niacinamide has been researched along with Alloxan Diabetes in 324 studies
nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Loganin is an iridoid glycoside with antioxidant, anti-inflammatory, glucose-lowering activities which may address the pathological mechanisms of painful diabetic neuropathy (PDN) related to inflammation, oxidative stress, and hyperglycemia." | 8.02 | Loganin Ameliorates Painful Diabetic Neuropathy by Modulating Oxidative Stress, Inflammation and Insulin Sensitivity in Streptozotocin-Nicotinamide-Induced Diabetic Rats. ( Cheng, YC; Chiu, YM; Dai, ZK; Wu, BN, 2021) |
| " The present study aimed to elucidate the association between stress and the PARP pathway by using resveratrol (RSV) and nicotinamide (NAM, PARP inhibitor) to treat diabetic cataract." | 8.02 | Biochemical Evidence Indicates the Preventive Effect of Resveratrol and Nicotinamide in the Treatment of STZ-induced Diabetic Cataract. ( Bodakhe, SH; Singh, A, 2021) |
| "Quercetin could potentially be used to ameliorate myocardial damage due to oxidative stress, inflammation and apoptosis in diabetes." | 7.85 | Quercetin ameliorates oxidative stress, inflammation and apoptosis in the heart of streptozotocin-nicotinamide-induced adult male diabetic rats. ( Giribabu, N; Karim, K; Roslan, J; Salleh, N, 2017) |
| "This study was designed to investigate the possible effectiveness of resveratrol (trans-3,5,4'-trihydroxystilbene) administration on oxidative stress, nuclear factor κB (NF-κB) activity and apoptosis rate in streptozotocin-nicotinamide-induced diabetic retinopathy." | 7.78 | Resveratrol improves diabetic retinopathy possibly through oxidative stress - nuclear factor κB - apoptosis pathway. ( Ahmadieh, H; Mohammad-Nejad, D; Soufi, FG, 2012) |
| " Thus, the present study was aimed to investigate the hypothesis that oral administration of resveratrol attenuates hyperglycemia, proinflammatory cytokines and antioxidant competence and protects beta-cell ultrastructure in streptozotocin-nicotinamide-induced diabetic rats." | 7.76 | Ameliorative potential of resveratrol on proinflammatory cytokines, hyperglycemia mediated oxidative stress, and pancreatic beta-cell dysfunction in streptozotocin-nicotinamide-induced diabetic rats. ( Palsamy, P; Subramanian, S, 2010) |
| "The present study was hypothesized to investigate the hepatoprotective nature of resveratrol in averting hyperglycemia-mediated oxidative stress by measuring extent of oxidant stress and levels of proinflammatory cytokines and antioxidant competence in the hepatic tissues of streptozotocin-nicotinamide-induced diabetic rats." | 7.76 | Resveratrol attenuates hyperglycemia-mediated oxidative stress, proinflammatory cytokines and protects hepatocytes ultrastructure in streptozotocin-nicotinamide-induced experimental diabetic rats. ( Palsamy, P; Sivakumar, S; Subramanian, S, 2010) |
| " We concluded that PD-CSNPs and PD ameliorate diabetic liver damage by modulating glucose transporter 2 expression, affecting the activity of carbohydrate metabolism enzymes, and suppressing oxidative stress and inflammation, PD-CSNPs being more efficient than PD, probably due to higher bioavailability and prolonged release." | 5.62 | Hepatoprotective Effects of Polydatin-Loaded Chitosan Nanoparticles in Diabetic Rats: Modulation of Glucose Metabolism, Oxidative Stress, and Inflammation Biomarkers. ( Abd El-Hameed, AM; Abd El-Twab, SM; Abdel-Moneim, A; El-Shahawy, AAG; Yousef, AI, 2021) |
| "Melatonin is a pineal hormone that regulates circadian and seasonal rhythms and most likely is involved in regulating glucose metabolism." | 5.48 | Oral supplementation with melatonin reduces oxidative damage and concentrations of inducible nitric oxide synthase, VEGF and matrix metalloproteinase 9 in the retina of rats with streptozotocin/nicotinamide induced pre-diabetes. ( Basic, J; Cvetkovic, T; Despotovic, M; Djordjevic, B; Kocic, G; Pavlovic, D; Sokolovic, D; Stoimenov, TJ; Velickov, A; Veljkovic, A; Zivanovic, S, 2018) |
| "Comparisons were made of the dose-response and time-course characteristics of nicotinamide (NIC) and its metabolite, N1-methylnicotinamide (MNIC), protection from alloxan-induced diabetes in mice." | 5.27 | Characteristics of nicotinamide and N1-methylnicotinamide protection from alloxan diabetes in mice. ( Falany, J; Fischer, LJ; Fisher, R, 1983) |
| "Diabetic-induced rats were treated with 14-deoxy, 11, 12-didehydro andrographolide concentrations between 10 and 500 mg/kg body weight." | 4.31 | Antihyperglycemic activity of 14-deoxy, 11, 12-didehydro andrographolide on streptozotocin-nicotinamide induced type 2 diabetic rats. ( Guru, A; Issac, PK; Kamaraj, N; Velumani, K, 2023) |
| "Loganin is an iridoid glycoside with antioxidant, anti-inflammatory, glucose-lowering activities which may address the pathological mechanisms of painful diabetic neuropathy (PDN) related to inflammation, oxidative stress, and hyperglycemia." | 4.02 | Loganin Ameliorates Painful Diabetic Neuropathy by Modulating Oxidative Stress, Inflammation and Insulin Sensitivity in Streptozotocin-Nicotinamide-Induced Diabetic Rats. ( Cheng, YC; Chiu, YM; Dai, ZK; Wu, BN, 2021) |
| " The present study aimed to elucidate the association between stress and the PARP pathway by using resveratrol (RSV) and nicotinamide (NAM, PARP inhibitor) to treat diabetic cataract." | 4.02 | Biochemical Evidence Indicates the Preventive Effect of Resveratrol and Nicotinamide in the Treatment of STZ-induced Diabetic Cataract. ( Bodakhe, SH; Singh, A, 2021) |
| "Quercetin could potentially be used to ameliorate myocardial damage due to oxidative stress, inflammation and apoptosis in diabetes." | 3.85 | Quercetin ameliorates oxidative stress, inflammation and apoptosis in the heart of streptozotocin-nicotinamide-induced adult male diabetic rats. ( Giribabu, N; Karim, K; Roslan, J; Salleh, N, 2017) |
| " After administration of different concentrations and molecular weights of β-d-glucan by oral gavage for 28 days, the body weight, fasting blood glucose, serum insulin, hepatic glycogen, glucose kinase and glucose-6-phosphatase activity of the diabetic mice were measured." | 3.83 | The anti-diabetic activity of oat β-d-glucan in streptozotocin-nicotinamide induced diabetic mice. ( Hu, B; Liu, M; Qi, X; Qian, H; Wang, L; Zhang, H; Zhang, Y, 2016) |
| "This study was designed to investigate the possible effectiveness of resveratrol (trans-3,5,4'-trihydroxystilbene) administration on oxidative stress, nuclear factor κB (NF-κB) activity and apoptosis rate in streptozotocin-nicotinamide-induced diabetic retinopathy." | 3.78 | Resveratrol improves diabetic retinopathy possibly through oxidative stress - nuclear factor κB - apoptosis pathway. ( Ahmadieh, H; Mohammad-Nejad, D; Soufi, FG, 2012) |
| " Thus, the present study was aimed to investigate the hypothesis that oral administration of resveratrol attenuates hyperglycemia, proinflammatory cytokines and antioxidant competence and protects beta-cell ultrastructure in streptozotocin-nicotinamide-induced diabetic rats." | 3.76 | Ameliorative potential of resveratrol on proinflammatory cytokines, hyperglycemia mediated oxidative stress, and pancreatic beta-cell dysfunction in streptozotocin-nicotinamide-induced diabetic rats. ( Palsamy, P; Subramanian, S, 2010) |
| "The present study was hypothesized to investigate the hepatoprotective nature of resveratrol in averting hyperglycemia-mediated oxidative stress by measuring extent of oxidant stress and levels of proinflammatory cytokines and antioxidant competence in the hepatic tissues of streptozotocin-nicotinamide-induced diabetic rats." | 3.76 | Resveratrol attenuates hyperglycemia-mediated oxidative stress, proinflammatory cytokines and protects hepatocytes ultrastructure in streptozotocin-nicotinamide-induced experimental diabetic rats. ( Palsamy, P; Sivakumar, S; Subramanian, S, 2010) |
