niacinamide has been researched along with Brain Edema in 20 studies
nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.
Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Brain edema was produced by 6-aminonicotinamide (6-AN) in the rat with accompanying metabolic disturbance due to the accumulation of an antimetabolite of nicotinamide in the CNS." | 7.66 | Brain edema and gliopathy induced by 6-aminonicotinamide intoxication in the central nervous system of rats. ( Sasaki, S, 1982) |
| "Brain edema was produced by 6-aminonicotinamide (6-AN) in the rat with accompanying metabolic disturbance due to the accumulation of an antimetabolite of nicotinamide in the CNS." | 3.66 | Brain edema and gliopathy induced by 6-aminonicotinamide intoxication in the central nervous system of rats. ( Sasaki, S, 1982) |
| "Ischemic stroke is one of the leading causes of human death and disability." | 1.72 | Acutely Inhibiting AQP4 With TGN-020 Improves Functional Outcome by Attenuating Edema and Peri-Infarct Astrogliosis After Cerebral Ischemia. ( Hao, X; Li, C; Lin, L; Ren, Y; Sun, C; Tian, J; Yang, Y; Yin, L; Zhang, X, 2022) |
| "High altitude cerebral edema (HACE) is a fulminant, deadly, and yet still unpredictable brain disease." | 1.43 | Preventing High Altitude Cerebral Edema in Rats with Repurposed Anti-Angiogenesis Pharmacotherapy. ( Irwin, DC; Loomis, Z; Maltzahn, J; Tarshis, S, 2016) |
| "Patients with renal cell and breast carcinoma metastases to the brain were identified from the prospective database at the Penn State Hershey Medical Center and Penn State Cancer Institute." | 1.35 | Brain magnetic resonance imaging changes after sorafenib and sunitinib chemotherapy in patients with advanced renal cell and breast carcinoma. ( Hill, KL; Lipson, AC; Sheehan, JM, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (45.00) | 18.7374 |
| 1990's | 3 (15.00) | 18.2507 |
| 2000's | 2 (10.00) | 29.6817 |
| 2010's | 5 (25.00) | 24.3611 |
| 2020's | 1 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sun, C | 1 |
| Lin, L | 1 |
| Yin, L | 1 |
| Hao, X | 1 |
| Tian, J | 1 |
| Zhang, X | 1 |
| Ren, Y | 1 |
| Li, C | 1 |
| Yang, Y | 1 |
| Tarshis, S | 1 |
| Maltzahn, J | 1 |
| Loomis, Z | 1 |
| Irwin, DC | 1 |
| Zhang, J | 1 |
| Xu, X | 1 |
| Zhou, D | 1 |
| Li, H | 1 |
| You, W | 1 |
| Wang, Z | 1 |
| Chen, G | 1 |
| Leitão, RA | 1 |
| Sereno, J | 1 |
| Castelhano, JM | 1 |
| Gonçalves, SI | 1 |
| Coelho-Santos, V | 1 |
| Fontes-Ribeiro, C | 1 |
| Castelo-Branco, M | 1 |
| Silva, AP | 1 |
| Hill, KL | 1 |
| Lipson, AC | 1 |
| Sheehan, JM | 1 |
| Igarashi, H | 1 |
| Huber, VJ | 1 |
| Tsujita, M | 1 |
| Nakada, T | 1 |
| Swan, AA | 1 |
| Chandrashekar, R | 1 |
| Beare, J | 1 |
| Hoane, MR | 1 |
| Leker, RR | 1 |
| Asano, T | 3 |
| Johshita, H | 2 |
| Koide, T | 3 |
| Takakura, K | 3 |
| Sasaki, S | 1 |
| Yoshimura, N | 1 |
| Okada, M | 1 |
| Ota, T | 1 |
| Nohara, H | 1 |
| Kamada, K | 2 |
| Houkin, K | 1 |
| Iwasaki, Y | 1 |
| Abe, H | 1 |
| Raedler, A | 1 |
| Sievers, J | 1 |
| Matsushita, H | 1 |
| Gotoh, O | 1 |
| Usui, M | 1 |
| Shigeno, T | 1 |
| Baethmann, A | 3 |
| Reulen, HJ | 2 |
| Brendel, W | 2 |
| Van Harreveld, A | 1 |
| Meyer-König, E | 1 |
1 review available for niacinamide and Brain Edema
| Article | Year |
|---|---|
Nicaraven Chugai.
Topics: Animals; Antioxidants; Brain Edema; Brain Ischemia; Cerebral Hemorrhage; Clinical Trials, Phase I as | 2003 |
19 other studies available for niacinamide and Brain Edema
| Article | Year |
|---|---|
Acutely Inhibiting AQP4 With TGN-020 Improves Functional Outcome by Attenuating Edema and Peri-Infarct Astrogliosis After Cerebral Ischemia.
Topics: Animals; Aquaporin 4; Brain Edema; Brain Ischemia; Gliosis; Infarction, Middle Cerebral Artery; Magn | 2022 |
Preventing High Altitude Cerebral Edema in Rats with Repurposed Anti-Angiogenesis Pharmacotherapy.
