niacinamide has been researched along with Brain Injuries in 23 studies
nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| " These data suggest that administration of NMN at a proper dosage has a strong protective effect against ischemic brain injury." | 5.43 | Nicotinamide mononucleotide inhibits post-ischemic NAD(+) degradation and dramatically ameliorates brain damage following global cerebral ischemia. ( Kristian, T; Long, A; Owens, K; Park, JH, 2016) |
| "4%) patients treated with cytoflavin in dosage 20-40 ml daily intravenously in drops during 10 days in addition to standard treatment." | 2.78 | [Correction of energy homeostasis in the acute period of concomitant brain injury]. ( Beletskiĭ, AV; Nikonov, VV; Pavlenko, AIu, 2013) |
| " These data suggest that administration of NMN at a proper dosage has a strong protective effect against ischemic brain injury." | 1.43 | Nicotinamide mononucleotide inhibits post-ischemic NAD(+) degradation and dramatically ameliorates brain damage following global cerebral ischemia. ( Kristian, T; Long, A; Owens, K; Park, JH, 2016) |
| "Previous research has demonstrated considerable preclinical efficacy of nicotinamide (NAM; vitamin B(3)) in animal models of TBI with systemic dosing at 50 and 500 mg/kg yielding improvements on sensory, motor, cognitive and histological measures." | 1.37 | Continuous nicotinamide administration improves behavioral recovery and reduces lesion size following bilateral frontal controlled cortical impact injury. ( Anderson, GD; Hoane, MR; Vonder Haar, C, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (8.70) | 18.2507 |
| 2000's | 8 (34.78) | 29.6817 |
| 2010's | 12 (52.17) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Cui, D | 1 |
| Jia, S | 1 |
| Li, T | 1 |
| Li, D | 1 |
| Wang, X | 1 |
| Liu, X | 1 |
| Wang, YF | 1 |
| Savvina, IA | 1 |
| Cherebillo, VY | 1 |
| Zabrodskaya, YM | 1 |
| Petrova, AO | 1 |
| Sergeev, AV | 1 |
| Paltsev, AA | 1 |
| Rutkovskiy, RV | 1 |
| Malkhozova, AM | 1 |
| Nikonov, VV | 1 |
| Pavlenko, AIu | 1 |
| Beletskiĭ, AV | 1 |
| Vonder Haar, C | 2 |
| Maass, WR | 1 |
| Jacobs, EA | 1 |
| Hoane, MR | 12 |
| Lebedeva, EA | 1 |
| Kurtasov, AA | 1 |
| Belousova, ME | 1 |
| Nemkova, ZA | 1 |
| Kaminskiĭ, MIu | 1 |
| Popov, RV | 1 |
| Trofimovich, SL | 1 |
| Peterson, TC | 2 |
| McConomy, KS | 1 |
| Farin, FM | 1 |
| Bammler, TK | 1 |
| MacDonald, JW | 1 |
| Kantor, ED | 2 |
| Anderson, GD | 5 |
| Park, JH | 1 |
| Long, A | 1 |
| Owens, K | 1 |
| Kristian, T | 1 |
| Pierce, JL | 3 |
| Holland, MA | 3 |
| Quigley, A | 1 |
| Tan, AA | 3 |
| Skoromets, AA | 1 |
| Pugacheva, EL | 1 |
| Swan, AA | 1 |
| Chandrashekar, R | 1 |
| Beare, J | 1 |
| Sung, JH | 1 |
| Kim, MO | 1 |
| Koh, PO | 1 |
| Batotsyrenova, KhV | 1 |
| Livanov, GA | 1 |
| Shestova, GV | 1 |
| Sizova, KV | 1 |
| Velikova, VD | 1 |
| Akstulewicz, SL | 1 |
| Toppen, J | 1 |
| Gilbert, DR | 1 |
| Smith, DC | 2 |
| Kaplan, SA | 1 |
| Ellis, AL | 1 |
| Kamada, K | 1 |
| Houkin, K | 1 |
| Iwasaki, Y | 1 |
| Abe, H | 1 |
| Yamanaka, K | 1 |
| Kumura, E | 1 |
| Yoshimine, T | 1 |
| Maruno, M | 1 |
| Taniguchi, M | 1 |
| Kosaka, H | 1 |
| Hayakawa, T | 1 |
| Vajragupta, O | 1 |
| Toasaksiri, S | 1 |
| Boonyarat, C | 1 |
| Wongkrajang, Y | 1 |
| Peungvicha, P | 1 |
| Watanabe, H | 1 |
| Boonchoong, P | 1 |
3 trials available for niacinamide and Brain Injuries
| Article | Year |
|---|---|
[Correction of energy homeostasis in the acute period of concomitant brain injury].
Topics: Adolescent; Adult; Brain Injuries; Critical Care; Drug Combinations; Energy Metabolism; Female; Flav | 2013 |
[Clinical effectiveness of cytoflavin inclusion in intensive care of patients with combined traumatic brain injury].
Topics: Adolescent; Adult; Aged; Brain Injuries; Critical Care; Drug Combinations; Female; Flavin Mononucleo | 2014 |
[Efficacy of the complex drug cytoflavin in the treatment of consequences of mild brain injury].
Topics: Adolescent; Adult; Brain Injuries; Drug Combinations; Flavin Mononucleotide; gamma-Aminobutyric Acid | 2010 |
20 other studies available for niacinamide and Brain Injuries
| Article | Year |
|---|---|
Alleviation of brain injury by applying TGN-020 in the supraoptic nucleus via inhibiting vasopressin neurons in rats of focal ischemic stroke.