| " Transplantation of ICC into nude mice with alloxan diabetes revealed that ICC formed in nicotinamide normalized the hyperglycemia faster than did control ICC (3 to 4 weeks compared with 6 to 8 weeks)." | 3.68 | Pretreatment of fetal porcine pancreas in culture with nicotinamide accelerates reversal of diabetes after transplantation to nude mice. ( Andersson, A; Korsgren, O; Sandler, S, 1993) |
| "Type 2 diabetes is more prevalent (90-95%) in adults than type 1." | 2.82 | Model of Streptozotocin-nicotinamide Induced Type 2 Diabetes: a Comparative Review. ( Ahmad, R; Bari, DG; Gaur, R; Gautam, GK; Parveen, K; Rais, N; Shukla, KS; Singh, AP; Ved, A, 2022) |
| "Madecassoside (MAD) is a triterpenoid constituent of Centella asiatica (L." | 1.91 | Effect of madecassoside in reducing oxidative stress and blood glucose in streptozotocin-nicotinamide-induced diabetes in rats. ( Ambu, S; Bhattamisra, SK; Candasamy, M; Chitra, E; Davamani, F; Furman, B; Krishnappa, P; Rajendran, R; Tan, SC, 2023) |
| "To overcome the low bioavailability of lipophilic free thymoquinone (TQ), this study aims to evaluate a novel oral formula of TQ-loaded chitosan nanoparticles (TQ-CsNPs) for the effective treatment of diabetes." | 1.72 | Therapeutic significance of thymoquinone-loaded chitosan nanoparticles on streptozotocin/nicotinamide-induced diabetic rats: In vitro and in vivo functional analysis. ( Abdel-Moneim, A; El-Shahawy, AAG; Eldin, ZE; Hosni, A; Hussien, M; Zanaty, MI, 2022) |
| " We concluded that PD-CSNPs and PD ameliorate diabetic liver damage by modulating glucose transporter 2 expression, affecting the activity of carbohydrate metabolism enzymes, and suppressing oxidative stress and inflammation, PD-CSNPs being more efficient than PD, probably due to higher bioavailability and prolonged release." | 1.62 | Hepatoprotective Effects of Polydatin-Loaded Chitosan Nanoparticles in Diabetic Rats: Modulation of Glucose Metabolism, Oxidative Stress, and Inflammation Biomarkers. ( Abd El-Hameed, AM; Abd El-Twab, SM; Abdel-Moneim, A; El-Shahawy, AAG; Yousef, AI, 2021) |
| "Experimental diabetes mellitus was induced by a single intraperitoneal injection of STZ (60 mg/kg body weight), 15 min after intraperitoneal injection of NA (120 mg/kg body weight)." | 1.62 | Musa paradisiaca L. leaf and fruit peel hydroethanolic extracts improved the lipid profile, glycemic index and oxidative stress in nicotinamide/streptozotocin-induced diabetic rats. ( Abd El-Twab, SM; Abdel Aziz, SM; Abdel-Gabbar, M; Adel Amin, K; Ahmed, OM; Al-Muzafar, HM, 2021) |
| "Mangiferin has potential to be used as an agent to promote wound healing in diabetic condition." | 1.62 | Topical administration of mangiferin promotes healing of the wound of streptozotocin-nicotinamide-induced type-2 diabetic male rats. ( Giribabu, N; Kilari, EK; Lwin, OM; Salleh, N, 2021) |
| "Zingerone-treated diabetic groups exhibited significant reduction in LPO levels and restoration of GSH contents." | 1.62 | Modulatory effect of zingerone against STZ-nicotinamide induced type-2 diabetes mellitus in rats. ( Alkarbi, ZA; Alshahrani, S; Anwer, T; Firoz Alam, M; Hassan Najmi, A; Khan, G; Siddiqui, R, 2021) |
| " The solubility, dissolution rate and bioavailability of gliclazide SGNCs were significantly improved compared to pure gliclazide." | 1.51 | Fabrication of Second Generation Smarter PLGA Based Nanocrystal Carriers for Improvement of Drug Delivery and Therapeutic Efficacy of Gliclazide in Type-2 Diabetes Rat Model. ( Bhattamisra, SK; Krishnamoorthy, R; Panda, BP; Patnaik, S; Seng, LB; Shivashekaregowda, NKH, 2019) |
| "Type 2 diabetes was induced using a single dose of streptozotocin and nicotinamide by intraperitoneal injection." | 1.51 | Resveratrol supplementation improves DNA integrity and sperm parameters in streptozotocin-nicotinamide-induced type 2 diabetic rats. ( Alizadeh, Z; Bahmanzadeh, M; Fathi, N; Goodarzi, MT; Rezaei Farimani, A, 2019) |
| "Melatonin is a pineal hormone that regulates circadian and seasonal rhythms and most likely is involved in regulating glucose metabolism." | 1.48 | Oral supplementation with melatonin reduces oxidative damage and concentrations of inducible nitric oxide synthase, VEGF and matrix metalloproteinase 9 in the retina of rats with streptozotocin/nicotinamide induced pre-diabetes. ( Basic, J; Cvetkovic, T; Despotovic, M; Djordjevic, B; Kocic, G; Pavlovic, D; Sokolovic, D; Stoimenov, TJ; Velickov, A; Veljkovic, A; Zivanovic, S, 2018) |
| "Type 2 diabetes was induced by injection of streptozotocin and nicotinamide." | 1.43 | Effects of Nitrate Intake on Myocardial Ischemia-Reperfusion Injury in Diabetic Rats. ( Bageripour, F; Ghanbari, M; Ghasemi, A; Jeddi, S; Khalifi, S, 2016) |
| " Sublingually delivered NPs with nicotinamide exhibited high pharmacological availability (>100%) and bioavailability (>80%) at a dose of 5 IU/kg." | 1.43 | Insulin-loaded alginic acid nanoparticles for sublingual delivery. ( Devarajan, PV; Patil, NH, 2016) |
| "Diabetic foot ulcer is a serious complication of diabetes, which affects a significant percentage (15%) of diabetics and up to 15%-24% of those affected may require amputation." | 1.43 | Evaluation of wound healing properties of bioactive aqueous fraction from Moringa oleifera Lam on experimentally induced diabetic animal model. ( Abas, F; Arulselvan, P; Cheah, PS; Fakurazi, S; Muhammad, AA, 2016) |
| " At 13 weeks of age, ZF rats were dosed orally with dapagliflozin once daily up to the 22(nd) day." | 1.42 | Efficacy of Mitiglinide Combined with Dapagliflozin in Streptozotocin-nicotinamide-induced Type 2 Diabetic Rats and in Zucker Fatty Rats. ( Akahane, K; Inoue, T; Kiguchi, S; Kobayashi, M; Maruyama, K; Mori, Y; Ojima, K; Yaguchi, A; Yokoyama, A, 2015) |
| "augusta leaves (AA) against type 2 diabetes mellitus (T2DM) and its associated nephropathy and cardiomyopathy in experimental rats." | 1.42 | Abroma augusta L. (Malvaceae) leaf extract attenuates diabetes induced nephropathy and cardiomyopathy via inhibition of oxidative stress and inflammatory response. ( De Feo, V; Dewanjee, S; Gangopadhyay, M; K Dua, T; Khanra, R; Sahu, R; Zia-Ul-Haq, M, 2015) |
| "Alveolar bone loss was histologically measured as the distance of the cementoenamel junction to the alveolar bone crest in distal and the percentage of periodontal ligament area in the first molar furcation, respectively." | 1.40 | Diabetic characteristics and alveolar bone loss in streptozotocin- and streptozotocin-nicotinamide-treated rats with periodontitis. ( Bak, EJ; Cha, JH; Choi, SH; Kim, JH; Lee, DE; Yoo, YJ, 2014) |
| " These results suggest that SeMet may improve glucose tolerance in a NA/STZ-induced mild diabetic mouse model by increasing bioavailability in the pancreas." | 1.40 | Effects of administering sodium selenite, methylseleninic acid, and seleno-L-methionine on glucose tolerance in a streptozotocin/nicotinamide-induced diabetic mouse model. ( Arakawa, T; Nakamuro, K; Ogino, H; Okuno, T; Sakazaki, F; Shimizu, R; Ueno, H, 2014) |
| "Eighteen rats with diabetic nephropathy and 6 rats without induced nephropathy were divided into 4 groups, each containing 6 animals." | 1.39 | Effect of silymarin on streptozotocin-nicotinamide-induced type 2 diabetic nephropathy in rats. ( Jose, MA; Kumar, BN; Sathyamurthy, D; Sheela, N, 2013) |
| "Disease progression was associated with slower glucose utilization." | 1.39 | Population pharmacodynamic modeling of exenatide after 2-week treatment in STZ/NA diabetic rats. ( Chen, T; Kagan, L; Mager, DE, 2013) |
| " In this study the effect of chronic administration (7 days) of methanolic extract of A." | 1.38 | Immunostimulant, cerebroprotective & nootropic activities of Andrographis paniculata leaves extract in normal & type 2 diabetic rats. ( Annapurna, A; Radhika, P; Rao, SN, 2012) |
