester-induced promotion of initiated NMRI mouse skin keratinocytes to papillomas could be largely prevented when nicotinamide-like inhibitors of poly(ADP-ribose)polymerase (nicotinamide, benzamide, 3-aminobenzamide) were applied simultaneously with 12-O-tetradecanoylphorbol-13-acetate (TPA)."3.68Nicotinamide and nicotinamide analogues as antitumor promoters in mouse skin. ( Dietel, M; Hilz, H; Ludwig, A; Müller, K; Schäfer, G, 1990)
"Chemoprophylaxis against nonmelanoma skin cancer (NMSC) should be considered in high-risk populations such as those with certain genetic disorders, immunosuppressive states, chronic radiation, excessive UV exposure, or extensive personal or family history of NMSC."3.01Preventative Options and the Future of Chemoprevention for Cutaneous Tumors. ( Anderson, JM; Moy, L; Moy, RL, 2023)
"The vitamin B3 deficiency in skin cancer patients was positively correlated with the expressions of HIF-1α and p53."2.90Correlation of changes in HIF-1α and p53 expressions with vitamin B3 deficiency in skin cancer patients. ( Liu, T; Mou, Y; Yang, H; Zhang, H, 2019)
"Patients with metastatic CM who are treated with the MEK inhibitor pimasertib are at high risk of development of ocular adverse events including serous retinopathy and possibly RVO, stressing the need of adequate ophthalmological follow-up including OCT during administration of pimasertib, despite the fact that SRF generally does not lead to ophthalmological complaints."2.87Pimasertib-associated ophthalmological adverse events. ( Boon, CJF; Jager, MJ; Kruit, WHJ; Luyten, GPM; van Dijk, EHC; Vingerling, JR, 2018)
"Nonmelanoma skin cancers, such as basal-cell carcinoma and squamous-cell carcinoma, are common cancers that are caused principally by ultraviolet (UV) radiation."2.80A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention. ( Chen, AC; Chinniah, N; Choy, B; Dalziell, RA; Damian, DL; Dhillon, HM; Fernández-Peñas, P; Halliday, GM; Kricker, A; Martin, AJ; McKenzie, CA; Scolyer, RA; St George, G; Vardy, JL, 2015)
" The lack of standardized dosing and standardized outcome measures makes comparison across existing studies challenging, and the lack of adverse events reporting in the majority of studies limits analysis of supplement safety."2.72Dietary supplements in dermatology: A review of the evidence for zinc, biotin, vitamin D, nicotinamide, and Polypodium. ( Kim, N; Thompson, KG, 2021)
"The incidence of skin cancer has gradually increased in the last years and exposition to ultraviolet radiation remains the main risk factor."2.72Oral nicotinamide: The role in skin cancer chemoprevention. ( Bortoluzzi, P; Giacalone, S; Nazzaro, G; Spigariolo, CB, 2021)
"Moreover, NAM reduces skin cancer incidence and prevents the immune-suppressive effects of UV in mice."2.61Role of Nicotinamide in Genomic Stability and Skin Cancer Chemoprevention. ( Abeni, D; Campione, E; Candi, E; Dellambra, E; Fania, L; Mazzanti, C, 2019)
"Chemoprevention of nonmelanoma skin cancer should be considered in patients likely to develop numerous, invasive, or metastatic nonmelanoma skin cancers."2.61Topical and Systemic Modalities for Chemoprevention of Nonmelanoma Skin Cancer. ( Council, ML; Nemer, KM, 2019)
"The incidence of non-melanoma skin cancer (NMSC) is dramatically increasing worldwide, despite the increased use of improved sunscreens."2.61Skin cancer prevention: a review of current topical options complementary to sunscreens. ( Chipps, L; Herrmann, J; Rosenthal, A; Stoddard, M, 2019)
"Ocular adverse events appeared early in the treatment."2.52Ocular Toxicity in Metastatic Melanoma Patients Treated With Mitogen-Activated Protein Kinase Kinase Inhibitors: A Case Series. ( Alessio, G; Guida, M; Niro, A; Recchimurzo, N; Sborgia, L; Strippoli, S, 2015)
"The use of topical nicotinamide in the treatment of acne vulgaris; melasma; atopic dermatitis; rosacea; and oral nicotinamide in preventing nonmelanoma skin cancer is discussed."2.50A review of nicotinamide: treatment of skin diseases and potential side effects. ( Rolfe, HM, 2014)
"We observed more cases of skin cancer during sorafenib treatment than during sunitinib treatment for advanced RCC; median MKI treatment duration before the identification of skin cancer was longer than 1 year."2.49Skin cancer associated with the use of sorafenib and sunitinib for renal cell carcinoma. ( Breaker, K; Flaig, IP; Flaig, TW; La Rosa, FG; Naam, M, 2013)
"Sorafenib is a newly developed multitargeted protein kinase inhibitor reported to induce a variety of adverse cutaneous effects, rarely including actinic keratoses, keratocanthomas, and squamous cell carcinomas (SCCs)."2.47Sorafenib-induced premalignant and malignant skin lesions. ( Cohen, PR; Stewart, DJ; Williams, VL, 2011)
"Skin cancer is by far the most common malignancy in Caucasian populations, and additional strategies to reduce the morbidity and economic burden of this disease are now urgently needed."2.46Photoprotective effects of nicotinamide. ( Damian, DL, 2010)
"Sorafenib is an oral multikinase inhibitor that targets 2 classes of kinases which are known to be involved in both tumor proliferation and angiogenesis."2.44Metastatic melanoma: scientific rationale for sorafenib treatment and clinical results. ( Egberts, F; Hauschild, A; Kahler, KC; Livingstone, E, 2008)
"Approved for the treatment of advanced renal cell carcinoma by the US FDA and other regulatory agencies, sorafenib is an agent with multiple targets that may also prove beneficial in other malignancies."2.44Sorafenib: delivering a targeted drug to the right targets. ( Flaherty, KT, 2007)
"To characterize oral skin cancer chemoprophylaxis education for acitretin and nicotinamide among current MSDO fellows and to compare the clinical indications felt most appropriate for prescribing to a previously published expert consensus."1.91Education and Perspectives on the Use of Oral Skin Cancer Chemoprophylaxis: A Cross-Sectional Survey of Current Fellows in Mohs Micrographic Surgery & Dermatologic Oncology. ( Guzman, AK; Ruiz, ES; Schmults, CD, 2023)
"Cutaneous immune-related adverse events (irAEs) occur in more than one-third of patients treated with immune checkpoint inhibitors; they are often the first clinical manifestation, although they may occur months after initiation of therapy."1.72Cutaneous immune-related adverse events and photodamaged skin in patients with metastatic melanoma: could nicotinamide be useful? ( Colombo, J; Covarelli, P; De Giorgi, V; Doni, L; Silvestri, F; Stanganelli, I; Trane, L; Venturi, F; Zuccaro, B, 2022)
"Sorafenib is a multikinase inhibitor increasingly used for the treatment of several solid tumors."1.62Penile and scrotal infundibular cysts in an adolescent treated with sorafenib. ( Colmenero, I; Hernández-Martín, Á; Martos-Cabrera, L; Mateos-Mayo, A; Ramírez-Lluch, M; Torrelo, A, 2021)
"Skin cancer is among the most common cancers worldwide and identifiable molecular changes for early and late stage of skin tumorigenesis can suggest the better targets for its control."1.43Preventive effects of butyric acid, nicotinamide, calcium glucarate alone or in combination during the 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis via modulation of K-Ras-PI3K-AKTpathway and associated micro RNAs. ( Gupta, KP; Pandey, M; Qadri, SS; Sahay, S; Tiwari, P, 2016)
"Cutaneous melanoma is a significant cause of morbidity and mortality."1.40Nicotinamide enhances repair of ultraviolet radiation-induced DNA damage in primary melanocytes. ( Damian, DL; Halliday, GM; Surjana, D; Thompson, BC, 2014)
"Melanoma is highly metastatic, but the mechanism of melanoma cell migration is still unclear."1.40SIRT1 regulates lamellipodium extension and migration of melanoma cells. ( Hayashi, T; Hirobe, T; Hisahara, S; Horimoto, K; Horio, Y; Jimbow, K; Kunimoto, R; Sato, M; Sugino, T; Tanimura, A; Yamashita, T, 2014)
"Metastatic melanoma is associated with a splicing switch to pro-angiogenic VEGF-A, previously shown to be regulated by SRSF1 phosphorylation by SRPK1."1.40Targeting SRPK1 to control VEGF-mediated tumour angiogenesis in metastatic melanoma. ( Bates, DO; Coupland, SE; Dean, R; Gammons, MV; Lucas, R; Oltean, S, 2014)
"A primary culture of renal cell carcinoma cells (KMRM-S2) was established from an advanced renal cell carcinoma patient with cutaneous metastasis, who had not responded to sorafenib."1.39Expression of angiogenesis-related gene profiles and development of resistance to tyrosine-kinase inhibitor in advanced renal cell carcinoma: characterization of sorafenib-resistant cells derived from a cutaneous metastasis. ( Ashida, S; Fukuhara, H; Inoue, K; Kamada, M; Karashima, T; Kuroda, N; Shuin, T; Taguchi, T; Tamura, K, 2013)
"The emergence of skin tumors in patients treated with sorafenib or with more recent BRAF inhibitors is an intriguing and potentially serious event."1.38Skin tumors induced by sorafenib; paradoxic RAS-RAF pathway activation and oncogenic mutations of HRAS, TP53, and TGFBR1. ( André, J; Arnault, JP; Boussemart, L; Druillennec, S; Dumaz, N; Eggermont, AM; Escudier, B; Eychène, A; Hollville, E; Kamsu-Kom, N; Lacroix, L; Larcher, M; Malka, D; Mateus, C; Robert, C; Sarasin, A; Soria, JC; Spatz, A; Tomasic, G; Vagner, S; Wechsler, J, 2012)
"Cotreatment with sorafenib and diclofenac interrupts a positive feedback signaling loop involving extracellular signal-regulated kinase, cellular phospholipase A2, and COX."1.38Synthetic lethal screening with small-molecule inhibitors provides a pathway to rational combination therapies for melanoma. ( Axelrod, M; Capaldo, BJ; Gioeli, D; Jensen, K; Mackey, A; Roller, DG; Weber, MJ, 2012)
"Sorafenib is a multikinase inhibitor approved for the treatment of renal cell carcinoma and hepatocellular carcinoma."1.37[Squamous cell carcinoma in a patient receiving sorafenib]. ( Adnot-Desanlis, L; Bernard, P; Reguiaï, Z, 2011)
"Sorafenib is a multikinase inhibitor that displays antiproliferative and antiangiogenic properties in the treatment of solid tumors."1.37Eruptive squamous cell carcinomas with keratoacanthoma-like features in a patient treated with sorafenib. ( Adams, DR; Lynch, MC; Straub, R, 2011)
"Cutaneous melanoma is a tumor with rising incidence and a very poor prognosis at the disseminated stage."1.37Fibroblast growth factor receptors as therapeutic targets in human melanoma: synergism with BRAF inhibition. ( Bedeir, A; Berger, W; Ghassemi, S; Grasl-Kraupp, B; Grusch, M; Heffeter, P; Heinzle, C; Held, G; Holzmann, K; Marian, B; Metzner, T; Micksche, M; Peter-Vörösmarty, B; Pirker, C; Spiegl-Kreinecker, S, 2011)
"Sorafenib is a multikinase inhibitor newly approved for the treatment of renal cell carcinoma and hepatocellular carcinoma."1.35The histologic spectrum of epithelial neoplasms induced by sorafenib. ( Jaworsky, C; Kish, LS; Kwon, EJ, 2009)
"Sorafenib is a new multikinase inhibitor recently approved for renal cell carcinoma and hepatocarcinoma."1.35[Eruptive nevi associated with sorafenib treatment]. ( Bennani-Lahlou, M; Escudier, B; Massard, C; Mateus, C; Robert, C; Soria, JC; Spatz, A, 2008)
"She had no history of skin cancer."1.35Multiple squamous cell carcinomas of the skin after therapy with sorafenib combined with tipifarnib. ( Cohen, PR; Diwan, AH; Evans, HL; Hong, DS; Kurzrock, R; Prieto, VG; Reddy, SB; Tannir, NM; Wright, JJ, 2008)
"The incidence of skin cancer continues to increase despite increased use of sunscreens, which are less effective at preventing immunosuppression than sunburn."1.35UV radiation-induced immunosuppression is greater in men and prevented by topical nicotinamide. ( Barnetson, RS; Damian, DL; Halliday, GM; Park, J; Patterson, CR; Stapelberg, M, 2008)
"The combined treatment of melanoma cells with sorafenib and rapamycin led to an approximately twofold increase of cell death compared with sorafenib monotreatment (P<0."1.35Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells. ( Flaherty, KT; Garbe, C; Kulms, D; Lasithiotakis, KG; Maczey, E; Meier, FE; Schittek, B; Sinnberg, TW, 2008)
"Cutaneous metastases from renal cell carcinoma (RCC) are uncommon, but may be painful and deforming."1.34Complete response in a cutaneous facial metastatic nodule from renal cell carcinoma after hypofractionated radiotherapy. ( Allison, RR; Cavalieri, R; Finley, J; Gay, HA; Quan, WD, 2007)

