Page last updated: 2024-10-19

niacinamide and Anoxemia

niacinamide has been researched along with Anoxemia in 58 studies

nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.

Research Excerpts

ExcerptRelevanceReference
"Results of an analysis of the efficiency of using cytoflavin, a drug possessing cytoprotective and antihypoxemic properties, in a group of 215 patients with a diagnosis of acute carbon monoxide poisoning in 2004-2010 are compared to analogous data for 215 patients with same diagnosis treated in 1999-2004 without cytoflavin administration."9.15[Experience of cytoflavin administration for treating acute carbon monoxide poisoning]. ( Afanas'ev, VV; Petrova, AG; Provado, IP; Zobnin, IuV, 2011)
" Sorafenib is a small-molecule multikinase inhibitor used in radioactive iodine ((131)I)-refractive papillary thyroid carcinoma."7.80Response to sorafenib in a pediatric patient with papillary thyroid carcinoma with diffuse nodular pulmonary disease requiring mechanical ventilation. ( Ewig, JM; Iyer, P; Mayer, JL, 2014)
"A multi-kinase inhibitor, sorafenib, was recently approved and is currently recommended for the treatment of advanced hepatocellular carcinoma (HCC)."7.79Sorafenib and TRAIL have synergistic effect on hepatocellular carcinoma. ( Inagaki, Y; Ito, M; Kasai, C; Kusagawa, S; Nobori, T; Nojiri, K; Ogura, S; Shiraki, K; Sugimoto, K; Takei, Y; Tameda, M; Yamamoto, N; Yoneda, M, 2013)
"Hypoxia induced by sustained sorafenib treatment confers sorafenib resistance to HCC through HIF-1α and NF-κB activation."7.79Hypoxia-mediated sorafenib resistance can be overcome by EF24 through Von Hippel-Lindau tumor suppressor-dependent HIF-1α inhibition in hepatocellular carcinoma. ( Fang, X; Jiang, H; Liang, Y; Liu, H; Liu, J; Liu, L; Meng, X; Song, R; Tian, L; Wang, J; Wang, L; Yin, D; Zheng, T, 2013)
" Sorafenib has considerable anti-angiogenic effects that lead to tumor starvation and induce tumor hypoxia in the highly vascularized renal cell carcinoma (RCC) xenografts."7.78Evaluation of changes in the tumor microenvironment after sorafenib therapy by sequential histology and 18F-fluoromisonidazole hypoxia imaging in renal cell carcinoma. ( Chowdhury, NF; Kuge, Y; Murakami, M; Nishijima, K; Takiguchi, M; Tamaki, N; Yu, W; Zhao, S; Zhao, Y, 2012)
"Sorafenib was administered orally to mice bearing subcutaneous (SC, ectopic) or sub-renal capsule (SRC, orthotopic) tumors of murine (Renca) or human (786-O) RCC."5.34Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models. ( Adnane, J; Bortolon, E; Carter, CA; Chang, YS; Chen, C; Henderson, A; Ichetovkin, M; Levy, J; Lynch, M; McNabola, A; Taylor, IC; Trail, PA; Wilhelm, S; Wilkie, D; Xue, D, 2007)
"Results of an analysis of the efficiency of using cytoflavin, a drug possessing cytoprotective and antihypoxemic properties, in a group of 215 patients with a diagnosis of acute carbon monoxide poisoning in 2004-2010 are compared to analogous data for 215 patients with same diagnosis treated in 1999-2004 without cytoflavin administration."5.15[Experience of cytoflavin administration for treating acute carbon monoxide poisoning]. ( Afanas'ev, VV; Petrova, AG; Provado, IP; Zobnin, IuV, 2011)
""ARCON" combines accelerated radiotherapy to counteract tumor repopulation with carbogen breathing and nicotinamide to reduce chronic and acute hypoxia."5.10ARCON: experience in 215 patients with advanced head-and-neck cancer. ( Bruaset, I; Kaanders, JH; Marres, HA; Merkx, MA; Pop, LA; van den Hoogen, FJ; van der Kogel, AJ, 2002)
" Sorafenib, the mainstay of treatment of HCC patients, however, leads to tumour hypoxia and thereby abrogates the efficacy of anti-PD-1 treatment."3.85CXCL12 expression and PD-L1 expression serve as prognostic biomarkers in HCC and are induced by hypoxia. ( Bergheim, D; Branchi, V; Dietrich, D; Dietrich, J; Fischer, HP; Goltz, D; Kalff, JC; Kristiansen, G; Matthaei, H; Semaan, A, 2017)
"This study was aimed at determining the influence of cytoflavin on the morphological features of contractile cardiomyocytes in female rats after gestation and in newborn rats exposed to hemic hypoxia induced by sodium nitrite (NaNO(2))."3.83[MORPHOLOGICAL CHANGES IN RAT MYOCARDIUM EXPOSED TO HEMIC HYPOXIA AND TREATED WITH CYTOFLAVIN.] ( Sataeva, TP; Tret'yakova, OS; Zadnipryanyi, IV, 2016)
" Sorafenib is a small-molecule multikinase inhibitor used in radioactive iodine ((131)I)-refractive papillary thyroid carcinoma."3.80Response to sorafenib in a pediatric patient with papillary thyroid carcinoma with diffuse nodular pulmonary disease requiring mechanical ventilation. ( Ewig, JM; Iyer, P; Mayer, JL, 2014)