| " Once-daily dosing of ipragliflozin (0." | 1.38 | Antidiabetic effects of SGLT2-selective inhibitor ipragliflozin in streptozotocin-nicotinamide-induced mildly diabetic mice. ( Hayashizaki, Y; Imamura, M; Kihara, R; Kobayashi, Y; Kurosaki, E; Noda, A; Qun, L; Sasamata, M; Shibasaki, M; Tahara, A; Takasu, T; Tomiyama, H; Yamajuku, D; Yokono, M, 2012) |
| " Diabetic rats were dosed with i." | 1.37 | Antihyperglycemic effects of baicalin on streptozotocin - nicotinamide induced diabetic rats. ( Davey, AK; Li, HT; Wang, J; Wu, XD, 2011) |
| "Type 2 diabetes was induced by single intraperitoneal injection of nicotinamide (110 mg/kg) followed by streptozotocin (65mg/kg)." | 1.37 | Antidiabetic activity of alcoholic leaves extract of Alangium lamarckii Thwaites on streptozotocin-nicotinamide induced type 2 diabetic rats. ( Hemalatha, S; Kumar, R; Pate, DK; Prasad, SK; Sairam, K, 2011) |
| " Together the present study clearly reflects that combined dosage of tetrahydrocurcumin and chlorogenic acid augments enzymic antioxidants with a concomitant decrease in lipid peroxidation and protects against streptozotocin-nicotinamide-induced type 2 diabetes in experimental rats." | 1.36 | Comparative and combined effect of chlorogenic acid and tetrahydrocurcumin on antioxidant disparities in chemical induced experimental diabetes. ( Karthikesan, K; Menon, VP; Pari, L, 2010) |
| "Diosmin was administered to streptozotocin-induced (45 mg/kg b." | 1.36 | Antihyperglycemic effect of diosmin on hepatic key enzymes of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats. ( Pari, L; Srinivasan, S, 2010) |
| " Hence, dosing will play a critical role in clinical studies assessing the merits of NIC and TAU as diabetes-preventing agents." | 1.36 | Comparative study of the binding characteristics to and inhibitory potencies towards PARP and in vivo antidiabetogenic potencies of taurine, 3-aminobenzamide and nicotinamide. ( Lau-Cam, CA; Pandya, KG; Patel, MR, 2010) |
| "Since blood levels of ADN are low in type 2 diabetes mellitus (DM), this study was designed to investigate the therapeutic effectiveness of increasing the ADN level through injection of plasmid DNA encoding ADN in type 2 DM." | 1.36 | Construction of adiponectin-encoding plasmid DNA and gene therapy of non-obese type 2 diabetes mellitus. ( Myung, CS; Nan, MH; Park, JS, 2010) |
| "Glimepiride (Gmp) is a third generation antidiabetic sulphonylurea known to possess the antioxidant effect in streptozotocin (STZ) induced diabetes." | 1.35 | Inhibitory effect of glimepiride on nicotinamide-streptozotocin induced nuclear damages and sperm abnormality in diabetic Wistar rats. ( Devi, K; Khanam, S; Rabbani, SI, 2009) |
| " Long-term administration of guava leaf extracts increased the plasma insulin level and glucose utilization in diabetic rats." | 1.35 | Effect of guava (Psidium guajava Linn.) leaf soluble solids on glucose metabolism in type 2 diabetic rats. ( Cheng, FC; Shen, SC; Wu, NJ, 2008) |
| " Subsequently, the effects of a 1-week chronic daily dosing of DPP-IV inhibitors and sulfonylureas were investigated." | 1.35 | Antidiabetic effects of dipeptidyl peptidase-IV inhibitors and sulfonylureas in streptozotocin-nicotinamide-induced mildly diabetic mice. ( Hayakawa, M; Matsuyama-Yokono, A; Nakano, R; Shibasaki, M; Shiraki, K; Someya, Y; Tahara, A, 2009) |
| "Both type 2 diabetes and AG affected E(max) and Q(max), and there was an interaction between diabetes and AG for these two variables." | 1.35 | Aminoguanidine prevents the impairment of cardiac pumping mechanics in rats with streptozotocin and nicotinamide-induced type 2 diabetes. ( Chang, KC; Liang, JT; Lin, YD; Tseng, YZ; Wu, ET; Wu, MS, 2008) |
| ") injection of 55 mg/kg STZ and a nicotinamide group (1g/kg/day) which were dosed orally for 3 days followed by (i." | 1.35 | Effect of nicotinamide on experimental induced diabetes. ( Alenzi, FQ, 2009) |
| "Treatment with pterostilbene resulted in a significant reduction of glycosylated hemoglobin and an increase in total hemoglobin level." | 1.33 | Effect of pterostilbene on hepatic key enzymes of glucose metabolism in streptozotocin- and nicotinamide-induced diabetic rats. ( Pari, L; Satheesh, MA, 2006) |
| " The dosage of 230 mg/kg of nicotinamide given intraperitoneally 15 min before STZ administration (65 mg/kg i." | 1.32 | Alterations in vascular endothelial function in the aorta and mesenteric artery in type II diabetic rats. ( Kamata, K; Kobayashi, T; Matsumoto, T; Wakabayashi, K, 2004) |
| "Glimepiride is an oral sulfonylurea drug; nicotinamide is an inhibitor of poly (ADP-ribose) synthetase and a precursor of NAD." | 1.29 | The effects of nicotinamide and glimepiride on diabetes prevention in BB rats. ( Chan, EK; Charles, MA; Cheta, D; Pan, J; Schranz, V, 1995) |
| "The effects of Type 1 diabetes mellitus and of exposure to mainstream cigarette smoke on noradrenaline (NA) uptake and its subsequent metabolism by catechol-O-methyltransferase (COMT) and monoamine oxidase (MAO) in the perfused lungs of rats were examined." | 1.28 | The effects of type 1 diabetes mellitus and of tobacco smoke on dissipation of catecholamines in pulmonary endothelial cells--a non-neuronal site of uptake1. ( Bryan-Lluka, LJ; McKee, GJ, 1991) |
| "Comparisons were made of the dose-response and time-course characteristics of nicotinamide (NIC) and its metabolite, N1-methylnicotinamide (MNIC), protection from alloxan-induced diabetes in mice." | 1.27 | Characteristics of nicotinamide and N1-methylnicotinamide protection from alloxan diabetes in mice. ( Falany, J; Fischer, LJ; Fisher, R, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 49 (15.12) | 18.7374 |
| 1990's | 30 (9.26) | 18.2507 |
| 2000's | 62 (19.14) | 29.6817 |
| 2010's | 136 (41.98) | 24.3611 |
| 2020's | 47 (14.51) | 2.80 |
| Authors | Studies |
|---|---|
| Shah, SAR | 1 |
| Khan, MI | 1 |
| Jawaid, H | 1 |
| Qureshi, U | 1 |
| Ul-Haq, Z | 2 |
| Hafizur, MR | 1 |
| Cheng, YC | 1 |
| Chiu, YM | 1 |
| Dai, ZK | 1 |
| Wu, BN | 2 |
| Abdelkader, NF | 1 |
| Ibrahim, SM | 1 |
| Moustafa, PE | 1 |
| Elbaset, MA | 1 |
| Rais, N | 1 |
| Ved, A | 1 |
| Ahmad, R | 1 |
| Parveen, K | 1 |
| Gautam, GK | 1 |
| Bari, DG | 1 |
| Shukla, KS | 1 |
| Gaur, R | 1 |
| Singh, AP | 1 |
| Parsa, H | 1 |
| Moradi-Khaligh, Z | 1 |
| Rajabi, S | 1 |
| Ranjbar, K | 1 |
| Komaki, A | 1 |
| Sarnobat, D | 1 |
| Charlotte Moffett, R | 1 |
| Flatt, PR | 4 |
| Irwin, N | 1 |
| Tarasov, AI | 1 |
| Omoaghe, A | 1 |
| Oyesola, O | 1 |
| Ezike, T | 1 |
| Omizu, B | 1 |
| Boone, K | 1 |
| Heidari, H | 1 |
| Khalaj, A | 1 |
| Khani, S | 2 |
| Abdollahi, M | 1 |
| Farahani, H | 1 |
| Tykhonenko, T | 1 |
| Guzyk, M | 1 |
| Tykhomyrov, A | 1 |
| Korsa, V | 1 |
| Yanitska, L | 1 |
| Kuchmerovska, T | 3 |
| Hosni, A | 1 |
| Abdel-Moneim, A | 2 |
| Hussien, M | 1 |
| Zanaty, MI | 1 |
| Eldin, ZE | 1 |
| El-Shahawy, AAG | 2 |
| Yan, LJ | 1 |
| Chellian, J | 2 |
| Mak, KK | 2 |
| Chellappan, DK | 2 |
| Krishnappa, P | 3 |
| Pichika, MR | 2 |
| Zolkeflee, NKZ | 1 |
| Wong, PL | 1 |
| Maulidiani, M | 1 |
| Ramli, NS | 1 |
| Azlan, A | 1 |
| Abas, F | 2 |
| Costa, CJ | 1 |
| Cohen, MW | 1 |
| Goldberg, DC | 1 |
| Mellado, W | 1 |
| Willis, DE | 1 |
| Noei Razliqi, R | 1 |
| Ahangarpour, A | 2 |
| Mard, SA | 2 |
| Khorsandi, L | 2 |
| Razliqi, RN | 1 |
| Tan, SC | 1 |
| Rajendran, R | 1 |
| Bhattamisra, SK | 2 |
| Davamani, F | 1 |
| Chitra, E | 1 |
| Ambu, S | 1 |
| Furman, B | 1 |
| Candasamy, M | 1 |
| Madeswaran, A | 1 |
| Mohan, S | 1 |
| Torres-Méndez, JK | 1 |
| Niño-Narvión, J | 1 |
| Martinez-Santos, P | 1 |
| Diarte-Añazco, EMG | 1 |
| Méndez-Lara, KA | 1 |
| Del Olmo, TV | 1 |
| Rotllan, N | 1 |
| Julián, MT | 1 |
| Alonso, N | 1 |
| Mauricio, D | 1 |
| Camacho, M | 1 |
| Muñoz, JP | 1 |
| Rossell, J | 1 |
| Julve, J | 1 |
| Wu, S | 1 |
| Ai, W | 1 |
| Nie, L | 1 |
| Lu, X | 1 |
| Kamaraj, N | 1 |
| Velumani, K | 1 |
| Guru, A | 1 |
| Issac, PK | 1 |
| Lee, HJ | 1 |