Research

Studies (142)

TimeframeStudies, this research(%)All Research%
pre-19901 (0.70)18.7374
1990's5 (3.52)18.2507
2000's25 (17.61)29.6817
2010's85 (59.86)24.3611
2020's26 (18.31)2.80

Authors

AuthorsStudies
Hunt, SV1
Jamison, A1
Malhotra, R1
De Giorgi, V1
Colombo, J1
Trane, L1
Silvestri, F1
Venturi, F1
Zuccaro, B1
Doni, L1
Stanganelli, I1
Covarelli, P1
Moreira, GA2
Caetano, MMM1
do Vale, JA1
de Paiva, JC1
Gonçalves, VHS2
Almeida, AA1
Silva, LVG1
Martim, FRG1
de Andrade Barros, MV1
Guimarães, GR1
de Oliveira Santos, L1
de Souza, APM2
Machado-Neves, M2
Teixeira, RR2
Silva-Júnior, A1
Fietto, JLR2
Boroni, M1
de Oliveira, LL1
Bressan, GC2
Anderson, JM3
Moy, L3
Moy, RL3
Allen, NC2
Martin, AJ10
Snaidr, VA2
Eggins, R1
Chong, AH1
Fernandéz-Peñas, P3
Gin, D1
Sidhu, S1
Paddon, VL1
Banney, LA1
Lim, A1
Upjohn, E1
Schaider, H1
Ganhewa, AD1
Nguyen, J1
McKenzie, CA5
Prakash, S1
McLean, C1
Lochhead, A1
Ibbetson, J1
Dettrick, A1
Landgren, A1
Allnutt, KJ1
Allison, C1
Davenport, RB1
Mumford, BP1
Wong, B1
Stagg, B1
Tedman, A1
Gribbin, H1
Edwards, HA1
De Rosa, N1
Stewart, T1
Doolan, BJ1
Kok, Y1
Simpson, K1
Low, ZM1
Kovitwanichkanont, T1
Scolyer, RA6
Dhillon, HM3
Vardy, JL3
Chadban, SJ1
Bowen, DG1
Chen, AC9
Damian, DL20
Schmults, CD2
Jambusaria-Pahlajani, A2
Ruiz, E1
Trepanowski, N1
Kim, DY1
Hartman, RI2
Boeri, M1
Skelsey, MK1
Schiro, JA1
Dozier, SE1
Glinert, R1
Okun, MM1
Riddle, AO1
Guzman, AK1
Ruiz, ES2
Fania, L1
Mazzanti, C1
Campione, E1
Candi, E1
Abeni, D1
Dellambra, E1
Malesu, R1
Lyons, JG2
Madore, J2
Halliday, GM14
Gollins, CE1
Shah, A1
Sinha, K1
Khan, S1
Paul, N1
Meeajun, B1
Abbott, RA1
Blasdale, C1
Cooper, H1
Harwood, CA1
Ismail, F1
Lear, JT1
Mackintosh, L1
McCormack, S1
Perrett, CM1
Proby, CM1
Durack, A1
Patalay, R1
Matin, RN1
Paugam, C1
Dréno, B1
Thompson, KG1
Kim, N1
Tee, LY1
Sultana, R1
Tam, SYC1
Oh, CC1
Vale, JAD1
Lima, GDA1
Barros, MVA1
Pereira, WL1
Merchid, NCLE1
Chen, CC2
Chen, YY1
Lo, YH1
Lin, MH1
Chang, CH1
Chen, CL1
Wang, HE1
Wu, CY1
Scatozza, F1
Moschella, F1
D'Arcangelo, D1
Rossi, S1
Tabolacci, C1
Giampietri, C1
Proietti, E1
Facchiano, F1
Facchiano, A1
Huber, R1
Wong, A1
Mateos-Mayo, A1
Colmenero, I1
Ramírez-Lluch, M1
Martos-Cabrera, L1
Hernández-Martín, Á1
Torrelo, A1
Hoegler, KM1
Khachemoune, A1
Arzeno, J1
Leavitt, E1
Lonowski, S1
Kim, J1
Giacalone, S1
Spigariolo, CB1
Bortoluzzi, P1
Nazzaro, G1
Knackstedt, TJ1
Knackstedt, RW1
Djohan, M1
Djohan, R1
Gastman, BR1
Crowe, DR1
Desai, S1
Olbricht, S1
Drago, F2
Ciccarese, G2
Cogorno, L1
Calvi, C1
Marsano, LA1
Parodi, A2
Lim, SY1
Menzies, AM1
Rizos, H1
Minocha, R2
Arenberger, P1
Arenbergerova, M1
Nazarali, S1
Kuzel, P1
Nestor, L1
Clowry, J1
Molloy, K1
Connolly, M1
Salim, A1
Tobin, AM1
Liu, T1
Yang, H1
Mou, Y1
Zhang, H1
Blomberg, M1
He, SY1
Harwood, C1
Arron, ST1
Demehri, S1
Green, A1
Asgari, MM1
Gilmore, SJ2
van Dijk, EHC1
Kruit, WHJ1
Jager, MJ1
Luyten, GPM1
Vingerling, JR1
Boon, CJF1
Phelan, PS1
Ballotti, R3
Healy, E1
Bertolotto, C1
Rosenthal, A1
Stoddard, M1
Chipps, L1
Herrmann, J1
Nemer, KM1
Council, ML1
Verhave, B1
Goldberg, M1
Hashim, P1
Levitt, J1
Azad, N1
Yu, M1
Davidson, B1
Choyke, P1
Wood, BJ1
Venkatesan, A1
Henning, R1
Calvo, K1
Minasian, L1
Edelman, DC1
Meltzer, P1
Steinberg, SM1
Annunziata, CM1
Kohn, EC1
Breaker, K1
Naam, M1
La Rosa, FG1
Flaig, IP1
Flaig, TW1
El Tal, AK1
Remichofsky, CJ1
Mehregan, DA1
Ganger, LK1
Bahadoran, P2
Allegra, M2
Le Duff, F1
Long-Mira, E1
Hofman, P1
Giacchero, D1
Passeron, T1
Lacour, JP1
Degen, A2
Weichenthal, M1
Ugurel, S1
Trefzer, U1
Kilian, K1
Garbe, C3
Egberts, F2
Poppe, LM1
Hauschild, A4
Gutzmer, R2
Botton, T1
Yeh, I1
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Vemula, SS1
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McCalmont, TH1
LeBoit, PE1
Burton, EA1
Bollag, G1
Bastian, BC1
Vin, H1
Ching, G1
Ojeda, SS1
Adelmann, CH1
Chitsazzadeh, V1
Dwyer, DW1
Ma, H1
Ehrenreiter, K1
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Ruggieri, R1
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Ciurea, AM1
Duvic, M1
Busaidy, NL1
Tannir, NM3
Tsai, KY1
Kunimoto, R1
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Tanimura, A1
Sato, M1
Horimoto, K1
Hayashi, T1
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Sugino, T1
Hirobe, T1
Yamashita, T1
Horio, Y1
Wilson, MA1
Zhao, F1
Letrero, R1
D'Andrea, K1
Rimm, DL3
Kirkwood, JM1
Kluger, HM3
Lee, SJ2
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Flaherty, KT4
Nathanson, KL3
Thompson, BC1
Surjana, D3
Gammons, MV1
Lucas, R1
Dean, R1
Coupland, SE1
Oltean, S1
Bates, DO1
Fathi, AT1
Lin, WM1
Durazzo, T1
Piris, A2
Sadrzadeh, H1
Bernardo, L1
Borger, DR1
McAfee, SL1
Kroshinsky, D1
Chen, YB1
Rolfe, HM1
Tiwari, P2
Sahay, S2
Pandey, M2
Qadri, SS2
Gupta, KP3
Kim, B1
de León, FJ1
Blanes, MM1
Albares, MP1
Berbegal, L1
Niro, A1
Strippoli, S1
Alessio, G1
Sborgia, L1
Recchimurzo, N1
Guida, M1
Djokovic, D1
Trindade, A1
Gigante, J1
Pinho, M1
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Duarte, A1
Choy, B1
Dalziell, RA3
Kricker, A1
St George, G1
Chinniah, N1
Sidaway, P1
Bagcchi, S1
Hajdenberg, J1
Okano, S1
Zhao, Y1
Lowe, PM1
Eris, JM1
Bielski, VA1
Grunwald, MR1
McDonnell, MH1
Induru, R1
Gerber, JM1
Escudero-Góngora, MM1
Yélamos, O1
Halpern, AC1
Weinstock, MA1
Forbat, E1
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Ali, FR1
Hong, DS1
Reddy, SB1
Prieto, VG2
Wright, JJ1
Cohen, PR2
Diwan, AH1
Evans, HL1
Kurzrock, R1
Kong, HH1
Sibaud, V2
Chanco Turner, ML1
Fojo, T1
Hornyak, TJ1
Chevreau, C2
Kahler, KC1