"A multi-kinase inhibitor, sorafenib, was recently approved and is currently recommended for the treatment of advanced hepatocellular carcinoma (HCC)."3.79Sorafenib and TRAIL have synergistic effect on hepatocellular carcinoma. ( Inagaki, Y; Ito, M; Kasai, C; Kusagawa, S; Nobori, T; Nojiri, K; Ogura, S; Shiraki, K; Sugimoto, K; Takei, Y; Tameda, M; Yamamoto, N; Yoneda, M, 2013)
"Hypoxia induced by sustained sorafenib treatment confers sorafenib resistance to HCC through HIF-1α and NF-κB activation."3.79Hypoxia-mediated sorafenib resistance can be overcome by EF24 through Von Hippel-Lindau tumor suppressor-dependent HIF-1α inhibition in hepatocellular carcinoma. ( Fang, X; Jiang, H; Liang, Y; Liu, H; Liu, J; Liu, L; Meng, X; Song, R; Tian, L; Wang, J; Wang, L; Yin, D; Zheng, T, 2013)
" Sorafenib has considerable anti-angiogenic effects that lead to tumor starvation and induce tumor hypoxia in the highly vascularized renal cell carcinoma (RCC) xenografts."3.78Evaluation of changes in the tumor microenvironment after sorafenib therapy by sequential histology and 18F-fluoromisonidazole hypoxia imaging in renal cell carcinoma. ( Chowdhury, NF; Kuge, Y; Murakami, M; Nishijima, K; Takiguchi, M; Tamaki, N; Yu, W; Zhao, S; Zhao, Y, 2012)
" Population spike amplitude (PSAP) and NADH were measured during hypoxic hypoxia (15 min) and recovery (45 min)."3.72Graded reoxygenation with chemical inhibition of oxidative phosphorylation improves posthypoxic recovery in murine hippocampal slices. ( Büchner, M; Huber, R; Riepe, MW; Spiegel, T, 2004)
" nicotinamide, isonicotinamide or nicotinic acid, as extra (axial) ligands, were tested in vivo on transplanted mice tumors, namely Lewis lung carcinoma (3LL), melanoma B16, and mammary adenocarcinoma Ca755."3.72Selectivity of effects of redox-active cobalt(III) complexes on tumor tissue. ( Bubnovskaya, L; Campanella, L; Ganusevich, I; Kovelskaya, A; Levitin, I; Osinsky, S; Sigan, A; Valkovskaya, N; Wardman, P, 2004)
"In both laryngeal squamous cell carcinoma xenograft tumour lines carbogen was very effective in reducing diffusion limited hypoxia."3.70Vascular architecture and microenvironmental parameters in human squamous cell carcinoma xenografts: effects of carbogen and nicotinamide. ( Bussink, J; Hodgkiss, RJ; Kaanders, JH; Marres, HA; Peters, JP; Rijken, PF; van der Kogel, AJ, 1999)
" The aims of this study were to compare in the rat isolated perfused lung preparation, the dilator actions of nicorandil, pinacidil and nitroglycerin on the hypoxic pulmonary pressure response with or without hypercapnic acidosis and to investigate the possible involvement of K channels and EDRF in these effects."3.69Comparison of the effects of nicorandil, pinacidil and nitroglycerin on hypoxic and hypercapnic pulmonary vasoconstriction in the isolated perfused lung of rat. ( Advenier, C; Dumas, JP; Dumas, M; Giudicelli, JF; Rochette, L, 1996)
"The myocardial protective effect of nicorandil, N-(2-hydroxyethyl) nicotinamide nitrate ester, against hypoxia was examined in comparison with that of nitroglycerin in 22 open chest dogs."3.67Examination of the direct effects of antianginal agents on the hypoxic canine myocardium. ( Hattori, S; Kojima, S; Miyamori, R; Miyazaki, T; Mori, H; Nagata, M; Nakamura, Y; Takahashi, M, 1987)
"Of 345 patients with cT2-4 laryngeal cancer, 174 were randomly assigned to accelerated radiotherapy and 171 to ARCON."2.79Improved recurrence-free survival with ARCON for anemic patients with laryngeal cancer. ( Bijl, HP; Bussink, J; Chin, A; de Bree, R; Doornaert, PA; Hoogsteen, IJ; Janssens, GO; Kaanders, JH; Rademakers, SE; Span, PN; Takes, RP; Terhaard, CH; van den Ende, P, 2014)
"Strategies to correct hypoxemia have the potential to improve clinical outcomes in ARDS."1.48GBT1118, a compound that increases the oxygen affinity of hemoglobin, improves survival in murine hypoxic acute lung injury. ( Bastarache, JA; Dufu, K; Hutchaleelaha, A; Lehrer-Graiwer, J; Li, CM; Majka, SM; Putz, ND; Shaver, CM; Ware, LB; Xu, Q, 2018)
" GBT1118 is a novel orally bioavailable small molecule that binds to hemoglobin and produces a concentration-dependent left shift of the oxygen-hemoglobin dissociation curve with subsequent increase in hemoglobin-oxygen affinity and arterial oxygen loading."1.43Increased hemoglobin-oxygen affinity ameliorates bleomycin-induced hypoxemia and pulmonary fibrosis. ( Dufu, K; Geng, X; Hutchaleelaha, A; Lehrer-Graiwer, J; Li, CM; Li, Z; Oksenberg, D; Patel, MP; Vlahakis, N; Xu, Q, 2016)
"Sorafenib was administered orally to mice bearing subcutaneous (SC, ectopic) or sub-renal capsule (SRC, orthotopic) tumors of murine (Renca) or human (786-O) RCC."1.34Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models. ( Adnane, J; Bortolon, E; Carter, CA; Chang, YS; Chen, C; Henderson, A; Ichetovkin, M; Levy, J; Lynch, M; McNabola, A; Taylor, IC; Trail, PA; Wilhelm, S; Wilkie, D; Xue, D, 2007)

