Page last updated: 2024-10-19

niacinamide and Autoimmune Disease

niacinamide has been researched along with Autoimmune Disease in 12 studies

nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.

Research Excerpts

ExcerptRelevanceReference
"A case of bullous pemphigoid responding to niacinamide as monotherapy is reported."3.70Autoimmune bullous eruption localized to a breast reconstruction site: response to niacinamide. ( Elston, DM; Honl, BA, 1998)
"A combination of niacinamide and tetracycline was used to treat 31 dogs with various autoimmune skin diseases (discoid lupus erythematosus, pemphigus foliaceus, pemphigus erythematosus, and bullous pemphigoid)."3.68Use of tetracycline and niacinamide for treatment of autoimmune skin disease in 31 dogs. ( Paradis, M; Reinke, SI; Rosychuk, RA; White, SD, 1992)
"Nicotinamide prevents autoimmune diabetes in animal models, possibly through inhibition of the DNA repair enzyme poly-ADP-ribose polymerase and prevention of beta-cell NAD depletion."2.71European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes. ( Bingley, PJ; Collier, T; Emmett, CL; Gale, EA, 2004)

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19903 (25.00)18.7374
1990's3 (25.00)18.2507
2000's4 (33.33)29.6817
2010's2 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chen, AC1
Damian, DL1
Simmons, K1
Michels, AW1
Gale, EA1
Bingley, PJ1
Emmett, CL1
Collier, T1
Penberthy, WT1
Honl, BA1
Elston, DM1
Palmer, JP1
Cutshall, NS1
Ursino, R1
Kucera, KA1
Latham, J1
Ihle, NC1
White, SD1
Rosychuk, RA1
Reinke, SI1
Paradis, M1
Oranje, AP1
Vuzevski, VD1
van Joost, T1
ten Kate, F1
Naafs, B1
Herskowitz, RD1
Jackson, RA1
Soeldner, JS1
Eisenbarth, GS1
Hermitte, L1
Vialettes, B1
Atlef, N1
Payan, MJ1
Doll, N1
Scheimann, A1
Vague, P1
Tochino, Y1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
TrialNet Pathway to Prevention of T1D[NCT00097292]75,000 participants (Anticipated)Observational2004-02-29Recruiting
Comparison of Nicotinamide and Sevelamer Hydrochloride on Phosphatemia Control on Chronic Hemodialysed Patients[NCT01011699]Phase 3176 participants (Actual)Interventional2010-01-31Terminated (stopped due to Financial problem)
Randomized Double-blinded Comparative Trial to Study the Add-on Activity of Combination Treatment of Nicotinamide on Progression Free Survival for EGFR Mutated Lung Cancer Terminal Stage Patients Being Treated With Gefitinib or Erlotinib[NCT02416739]Phase 2/Phase 3110 participants (Actual)Interventional2015-03-31Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for niacinamide and Autoimmune Disease

ArticleYear
Nicotinamide and the skin.
    The Australasian journal of dermatology, 2014, Volume: 55, Issue:3

    Topics: Acne Vulgaris; Animals; Autoimmune Diseases; Carcinogenesis; Dermatitis, Atopic; Humans; Keratosis,

2014
Lessons from type 1 diabetes for understanding natural history and prevention of autoimmune disease.
    Rheumatic diseases clinics of North America, 2014, Volume: 40, Issue:4

    Topics: Abatacept; Antibodies, Monoclonal, Humanized; Autoantibodies; Autoimmune Diseases; Diabetes Mellitus

2014
Pharmacological targeting of IDO-mediated tolerance for treating autoimmune disease.
    Current drug metabolism, 2007, Volume: 8, Issue:3

    Topics: Animals; Autoimmune Diseases; Humans; Immune Tolerance; Indoleamine-Pyrrole 2,3,-Dioxygenase; NAD; N

2007
The NOD mouse as a model of type I diabetes.
    Critical reviews in immunology, 1987, Volume: 8, Issue:1

    Topics: Animals; Autoimmune Diseases; Diabetes Mellitus, Experimental; Female; Gonadal Steroid Hormones; Imm

1987

Trials

1 trial available for niacinamide and Autoimmune Disease

ArticleYear
European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes.
    Lancet (London, England), 2004, Mar-20, Volume: 363, Issue:9413

    Topics: Autoimmune Diseases; Diabetes Mellitus, Type 1; Disease Models, Animal; Double-Blind Method; Europe;