Topics: Animals; Brain Injuries; Ischemic Stroke; Male; Microinjections; Neurons; Niacinamide; Rats; Rats, W | 2021 |
[The intraoperative prophylaxis of local ischemical brain damage in neurosurgical patients with cerebral aneurysm].
Topics: Brain; Brain Injuries; Brain Ischemia; Drug Combinations; Flavin Mononucleotide; Humans; Inosine Dip | 2019 |
Deficits in discrimination after experimental frontal brain injury are mediated by motivation and can be improved by nicotinamide administration.
Topics: Animals; Brain Injuries; Cognition; Discrimination Learning; Discrimination, Psychological; Frontal | 2014 |
A Combination Therapy of Nicotinamide and Progesterone Improves Functional Recovery following Traumatic Brain Injury.
Topics: Animals; Brain Injuries; Drug Therapy, Combination; Male; Niacinamide; Progesterone; Rats; Rats, Spr | 2015 |
Nicotinamide mononucleotide inhibits post-ischemic NAD(+) degradation and dramatically ameliorates brain damage following global cerebral ischemia.
Topics: Animals; Brain Injuries; Brain Ischemia; Cell Death; Disease Models, Animal; Hippocampus; Male; Mice | 2016 |
Nicotinamide treatment induces behavioral recovery when administered up to 4 hours following cortical contusion injury in the rat.
Topics: Animals; Behavior, Animal; Brain; Brain Injuries; Memory; Niacinamide; Rats; Rats, Sprague-Dawley; T | 2008 |
The effects of hypertonic saline and nicotinamide on sensorimotor and cognitive function following cortical contusion injury in the rat.
Topics: Animals; Behavior, Animal; Brain; Brain Injuries; Central Nervous System Agents; Cognition; Locomoti | 2009 |
Preclinical efficacy testing in middle-aged rats: nicotinamide, a novel neuroprotectant, demonstrates diminished preclinical efficacy after controlled cortical impact.
Topics: Age Factors; Analysis of Variance; Animals; Astrocytes; Blood-Brain Barrier; Brain Edema; Brain Inju | 2011 |
Continuous nicotinamide administration improves behavioral recovery and reduces lesion size following bilateral frontal controlled cortical impact injury.
Topics: Animals; Behavior, Animal; Brain Injuries; Cognition; Data Interpretation, Statistical; Frontal Lobe | 2011 |
Nicotinamide prevents the down-regulation of MEK/ERK/p90RSK signaling cascade in brain ischemic injury.
Topics: Animals; Brain Injuries; Brain Ischemia; Cerebral Infarction; Down-Regulation; Extracellular Signal- | 2012 |
A comparison of the effects of nicotinamide and progesterone on functional recovery of cognitive behavior following cortical contusion injury in the rat.
Topics: Analysis of Variance; Animals; Behavior, Animal; Brain; Brain Injuries; Cognition; Hippocampus; Infu | 2012 |
[Using cytoflavin for prophylaxis and treatment of cognitive amnestic disorders in patients with heavy toxicohypoxic damage of brain].
Topics: Adult; Brain Injuries; Cognition Disorders; Drug Combinations; Female; Flavin Mononucleotide; Humans | 2012 |
Treatment with vitamin B3 improves functional recovery and reduces GFAP expression following traumatic brain injury in rats.
Topics: Animals; Astrocytes; Brain Injuries; Cognition; Disease Models, Animal; Glial Fibrillary Acidic Prot | 2003 |
Nicotinamide reduces acute cortical neuronal death and edema in the traumatically injured brain.
Topics: Animals; Brain Injuries; Cerebral Cortex; Edema; Male; Neuroprotective Agents; Niacinamide; Rats; Ra | 2006 |
Nicotinamide treatment reduces behavioral impairments and provides cortical protection after fluid percussion injury in the rat.
Topics: Animals; Brain Injuries; Cognition; Disease Models, Animal; Dose-Response Relationship, Drug; Mental | 2006 |
The effects of nicotinamide on apoptosis and blood-brain barrier breakdown following traumatic brain injury.
Topics: Analysis of Variance; Animals; Apoptosis; Blood-Brain Barrier; Brain Injuries; Disease Models, Anima | 2006 |
Nicotinamide treatment provides acute neuroprotection and GFAP regulation following fluid percussion injury.
Topics: Animals; Astrocytes; Behavior, Animal; Brain Chemistry; Brain Injuries; Cell Count; Cerebral Cortex; | 2008 |
A high-field magnetic resonance imaging study of experimental vasogenic brain edema and its response to AVS: 1,2-bis (nicotinamido)-propane.
Topics: Animals; Antioxidants; Blood-Brain Barrier; Brain Edema; Brain Injuries; Cerebral Cortex; Corpus Cal | 1994 |
Cellular expression of inducible nitric oxide synthase following rat cortical incision and its suppression by hydroxyl radical scavenger, 1,2-bis(nicotinamido)propane.
Topics: Animals; Antibodies; Brain Injuries; Cerebral Cortex; Free Radical Scavengers; Hydroxyl Radical; Mac | 1998 |
Chroman amide and nicotinyl amide derivatives: inhibition of lipid peroxidation and protection against head trauma.
Topics: Animals; Brain Injuries; Chromans; Craniocerebral Trauma; Disease Models, Animal; Dopamine; Electron | 2000 |