Livingstone, E1
Ardavanis, A1
Doufexis, D1
Kountourakis, P1
Rigatos, G1
Melnikova, VO1
Bar-Eli, M1
Lopez, V1
Pinazo, I1
Marti, N1
Monteagudo, C1
Jorda, E1
Bennani-Lahlou, M1
Mateus, C3
Escudier, B3
Massard, C1
Soria, JC3
Spatz, A3
Robert, C5
Poust, J1
Jilaveanu, L1
Zito, C1
Camp, RL2
Arbiser, JL1
Dubauskas, Z1
Kunishige, J1
Jonasch, E1
Hwu, P1
Yang, J1
Zaja-Milatovic, S1
Thu, YM1
Lee, F1
Smykla, R1
Richmond, A1
Frieling, T1
Heise, J1
Wassilew, SW1
Arnault, JP2
Wechsler, J2
Tomasic, G2
Aractingi, S1
Grange, JD1
Poirier-Colame, V1
Malka, D2
Smith, KJ1
Haley, H1
Hamza, S1
Skelton, HG1
Kwon, EJ1
Kish, LS1
Jaworsky, C1
Spector, E1
Franklin, MJ1
Truskinovsky, AM1
Dudek, AZ1
Jilaveanu, LB1
Zito, CR1
Aziz, SA1
Conrad, PJ1
Schmitz, JC1
Sznol, M1
Sivapirabu, G1
Yiasemides, E1
Park, J2
Donghi, D1
Dummer, R1
Cozzio, A1
Wellbrock, C1
Hurlstone, A1
Handolias, D1
Hamilton, AL1
Salemi, R1
Tan, A1
Moodie, K1
Kerr, L1
Dobrovic, A1
McArthur, GA2
Satzger, I1
Voelker, B1
Kapp, A1
Niessner, H1
Beck, D1
Sinnberg, T1
Lasithiotakis, K1
Maczey, E2
Gogel, J1
Venturelli, S1
Berger, A1
Mauthe, M1
Toulany, M1
Flaherty, K1
Schaller, M1
Schadendorf, D2
Proikas-Cezanne, T1
Schittek, B2
Kulms, D2
Meier, F1
Denoyer, D1
Potdevin, T1
Roselt, P1
Neels, OC1
Kirby, L1
Greguric, I1
Katsifis, A1
Dorow, DS1
Hicks, RJ1
Raymond, AK1
Puri, PK1
Selim, MA2
Tyler, DS2
Nelson, KC1
Donaldson, MR1
Stetson, CL1
Smith, JL1
Ma, XH1
Piao, S1
Wang, D1
McAfee, QW1
Lum, JJ1
Li, LZ1
Amaravadi, RK1
Adnot-Desanlis, L1
Bernard, P1
Reguiaï, Z1
Lynch, MC1
Straub, R1
Adams, DR1
Williams, VL1
Stewart, DJ1
El-Gamal, MI1
Jung, MH1
Lee, WS1
Sim, T1
Yoo, KH1
Oh, CH1
Boulinguez, S1
Eisen, T1
Marais, R1
Affolter, A1
Lorigan, P1
Corrie, P1
Ottensmeier, C1
Chao, D1
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Jouary, T1
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Negrier, S1
Montegriffo, E1
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Gibbens, I1
James, MG1
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Marian, B1
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Grasl-Kraupp, B1
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Oberholzer, PA1
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Tamiya, H1
Kamo, R1
Kumei, A1
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Ishii, M1
Kobayashi, H1
Masunaga, S1
Sakurai, Y1
Tanaka, H1
Suzuki, M1
Liu, Y1
Kondo, N1
Maruhashi, A1
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Svoboda, RM1
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Welsch, MJ1
Anderson, BE1
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Miyachi, Y1
Matsumura, Y1
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Gioeli, D1
Karashima, T1
Fukuhara, H1
Tamura, K1
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Inoue, K1
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Kuroda, N1
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Patterson, CR1
Stapelberg, M1
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Stalpers, LJ1
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Rett, M1
Krüll, A1
Beck-Bornholdt, HP1
Gensler, HL1
Stüben, G1
Stuschke, M1
Knühmann, K1
Horsman, MR1
Sack, H1
Chen, B1
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de Witte, PA1
Ludwig, A1
Dietel, M1
Schäfer, G1
Müller, K1
Hilz, H1
Carruthers, C1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Detection of Plasmatic Cell-free BRAF and NRAS Mutations: a New Tool for Monitoring Patients With Metastatic Malignant Melanoma Treated With Targeted Therapies or Immunotherapy ( MALT )[NCT03493230]35 participants (Anticipated)Interventional2018-04-30Not yet recruiting
A Phase II, Multi-center, Open-label, Uncontrolled Study to Evaluate the Efficacy and Safety of BAY 43-9006 Given Daily in Combination With Repeated 21-Day Cycles of Dacarbazine (DTIC) Chemotherapy in Subjects With Advanced Metastatic Melanoma.[NCT00492297]Phase 283 participants (Actual)Interventional2005-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Duration of Complete Response

Duration of complete response was the number of days from the date that a complete response was first documented to the date that recurrent or progressive disease was first objectively documented (if patient progressed then censored=no) or to last observation (if patient did not progress then censored=yes). (NCT00492297)
Timeframe: from confirmed CR until PD (median 259 days)

Interventiondays (Number)
Sorafenib + Dacarbazine420

Duration of Partial Response

Duration of partial response was the number of days from the date that a partial response was first documented to the date that recurrent or progressive disease was first objectively documented (if patient progressed then censored=no) or to last observation (if patient did not progress then censored=yes). (NCT00492297)
Timeframe: from confirmed PR until PD (median 259 days)

Interventiondays (Median)
Sorafenib + Dacarbazine255

Duration of Response

Duration of Response was assessed in subjects who showed a Partial Response (PR) or Complete Response (CR). It was defined as the time from the first documented objective response to Progressive Disease (PD), or death if before documented progression. Duration of response for subjects who have not progressed or died at the time of analysis was censored at the date of last tumor assessment. (NCT00492297)
Timeframe: from confirmed Complete Response (CR) or Partial Response (PR) until Progressive Disease (PD) (median 259 days)