2004
European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes.
    Lancet (London, England), 2004, Mar-20, Volume: 363, Issue:9413

    Topics: Autoimmune Diseases; Diabetes Mellitus, Type 1; Disease Models, Animal; Double-Blind Method; Europe;

2004
European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes.
    Lancet (London, England), 2004, Mar-20, Volume: 363, Issue:9413

    Topics: Autoimmune Diseases; Diabetes Mellitus, Type 1; Disease Models, Animal; Double-Blind Method; Europe;

2004
European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes.
    Lancet (London, England), 2004, Mar-20, Volume: 363, Issue:9413

    Topics: Autoimmune Diseases; Diabetes Mellitus, Type 1; Disease Models, Animal; Double-Blind Method; Europe;

2004
European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes.
    Lancet (London, England), 2004, Mar-20, Volume: 363, Issue:9413

    Topics: Autoimmune Diseases; Diabetes Mellitus, Type 1; Disease Models, Animal; Double-Blind Method; Europe;

2004
European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes.
    Lancet (London, England), 2004, Mar-20, Volume: 363, Issue:9413

    Topics: Autoimmune Diseases; Diabetes Mellitus, Type 1; Disease Models, Animal; Double-Blind Method; Europe;

2004
European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes.
    Lancet (London, England), 2004, Mar-20, Volume: 363, Issue:9413

    Topics: Autoimmune Diseases; Diabetes Mellitus, Type 1; Disease Models, Animal; Double-Blind Method; Europe;

2004
European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes.
    Lancet (London, England), 2004, Mar-20, Volume: 363, Issue:9413

    Topics: Autoimmune Diseases; Diabetes Mellitus, Type 1; Disease Models, Animal; Double-Blind Method; Europe;

2004
European Nicotinamide Diabetes Intervention Trial (ENDIT): a randomised controlled trial of intervention before the onset of type 1 diabetes.
    Lancet (London, England), 2004, Mar-20, Volume: 363, Issue:9413

    Topics: Autoimmune Diseases; Diabetes Mellitus, Type 1; Disease Models, Animal; Double-Blind Method; Europe;

2004

Other Studies

7 other studies available for niacinamide and Autoimmune Disease

ArticleYear
Autoimmune bullous eruption localized to a breast reconstruction site: response to niacinamide.
    Cutis, 1998, Volume: 62, Issue:2

    Topics: Autoimmune Diseases; Breast Diseases; Dermatologic Agents; Diagnosis, Differential; Female; Humans;

1998
Immunomodulatory therapy of human type 1 diabetes: lessons from the mouse.
    The Journal of clinical investigation, 2001, Volume: 108, Issue:1

    Topics: Adoptive Transfer; Adult; Animals; Autoantibodies; Autoimmune Diseases; Cell Transplantation; Clinic

2001
Nicotinamide N-oxides as CXCR2 antagonists.
    Bioorganic & medicinal chemistry letters, 2001, Jul-23, Volume: 11, Issue:14

    Topics: Autoimmune Diseases; Binding Sites; Chemokine CXCL1; Chemokines, CXC; Chemotactic Factors; Chemotaxi

2001
Use of tetracycline and niacinamide for treatment of autoimmune skin disease in 31 dogs.
    Journal of the American Veterinary Medical Association, 1992, May-15, Volume: 200, Issue:10

    Topics: Animals; Autoimmune Diseases; Dog Diseases; Dogs; Drug Combinations; Female; Lupus Erythematosus, Di

1992
Bullous pemphigoid in children. Report of three cases with special emphasis on therapy.
    International journal of dermatology, 1991, Volume: 30, Issue:5

    Topics: Adolescent; Autoimmune Diseases; Child; Drug Therapy, Combination; Erythromycin; Humans; Male; Niaci

1991
Pilot trial to prevent type I diabetes: progression to overt IDDM despite oral nicotinamide.
    Journal of autoimmunity, 1989, Volume: 2, Issue:5

    Topics: Administration, Oral; Autoantibodies; Autoimmune Diseases; Diabetes Mellitus, Type 1; Drug Evaluatio

1989
High dose nicotinamide fails to prevent diabetes in BB rats.
    Autoimmunity, 1989, Volume: 5, Issue:1-2

    Topics: Age Factors; Animals; Autoimmune Diseases; Blood Glucose; Cyclosporine; Deferoxamine; Diabetes Melli

1989