Research

Studies (58)

TimeframeStudies, this research(%)All Research%
pre-199011 (18.97)18.7374
1990's9 (15.52)18.2507
2000's7 (12.07)29.6817
2010's28 (48.28)24.3611
2020's3 (5.17)2.80

Authors

AuthorsStudies
Curran, CS1
Dougherty, EJ1
Cui, X1
Li, Y1
Jeakle, M1
Gamble, T1
Demirkale, CY1
Torabi-Parizi, P1
Liu, M1
Zhou, P1
Li, J1
Jiang, Y1
Dufu, K3
Williams, AT1
Muller, CR1
Walser, CM1
Lucas, A1
Eaker, AM1
Alt, C1
Cathers, BE1
Oksenberg, D2
Cabrales, P1
Yang, L1
Taylor, J1
Eustace, A1
Irlam, JJ1
Denley, H1
Hoskin, PJ1
Alsner, J1
Buffa, FM1
Harris, AL1
Choudhury, A1
West, CML1
Putz, ND1
Shaver, CM1
Li, CM2
Xu, Q2
Hutchaleelaha, A2
Lehrer-Graiwer, J2
Majka, SM1
Ware, LB1
Bastarache, JA1
Zabielska, MA1
Adamus, J1
Kowalski, R1
Gebicki, J1
Slominska, EM1
Khalpey, Z1
Smolenski, RT1
Skrypko, V1
Pasko, A1
Churpiy, I1
Kovalenko, A1
Zaplutanov, V1
Zadnipryanyi, IV1
Tret'yakova, OS1
Sataeva, TP1
Iyer, P1
Mayer, JL1
Ewig, JM1
Zhang, K1
Waxman, DJ1
Zinov'ev, EV1
Nesterov, IuV1
Lagvilava, TO1
Janssens, GO1
Rademakers, SE1
Terhaard, CH1
Doornaert, PA1
Bijl, HP1
van den Ende, P1
Chin, A1
Takes, RP1
de Bree, R1
Hoogsteen, IJ1
Bussink, J2
Span, PN1
Kaanders, JH4
Zhao, CX1
Luo, CL1
Wu, XH1
Xu, H1
Zhao, L1
Fang, Q1
Sun, J1
Zhang, S1
Zhan, C1
Liu, S1
Zhang, Y1
Mouraret, N1
Houssaïni, A1
Abid, S1
Quarck, R1
Marcos, E1
Parpaleix, A1
Gary-Bobo, G1
Dubois-Randé, JL1
Derumeaux, G1
Boczkowski, J1
Delcroix, M1
Blasco, MA1
Lipskaia, L1
Amsellem, V1
Adnot, S1
Jones, HD1
Yoo, J1
Crother, TR1
Kyme, P1
Ben-Shlomo, A1
Khalafi, R1
Tseng, CW1
Parks, WC1
Arditi, M1
Liu, GY1
Shimada, K1
Wang, H1
Liang, X1
Luo, G1
Ding, M1
Liang, Q1
Geng, X1
Li, Z1
Patel, MP1
Vlahakis, N1
Semaan, A1
Dietrich, D1
Bergheim, D1
Dietrich, J1
Kalff, JC1
Branchi, V1
Matthaei, H1
Kristiansen, G1
Fischer, HP1
Goltz, D1
Vasilyev, KY1
Khazanov, VA1
Fatullaeva, KF1
Nurov, AU1
Saltanov, AI1
Livanov, GA1
Amagyrov, VP1
Batotsyrenov, BV3
Lodiagin, AN1
Batotsyrenova, KhV1
Liu, J3
Wu, JQ2
Yang, JJ2
Wei, JY2
Gao, WN2
Guo, CJ2
Raskopf, E1
Vogt, A1
Decker, G1
Hirt, S1
Daskalow, K1
Cramer, T1
Standop, J1
Gonzalez-Carmona, MA1
Sauerbruch, T1
Schmitz, V1
Bi, J1
Li, H1
Ye, SQ1
Ding, S1
Zobnin, IuV1
Petrova, AG1
Provado, IP1
Afanas'ev, VV1
Murakami, M1
Zhao, S1