Interventiondays (Median)
Sorafenib + Dacarbazine327

Duration of Stable Disease

Duration of Stable Disease (DSD), defined as the time from the first documented objective evidence of Stable Disease (SD) to disease progression (DP) or death if death occurred before DP, was assessed in subjects who showed SD as best response. DSD for subjects who had not progressed or died was censored at the date of last tumor assessment. (NCT00492297)
Timeframe: from start of therapy to PD, only in non-responders (median 259 days)

Interventiondays (Median)
Sorafenib + Dacarbazine93

Overall Survival

Overall Survival was the number of days from the date that combination treatment started until the date of death. (NCT00492297)
Timeframe: from start of treatment until death (median 259 days)

Interventiondays (Median)
Sorafenib + Dacarbazine259

Progression-free Survival

Progression-free Survival (PFS) was the time from the first dose of combination therapy to disease progression (radiological or clinical, whichever is earlier) or death (if death occurs before progression is documented). PFS for subjects without tumor progression or death at the time of analysis were censored at the date of last tumor evaluation. (NCT00492297)
Timeframe: from start of treatment until progression or death before progression (median 259 days)

Interventiondays (Median)
Sorafenib + Dacarbazine102

Time to Progression

Time to Progression was the number of days from the start of therapy to progression (if patient progressed then censored=no) or to the last observation at which the patient was known to have not progressed, that is, the last observation with a best response of CR, PR, or SD. (NCT00492297)
Timeframe: From start of treatment until progression (median 259 days)

Interventiondays (Median)
Sorafenib + Dacarbazine102

Time to Response

Time to Response in subjects who achieved an objective response (PR or CR with confirmation) was measured from the date of starting study combination treatment until the earliest date that the response was first documented. (NCT00492297)
Timeframe: start of therapy to confirmed CR or PR (median 259 days)

Interventiondays (Median)
Sorafenib + Dacarbazine48

Disease Control (DC)

DC was defined as the total number of subjects whose best response was not progressive disease (PD) (total number of CRs + total number of PRs + total number of Stable Diseases (SD)). The DC at specific time points could also be calculated as the total number of subjects whose response was not PD at that time point. (NCT00492297)
Timeframe: after start of treatment, at 6 months and 12 months

Interventionparticipants (Number)
DC based on overall best responseDC at 6 monthsDC at 12 months
Sorafenib + Dacarbazine413838

Overall Best Response

Best Overall Response (BOR): Best tumor response achieved during or within 30 days after active therapy confirmed according to the Response Evaluation Criteria in Solid Tumors (RECIST). Complete response (CR): The disappearance of all target and non-target lesions. Partial response (PR): At least a 30% decrease in the sum of the longest diameter (LD) of target lesions, taking as reference the baseline sum LD. SD was defined as steady state of disease, PD was defined as an increase of at least 20% increase in the sum of the LD of target lesions or appearance of new lesions. (NCT00492297)
Timeframe: during or within 30 days after active therapy

Interventionparticipants (Number)
Overall response (CR+PR)Complete response (CR)Partial response (PR)Stable disease (SD)Progressive disease (PD)
Sorafenib + Dacarbazine10193134

Percentage of Subjects With Progression-free Survival at Specific Time-points

Progression-free Survival (PFS) was the time from the first dose of combination therapy to disease progression (radiological or clinical, whichever is earlier) or death (if death occurs before progression is documented). PFS for subjects without tumor progression or death at the time of analysis were censored at the date of last tumor evaluation. (NCT00492297)
Timeframe: from start of treatment until progression or death before progression after 3, 6 and 12 months

Interventionpercentage of participants (Number)
PFS at month 3PFS at month 6PFS at month 12
Sorafenib + Dacarbazine56.6333.7310.84

Reviews

31 reviews available for niacinamide and Cancer of Skin

ArticleYear
Oral nicotinamide for non-melanoma skin cancers: A review.
    Eye (London, England), 2023, Volume: 37, Issue:5

    Topics: Humans; Keratosis, Actinic; Niacinamide; Research Design; Skin Neoplasms

2023
Preventative Options and the Future of Chemoprevention for Cutaneous Tumors.
    Dermatologic clinics, 2023, Volume: 41, Issue:1

    Topics: Chemoprevention; Hedgehog Proteins; Humans; Niacinamide; Retinoids; Skin Neoplasms

2023
Preventative Options and the Future of Chemoprevention for Cutaneous Tumors.
    Dermatologic clinics, 2023, Volume: 41, Issue:1

    Topics: Chemoprevention; Hedgehog Proteins; Humans; Niacinamide; Retinoids; Skin Neoplasms

2023
Preventative Options and the Future of Chemoprevention for Cutaneous Tumors.
    Dermatologic clinics, 2023, Volume: 41, Issue:1

    Topics: Chemoprevention; Hedgehog Proteins; Humans; Niacinamide; Retinoids; Skin Neoplasms

2023
Preventative Options and the Future of Chemoprevention for Cutaneous Tumors.
    Dermatologic clinics, 2023, Volume: 41, Issue:1

    Topics: Chemoprevention; Hedgehog Proteins; Humans; Niacinamide; Retinoids; Skin Neoplasms

2023
Preventative Options and the Future of Chemoprevention for Cutaneous Tumors.
    Dermatologic clinics, 2023, Volume: 41, Issue:1

    Topics: Chemoprevention; Hedgehog Proteins; Humans; Niacinamide; Retinoids; Skin Neoplasms

2023
Preventative Options and the Future of Chemoprevention for Cutaneous Tumors.
    Dermatologic clinics, 2023, Volume: 41, Issue:1

    Topics: Chemoprevention; Hedgehog Proteins; Humans; Niacinamide; Retinoids; Skin Neoplasms

2023
Preventative Options and the Future of Chemoprevention for Cutaneous Tumors.
    Dermatologic clinics, 2023, Volume: 41, Issue:1

    Topics: Chemoprevention; Hedgehog Proteins; Humans; Niacinamide; Retinoids; Skin Neoplasms

2023
Preventative Options and the Future of Chemoprevention for Cutaneous Tumors.
    Dermatologic clinics, 2023, Volume: 41, Issue:1

    Topics: Chemoprevention; Hedgehog Proteins; Humans; Niacinamide; Retinoids; Skin Neoplasms

2023
Preventative Options and the Future of Chemoprevention for Cutaneous Tumors.
    Dermatologic clinics, 2023, Volume: 41, Issue:1

    Topics: Chemoprevention; Hedgehog Proteins; Humans; Niacinamide; Retinoids; Skin Neoplasms

2023
Role of Nicotinamide in Genomic Stability and Skin Cancer Chemoprevention.
    International journal of molecular sciences, 2019, Nov-26, Volume: 20, Issue:23

    Topics: Animals; Energy Metabolism; Genomic Instability; Humans; Immunosuppression Therapy; NAD; Niacinamide

2019
Dietary supplements in dermatology: A review of the evidence for zinc, biotin, vitamin D, nicotinamide, and Polypodium.
    Journal of the American Academy of Dermatology, 2021, Volume: 84, Issue:4

    Topics: Biotin; Dietary Supplements; Humans; Niacinamide; Phytotherapy; Polypodium; Skin Diseases; Skin Neop

2021
Chemoprevention of keratinocyte carcinoma and actinic keratosis in solid-organ transplant recipients: Systematic review and meta-analyses.
    Journal of the American Academy of Dermatology, 2021, Volume: 84, Issue:2

    Topics: Acitretin; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Humans; Keratosis, Actinic; Niacinamide;

2021
Oral nicotinamide: The role in skin cancer chemoprevention.
    Dermatologic therapy, 2021, Volume: 34, Issue:3

    Topics: Chemoprevention; Humans; Niacinamide; Skin; Skin Neoplasms; Ultraviolet Rays

2021
New Developments in the Management of Cutaneous Squamous Cell Carcinoma.
    Plastic and reconstructive surgery, 2021, 03-01, Volume: 147, Issue:3

    Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Chemoprevention; Chemotherapy, Adjuvant; Humans; Ly

2021
Nicotinamide for skin cancer chemoprevention.
    The Australasian journal of dermatology, 2017, Volume: 58, Issue:3

    Topics: Carcinoma, Basal Cell; Carcinoma, Squamous Cell; DNA Repair; Humans; Immune Tolerance; Keratosis, Ac

2017
Mechanisms and strategies to overcome resistance to molecularly targeted therapy for melanoma.
    Cancer, 2017, 06-01, Volume: 123, Issue:S11

    Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Antineoplastic Com

2017
Melanoma and nonmelanoma skin cancer chemoprevention: A role for nicotinamide?
    Photodermatology, photoimmunology & photomedicine, 2018, Volume: 34, Issue:1

    Topics: Animals; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; DNA Repair; Humans; Immunomodulation; Mela

2018
New and current preventive treatment options in actinic keratosis.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2017, Volume: 31 Suppl 5

    Topics: Carcinoma, Squamous Cell; Disease Progression; Female; Humans; Keratosis, Actinic; Male; Niacinamide

2017
Vitamin B Derivative (Nicotinamide)Appears to Reduce Skin Cancer Risk.
    Skin therapy letter, 2017, Volume: 22, Issue:5

    Topics: Humans; Niacinamide; Risk; Skin Neoplasms; Vitamin B Complex

2017
Research gaps in the management and prevention of cutaneous squamous cell carcinoma in organ transplant recipients.
    The British journal of dermatology, 2017, Volume: 177, Issue:5

    Topics: Antimetabolites, Antineoplastic; Capecitabine; Carcinoma, Squamous Cell; Health Behavior; Humans; Im