| Yang, SJ | 2 |
| Kong, ZL | 1 |
| Sudirman, S | 1 |
| Hsu, YC | 1 |
| Su, CY | 1 |
| Kuo, HP | 1 |
| Panda, BP | 1 |
| Krishnamoorthy, R | 1 |
| Shivashekaregowda, NKH | 1 |
| Seng, LB | 1 |
| Patnaik, S | 1 |
| Bayat, M | 1 |
| Alaee, M | 1 |
| Akbari, A | 1 |
| Sadegh, M | 1 |
| Latifi, SA | 1 |
| Parastesh, M | 1 |
| Salehi, M | 1 |
| Karami, H | 1 |
| Amri, J | 1 |
| Kalidhindi, S | 1 |
| Uddandrao, VVS | 2 |
| Sasikumar, V | 1 |
| Raveendran, N | 1 |
| Ganapathy, S | 2 |
| Lwin, OM | 1 |
| Giribabu, N | 7 |
| Kilari, EK | 2 |
| Salleh, N | 7 |
| Mohammad Noor, HS | 1 |
| Ismail, NH | 1 |
| Kasim, N | 1 |
| Mediani, A | 1 |
| Mohd Zohdi, R | 1 |
| Ali, AM | 1 |
| Mat, N | 1 |
| Al-Mekhlafi, NA | 1 |
| Oosuka, S | 1 |
| Kida, T | 1 |
| Oku, H | 1 |
| Horie, T | 1 |
| Morishita, S | 1 |
| Fukumoto, M | 1 |
| Sato, T | 1 |
| Ikeda, T | 1 |
| Boye, A | 1 |
| Acheampong, DO | 1 |
| Gyamerah, EO | 1 |
| Asiamah, EA | 1 |
| Addo, JK | 1 |
| Mensah, DA | 1 |
| Brah, AS | 1 |
| Ayiku, PJ | 1 |
| Neyshaburinezhad, N | 1 |
| Seidabadi, M | 1 |
| Rouini, M | 1 |
| Lavasani, H | 1 |
| Foroumadi, A | 1 |
| Ardakani, YH | 1 |
| Kurylo, K | 1 |
| Budniak, L | 1 |
| Volska, A | 1 |
| Zablotskyy, B | 1 |
| Klishch, I | 1 |
| Bathina, S | 2 |
| Gundala, NKV | 1 |
| Rhenghachar, P | 1 |
| Polavarapu, S | 1 |
| Hari, AD | 1 |
| Sadananda, M | 1 |
| Das, UN | 2 |
| Olaniyi, KS | 2 |
| Amusa, OA | 2 |
| Singh, A | 1 |
| Bodakhe, SH | 1 |
| Kpemissi, M | 1 |
| Potârniche, AV | 1 |
| Lawson-Evi, P | 1 |
| Metowogo, K | 1 |
| Melila, M | 1 |
| Dramane, P | 1 |
| Taulescu, M | 1 |
| Chandramohan, V | 1 |
| Suhas, DS | 1 |
| Puneeth, TA | 1 |
| S, VK | 1 |
| Vlase, L | 1 |
| Andrei, S | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Center-Based and Home-Based Walking Exercise Intervention to Reduce Fatigue in Older Breast Cancer Survivors[NCT05684367] | 24 participants (Anticipated) | Interventional | 2023-11-29 | Recruiting | |||
| Vitamin B3 as a Novel Mitochondrial Therapy for Obesity[NCT03951285] | 56 participants (Actual) | Interventional | 2016-05-25 | Completed | |||
| Nicotinamide Riboside (NR) in Paclitaxel-induced Peripheral Neuropathy[NCT03642990] | Phase 2 | 5 participants (Actual) | Interventional | 2019-11-08 | Terminated (stopped due to Enrollment challenges) | ||
| Effect of Pterostilbene on Cholesterol, Blood Pressure and Oxidative Stress[NCT01267227] | Phase 2/Phase 3 | 80 participants (Actual) | Interventional | 2010-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Difference in Score on the Functional Assessment of Cancer Therapy/Gynecologic Oncology Group - neurotoxicity questionnaire at the end of treatment; i.e. Score at screening - score at end of treatment. This questionnaire asks 11 questions that are specific to chemotherapy-induced peripheral neuropathies. Maximum score is 44, minimum score is 0. Positive differences indicate a decrease in neuropathy. Negative differences indicate a worsening of neuropathy. Zero means unchanged. (NCT03642990)
Timeframe: 4 weeks
| Intervention | units on a scale (Median) |
|---|---|
| NIAGEN®) | 7 |
Exploratory analysis of ability of the clinical version of the Total Neuropathy Score questionnaire to detect changes in CIPN severity over time. Unlike the CTCAE or the FACT&GOG-NTX questionnaires, the TNS is a patient reported outcome measure. HIghest score (worse neuropathy is 24, lowest score is 0. Outcome assessed difference between end of treatment and screening. A positive number indicates improvement in neuropathy (NCT03642990)
Timeframe: 4 weeks
| Intervention | score on a scale (Median) |
|---|---|
| NIAGEN®) | 2 |
Count the number of (i.e. the incidence) of dose reduction events due to neuropathy (each occasion of dose reduction is a separate event); (NCT03642990)
Timeframe: 3 weeks
| Intervention | event (Number) |
|---|---|
| NIAGEN®) | 0 |
"The primary outcome variable is defined as no worsening of the grade of peripheral sensory neuropathy as scored according to the Common Terminology Criteria for Adverse Events (CTCAE) version 4.03 guidelines. Per the CTCAE a score of 1 would be assigned in the instance of parethesias or a loss of deep tendon reflexes. A score of 2 would be assigned in the instance of moderate symptoms that limit instrumental activities of daily living. A score of 3 would be assigned in the instance of severe symptoms that limit self-care activities of daily living. Because the outcome measure is defined as no worsening of the grade, it was recorded as either yes( i.e. it worsened) or no (i.e. it did not worsen)." (NCT03642990)
Timeframe: approximately 4 weeks
| Intervention | Participants (Count of Participants) |
|---|---|
| NIAGEN®) | 3 |
Quantitate the percentage of patients that experience a dose reduction of paclitaxel or nab-paclitaxel therapy due to neuropathy. (NCT03642990)
Timeframe: 3 weeks
| Intervention | Participants (Count of Participants) |
|---|---|
| NIAGEN®) | 0 |
Paclitaxel levels in plasma were measured ~30 min after each infusion of taxane. This was undertaken to ascertain whether NIAGEN altered plasma levels of paclitaxel because increases or decreases in plasma levels of paclitaxel by itself could lead to an apparent worsening or improvement, respectively, in CIPN and confound interpretation of NIAGEN's effect. (NCT03642990)
Timeframe: up to 3 weeks
| Intervention | ng/ml (Median) |
|---|---|
| NIAGEN®) | 810 |
Quantitate the total cumulative dose of paclitaxel administered over the 12 weeks. (NCT03642990)
Timeframe: 3 weeks
| Intervention | mg/M^2 (Number) |
|---|---|
| NIAGEN®) | 200 |
Reduction in systolic blood pressure versus placebo (NCT01267227)
Timeframe: 6-8 weeks
| Intervention | mmHg (Mean) |
|---|---|
| High Dose | 7.77 |
| Low Dose | 3.67 |
| Low Dose Combination | 6.72 |
| Placebo | 0 |
Increase in low density lipoprotein (LDL) (NCT01267227)
Timeframe: Baseline and 6-8 weeks
| Intervention | mg/dL (Mean) |
|---|---|
| High Dose | 19.67 |
| Low Dose | 20.04 |
| Low Dose Combination | 5.33 |
| Placebo | 0 |
Number of participants with adverse effects as a measure of safety (NCT01267227)
Timeframe: Baseline and 6-8 weeks
| Intervention | participants (Number) |
|---|---|
| High Dose | 5 |
| Low Dose | 3 |
| Low Dose Combination | 2 |
| Placebo | 2 |
7 reviews available for niacinamide and Alloxan Diabetes
| Article | Year |
|---|---|
Model of Streptozotocin-nicotinamide Induced Type 2 Diabetes: a Comparative Review.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Humans; NAD; Niacinami | 2022 |
The Nicotinamide/Streptozotocin Rodent Model of Type 2 Diabetes: Renal Pathophysiology and Redox Imbalance Features.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Glucose | 2022 |
Streptozotocin-nicotinamide-induced diabetes in the rat. Characteristics of the experimental model.
Topics: Animals; Diabetes Mellitus, Experimental; DNA Repair; Glucose; Glucose Transporter Type 2; Insulin; | 2012 |
Nicotinamide treatment in the prevention of insulin-dependent diabetes mellitus.
Topics: Animals; Autoimmunity; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Free Radicals; Hu | 1993 |
Type 1 (insulin-dependent) diabetes mellitus and nitric oxide.
Topics: Animals; Cell Death; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Free Radicals; Huma | 1992 |
The NOD mouse as a model of type I diabetes.
Topics: Animals; Autoimmune Diseases; Diabetes Mellitus, Experimental; Female; Gonadal Steroid Hormones; Imm | 1987 |
Regulation of the urea cycle and TCA cycle by ammonia.
Topics: Alanine Transaminase; Amino Acids; Ammonia; Amobarbital; Animals; Aspartate Aminotransferases; Aspar | 1966 |
317 other studies available for niacinamide and Alloxan Diabetes
| Article | Year |
|---|---|
Nicotinamide-cinnamic acid cocktail exerts pancreatic β-cells survival coupled with insulin secretion through ERK1/2 signaling pathway in an animal model of apoptosis.