Zhao, Y1
Chowdhury, NF1
Yu, W1
Nishijima, K1
Takiguchi, M1
Tamaki, N1
Kuge, Y1
Shilov, VV2
Vasil'ev, SA1
Kuznetsov, OA1
Loladze, AT2
Nojiri, K1
Sugimoto, K1
Shiraki, K1
Tameda, M1
Inagaki, Y1
Ogura, S1
Kasai, C1
Kusagawa, S1
Yoneda, M1
Yamamoto, N1
Takei, Y1
Nobori, T1
Ito, M1
Andriaov, AY1
Liang, Y1
Zheng, T1
Song, R1
Wang, J1
Yin, D1
Wang, L1
Liu, H1
Tian, L1
Fang, X1
Meng, X1
Jiang, H1
Liu, L1
INGALLS, TH1
INGENITO, EF1
CURLEY, FJ1
Huber, R1
Spiegel, T1
Büchner, M1
Riepe, MW1
Osinsky, S1
Levitin, I1
Bubnovskaya, L1
Sigan, A1
Ganusevich, I1
Kovelskaya, A1
Valkovskaya, N1
Campanella, L1
Wardman, P1
Jonathan, RA1
Wijffels, KI1
Peeters, W1
de Wilde, PC1
Marres, HA3
Merkx, MA2
Oosterwijk, E1
van der Kogel, AJ3
Chang, YS1
Adnane, J1
Trail, PA1
Levy, J1
Henderson, A1
Xue, D1
Bortolon, E1
Ichetovkin, M1
Chen, C1
McNabola, A1
Wilkie, D1
Carter, CA1
Taylor, IC1
Lynch, M1
Wilhelm, S1
Akhundov, RA2
Voronina, TA2
Siess, M1
Delabar, U1
Seifart, HJ1
Thomas, CD1
Prade, M1
Guichard, M1
Dumas, M1
Dumas, JP1
Rochette, L1
Advenier, C1
Giudicelli, JF1
Takizawa, T1
Hara, Y1
Saito, T1
Masuda, Y1
Nakaya, H1
Brown, JM1
Wouters, BG1
Hartmann, KA1
Van der Kleij, AJ1
Schneider, CJ1
Sminia, P1
Rijken, PF1
Peters, JP1
Hodgkiss, RJ1
Vajragupta, O1
Toasaksiri, S1
Boonyarat, C1
Wongkrajang, Y1
Peungvicha, P1
Watanabe, H1
Boonchoong, P1
Pop, LA1
Bruaset, I1
van den Hoogen, FJ1
Horsman, MR3
Chaplin, DJ2
Trotter, MJ2
Skov, KA1
Zagorevskiĭ, VA1
Overgaard, J1
Christensen, KL1
Leitold, M1
Hader, S1
Nakamura, Y1
Kojima, S1
Mori, H1
Nagata, M1
Miyazaki, T1
Miyamori, R1
Hattori, S1
Takahashi, M1
Nurmukhambetov, AN1
Riabtseva, TA1
Magour, S1
Farah, A1
Sroka, A1
Severin, SE1
Baran, LA1
Surkov, GG1
Berlet, HH1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Multicentre, Randomised, Phase III Clinical Trial Comparing Accelerated Radiotherapy With Accelerated Radiotherapy Plus Carbogen and Nicotinamide (ARCON) in Clinical Stage T2-4 Laryngeal Carcinoma.[NCT00147732]Phase 3345 participants (Actual)Interventional2001-04-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for niacinamide and Anoxemia

ArticleYear
Nicotinamide and the hypoxia problem.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1991, Volume: 22, Issue:2