2017
Nicotinamide for photoprotection and skin cancer chemoprevention: A review of efficacy and safety.
    Experimental dermatology, 2019, Volume: 28 Suppl 1

    Topics: Adenosine Triphosphate; Animals; Anti-Inflammatory Agents; Chemoprevention; Dermatology; DNA Damage;

2019
Skin cancer prevention: a review of current topical options complementary to sunscreens.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2019, Volume: 33, Issue:7

    Topics: Administration, Cutaneous; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cyclooxygenase 2 Inhibit

2019
Topical and Systemic Modalities for Chemoprevention of Nonmelanoma Skin Cancer.
    Dermatologic clinics, 2019, Volume: 37, Issue:3

    Topics: Administration, Cutaneous; Administration, Oral; Antineoplastic Agents; Carcinoma, Basal Cell; Carci

2019
Skin cancer associated with the use of sorafenib and sunitinib for renal cell carcinoma.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2013, Volume: 39, Issue:7

    Topics: Adult; Antineoplastic Agents; Carcinoma, Basal Cell; Carcinoma, Renal Cell; Carcinoma, Squamous Cell

2013
Nicotinamide and the skin.
    The Australasian journal of dermatology, 2014, Volume: 55, Issue:3

    Topics: Acne Vulgaris; Animals; Autoimmune Diseases; Carcinogenesis; Dermatitis, Atopic; Humans; Keratosis,

2014
A review of nicotinamide: treatment of skin diseases and potential side effects.
    Journal of cosmetic dermatology, 2014, Volume: 13, Issue:4

    Topics: Acne Vulgaris; Administration, Cutaneous; Administration, Oral; Chemical and Drug Induced Liver Inju

2014
Ocular Toxicity in Metastatic Melanoma Patients Treated With Mitogen-Activated Protein Kinase Kinase Inhibitors: A Case Series.
    American journal of ophthalmology, 2015, Volume: 160, Issue:5

    Topics: Aged; Female; Humans; Male; Melanoma; Melanoma, Cutaneous Malignant; Middle Aged; Mitogen-Activated

2015
[New molecular target therapy for thyroid neoplasms and malignant melanomas].
    Nihon Jibiinkoka Gakkai kaiho, 2015, Volume: 118, Issue:11

    Topics: Antibodies, Monoclonal; Antineoplastic Agents; Clinical Trials as Topic; Humans; Indoles; Ipilimumab

2015
Cutaneous manifestations in leukemia patients.
    Seminars in oncology, 2016, Volume: 43, Issue:3

    Topics: Adenine Nucleotides; Antineoplastic Agents; Arabinonucleosides; Clofarabine; Cytarabine; Dermatomyco

2016
Nicotinamide: New Indications in Dermatology.
    Actas dermo-sifiliograficas, 2016, Volume: 107, Issue:9

    Topics: Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Chemoprevention; Clinical Trials, Phase III as Topi

2016
Use of nicotinamide in dermatology.
    Clinical and experimental dermatology, 2017, Volume: 42, Issue:2

    Topics: Acne Vulgaris; Dermatitis, Atopic; Humans; Niacinamide; Pigmentation Disorders; Pruritus; Skin Disea

2017
Metastatic melanoma: scientific rationale for sorafenib treatment and clinical results.
    Onkologie, 2008, Volume: 31, Issue:7

    Topics: Antineoplastic Agents; Benzenesulfonates; Clinical Trials as Topic; Evidence-Based Medicine; Humans;

2008
BRAF as therapeutic target in melanoma.
    Biochemical pharmacology, 2010, Sep-01, Volume: 80, Issue:5

    Topics: Antineoplastic Agents; Benzenesulfonates; Humans; Melanoma; Niacinamide; Phenylurea Compounds; Proto

2010
Photoprotective effects of nicotinamide.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2010, Volume: 9, Issue:4

    Topics: Animals; Dermatology; Humans; Immune Tolerance; Niacinamide; Poly(ADP-ribose) Polymerase Inhibitors;

2010
Does basal cell carcinoma belong to the spectrum of sorafenib-induced epithelial skin cancers?
    Dermatology (Basel, Switzerland), 2010, Volume: 221, Issue:3

    Topics: Aged; Antineoplastic Agents; Benzenesulfonates; Carcinoma, Basal Cell; Carcinoma, Renal Cell; Female

2010
Sorafenib-induced premalignant and malignant skin lesions.
    International journal of dermatology, 2011, Volume: 50, Issue:4

    Topics: Antineoplastic Agents; Benzenesulfonates; Humans; Niacinamide; Phenylurea Compounds; Precancerous Co

2011
[Clinical studies with sorafenib (Nexavar) in metastatic melanoma].
    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2007, Volume: 5, Issue:4

    Topics: Antineoplastic Agents; Benzenesulfonates; Clinical Trials as Topic; Humans; Melanoma; Niacinamide; P

2007
Sorafenib: delivering a targeted drug to the right targets.
    Expert review of anticancer therapy, 2007, Volume: 7, Issue:5

    Topics: Antineoplastic Agents; Benzenesulfonates; Carcinoma, Hepatocellular; Carcinoma, Renal Cell; Clinical

2007

Trials

18 trials available for niacinamide and Cancer of Skin

ArticleYear
Nicotinamide for Skin-Cancer Chemoprevention in Transplant Recipients.
    The New England journal of medicine, 2023, Mar-02, Volume: 388, Issue:9

    Topics: Antineoplastic Agents; Australia; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Chemoprevention;

2023
Patients' willingness to accept adverse event and cost tradeoffs from oral nicotinamide for reduced risk of non-melanoma skin cancer.
    The Journal of dermatological treatment, 2023, Volume: 34, Issue:1

    Topics: Adult; Aged; COVID-19; Female; Humans; Logistic Models; Male; Niacinamide; Pandemics; Skin Neoplasms

2023
Prevention of non-melanoma skin cancers with nicotinamide in transplant recipients: a case-control study.
    European journal of dermatology : EJD, 2017, Aug-01, Volume: 27, Issue:4

    Topics: Carcinoma, Squamous Cell; Case-Control Studies; Female; Humans; Keratosis, Actinic; Kidney Transplan

2017
Nicotinamide for prevention of nonmelanoma skin cancers: a change in practice?
    Clinical and experimental dermatology, 2017, Volume: 42, Issue:8

    Topics: Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cost of Illness; Humans; Keratosis, Actinic; Niacin

2017
Correlation of changes in HIF-1α and p53 expressions with vitamin B3 deficiency in skin cancer patients.
    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 2019, Volume: 154, Issue:5

    Topics: Administration, Oral; Gene Expression Regulation, Neoplastic; Humans; Hypoxia-Inducible Factor 1, al

2019
Pimasertib-associated ophthalmological adverse events.
    Acta ophthalmologica, 2018, Volume: 96, Issue:7

    Topics: Aged; Antineoplastic Agents; Color Perception Tests; Cross-Sectional Studies; Drug-Related Side Effe

2018
A Reduction in Inflammatory Macrophages May Contribute to Skin Cancer Chemoprevention by Nicotinamide.
    The Journal of investigative dermatology, 2019, Volume: 139, Issue:2

    Topics: Carcinogenesis; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cell Count; Humans; Incidence; Macr

2019
Translational predictive biomarker analysis of the phase 1b sorafenib and bevacizumab study expansion cohort.
    Molecular & cellular proteomics : MCP, 2013, Volume: 12, Issue:6

    Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab; Biomarkers, Phar

2013
Cutaneous side effects of combined therapy with sorafenib and pegylated interferon alpha-2b in metastatic melanoma (phase II DeCOG trial).
    Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 2013, Volume: 11, Issue:9

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Causality; Comorbidity; Drug Eruptions; Female

2013
Correlation of somatic mutations and clinical outcome in melanoma patients treated with Carboplatin, Paclitaxel, and sorafenib.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2014, Jun-15, Volume: 20, Issue:12

    Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Carboplatin; Double-Blind

2014
A Phase 3 Randomized Trial of Nicotinamide for Skin-Cancer Chemoprevention.
    The New England journal of medicine, 2015, Oct-22, Volume: 373, Issue:17

    Topics: Adult; Aged; Aged, 80 and over; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Double-Blind Method

2015
A phase II randomized controlled trial of nicotinamide for skin cancer chemoprevention in renal transplant recipients.
    The British journal of dermatology, 2016, Volume: 175, Issue:5

    Topics: Administration, Oral; Adult; Aged; Anticarcinogenic Agents; Carcinoma, Squamous Cell; Chemopreventio

2016
Oral nicotinamide reduces transepidermal water loss: a randomized controlled trial.
    The British journal of dermatology, 2016, Volume: 175, Issue:6

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Double-Blind Method; Dr

2016
Expression of sorafenib targets in melanoma patients treated with carboplatin, paclitaxel and sorafenib.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, Feb-01, Volume: 15, Issue:3

    Topics: Antineoplastic Combined Chemotherapy Protocols; Benzenesulfonates; Carboplatin; Cell Line, Tumor; Di

2009
Topical nicotinamide modulates cellular energy metabolism and provides broad-spectrum protection against ultraviolet radiation-induced immunosuppression in humans.
    The British journal of dermatology, 2009, Volume: 161, Issue:6

    Topics: Administration, Topical; Adult; Aged; Animals; Apoptosis; Cells, Cultured; Dose-Response Relationshi

2009
Sorafenib and dacarbazine as first-line therapy for advanced melanoma: phase I and open-label phase II studies.
    British journal of cancer, 2011, Jul-26, Volume: 105, Issue:3

    Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Benzenesulfonates; Dacarbazine; Disease

2011
Oral nicotinamide reduces actinic keratoses in phase II double-blinded randomized controlled trials.
    The Journal of investigative dermatology, 2012, Volume: 132, Issue:5

    Topics: Aged; Aged, 80 and over; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Cell Transformation, Neopl

2012
A phase I multi-institutional study of systemic sorafenib in conjunction with regional melphalan for in-transit melanoma of the extremity.
    Annals of surgical oncology, 2012, Volume: 19, Issue:12

    Topics: Antineoplastic Combined Chemotherapy Protocols; Extremities; Female; Follow-Up Studies; Humans; Male

2012

Other Studies

93 other studies available for niacinamide and Cancer of Skin

ArticleYear
Cutaneous immune-related adverse events and photodamaged skin in patients with metastatic melanoma: could nicotinamide be useful?
    Clinical and experimental dermatology, 2022, Volume: 47, Issue:8

    Topics: Humans; Immunotherapy; Melanoma; Neoplasms, Second Primary; Niacinamide; Retrospective Studies; Skin

2022
The SRPK inhibitor N-(2-(piperidin-1-yl)-5-(trifluoromethyl)phenyl) isonicotinamide (SRPIN340) increases the immune response against metastatic melanoma in mice.
    Biochemical pharmacology, 2022, Volume: 203

    Topics: Animals; Humans; Immunity; Melanoma; Mice; Niacinamide; Piperidines; Protein Serine-Threonine Kinase

2022
Nicotinamide for Skin-Cancer Chemoprevention in Transplantation.
    The New England journal of medicine, 2023, Jun-29, Volume: 388, Issue:26

    Topics: Carcinoma, Basal Cell; Chemoprevention; Humans; Niacinamide; Skin Neoplasms; Transplant Recipients

2023
Nicotinamide for Skin-Cancer Chemoprevention in Transplantation.
    The New England journal of medicine, 2023, Jun-29, Volume: 388, Issue:26

    Topics: Carcinoma, Basal Cell; Chemoprevention; Humans; Niacinamide; Skin Neoplasms; Transplant Recipients

2023
Nicotinamide for Skin-Cancer Chemoprevention in Transplantation. Reply.
    The New England journal of medicine, 2023, Jun-29, Volume: 388, Issue:26

    Topics: Carcinoma, Basal Cell; Chemoprevention; Humans; Niacinamide; Skin Neoplasms; Transplant Recipients

2023
Nicotinamide for skin cancer chemoprevention in transplant recipients: a critically appraised topic.
    The British journal of dermatology, 2023, 11-16, Volume: 189, Issue:6

    Topics: Chemoprevention; Humans; Niacinamide; Organ Transplantation; Skin Neoplasms; Transplant Recipients

2023
Education and Perspectives on the Use of Oral Skin Cancer Chemoprophylaxis: A Cross-Sectional Survey of Current Fellows in Mohs Micrographic Surgery & Dermatologic Oncology.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2023, 12-01, Volume: 49, Issue:12

    Topics: Acitretin; Cross-Sectional Studies; Curriculum; Education, Medical, Graduate; Educational Status; Fe

2023
Nicotinamide for skin cancer chemoprevention: effects of nicotinamide on melanoma in vitro and in vivo.
    Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology, 2020, Feb-19, Volume: 19, Issue:2

    Topics: CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Cell Movement; Cell Surviv

2020
Feasibility of a trial to evaluate nicotinamide for chemoprevention of skin cancers in organ transplant recipients in the UK.
    The British journal of dermatology, 2020, Volume: 183, Issue:2

    Topics: Chemoprevention; Feasibility Studies; Humans; Niacinamide; Organ Transplantation; Skin Neoplasms; Tr

2020
Is nicotinamide a sustainable therapy for resistant actinic keratoses?
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2020, Volume: 34, Issue:10

    Topics: Humans; Keratosis, Actinic; Niacinamide; Skin Neoplasms

2020
Effect of the topical administration of N-(2-(4-bromophenylamino)-5-(trifluoromethyl)phenyl)nicotinamide compound in a murine subcutaneous melanoma model.
    Anti-cancer drugs, 2020, Volume: 31, Issue:7

    Topics: Administration, Topical; Animals; Caspase 3; Cell Death; Male; Melanoma, Experimental; Mice; Mice, I

2020
Evaluation of Radioiodinated Fluoronicotinamide/Fluoropicolinamide-Benzamide Derivatives as Theranostic Agents for Melanoma.
    International journal of molecular sciences, 2020, Sep-09, Volume: 21, Issue:18

    Topics: Animals; Benzamides; Cell Line, Tumor; Humans; Iodine Radioisotopes; Melanins; Melanoma, Experimenta

2020
Nicotinamide inhibits melanoma in vitro and in vivo.
    Journal of experimental & clinical cancer research : CR, 2020, Oct-07, Volume: 39, Issue:1

    Topics: Aged; Animals; Apoptosis; Cell Cycle; Cell Proliferation; Female; Humans; In Vitro Techniques; Male;

2020
Nicotinamide: An Update and Review of Safety & Differences from Niacin.
    Skin therapy letter, 2020, Volume: 25, Issue:5

    Topics: Administration, Oral; Dietary Supplements; Humans; Niacinamide; Skin Neoplasms; Vitamin B Complex

2020
Penile and scrotal infundibular cysts in an adolescent treated with sorafenib.
    Pediatric dermatology, 2021, Volume: 38, Issue:2

    Topics: Adolescent; Carcinoma, Squamous Cell; Humans; Male; Niacinamide; Phenylurea Compounds; Skin Neoplasm

2021
Is the first-line systemic chemoprevention of nonmelanoma skin cancer nicotinamide or acitretin?
    International journal of dermatology, 2021, Volume: 60, Issue:6

    Topics: Acitretin; Chemoprevention; Humans; Niacinamide; Skin Neoplasms

2021
Current Practices for Preventative Interventions for Nonmelanoma Skin Cancers Among Dermatologic Surgeons.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2021, 07-01, Volume: 47, Issue:7

    Topics: Acitretin; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Dermatologic Agents; Humans; Institution

2021
Nicotinamide for Keratinocyte Carcinoma Chemoprevention: A Nationwide Survey of Mohs Surgeons.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2021, 04-01, Volume: 47, Issue:4

    Topics: Chemoprevention; Humans; Keratinocytes; Mohs Surgery; Niacinamide; Practice Patterns, Physicians'; R

2021
Nicotinamide and skin cancer chemoprevention: The jury is still out.
    The Australasian journal of dermatology, 2018, Volume: 59, Issue:1

    Topics: Bayes Theorem; Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Clinical Trials, Phase III as Topic;

2018
Chemopreventive potential of nicotinamide in Gilmore's Bayesian analysis.
    The Australasian journal of dermatology, 2018, Volume: 59, Issue:3

    Topics: Bayes Theorem; Humans; Niacinamide; Skin Neoplasms

2018
Response to 'Considering the chemopreventive potential of nicotinamide in Gilmore's Bayesian analysis'.
    The Australasian journal of dermatology, 2018, Volume: 59, Issue:3

    Topics: Bayes Theorem; Chemoprevention; Humans; Niacinamide; Skin; Skin Neoplasms

2018
Nicotinamide as a chemopreventive therapy of skin cancers. Too much of good thing?
    Pigment cell & melanoma research, 2019, Volume: 32, Issue:4

    Topics: Chemoprevention; Humans; NAD; Niacinamide; Signal Transduction; Skin Neoplasms

2019
Treatment of Arsenic-Induced Bowen’s Disease With Topical 5-Fluorouracil
    Journal of drugs in dermatology : JDD, 2019, May-01, Volume: 18, Issue:5

    Topics: Administration, Cutaneous; Administration, Oral; Antimetabolites, Antineoplastic; Arsenic; Bowen's D

2019
Multiple squamous cell carcinomas following treatment with sorafenib for renal cell carcinoma.
    International journal of dermatology, 2013, Volume: 52, Issue:12

    Topics: Aged; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Humans; Kidney Neoplasms; Male; Neoplasms, Se

2013
Major clinical response to a BRAF inhibitor in a patient with a BRAF L597R-mutated melanoma.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2013, Jul-01, Volume: 31, Issue:19

    Topics: Aged; Antineoplastic Agents; Arginine; Back; Cell Survival; Enzyme Activation; Extracellular Signal-

2013
Recurrent BRAF kinase fusions in melanocytic tumors offer an opportunity for targeted therapy.
    Pigment cell & melanoma research, 2013, Volume: 26, Issue:6

    Topics: Adolescent; Adult; Child, Preschool; Enzyme Activation; Female; Gene Rearrangement; Humans; Indoles;

2013
Sorafenib suppresses JNK-dependent apoptosis through inhibition of ZAK.
    Molecular cancer therapeutics, 2014, Volume: 13, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Proliferation; Ce

2014
SIRT1 regulates lamellipodium extension and migration of melanoma cells.
    The Journal of investigative dermatology, 2014, Volume: 134, Issue:6

    Topics: Animals; Cell Movement; Female; Gene Expression Regulation, Neoplastic; Melanoma; Melanoma, Experime

2014
Nicotinamide enhances repair of ultraviolet radiation-induced DNA damage in primary melanocytes.
    Experimental dermatology, 2014, Volume: 23, Issue:7

    Topics: Cell Line, Tumor; Cell Survival; Cells, Cultured; DNA Damage; DNA Repair; Humans; Melanocytes; Melan