Topics: Animals; Apoptosis; Blood Glucose; Cell Survival; Cinnamates; Diabetes Mellitus, Experimental; Gene | 2021 |
Loganin Ameliorates Painful Diabetic Neuropathy by Modulating Oxidative Stress, Inflammation and Insulin Sensitivity in Streptozotocin-Nicotinamide-Induced Diabetic Rats.
Topics: Animals; Antioxidants; Behavior, Animal; Blood Glucose; Body Weight; Calcitonin Gene-Related Peptide | 2021 |
Inosine mitigated diabetic peripheral neuropathy via modulating GLO1/AGEs/RAGE/NF-κB/Nrf2 and TGF-β/PKC/TRPV1 signaling pathways.
Topics: Animals; Caffeine; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Hyperglycemia; Hypoglycem | 2022 |
Swimming training and Plantago psyllium ameliorate cognitive impairment and glucose tolerance in streptozotocin-nicotinamide-induced type 2 diabetic rats.
Topics: Animals; Blood Glucose; Cognitive Dysfunction; Diabetes Mellitus, Experimental; Diabetes Mellitus, T | 2021 |
GABA and insulin but not nicotinamide augment α- to β-cell transdifferentiation in insulin-deficient diabetic mice.
Topics: Animals; Blood Glucose; Cell Transdifferentiation; Diabetes Mellitus, Experimental; gamma-Aminobutyr | 2022 |
Effects of Combined
Topics: Animals; Aryldialkylphosphatase; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, | 2022 |
Hypoglycemic, hypolipidemic and hepatoprotective effects of
Topics: Alpinia; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glyburi | 2022 |
Modulatory effects of vitamin B3 and its derivative on the levels of apoptotic and vascular regulators and cytoskeletal proteins in diabetic rat brain as signs of neuroprotection.
Topics: Animals; Brain; Cytoskeletal Proteins; Diabetes Mellitus, Experimental; gamma-Aminobutyric Acid; Hyp | 2022 |
Therapeutic significance of thymoquinone-loaded chitosan nanoparticles on streptozotocin/nicotinamide-induced diabetic rats: In vitro and in vivo functional analysis.
Topics: Animals; Benzoquinones; Chitosan; Diabetes Mellitus, Experimental; Humans; Hypoglycemic Agents; Nano | 2022 |
Quercetin and metformin synergistically reverse endothelial dysfunction in the isolated aorta of streptozotocin-nicotinamide- induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Endothelium, Vascular; Hypoglycemic Agents; Metformin; Nia | 2022 |
Quercetin and metformin synergistically reverse endothelial dysfunction in the isolated aorta of streptozotocin-nicotinamide- induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Endothelium, Vascular; Hypoglycemic Agents; Metformin; Nia | 2022 |
Quercetin and metformin synergistically reverse endothelial dysfunction in the isolated aorta of streptozotocin-nicotinamide- induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Endothelium, Vascular; Hypoglycemic Agents; Metformin; Nia | 2022 |
Quercetin and metformin synergistically reverse endothelial dysfunction in the isolated aorta of streptozotocin-nicotinamide- induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Endothelium, Vascular; Hypoglycemic Agents; Metformin; Nia | 2022 |
Metabolic Alterations in Streptozotocin-nicotinamide-induced Diabetic Rats Treated with Muntingia calabura Extract via 1H-NMR-based Metabolomics.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucose; Hypoglycemic Agents; Insulin; Meta | 2023 |
Nicotinamide Riboside Improves Enteric Neuropathy in Streptozocin-Induced Diabetic Rats Through Myenteric Plexus Neuroprotection.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Humans; Intestinal Pseudo-Obstructi | 2023 |
Gentisic acid protects against diabetic nephropathy in Nicotinamide-Streptozotocin administered male mice by attenuating oxidative stress and inflammation: The role of miR-200a/Keap1/Nrf2 pathway, renin-angiotensin system (RAS) and NF-кB.
Topics: Angiotensins; Animals; Anti-Inflammatory Agents; Antioxidants; Diabetes Mellitus, Experimental; Diab | 2023 |
Gentisic acid ameliorates type 2 diabetes induced by Nicotinamide-Streptozotocin in male mice by attenuating pancreatic oxidative stress and inflammation through modulation of Nrf2 and NF-кB pathways.
Topics: Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Inflammation; Kel | 2023 |
Effect of madecassoside in reducing oxidative stress and blood glucose in streptozotocin-nicotinamide-induced diabetes in rats.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Insulins | 2023 |
Neuroprotective effects of terpenoids against streptozotocin-nicotinamide-induced diabetic rats: An in silico, in vitro and in vivo study.
Topics: Acetylcholinesterase; Animals; Antioxidants; Diabetes Mellitus, Experimental; Diabetes Mellitus, Typ | 2023 |
Nicotinamide Prevents Diabetic Brain Inflammation via NAD+-Dependent Deacetylation Mechanisms.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Encephalitis; Male; Mice; Mice, | 2023 |
Antidiabetic activity of eupafolin through peroxisome proliferator-activated receptor-gamma and PI3K/Akt signaling in Type 2 diabetic rats.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fl | 2023 |
Antihyperglycemic activity of 14-deoxy, 11, 12-didehydro andrographolide on streptozotocin-nicotinamide induced type 2 diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Hyp | 2023 |
Supplementation with Nicotinamide Riboside Reduces Brain Inflammation and Improves Cognitive Function in Diabetic Mice.
Topics: Animals; Anti-Inflammatory Agents; Brain; CARD Signaling Adaptor Proteins; Caspase 3; Cognition; Cog | 2019 |
Fucoxanthin-Rich Brown Algae Extract Improves Male Reproductive Function on Streptozotocin-Nicotinamide-Induced Diabetic Rat Model.
Topics: Animals; Antioxidants; Blood Glucose; Cell Survival; Diabetes Mellitus, Experimental; Disease Models | 2019 |
Fabrication of Second Generation Smarter PLGA Based Nanocrystal Carriers for Improvement of Drug Delivery and Therapeutic Efficacy of Gliclazide in Type-2 Diabetes Rat Model.
Topics: Animals; Biological Availability; Delayed-Action Preparations; Diabetes Mellitus, Experimental; Diab | 2019 |
A comparative study of the antidiabetic effect of two training protocols in streptozotocin-nicotinamide diabetic rats.
Topics: Angiopoietin-Like Protein 8; Angiopoietin-like Proteins; Animals; Blood Glucose; Body Weight; Diabet | 2020 |
Mitigating Perspectives of Asiatic Acid in the Renal Derangements of Streptozotocin-Nicotinamide Induced Diabetic Rats.
Topics: Animals; Blood Glucose; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Gene Expression Re | 2020 |
Topical administration of mangiferin promotes healing of the wound of streptozotocin-nicotinamide-induced type-2 diabetic male rats.
Topics: Administration, Topical; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Male; | 2021 |
Urinary Metabolomics and Biochemical Analysis of Antihyperglycemic Effect of Ficus deltoidea Jack Varieties in Streptozotocin-Nicotinamide-Induced Diabetic Rats.
Topics: Animals; Blood Glucose; Chromatography, High Pressure Liquid; Diabetes Mellitus, Experimental; Ethan | 2020 |
Effects of an Aquaporin 4 Inhibitor, TGN-020, on Murine Diabetic Retina.
Topics: Animals; Aquaporin 4; Blood Vessels; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Ependymo | 2020 |
Glucose lowering and pancreato-protective effects of Abrus Precatorius (L.) leaf extract in normoglycemic and STZ/Nicotinamide - Induced diabetic rats.
Topics: Abrus; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Fe | 2020 |
Evaluation of hepatic CYP2D1 activity and hepatic clearance in type I and type II diabetic rat models, before and after treatment with insulin and metformin.
Topics: Animals; Cytochrome P450 Family 2; Dextromethorphan; Diabetes Mellitus, Experimental; Diabetes Melli | 2020 |
INFLUENCE OF PHYTOCOMPOSITIONS ON DYNAMICS OF CHANGES IN BASAL GLYCEMIA AND GLYCEMIA IN ORAL GLUCOSE TOLERANCE TEST IN RATS WITH STREPTOZOTOCIN-NICOTINAMIDE-INDUCED DIABETES MELLITUS TYPE 2.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucose Tolerance Test; Hypoglycemic Agents | 2020 |
Resolvin D1 Ameliorates Nicotinamide-streptozotocin-induced Type 2 Diabetes Mellitus by its Anti-inflammatory Action and Modulating PI3K/Akt/mTOR Pathway in the Brain.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Brain; Diabetes Mellitus, Experimental; Diabetes Melli | 2020 |
Sodium acetate-mediated inhibition of histone deacetylase alleviates hepatic lipid dysregulation and its accompanied injury in streptozotocin-nicotinamide-induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Histone Deacetylase Inhibitors; Inflammation Mediators; Li | 2020 |
Biochemical Evidence Indicates the Preventive Effect of Resveratrol and Nicotinamide in the Treatment of STZ-induced Diabetic Cataract.
Topics: Aldehyde Reductase; Animals; Antioxidants; Blood Glucose; Cataract; Diabetes Mellitus, Experimental; | 2021 |
Nephroprotective effect of Combretum micranthum G. Don in nicotinamide-streptozotocin induced diabetic nephropathy in rats: In-vivo and in-silico experiments.