Topics: Acetazolamide; Altitude; Altitude Sickness; Angiogenesis Inducing Agents; Angiogenesis Inhibitors; A | 2016 |
Possible Role of Raf-1 Kinase in the Development of Cerebral Vasospasm and Early Brain Injury After Experimental Subarachnoid Hemorrhage in Rats.
Topics: Animals; Basilar Artery; Blood-Brain Barrier; Brain Damage, Chronic; Brain Edema; Cyclooxygenase 2; | 2015 |
Aquaporin-4 as a New Target against Methamphetamine-Induced Brain Alterations: Focus on the Neurogliovascular Unit and Motivational Behavior.
Topics: Animals; Aquaporin 4; Blood-Brain Barrier; Brain; Brain Edema; Locomotion; Male; Methamphetamine; Mi | 2018 |
Brain magnetic resonance imaging changes after sorafenib and sunitinib chemotherapy in patients with advanced renal cell and breast carcinoma.
Topics: Aged; Antineoplastic Agents; Benzenesulfonates; Brain; Brain Edema; Brain Neoplasms; Breast Neoplasm | 2009 |
Pretreatment with a novel aquaporin 4 inhibitor, TGN-020, significantly reduces ischemic cerebral edema.
Topics: Analysis of Variance; Animals; Aquaporin 4; Brain Edema; Brain Ischemia; Cerebrovascular Circulation | 2011 |
Preclinical efficacy testing in middle-aged rats: nicotinamide, a novel neuroprotectant, demonstrates diminished preclinical efficacy after controlled cortical impact.
Topics: Age Factors; Analysis of Variance; Animals; Astrocytes; Blood-Brain Barrier; Brain Edema; Brain Inju | 2011 |
Amelioration of ischaemic cerebral oedema by a free radical scavenger, AVS: 1,2-bis(nicotinamido)-propane. An experimental study using a regional ischaemia model in cats.
Topics: Animals; Brain Edema; Brain Ischemia; Cats; Cerebral Cortex; Disease Models, Animal; Energy Metaboli | 1984 |
Brain edema and gliopathy induced by 6-aminonicotinamide intoxication in the central nervous system of rats.
Topics: 6-Aminonicotinamide; Animals; Astrocytes; Blood-Brain Barrier; Brain Edema; Male; Neuroglia; Niacina | 1982 |
Pharmacologic intervention for ischemic brain edema after retrograde cerebral perfusion.
Topics: Animals; Aorta, Thoracic; Aortic Aneurysm, Thoracic; Brain; Brain Edema; Brain Ischemia; Cardiopulmo | 1995 |
A high-field magnetic resonance imaging study of experimental vasogenic brain edema and its response to AVS: 1,2-bis (nicotinamido)-propane.
Topics: Animals; Antioxidants; Blood-Brain Barrier; Brain Edema; Brain Injuries; Cerebral Cortex; Corpus Cal | 1994 |
[Sequential observations of brain edema with proton magnetic resonance imaging and spectroscopy].
Topics: Aged; Animals; Brain Edema; Female; Free Radical Scavengers; Glutamine; Humans; Lactates; Magnetic R | 1996 |
Influences of experimental brain edema on the development of the visual system.
Topics: Age Factors; Animals; Animals, Newborn; Antimetabolites; Brain Edema; Brain Stem; Cell Differentiati | 1975 |
Enhancement of ATPase activity by a lipid peroxide of arachidonic acid in rat brain microvessels.
Topics: Adenosine Triphosphatases; Animals; Arachidonic Acids; Brain; Brain Edema; Ca(2+) Mg(2+)-ATPase; Dos | 1986 |
[The pathomechanism underlying ischemic brain edema: the role of Na+, K+-ATPase of the brain microvessels].
Topics: Animals; Brain Chemistry; Brain Edema; Brain Ischemia; Cats; Cerebrovascular Circulation; Disease Mo | 1985 |
[The effect of the Antimetabolite 6-aminonicotinamide (6-ANA) on the water- and electrolyte content in the brain of rats and its inhibition by niacin].
Topics: Animals; Biological Transport, Active; Brain; Brain Edema; Myocardium; Niacinamide; Nicotinic Acids; | 1968 |
Water and electrolyte distribution in gray matter rendered edematous with a metabolic inhibitor.
Topics: Animals; Antimetabolites; Brain Edema; Cerebellum; Cerebral Cortex; Craniotomy; Disease Models, Anim | 1973 |
[Ultrastructure of glial and axonal changes in the optic nerve of the rat induced by 6-aminonicotinamide (author's transl)].
Topics: Animals; Axons; Brain Edema; Endoplasmic Reticulum; Microscopy, Electron; Nerve Degeneration; Neurog | 1973 |
[Experimental brain edema caused by 6-aminonicotinamide--an antimetabolite of nicotinic acid].
Topics: Animals; Antimetabolites; Brain; Brain Edema; Myocardium; NAD; NADP; Niacinamide; Nicotinic Acids; P | 1968 |