    Topics: Humans; Hypoxia; Neoplasms; Niacinamide; Radiation Injuries; Radiation Tolerance

1991

Trials

4 trials available for niacinamide and Anoxemia

ArticleYear
Improved recurrence-free survival with ARCON for anemic patients with laryngeal cancer.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2014, Mar-01, Volume: 20, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Anemia; Biomarkers; Carbon Dioxide; Female; Hemoglobins; Humans; Hyp

2014
[Experience of cytoflavin administration for treating acute carbon monoxide poisoning].
    Eksperimental'naia i klinicheskaia farmakologiia, 2011, Volume: 74, Issue:10

    Topics: Adult; Carbon Monoxide; Carbon Monoxide Poisoning; Carboxyhemoglobin; Case-Control Studies; Drug Adm

2011
[Pharmacologic correction of hypoxia in patients with acute cerebral failure due to acute poisoning with carbon monoxide and combustion products].
    Meditsina truda i promyshlennaia ekologiia, 2012, Issue:6

    Topics: Acute Disease; Adult; Blood Gas Analysis; Carbon Monoxide Poisoning; Combined Modality Therapy; Crit

2012
ARCON: experience in 215 patients with advanced head-and-neck cancer.
    International journal of radiation oncology, biology, physics, 2002, Mar-01, Volume: 52, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Carbon Dioxide; Dose Fractionation, Radiation; Feasibility Studies;

2002

Other Studies

53 other studies available for niacinamide and Anoxemia

ArticleYear
Nicotinamide Antagonizes Lipopolysaccharide-Induced Hypoxic Cell Signals in Human Macrophages.
    Journal of immunology (Baltimore, Md. : 1950), 2023, 07-15, Volume: 211, Issue:2

    Topics: Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammation; Lipopolysaccharides; Macro

2023
Nicotinamide Inhibits Glycolysis of HL-60 Cells by Modulating Sirtuin 1 (SIRT1)/Peroxisome Proliferator-Activated Receptor γ Coactivator 1α (PGC-1α)/Hypoxia-Inducible Factor-2α (HIF2α) Signaling Pathway.
    Medical science monitor : international medical journal of experimental and clinical research, 2020, May-29, Volume: 26

    Topics: Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Gene Expression Regulation; HL-60 Cells; Hu

2020
Increased hemoglobin affinity for oxygen with GBT1118 improves hypoxia tolerance in sickle cell mice.
    American journal of physiology. Heart and circulatory physiology, 2021, 08-01, Volume: 321, Issue:2

    Topics: Allosteric Regulation; Anemia, Sickle Cell; Animals; Benzaldehydes; Brain; Cerebral Cortex; Disease

2021
A Gene Signature for Selecting Benefit from Hypoxia Modification of Radiotherapy for High-Risk Bladder Cancer Patients.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2017, Aug-15, Volume: 23, Issue:16

    Topics: Aged; Carbon Dioxide; Clinical Trials, Phase III as Topic; Female; Gene Expression Profiling; Gene E

2017
GBT1118, a compound that increases the oxygen affinity of hemoglobin, improves survival in murine hypoxic acute lung injury.
    Journal of applied physiology (Bethesda, Md. : 1985), 2018, 04-01, Volume: 124, Issue:4

    Topics: Acute Lung Injury; Animals; Benzaldehydes; Disease Models, Animal; Drug Evaluation, Preclinical; Hyp

2018
Cardioprotective effect of N-methylnicotinamide salt of pyruvate in experimental model of cardiac hypoxia.
    Pharmacological reports : PR, 2018, Volume: 70, Issue:2

    Topics: Animals; Apolipoproteins E; Cardiotonic Agents; Creatine Kinase; Electrocardiography; Heart; Hypoxia

2018
SURGICAL PREVENTION AND TREATMENT OF POSTOPERATIVE HYPOPARATHYROIDISM IN PATIENTS OPERATED ON THYROID GLAND.
    Georgian medical news, 2018, Issue:276

    Topics: Antioxidants; Drug Combinations; Flavin Mononucleotide; Humans; Hypoparathyroidism; Hypoxia; Inosine

2018
[MORPHOLOGICAL CHANGES IN RAT MYOCARDIUM EXPOSED TO HEMIC HYPOXIA AND TREATED WITH CYTOFLAVIN.]
    Eksperimental'naia i klinicheskaia farmakologiia, 2016, Volume: 79, Issue:5

    Topics: Animals; Dose-Response Relationship, Drug; Drug Combinations; Female; Flavin Mononucleotide; Hypoxia

2016
Response to sorafenib in a pediatric patient with papillary thyroid carcinoma with diffuse nodular pulmonary disease requiring mechanical ventilation.
    Thyroid : official journal of the American Thyroid Association, 2014, Volume: 24, Issue:1