Topics: Animals; Biomarkers; Blood Glucose; Catechin; Combretum; Diabetes Mellitus, Experimental; Diabetic N | 2020 |
Nicotinamide and heat preconditioning - Effects on hepatic HSP70, carbohydrate and oxidative disturbances in STZ-induced diabetic rats.
Topics: Animals; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Female; Heat-Shock Response; HSP7 | 2020 |
Effect of stevia aqueous extract on the antidiabetic activity of saxagliptin in diabetic rats.
Topics: Adamantane; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Dipeptides; Herb- | 2021 |
Effect of S-allylcysteine against diabetic nephropathy via inhibition of MEK1/2-ERK1/2-RSK2 signalling pathway in streptozotocin-nicotinamide-induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Kidney; MAP Kinase Signaling Syste | 2023 |
Evaluation of antidiabetic effect of
Topics: Animals; Blood Glucose; Body Weight; Cistus; Diabetes Mellitus, Experimental; Hypoglycemic Agents; M | 2020 |
Transdifferentiation of both intra- and extra-islet cells into beta cells in nicotinamide treated neonatal diabetic rats: An in situ hybridization and double immunohistochemical study.
Topics: Animals; Blood Glucose; Cell Transdifferentiation; Diabetes Mellitus, Experimental; Glucagon; In Sit | 2020 |
Musa paradisiaca L. leaf and fruit peel hydroethanolic extracts improved the lipid profile, glycemic index and oxidative stress in nicotinamide/streptozotocin-induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fruit; Glycemic Index; Hypoglyc | 2021 |
Evaluation of synergistic combination comprising magnesium orotate, menaquinone-7, and cholecalciferol for management of type 2 diabetes and dyslipidemia.
Topics: Animals; Cholecalciferol; Diabetes Mellitus, Experimental; Disease Models, Animal; Dyslipidemias; Hy | 2020 |
N1‑methylnicotinamide ameliorates insulin resistance in skeletal muscle of type 2 diabetic mice by activating the SIRT1/PGC‑1α signaling pathway.
Topics: Animals; Cell Line; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Insulin Receptor Sub | 2021 |
Acetate ameliorates nephrotoxicity in streptozotocin-nicotinamide-induced diabetic rats: Involvement of xanthine oxidase activity.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Atherosclerosis; Blood Glucose; Choleste | 2021 |
Novel compounds from Premna herbacea Roxb. with antidiabetic potential.
Topics: alpha-Amylases; Animals; Antioxidants; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; F | 2020 |
Hepatoprotective Effects of Polydatin-Loaded Chitosan Nanoparticles in Diabetic Rats: Modulation of Glucose Metabolism, Oxidative Stress, and Inflammation Biomarkers.
Topics: Animals; Chitosan; Diabetes Mellitus, Experimental; Glucose; Glucosides; Inflammation; Lipid Peroxid | 2021 |
Ameliorative effect of rubiadin-loaded nanocarriers in STZ-NA-induced diabetic nephropathy in rats: formulation optimization, molecular docking, and in vivo biological evaluation.
Topics: Animals; Anthraquinones; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Liposomes; Molecul | 2022 |
Nicotinamide attenuates streptozotocin-induced diabetes complications and increases survival rate in rats: role of autonomic nervous system.
Topics: Animals; Autonomic Nervous System; Baroreflex; Blood Pressure; Diabetes Mellitus, Experimental; Hear | 2021 |
Streptozotocin produces oxidative stress, inflammation and decreases BDNF concentrations to induce apoptosis of RIN5F cells and type 2 diabetes mellitus in Wistar rats.
Topics: Animals; Apoptosis; Blood Glucose; Brain-Derived Neurotrophic Factor; Cell Line; Cell Survival; Diab | 2017 |
Effects of different aerobic exercise frequencies on streptozotocin-nicotinamide-induced type 2 diabetic rats: Continuous versus short bouts and weekend warrior exercises.
Topics: Animals; Antibiotics, Antineoplastic; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Gl | 2018 |
Antidiabetogenic efficiency of menthol, improves glucose homeostasis and attenuates pancreatic β-cell apoptosis in streptozotocin-nicotinamide induced experimental rats through ameliorating glucose metabolic enzymes.
Topics: Animals; Apoptosis; Blood Glucose; Diabetes Mellitus, Experimental; Glucose; Homeostasis; Hypoglycem | 2017 |
Antihyperalgesic activity of a mexicanolide isolated from Swietenia humilis extract in nicotinamide-streptozotocin hyperglycemic mice.
Topics: Analgesics; Animals; Diabetes Mellitus, Experimental; Hyperalgesia; Hyperglycemia; Hypoglycemic Agen | 2017 |
Evaluation of anti-diabetic activity of glycyrrhizin-loaded nanoparticles in nicotinamide-streptozotocin-induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Drug Delivery Systems; Drug Lib | 2017 |
Anti-Inflammatory, Antiapoptotic and Proproliferative Effects of Vitis vinifera Seed Ethanolic Extract in the Liver of Streptozotocin-Nicotinamide-Induced Type 2 Diabetes in Male Rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Apoptosis; Cell Proliferation; Diabetes Mellitus, E | 2018 |
Effect of the Polyphenol Rich Ethyl Acetate Fraction from the Leaves of Lycium chinenseMill. on Oxidative Stress, Dyslipidemia, and Diabetes Mellitus in Streptozotocin-Nicotinamide Induced Diabetic Rats.
Topics: Acetates; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Dyslipidemias; Lyciu | 2017 |
Urine Metabonomics Reveals Early Biomarkers in Diabetic Cognitive Dysfunction.
Topics: 5-Hydroxytryptophan; Animals; Biomarkers; Cognitive Dysfunction; Diabetes Mellitus, Experimental; Di | 2017 |
Epigallocatechin-3-gallate protects against diabetic cardiomyopathy through modulating the cardiometabolic risk factors, oxidative stress, inflammation, cell death and fibrosis in streptozotocin-nicotinamide-induced diabetic rats.
Topics: Animals; Apoptosis; Biomarkers; Cardiotonic Agents; Catechin; Cytokines; Diabetes Mellitus, Experime | 2017 |
The SGLT2 Inhibitor Luseogliflozin Rapidly Normalizes Aortic mRNA Levels of Inflammation-Related but Not Lipid-Metabolism-Related Genes and Suppresses Atherosclerosis in Diabetic ApoE KO Mice.
Topics: Animals; Aorta; Apolipoproteins E; Atherosclerosis; Cell Adhesion Molecules; Cytokines; Diabetes Mel | 2017 |
Myrciaria cauliflora extract improves diabetic nephropathy via suppression of oxidative stress and inflammation in streptozotocin-nicotinamide mice.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Inflammation; Mice; Myrtaceae; Nia | 2016 |
Nephroprotective effect of Paeonia emodi via inhibition of advanced glycation end products and oxidative stress in streptozotocin-nicotinamide induced diabetic nephropathy.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Glycation End Products, Advanced; | 2017 |
Marantodes pumilum (Kacip fatimah) enhances in-vitro glucose uptake in 3T3-L1 adipocyte cells and reduces pancreatic complications in streptozotocin-nicotinamide induced male diabetic rats.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Antioxidants; Biological Transport; Blood Glucose; Diabetes Melli | 2017 |
Caffeine at a Moderate Dose Did Not Affect the Skeletal System of Rats with Streptozotocin-Induced Diabetes.
Topics: Animals; Bone and Bones; Caffeine; Coffee; Diabetes Mellitus, Experimental; Dose-Response Relationsh | 2017 |
Exenatide upregulates gene expression of glucagon-like peptide-1 receptor and nerve growth factor in streptozotocin/nicotinamide-induced diabetic mice.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Exenatide; Glucagon-Like Peptid | 2018 |
Effect of Seleno-L-methionine on Oxidative Stress in the Pancreatic Islets of a Short-Term Induced Diabetic Mouse Model in Insufficient Selenium Status.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose Tolerance Test; Glycate | 2018 |
Eugenosedin-A improves glucose metabolism and inhibits MAPKs expression in streptozotocin/nicotinamide-induced diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diet, High-Fat; Gene Expression Regulation; | 2018 |
Silymarin prevents lipid accumulation in the liver of rats with type 2 diabetes via sirtuin1 and SREBP-1c.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dose-Response Relationship, Dru | 2018 |
Oral Glucose Tolerance and Tryptophan Metabolism in Non-Obese and Non-Insulin-Dependent Diabetic Goto-Kakizaki Rats Fed High-Tryptophan Diets.
Topics: Animals; Blood Glucose; Body Weight; Cholesterol; Creatinine; Diabetes Mellitus, Experimental; Diet; | 2018 |
Effects of exercise training on adipose tissue apelin expression in streptozotocin-nicotinamide induced diabetic rats.
Topics: Adipose Tissue; Animals; Apelin; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabet | 2018 |
Garlic (Allium sativum) increases SIRT1 and SIRT2 gene expressions in the kidney and liver tissues of STZ- and STZ+niacinamide-induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Garlic; Gene Expression; Kidney; Liver; Male; Niacinamide; | 2018 |
Betanin exhibits significant potential as an antihyperglycemic and attenuating the glycoprotein components in streptozotocin-nicotinamide-induced experimental rats.