2014
Targeting SRPK1 to control VEGF-mediated tumour angiogenesis in metastatic melanoma.
    British journal of cancer, 2014, Jul-29, Volume: 111, Issue:3

    Topics: Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Gene Knockdown Techniques; Humans; Melanoma; Mic

2014
Extensive Squamous Cell Carcinoma of the Skin Related to Use of Sorafenib for Treatment of FLT3-Mutant Acute Myeloid Leukemia.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2016, Mar-10, Volume: 34, Issue:8

    Topics: Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; fms-Like Tyrosine Kinase 3; Humans; Leukemia,

2016
Combinatorial chemopreventive effect of butyric acid, nicotinamide and calcium glucarate against the 7,12-dimethylbenz(a)anthracene induced mouse skin tumorigenesis attained by enhancing the induction of intrinsic apoptotic events.
    Chemico-biological interactions, 2015, Jan-25, Volume: 226

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Anticarcinogenic Agents; Apoptosis; Apoptotic Protease-Ac

2015
Oral nicotinamide and actinic keratosis: a supplement success story.
    Current problems in dermatology, 2015, Volume: 46

    Topics: Administration, Oral; Animals; Antineoplastic Agents; Dietary Supplements; DNA Repair; Humans; Immun

2015
Cutaneous metastasis from hepatocellular carcinoma after a percutaneous interventional procedure.
    Actas dermo-sifiliograficas, 2015, Volume: 106, Issue:5

    Topics: Adult; Antineoplastic Agents; Carcinoma, Hepatocellular; Combined Modality Therapy; Diathermy; Ethan

2015
Incomplete Dll4/Notch signaling inhibition promotes functional angiogenesis supporting the growth of skin papillomas.
    BMC cancer, 2015, Aug-28, Volume: 15

    Topics: Adaptor Proteins, Signal Transducing; Animals; Antineoplastic Agents; Calcium-Binding Proteins; Dise

2015
Skin cancer: Nicotinamide reduces new skin cancer risk.
    Nature reviews. Clinical oncology, 2016, Volume: 13, Issue:1

    Topics: Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Female; Humans; Keratosis, Actinic; Male; Niacinami

2016
Nicotinamide yields impressive results in skin cancer.
    The Lancet. Oncology, 2015, Volume: 16, Issue:16

    Topics: Administration, Oral; Anticarcinogenic Agents; Humans; Neoplasm Recurrence, Local; Niacinamide; Rand

2015
Preventive effects of butyric acid, nicotinamide, calcium glucarate alone or in combination during the 7, 12-dimethylbenz (a) anthracene induced mouse skin tumorigenesis via modulation of K-Ras-PI3K-AKTpathway and associated micro RNAs.
    Biochimie, 2016, Volume: 121

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Blotting, Western; Butyric Acid; G

2016
ACP Journal Club. In high-risk patients, oral nicotinamide reduced number of new nonmelanoma skin cancers during treatment.
    Annals of internal medicine, 2016, Feb-16, Volume: 164, Issue:4

    Topics: Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Female; Humans; Keratosis, Actinic; Male; Niacinami

2016
Nicotinamide for Skin-Cancer Chemoprevention.
    The New England journal of medicine, 2016, 02-25, Volume: 374, Issue:8

    Topics: Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Female; Humans; Keratosis, Actinic; Male; Niacinami

2016
Nicotinamide for Skin-Cancer Chemoprevention.
    The New England journal of medicine, 2016, 02-25, Volume: 374, Issue:8

    Topics: Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Female; Humans; Keratosis, Actinic; Male; Niacinami

2016
Nicotinamide for Skin-Cancer Chemoprevention.
    The New England journal of medicine, 2016, 02-25, Volume: 374, Issue:8

    Topics: Carcinoma, Basal Cell; Carcinoma, Squamous Cell; Female; Humans; Keratosis, Actinic; Male; Niacinami

2016
Reply to 'A phase II randomized controlled trial of nicotinamide for skin cancer chemoprevention in renal transplant recipients'.
    The British journal of dermatology, 2017, Volume: 176, Issue:2

    Topics: Chemoprevention; Humans; Kidney Transplantation; Niacinamide; Skin Neoplasms; Transplant Recipients

2017
Authors' response to a reply to 'A phase II randomized controlled trial of nicotinamide for skin cancer chemoprevention in renal transplant recipients'.
    The British journal of dermatology, 2017, Volume: 176, Issue:2

    Topics: Chemoprevention; Humans; Kidney Transplantation; Niacin; Niacinamide; Skin Neoplasms

2017
Multiple squamous cell carcinomas of the skin after therapy with sorafenib combined with tipifarnib.
    Archives of dermatology, 2008, Volume: 144, Issue:6

    Topics: Aged; Antineoplastic Agents; Benzenesulfonates; Biopsy; Carcinoma, Renal Cell; Carcinoma, Squamous C

2008
Sorafenib-induced eruptive melanocytic lesions.
    Archives of dermatology, 2008, Volume: 144, Issue:6

    Topics: Administration, Oral; Antineoplastic Agents; Benzenesulfonates; Biopsy; Carcinoma, Renal Cell; Diagn

2008
A Kaposi's sarcoma complete clinical response after sorafenib administration.
    Annals of oncology : official journal of the European Society for Medical Oncology, 2008, Volume: 19, Issue:9

    Topics: Benzenesulfonates; Carcinoma, Renal Cell; Drug Administration Schedule; Follow-Up Studies; Humans; K

2008
Searching for the Achilles' heel of melanoma cells: new treatment modalities.
    Pigment cell & melanoma research, 2008, Volume: 21, Issue:5

    Topics: Animals; Antineoplastic Agents; Apoptosis; Benzenesulfonates; Clinical Trials as Topic; Enzyme Inhib

2008
Follicular hyperplasia on the face subsequent to therapy with sorafenib. A new skin side effect.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2009, Volume: 23, Issue:8

    Topics: Aged, 80 and over; Antineoplastic Agents; Benzenesulfonates; Humans; Hyperplasia; Lung Neoplasms; Ma

2009
[Eruptive nevi associated with sorafenib treatment].
    Annales de dermatologie et de venereologie, 2008, Volume: 135, Issue:10

    Topics: Adult; Aged; Antineoplastic Agents; Benzenesulfonates; Humans; Male; Middle Aged; Nevus; Niacinamide

2008
Targeting metastatic melanoma.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2008, Dec-15, Volume: 65, Issue:24 Suppl 9

    Topics: Antibodies, Monoclonal; Antigens, CD; Antineoplastic Agents; Benzenesulfonates; Cancer Vaccines; Cli

2008
Unexpected autocrine role of vascular endothelial growth factor in squamous cell carcinoma.
    The Journal of investigative dermatology, 2009, Volume: 129, Issue:3

    Topics: Aneuploidy; Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Benzenesulfonates; B

2009
Cutaneous squamous cell carcinoma and inflammation of actinic keratoses associated with sorafenib.
    Clinical genitourinary cancer, 2009, Volume: 7, Issue:1

    Topics: Aged; Benzenesulfonates; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Drug Eruptions; Female; Hu

2009
Molecular determinants of melanoma malignancy: selecting targets for improved efficacy of chemotherapy.
    Molecular cancer therapeutics, 2009, Volume: 8, Issue:3

    Topics: Animals; Antineoplastic Agents; Benzenesulfonates; Biomarkers, Tumor; Dacarbazine; Drug Delivery Sys

2009
Multiple colon ulcerations, perforation and death during treatment of malignant melanoma with sorafenib.
    Deutsche medizinische Wochenschrift (1946), 2009, Volume: 134, Issue:28-29

    Topics: Abdomen, Acute; Aged; Antineoplastic Agents; Benzenesulfonates; Colectomy; Colonic Diseases; Diarrhe

2009
Keratoacanthomas and squamous cell carcinomas in patients receiving sorafenib.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2009, Aug-10, Volume: 27, Issue:23

    Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Benzenesulfonates; Carcinoma, Squamous Cell;

2009
Eruptive keratoacanthoma-type squamous cell carcinomas in patients taking sorafenib for the treatment of solid tumors.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2009, Volume: 35, Issue:11

    Topics: Adult; Antineoplastic Agents; Benzenesulfonates; Carcinoma, Squamous Cell; Female; Humans; Keratoaca

2009
The histologic spectrum of epithelial neoplasms induced by sorafenib.
    Journal of the American Academy of Dermatology, 2009, Volume: 61, Issue:3

    Topics: Aged; Antineoplastic Agents; Benzenesulfonates; Biopsy; Carcinoma, Renal Cell; Carcinoma, Squamous C

2009
Sorafenib induces partial response in metastatic medullary thyroid carcinoma.
    Acta oncologica (Stockholm, Sweden), 2010, Volume: 49, Issue:1

    Topics: Adult; Antineoplastic Agents; Benzenesulfonates; Bone Neoplasms; Carcinoma, Neuroendocrine; Humans;

2010
C-Raf is associated with disease progression and cell proliferation in a subset of melanomas.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2009, Sep-15, Volume: 15, Issue:18

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Benzenesulfonates; Cell Line, Tumor; Cell Proliferation;

2009
Complete remission in a patient with multifocal metastatic cutaneous angiosarcoma with a combination of paclitaxel and sorafenib.
    The British journal of dermatology, 2010, Volume: 162, Issue:3

    Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Benzenesulfonates; Head and Neck Neoplasms; He

2010
Clinical responses observed with imatinib or sorafenib in melanoma patients expressing mutations in KIT.
    British journal of cancer, 2010, Apr-13, Volume: 102, Issue:8