    Topics: Carcinoma; Carcinoma, Papillary; Child; Humans; Hypoxia; Iodine Radioisotopes; Lung Neoplasms; Male;

2014
Impact of tumor vascularity on responsiveness to antiangiogenesis in a prostate cancer stem cell-derived tumor model.
    Molecular cancer therapeutics, 2013, Volume: 12, Issue:5

    Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Axitinib; Cell Line, Tumor; Dise

2013
[Experimental evaluation of reamberin and cytoflavin effects on the course and outcome of acute burn injury].
    Eksperimental'naia i klinicheskaia farmakologiia, 2013, Volume: 76, Issue:4

    Topics: Acute Disease; Animals; Burns; Drug Combinations; Drug Evaluation, Preclinical; Female; Flavin Monon

2013
Hypoxia promotes 786-O cells invasiveness and resistance to sorafenib via HIF-2α/COX-2.
    Medical oncology (Northwood, London, England), 2015, Volume: 32, Issue:1

    Topics: Animals; Antineoplastic Agents; Basic Helix-Loop-Helix Transcription Factors; Cadherins; Cyclooxygen

2015
MiR-338-3p inhibits hepatocarcinoma cells and sensitizes these cells to sorafenib by targeting hypoxia-induced factor 1α.
    PloS one, 2014, Volume: 9, Issue:12

    Topics: Animals; Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Cell Prolif

2014
Role for telomerase in pulmonary hypertension.
    Circulation, 2015, Feb-24, Volume: 131, Issue:8

    Topics: Adult; Animals; Cell Proliferation; Cells, Cultured; Disease Models, Animal; Female; Humans; Hyperte

2015
Nicotinamide exacerbates hypoxemia in ventilator-induced lung injury independent of neutrophil infiltration.
    PloS one, 2015, Volume: 10, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Bronchoalveolar Lavage; CCAAT-Enhancer-Binding Proteins; Female;

2015
Protection effect of nicotinamide on cardiomyoblast hypoxia/re-oxygenation injury: study of cellular mitochondrial metabolism.
    Molecular bioSystems, 2016, 06-21, Volume: 12, Issue:7

    Topics: Animals; Cell Line; Cell Survival; Cells, Cultured; Citric Acid Cycle; Dose-Response Relationship, D

2016
Increased hemoglobin-oxygen affinity ameliorates bleomycin-induced hypoxemia and pulmonary fibrosis.
    Physiological reports, 2016, Volume: 4, Issue:17

    Topics: Administration, Oral; Animals; Benzaldehydes; Bleomycin; Bronchoalveolar Lavage Fluid; Collagen; Dys

2016
CXCL12 expression and PD-L1 expression serve as prognostic biomarkers in HCC and are induced by hypoxia.
    Virchows Archiv : an international journal of pathology, 2017, Volume: 470, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Antineoplastic Combined Chemother

2017
Effect of cerebronorm on energy metabolism and lipid peroxidation in rat brain during hypoxia.
    Bulletin of experimental biology and medicine, 2007, Volume: 144, Issue:5

    Topics: Animals; Brain; Energy Metabolism; Hypoxia; Inosine Diphosphate; Lipid Peroxidation; Male; Mitochond

2007
[Correction of metabolic disturbances in cancer patients in the early postanesthesia period].
    Khirurgiia, 2010, Issue:4

    Topics: Adult; Aged; Anesthesia, General; Dose-Response Relationship, Drug; Drug Combinations; Female; Flavi

2010
[Pharmacological correction of hypoxic and free-radical disorders in patients with acute myocardial infarction complicated by acute heart failure].
    Eksperimental'naia i klinicheskaia farmakologiia, 2010, Volume: 73, Issue:5

    Topics: Acute Disease; Critical Care; Drug Combinations; Flavin Mononucleotide; Fluorocarbons; Free Radicals

2010
Metabolomic study on vitamins B₁, B₂, and PP supplementation to improve serum metabolic profiles in mice under acute hypoxia based on ¹H NMR analysis.
    Biomedical and environmental sciences : BES, 2010, Volume: 23, Issue:4

    Topics: Acute Disease; Animals; Dose-Response Relationship, Drug; Hypoxia; Lipid Metabolism; Magnetic Resona

2010
Combination of hypoxia and RNA-interference targeting VEGF induces apoptosis in hepatoma cells via autocrine mechanisms.
    Current pharmaceutical biotechnology, 2012, Volume: 13, Issue:11

    Topics: Animals; Antineoplastic Agents; Apoptosis; Benzenesulfonates; Carcinoma, Hepatocellular; Cell Line,

2012
[Improvement effect of vitamins B1, B2 and PP supplementation on substance metabolism of mice exposed to acute hypoxia].
    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2011, Volume: 27, Issue:2