Topics: Animals; Betacyanins; Biomarkers; Body Weight; Combined Modality Therapy; Diabetes Mellitus, Experim | 2018 |
Oral supplementation with melatonin reduces oxidative damage and concentrations of inducible nitric oxide synthase, VEGF and matrix metalloproteinase 9 in the retina of rats with streptozotocin/nicotinamide induced pre-diabetes.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Retinopathy; Humans; | 2018 |
The response of serum Glypican-4 levels and its potential regulatory mechanism to endurance training and chamomile flowers' hydroethanolic extract in streptozotocin-nicotinamide-induced diabetic rats.
Topics: Animals; Blood Glucose; Chamomile; Diabetes Mellitus, Experimental; Ethanol; Flowers; Glypicans; Ins | 2018 |
Mechanistic insights into the augmented effect of bone marrow mesenchymal stem cells and thiazolidinediones in streptozotocin-nicotinamide induced diabetic rats.
Topics: Animals; Antibiotics, Antineoplastic; Cells, Cultured; Combined Modality Therapy; Diabetes Mellitus, | 2018 |
Therapeutic effect of vitamin B
Topics: Alloxan; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, T | 2018 |
Restorative potentiality of S-allylcysteine against diabetic nephropathy through attenuation of oxidative stress and inflammation in streptozotocin-nicotinamide-induced diabetic rats.
Topics: Animals; Antineoplastic Agents; Antioxidants; Cysteine; Diabetes Mellitus, Experimental; Diabetic Ne | 2019 |
Ameliorative potential of Cortex Lycii on enzymes involved in carbohydrate metabolism in streptozotocin-nicotinamide induced diabetic rats.
Topics: Animals; Biomarkers; Blood Glucose; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Dose-R | 2018 |
Moringa concanensis Nimmo extracts ameliorates hyperglycemia-mediated oxidative stress and upregulates PPARγ and GLUT4 gene expression in liver and pancreas of streptozotocin-nicotinamide induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Gene Expression; Glucose Transporter Type 4; Hyperglycemia | 2019 |
Anti-hyperglycemic and anti-hyperlipidemic effects of rhinacanthins-rich extract from Rhinacanthus nasutus leaves in nicotinamide-streptozotocin induced diabetic rats.
Topics: Acanthaceae; Animals; Body Weight; Computer Simulation; Diabetes Mellitus, Experimental; Eating; Gly | 2019 |
Hepato-protective effects of Glossogyne tenuifolia in Streptozotocin-nicotinamide-induced diabetic rats on high fat diet.
Topics: Animals; Asteraceae; Diabetes Mellitus, Experimental; Diet, High-Fat; Drug Evaluation, Preclinical; | 2019 |
Resveratrol supplementation improves DNA integrity and sperm parameters in streptozotocin-nicotinamide-induced type 2 diabetic rats.
Topics: Animals; Antioxidants; Chromatin; Chromatin Assembly and Disassembly; Diabetes Mellitus, Experimenta | 2019 |
Antidiabetic activity enhancement in streptozotocin + nicotinamide-induced diabetic rats through combinational polymeric nanoformulation.
Topics: Animals; Benzoquinones; Blood Glucose; Body Weight; Calorimetry, Differential Scanning; Diabetes Mel | 2019 |
Modulatory effect of zingerone against STZ-nicotinamide induced type-2 diabetes mellitus in rats.
Topics: Animals; Antibiotics, Antineoplastic; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Melli | 2021 |
Resveratrol improves diabetic retinopathy possibly through oxidative stress - nuclear factor κB - apoptosis pathway.
Topics: Administration, Oral; Animals; Antioxidants; Apoptosis; Blood Glucose; Body Weight; Diabetes Mellitu | 2012 |
Oral L-glutamine increases active GLP-1 (7-36) amide secretion and improves glycemic control in stretpozotocin-nicotinamide induced diabetic rats.
Topics: Administration, Oral; Animals; Blood Glucose; Body Weight; Colon; Diabetes Mellitus, Experimental; D | 2013 |
Effect of silymarin on streptozotocin-nicotinamide-induced type 2 diabetic nephropathy in rats.
Topics: Albuminuria; Animals; Blood Glucose; Case-Control Studies; Creatinine; Diabetes Mellitus, Experiment | 2013 |
Antidiabetic activity of alkaloids of Aerva lanata roots on streptozotocin-nicotinamide induced type-II diabetes in rats.
Topics: Administration, Oral; Alkaloids; Amaranthaceae; Animals; Blood Glucose; Chromatography, Thin Layer; | 2013 |
Effect of Biophytum sensitivum on streptozotocin and nicotinamide-induced diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Enzymes; Glycated Hemoglobin; Glycogen; Hyp | 2012 |
[Protective effect of cytoflavin and its components in mice with acute alloxan intoxication].
Topics: Acute Disease; Animals; Behavior, Animal; Diabetes Mellitus, Experimental; Drug Combinations; Female | 2013 |
Exacerbation of glycoprotein VI-dependent platelet responses in a rhesus monkey model of Type 1 diabetes.
Topics: Animals; Blood Platelets; Calcium; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Femal | 2013 |
Ameliorative effect of naringenin on hyperglycemia-mediated inflammation in hepatic and pancreatic tissues of Wistar rats with streptozotocin- nicotinamide-induced experimental diabetes mellitus.
Topics: Animals; Antioxidants; C-Reactive Protein; Cytokines; Diabetes Mellitus, Experimental; Flavanones; H | 2013 |
Metabolic disturbances and defects in insulin secretion in rats with streptozotocin-nicotinamide-induced diabetes.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Disease Models, Animal; Glucagon; Glucose | 2013 |
Population pharmacodynamic modeling of exenatide after 2-week treatment in STZ/NA diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Progress | 2013 |
Effect of concomitant administration of L-glutamine and cycloart-23-ene-3β, 25-diol (B2) with sitagliptin in GLP-1 (7-36) amide secretion, biochemical and oxidative stress in streptozotocin - nicotinamide induced diabetic Sprague Dawley rats.
Topics: Animals; Biomarkers; Blood Glucose; Body Weight; Colon; Diabetes Mellitus, Experimental; Drinking Be | 2013 |
Evaluation of in silico, in vitro α-amylase inhibition potential and antidiabetic activity of Pterospermum acerifolium bark.
Topics: Animals; Computer Simulation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dose-Respo | 2014 |
Amelioration of diabetes-induced neurobehavioral and neurochemical changes by melatonin and nicotinamide: implication of oxidative stress-PARP pathway.
Topics: Animals; Diabetes Mellitus, Experimental; Male; Melatonin; Niacinamide; Oxidative Stress; Poly(ADP-r | 2013 |
Protective effects of a nicotinamide derivative, isonicotinamide, against streptozotocin-induced β-cell damage and diabetes in mice.
Topics: Animals; Apoptosis; Cytoprotection; Diabetes Mellitus, Experimental; Diet, High-Fat; Hypoglycemic Ag | 2013 |
Nicotinamide improves glucose metabolism and affects the hepatic NAD-sirtuin pathway in a rodent model of obesity and type 2 diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, | 2014 |
Diabetic characteristics and alveolar bone loss in streptozotocin- and streptozotocin-nicotinamide-treated rats with periodontitis.
Topics: Alveolar Bone Loss; Animals; Blood Glucose; Body Weight; Bone Matrix; Bone Resorption; Diabetes Mell | 2014 |
Antihyperglycemic, hypolipidemic and antioxidant activities of total saponins extracted from Aralia taibaiensis in experimental type 2 diabetic rats.
Topics: Animals; Antioxidants; Aralia; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Ty | 2014 |
Anti-diabetic properties of a non-conventional radical scavenger, as compared to pioglitazone and exendin-4, in streptozotocin-nicotinamide diabetic mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Exenatide; Free Radical Scavengers; Hypogly | 2014 |
Two new compounds from the aerial parts of Bergenia himalaica Boriss and their anti-hyperglycemic effect in streptozotocin-nicotinamide induced diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Furans; Heterocyclic Compounds, 4 o | 2014 |
Adipocyte dysfunction in rats with streptozotocin-nicotinamide-induced diabetes.
Topics: Adipocytes; Adipose Tissue; Alanine; Animals; Diabetes Mellitus, Experimental; Glucose; Lipogenesis; | 2014 |
Mechanism of protection by soluble epoxide hydrolase inhibition in type 2 diabetic stroke.
Topics: Analysis of Variance; Animals; Benzoates; Blood Glucose; Blotting, Western; Brain; Diabetes Mellitus | 2014 |
Insulin-loaded alginic acid nanoparticles for sublingual delivery.
Topics: Adhesiveness; Administration, Sublingual; Alginates; Animals; Biomarkers; Blood Glucose; Calorimetry | 2016 |
Inhibition of phosphodiesterase 3B in insulin-secreting cells of normal and streptozocin-nicotinamide-induced diabetic rats: implications for insulin secretion.
Topics: Amrinone; Animals; Cyclic Nucleotide Phosphodiesterases, Type 3; Diabetes Mellitus, Experimental; Do | 2014 |
Antidiabetic activity of Acacia tortilis (Forsk.) Hayne ssp. raddiana polysaccharide on streptozotocin-nicotinamide induced diabetic rats.
Topics: Acacia; Alanine Transaminase; Animals; Aspartate Aminotransferases; Blood Glucose; Body Weight; Chol | 2014 |
Effects of administering sodium selenite, methylseleninic acid, and seleno-L-methionine on glucose tolerance in a streptozotocin/nicotinamide-induced diabetic mouse model.