    Topics: Adult; Aged; Antineoplastic Agents; Benzamides; Benzenesulfonates; Female; Humans; Imatinib Mesylate

2010
The farnesyl transferase inhibitor lonafarnib inhibits mTOR signaling and enforces sorafenib-induced apoptosis in melanoma cells.
    The Journal of investigative dermatology, 2011, Volume: 131, Issue:2

    Topics: Antineoplastic Agents; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Benzenesulfonates; C

2011
Improved detection of regional melanoma metastasis using 18F-6-fluoro-N-[2-(diethylamino)ethyl] pyridine-3-carboxamide, a melanin-specific PET probe, by perilesional administration.
    Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2011, Volume: 52, Issue:1

    Topics: Animals; Fluorine Radioisotopes; Lymphatic Metastasis; Melanins; Melanoma; Mice; Mice, Inbred C57BL;

2011
Regional squamous cell carcinomas following systemic sorafenib therapy and isolated limb infusion for regionally advanced metastatic melanoma of the limb.
    Archives of dermatology, 2010, Volume: 146, Issue:12

    Topics: Aged; Antineoplastic Agents; Benzenesulfonates; Carcinoma, Squamous Cell; Drug Administration Routes

2010
Invasive squamous cell carcinoma and sorafenib in a black patient.
    Archives of dermatology, 2011, Volume: 147, Issue:1

    Topics: Antineoplastic Agents; Benzenesulfonates; Black People; Carcinoma, Hepatocellular; Carcinoma, Squamo

2011
Measurements of tumor cell autophagy predict invasiveness, resistance to chemotherapy, and survival in melanoma.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2011, May-15, Volume: 17, Issue:10

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Autophagy; Benzenesulfonates; Cell Count; C

2011
[Squamous cell carcinoma in a patient receiving sorafenib].
    Annales de dermatologie et de venereologie, 2011, Volume: 138, Issue:2

    Topics: Antineoplastic Agents; Benzenesulfonates; Biopsy; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; C

2011
Eruptive squamous cell carcinomas with keratoacanthoma-like features in a patient treated with sorafenib.
    Journal of drugs in dermatology : JDD, 2011, Volume: 10, Issue:3

    Topics: Aged, 80 and over; Antineoplastic Agents; Benzenesulfonates; Carcinoma, Hepatocellular; Carcinoma, S

2011
Design, synthesis, and antiproliferative activity of new 1H-pyrrolo[3,2-c]pyridine derivatives against melanoma cell lines.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:8

    Topics: Animals; Antineoplastic Agents; Benzenesulfonates; Cell Line, Tumor; Cell Proliferation; Drug Screen

2011
[News on melanoma from the 2010 Dermatology Days in Paris].
    Annales de dermatologie et de venereologie, 2011, Volume: 138, Issue:5 Suppl 1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Benzenesulfonates; Biomarkers, Tumor; Chemotherapy,

2011
Fibroblast growth factor receptors as therapeutic targets in human melanoma: synergism with BRAF inhibition.
    The Journal of investigative dermatology, 2011, Volume: 131, Issue:10

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Benzenesulfonates;

2011
RAS mutations are associated with the development of cutaneous squamous cell tumors in patients treated with RAF inhibitors.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2012, Jan-20, Volume: 30, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Benzenesulfonates; Carcinoma, Squamous Cell; Female; Gene Expression

2012
Skin tumors induced by sorafenib; paradoxic RAS-RAF pathway activation and oncogenic mutations of HRAS, TP53, and TGFBR1.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2012, Jan-01, Volume: 18, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents; Benzenesulfonates; Biomarkers, Tumor; Blotting, Western; Carcino

2012
Partial response of angiosarcoma of the scalp to sorafenib: association with decreased expression of vascular endothelial growth factors and their receptors.
    Clinical and experimental dermatology, 2012, Volume: 37, Issue:7

    Topics: Antineoplastic Agents; Head and Neck Neoplasms; Hemangiosarcoma; Humans; Male; Middle Aged; Niacinam

2012
Effects of employing a ¹⁰B-carrier and manipulating intratumour hypoxia on local tumour response and lung metastatic potential in boron neutron capture therapy.
    The British journal of radiology, 2012, Volume: 85, Issue:1011

    Topics: Animals; Antineoplastic Agents; Borohydrides; Boron Neutron Capture Therapy; Bromodeoxyuridine; Cell

2012
Painful leg mass.
    The Journal of family practice, 2012, Volume: 61, Issue:5

    Topics: Antineoplastic Agents; Benzenesulfonates; Carcinoma, Renal Cell; Hospice Care; Humans; Kidney Neopla

2012
Multiple cutaneous metastatic chordomas from the sacrum.
    Journal of the American Academy of Dermatology, 2012, Volume: 66, Issue:6

    Topics: Aged; Antineoplastic Agents; Benzenesulfonates; Bone Neoplasms; Chordoma; Female; Humans; Niacinamid

2012
Angiosarcoma of the scalp successfully treated with a single therapy of sorafenib.
    Archives of dermatology, 2012, Volume: 148, Issue:6

    Topics: Aged; Antineoplastic Agents; Benzenesulfonates; Female; Head and Neck Neoplasms; Hemangiosarcoma; Hu

2012
Synthetic lethal screening with small-molecule inhibitors provides a pathway to rational combination therapies for melanoma.
    Molecular cancer therapeutics, 2012, Volume: 11, Issue:11

    Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Death; Cell Line, Tumor;

2012
Nicotinamide enhances repair of ultraviolet radiation-induced DNA damage in human keratinocytes and ex vivo skin.
    Carcinogenesis, 2013, Volume: 34, Issue:5

    Topics: 8-Hydroxy-2'-Deoxyguanosine; Cell Line; Deoxyguanosine; DNA; DNA Damage; DNA Glycosylases; DNA Repai

2013
Expression of angiogenesis-related gene profiles and development of resistance to tyrosine-kinase inhibitor in advanced renal cell carcinoma: characterization of sorafenib-resistant cells derived from a cutaneous metastasis.
    International journal of urology : official journal of the Japanese Urological Association, 2013, Volume: 20, Issue:9

    Topics: Aneuploidy; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation; Drug Resistance, Neoplasm;

2013
UV radiation-induced immunosuppression is greater in men and prevented by topical nicotinamide.
    The Journal of investigative dermatology, 2008, Volume: 128, Issue:2

    Topics: Administration, Topical; Adult; Apoptosis; Complement System Proteins; Energy Metabolism; Erythema;

2008
Complete response in a cutaneous facial metastatic nodule from renal cell carcinoma after hypofractionated radiotherapy.
    Dermatology online journal, 2007, Oct-13, Volume: 13, Issue:4

    Topics: Antineoplastic Agents; Benzenesulfonates; Carcinoma, Renal Cell; Facial Neoplasms; Humans; Interleuk

2007
Combined inhibition of MAPK and mTOR signaling inhibits growth, induces cell death, and abrogates invasive growth of melanoma cells.
    The Journal of investigative dermatology, 2008, Volume: 128, Issue:8

    Topics: Androstadienes; Apoptosis; Benzenesulfonates; Butadienes; Cell Line, Tumor; Cell Proliferation; Chro

2008
Bowel perforation after radiotherapy in a patient receiving sorafenib.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2008, May-10, Volume: 26, Issue:14

    Topics: Antineoplastic Agents; Benzenesulfonates; Carcinoma, Renal Cell; Combined Modality Therapy; Female;

2008
Combination of fractionated irradiation with nicotinamide and carbogen in R1H-tumours of the rat and its pulmonary metastases.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1997, Volume: 45, Issue:2

    Topics: Animals; Carbon Dioxide; Combined Modality Therapy; Disease Models, Animal; Dose Fractionation, Radi

1997
Prevention of photoimmunosuppression and photocarcinogenesis by topical nicotinamide.
    Nutrition and cancer, 1997, Volume: 29, Issue:2

    Topics: Administration, Topical; Adoptive Transfer; Animals; Antibodies, Monoclonal; Carcinoma, Squamous Cel

1997
The effect of combined nicotinamide and carbogen treatments in human tumour xenografts: oxygenation and tumour control studies.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1998, Volume: 48, Issue:2

    Topics: Administration, Inhalation; Animals; Carbon Dioxide; Cell Hypoxia; Drug Combinations; Glioblastoma;

1998
Effects of nicotinamide on mouse skin tumor development and its mode of action.
    Biomedical and environmental sciences : BES, 1999, Volume: 12, Issue:3

    Topics: Animals; Apoptosis; Female; Mice; Niacinamide; Ornithine Decarboxylase; Skin Neoplasms; Tetradecanoy

1999
Photodynamic therapy with hypericin in a mouse P388 tumor model: vascular effects determine the efficacy.
    International journal of oncology, 2001, Volume: 18, Issue:4

    Topics: Animals; Anthracenes; Blood Vessels; Dose-Response Relationship, Drug; Female; Fluorescein; Hydralaz

2001
Nicotinamide and nicotinamide analogues as antitumor promoters in mouse skin.
    Cancer research, 1990, Apr-15, Volume: 50, Issue:8

    Topics: 9,10-Dimethyl-1,2-benzanthracene; Aminobenzoates; Animals; Antineoplastic Agents; Benzamides; Benzoa

1990
Urocanic acid in epidermal carcinogenesis.
    The Journal of investigative dermatology, 1968, Volume: 50, Issue:1

    Topics: Animals; Carcinoma, Squamous Cell; Humans; Imidazoles; Methylcholanthrene; Mice; Neoplasms, Experime

1968