    Topics: Animals; Carbohydrate Metabolism; Hypoxia; Lipid Metabolism; Male; Mice; Niacinamide; Proteins; Ribo

2011
Pre-B-cell colony-enhancing factor exerts a neuronal protection through its enzymatic activity and the reduction of mitochondrial dysfunction in in vitro ischemic models.
    Journal of neurochemistry, 2012, Volume: 120, Issue:2

    Topics: Acrylamides; Animals; Brain; Cell Death; Cells, Cultured; DNA, Mitochondrial; Embryo, Mammalian; Fem

2012
Evaluation of changes in the tumor microenvironment after sorafenib therapy by sequential histology and 18F-fluoromisonidazole hypoxia imaging in renal cell carcinoma.
    International journal of oncology, 2012, Volume: 41, Issue:5

    Topics: Animals; Antineoplastic Agents; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation; Humans;

2012
Sorafenib and TRAIL have synergistic effect on hepatocellular carcinoma.
    International journal of oncology, 2013, Volume: 42, Issue:1

    Topics: Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Cell Proliferation;

2013
[Approaches to the improvement of treatment efficacy in patients with acute severe asaleptin intoxication complicated by acute respiratory insufficiency of mixed genesis].
    Klinicheskaia meditsina, 2012, Volume: 90, Issue:10

    Topics: Acute Disease; Adult; Antipsychotic Agents; Clozapine; Drug Combinations; Female; Flavin Mononucleot

2012
Hypoxia-mediated sorafenib resistance can be overcome by EF24 through Von Hippel-Lindau tumor suppressor-dependent HIF-1α inhibition in hepatocellular carcinoma.
    Hepatology (Baltimore, Md.), 2013, Volume: 57, Issue:5

    Topics: Animals; Antineoplastic Agents; Apoptosis; Benzylidene Compounds; Carcinoma, Hepatocellular; Cell Li

2013
ACQUIRED CHROMOSOMAL ANOMALIES INDUCED IN MICE BY KNOWN TERATOGEN.
    JAMA, 1964, Mar-14, Volume: 187

    Topics: Alloxan; Animals; Chromosome Aberrations; Cleft Palate; Embryo, Mammalian; Embryo, Nonmammalian; Fem

1964
Graded reoxygenation with chemical inhibition of oxidative phosphorylation improves posthypoxic recovery in murine hippocampal slices.
    Journal of neuroscience research, 2004, Feb-01, Volume: 75, Issue:3

    Topics: Action Potentials; Amobarbital; Animals; Cyanides; Electron Transport Complex I; Electron Transport

2004
Selectivity of effects of redox-active cobalt(III) complexes on tumor tissue.
    Experimental oncology, 2004, Volume: 26, Issue:2

    Topics: Adenocarcinoma; Animals; Carcinoma, Lewis Lung; Cobalt; DNA Damage; Ethylenediamines; Female; Hypoxi

2004
The prognostic value of endogenous hypoxia-related markers for head and neck squamous cell carcinomas treated with ARCON.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2006, Volume: 79, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Antigens, Neoplasm; Biomarkers, Tumor; Carbon Dioxide; Carbonic Anhy

2006
Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models.
    Cancer chemotherapy and pharmacology, 2007, Volume: 59, Issue:5

    Topics: Actins; Adenocarcinoma, Clear Cell; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Benzene

2007
[Nootropic and anxiolytic properties of endogenous ligands of benzodiazepine receptors and their structural analogs].
    Biulleten' eksperimental'noi biologii i meditsiny, 1984, Volume: 97, Issue:2

    Topics: Amnesia; Amnesia, Retrograde; Animals; Anti-Anxiety Agents; Anxiety; Avoidance Learning; Conflict, P

1984
Cardiac synthesis and degradation of pyridine nucleotides and the level of energy-rich phosphates influenced by various precursors.
    Advances in myocardiology, 1983, Volume: 4

    Topics: Adenine; Adenosine Triphosphate; Animals; Glycoside Hydrolases; Guinea Pigs; Hypoxia; Myocardial Con

1983
Tumour oxygenation, radiosensitivity, and necrosis before and/or after nicotinamide, carbogen and perflubron emulsion administration.
    International journal of radiation biology, 1995, Volume: 67, Issue:5

    Topics: Animals; Carbon Dioxide; Cell Survival; Fluorocarbons; Humans; Hydrocarbons, Brominated; Hypoxia; Mi

1995
Comparison of the effects of nicorandil, pinacidil and nitroglycerin on hypoxic and hypercapnic pulmonary vasoconstriction in the isolated perfused lung of rat.
    British journal of pharmacology, 1996, Volume: 117, Issue:4

    Topics: Acidosis; Animals; Guanidines; Hypercapnia; Hypoxia; In Vitro Techniques; Lung; Male; Niacinamide; N

1996
alpha 1-Adrenoceptor stimulation partially inhibits ATP-sensitive K+ current in guinea pig ventricular cells: attenuation of the action potential shortening induced by hypoxia and K+ channel openers.
    Journal of cardiovascular pharmacology, 1996, Volume: 28, Issue:6

    Topics: Action Potentials; Adrenergic alpha-Agonists; Animals; Benzopyrans; Cells, Cultured; Cromakalim; Fem

1996
Comments on hyperbaric oxygen and carbogen/nicotinamide with fractionated radiation.
    Radiation research, 1997, Volume: 148, Issue:5

    Topics: Carbon Dioxide; Humans; Hyperbaric Oxygenation; Hypoxia; Models, Biological; Neoplasms; Niacinamide;

1997
Is hyperbaric oxygen more effective than carbogen/nicotinamide in tumor radiation response?
    Radiation research, 1997, Volume: 148, Issue:5

    Topics: Animals; Carbon Dioxide; Hyperbaric Oxygenation; Hypoxia; Neoplasms, Experimental; Niacinamide; Oxyg

1997
Vascular architecture and microenvironmental parameters in human squamous cell carcinoma xenografts: effects of carbogen and nicotinamide.
    Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 1999, Volume: 50, Issue:2

    Topics: Animals; Benzimidazoles; Blood Vessels; Carbon Dioxide; Carcinoma, Squamous Cell; Cell Division; End

1999
Chroman amide and nicotinyl amide derivatives: inhibition of lipid peroxidation and protection against head trauma.
    Free radical research, 2000, Volume: 32, Issue:2

    Topics: Animals; Brain Injuries; Chromans; Craniocerebral Trauma; Disease Models, Animal; Dopamine; Electron

2000
Modification of tumour radiation response in vivo by the benzamide analogue pyrazinamide.
    British journal of cancer, 1990, Volume: 62, Issue:4

    Topics: Animals; Cell Survival; Cells, Cultured; Hypoxia; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Neopl

1990
[Nootropic activity of nicotinamide and its structural analogs].
    Biulleten' eksperimental'noi biologii i meditsiny, 1990, Volume: 110, Issue:10

    Topics: Amnesia; Animals; Hypoxia; Male; Meclofenoxate; Mice; Niacinamide; Piracetam; Psychotropic Drugs; Py

1990
Mechanism for the reduction of tumour hypoxia by nicotinamide and the clinical relevance for radiotherapy.
    Biomedica biochimica acta, 1989, Volume: 48, Issue:2-3

    Topics: Animals; Benzimidazoles; Blood Pressure; Carcinoma, Squamous Cell; Cell Survival; Female; Fluorescen

1989
[Influence of antianginal drugs on Lypressin induced T-wave enhancement in the electrocardiogram of the rat].
    Arzneimittel-Forschung, 1986, Volume: 36, Issue:10

    Topics: Administration, Oral; Angina Pectoris; Animals; Coronary Vasospasm; Electrocardiography; Hypoxia; Is

1986
Examination of the direct effects of antianginal agents on the hypoxic canine myocardium.
    Japanese heart journal, 1987, Volume: 28, Issue:5

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Cardiomyopathies; Coronary Circulation; Dogs

1987
[Prevention of disorders of cardiac contractility with nicotinamide in adriblastin -related damage].
    Kardiologiia, 1988, Volume: 28, Issue:12

    Topics: Animals; Cardiomyopathies; Doxorubicin; Heart Failure; Hypoxia; Myocardial Contraction; Niacinamide;

1988
The partial purification of a carrier-like protein for organic bases from the kidney.
    The Journal of pharmacology and experimental therapeutics, 1969, Volume: 167, Issue:2

    Topics: Aminohippuric Acids; Animals; Binding Sites; Carbon Isotopes; Centrifugation; Chromatography; Dibenz

1969
[Basic directions in the study of the biochemistry of the myocardium].
    Kardiologiia, 1967, Volume: 7, Issue:11

    Topics: Adaptation, Physiological; Animals; Camphor; Cardiac Glycosides; Cardiomegaly; Cardiovascular Diseas

1967
[The effect of oxygen on the status of blood gases in oncological patients receiving radiation therapy].
    Vrachebnoe delo, 1968, Volume: 7

    Topics: Blood Gas Analysis; Carbon Dioxide; Humans; Hypoxia; Neoplasms; Niacinamide; Oxygen; Oxygen Consumpt

1968
Effect of 6-amino-nicotinamide on the tolerance of mice to hypoxic hypoxia.
    Experientia, 1974, Sep-15, Volume: 30, Issue:9

    Topics: Amines; Animals; Blood Glucose; Body Temperature; Brain; Glucose; Hyperglycemia; Hypoxia; Male; Mice

1974