Topics: Animals; Biological Availability; Blood Glucose; Diabetes Mellitus, Experimental; Glucose Tolerance | 2014 |
Oxidative stress and cannabinoid receptor expression in type-2 diabetic rat pancreas following treatment with Δ⁹-THC.
Topics: Animals; Body Weight; Cannabinoid Receptor Agonists; Catalase; Diabetes Mellitus, Experimental; Dron | 2014 |
Efficacy of Mitiglinide Combined with Dapagliflozin in Streptozotocin-nicotinamide-induced Type 2 Diabetic Rats and in Zucker Fatty Rats.
Topics: Animals; Benzhydryl Compounds; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Ty | 2015 |
Antidiabetic activity of benzopyrone analogues in nicotinamide-streptozotocin induced type 2 diabetes in rats.
Topics: Animals; Biomarkers; Blood Glucose; Coumarins; Creatinine; Diabetes Mellitus, Experimental; Diabetes | 2014 |
Abroma augusta L. (Malvaceae) leaf extract attenuates diabetes induced nephropathy and cardiomyopathy via inhibition of oxidative stress and inflammatory response.
Topics: Adenosine Triphosphate; Animals; Biomarkers; Blood Glucose; Body Weight; Cardiomyopathies; Diabetes | 2015 |
Δ9-tetrahydrocannabinol treatment improved endothelium-dependent relaxation on streptozotocin/nicotinamide-induced diabetic rat aorta.
Topics: Animals; Aorta; Diabetes Mellitus, Experimental; Diabetic Angiopathies; Dronabinol; Endothelium, Vas | 2015 |
Cardioprotective Activity of Pongamia pinnata in Streptozotocin-Nicotinamide Induced Diabetic Rats.
Topics: Animals; Antioxidants; Blood Glucose; Cardiotonic Agents; Diabetes Mellitus, Experimental; Glucose T | 2015 |
Puerarin improves cardiac function through regulation of energy metabolism in Streptozotocin-Nicotinamide induced diabetic mice after myocardial infarction.
Topics: Animals; Diabetes Mellitus, Experimental; Energy Metabolism; Heart; Isoflavones; Male; Mice; Mice, I | 2015 |
Effects of 1-Methylnicotinamide (MNA) on Exercise Capacity and Endothelial Response in Diabetic Mice.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Epoprostenol; | 2015 |
Dietary resistant maltodextrin ameliorates testicular function and spermatogenesis in streptozotocin-nicotinamide-induced diabetic rats.
Topics: 17-Hydroxysteroid Dehydrogenases; 3-Hydroxysteroid Dehydrogenases; Animals; Apoptosis; Diabetes Mell | 2016 |
Ethyl acetate fraction of Cissus quadrangularis stem ameliorates hyperglycaemia-mediated oxidative stress and suppresses inflammatory response in nicotinamide/streptozotocin induced type 2 diabetic rats.
Topics: Animals; Antioxidants; Blood Glucose; Cissus; Cytokines; Diabetes Mellitus, Experimental; Glycated H | 2015 |
Streptozotocin-Induced Diabetic Models in Mice and Rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diet | 2015 |
Extract of Woodfordia fruticosa flowers ameliorates hyperglycemia, oxidative stress and improves β-cell function in streptozotocin-nicotinamide induced diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Flowers; Glucose Transporter Type 2; Glucose Transporter T | 2015 |
Potential impact of sitagliptin on collagen-derived dipeptides in diabetic osteoporosis.
Topics: Amino Acids; Animals; Collagen; Diabetes Mellitus, Experimental; Dipeptides; Dipeptidyl Peptidase 4; | 2015 |
The Effects of Probiotic Soymilk Fortified with Omega-3 on Blood Glucose, Lipid Profile, Haematological and Oxidative Stress, and Inflammatory Parameters in Streptozotocin Nicotinamide-Induced Diabetic Rats.
Topics: Animals; Blood Glucose; Body Weight; C-Reactive Protein; Cholesterol; Diabetes Mellitus, Experimenta | 2015 |
Antinociceptive and hypoglycaemic evaluation of Conyza filaginoides (D.C.) Hieron Asteraceae.
Topics: Analgesics; Animals; Behavior, Animal; Biomarkers; Blood Glucose; Conyza; Diabetes Mellitus, Experim | 2015 |
Coadministration of alloxan and nicotinamide in rats produces biochemical changes in blood and pathological alterations comparable to the changes in type II diabetes mellitus.
Topics: Adiponectin; Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Ty | 2016 |
Effects of the combination of SGLT2 selective inhibitor ipragliflozin and various antidiabetic drugs in type 2 diabetic mice.
Topics: Animals; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet | 2016 |
Rhinacanthin C ameliorates hyperglycaemia, hyperlipidemia and pancreatic destruction in streptozotocin-nicotinamide induced adult male diabetic rats.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, D | 2016 |
Antidiabetic, antihyperlipidaemic, and antioxidant activity of Syzygium densiflorum fruits in streptozotocin and nicotinamide-induced diabetic rats.
Topics: Animals; Antioxidants; Biomarkers; Blood Glucose; Cell Proliferation; Diabetes Mellitus, Experimenta | 2016 |
Insulin-Producing Cells Differentiated from Human Bone Marrow Mesenchymal Stem Cells In Vitro Ameliorate Streptozotocin-Induced Diabetic Hyperglycemia.
Topics: Adipocytes; Animals; Apoptosis; Bone Marrow Cells; Calcium Channels; Cell Differentiation; Chondrocy | 2016 |
Effects of Trigonelline, an Alkaloid Present in Coffee, on Diabetes-Induced Disorders in the Rat Skeletal System.
Topics: Alkaloids; Animals; Biomarkers; Bone Density; Coffea; Diabetes Complications; Diabetes Mellitus, Exp | 2016 |
Dietary flaxseed oil and fish oil ameliorates renal oxidative stress, protein glycation, and inflammation in streptozotocin-nicotinamide-induced diabetic rats.
Topics: Animals; Biomarkers; Diabetes Mellitus, Experimental; Dietary Fats, Unsaturated; Fatty Acids, Omega- | 2016 |
Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice.
Topics: Animals; Blood Glucose; Cornea; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Diet, High-F | 2016 |
Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice.
Topics: Animals; Blood Glucose; Cornea; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Diet, High-F | 2016 |
Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice.
Topics: Animals; Blood Glucose; Cornea; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Diet, High-F | 2016 |
Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice.
Topics: Animals; Blood Glucose; Cornea; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Diet, High-F | 2016 |
Evaluation of wound healing properties of bioactive aqueous fraction from Moringa oleifera Lam on experimentally induced diabetic animal model.
Topics: Animals; Anti-Bacterial Agents; Apigenin; Diabetes Mellitus, Experimental; Diabetic Foot; Disease Mo | 2016 |
The anti-diabetic activity of oat β-d-glucan in streptozotocin-nicotinamide induced diabetic mice.
Topics: Animals; beta-Glucans; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Drinking; Fastin | 2016 |
Preparation and characterization of alginate/silver/nicotinamide nanocomposites for treating diabetic wounds.
Topics: Administration, Cutaneous; Alginates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Bandages; Bu | 2016 |
Antidiabetic activity of Syzygium calophyllifolium in Streptozotocin-Nicotinamide induced Type-2 diabetic rats.
Topics: Animals; Antioxidants; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Hypo | 2016 |
Antidiabetic, antihyperlipidemic and anti-inflammatory effects of tilianin in streptozotocin-nicotinamide diabetic rats.
Topics: 3T3-L1 Cells; Adipose Tissue; Animals; Anti-Inflammatory Agents; Aorta; Blood Glucose; Diabetes Mell | 2016 |
Methanolic seed extract of Vitis vinifera ameliorates oxidative stress, inflammation and ATPase dysfunction in infarcted and non-infarcted heart of streptozotocin-nicotinamide induced male diabetic rats.
Topics: Adenosine Triphosphatases; Animals; Diabetes Mellitus, Experimental; Grape Seed Extract; Inflammatio | 2016 |
Hypoglycemic and Antioxidant Activities of the Water Extract of Aquilaria crassna Leaves in Streptozotocin-Nicotinamide-Induced Type-2 Diabetic Mice.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Hu | 2016 |
Effects of Nitrate Intake on Myocardial Ischemia-Reperfusion Injury in Diabetic Rats.
Topics: Animals; Cardiotonic Agents; Coronary Vessels; Diabetes Mellitus, Experimental; Diabetes Mellitus, T | 2016 |
Effects of ferric citrate supplementation on advanced glycation end products in a rat model of streptozotocin/nicotinamide-induced diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Dietary Supplements; Dose-Response Relationship, Drug; Fat | 2017 |
Effects of garlic extract on TNF-α expression and oxidative stress status in the kidneys of rats with STZ + nicotinamide-induced diabetes.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Blood Glucose; Diabetes Mellitus, Exper | 2017 |
Quercetin ameliorates oxidative stress, inflammation and apoptosis in the heart of streptozotocin-nicotinamide-induced adult male diabetic rats.
Topics: Animals; Apoptosis; Blood Glucose; Blood Pressure; Diabetes Mellitus, Experimental; Heart; Heart Rat | 2017 |
Differentiation of Islet Progenitors Regulated by Nicotinamide into Transcriptome-Verified β Cells That Ameliorate Diabetes.
Topics: Animals; Cell Differentiation; Diabetes Mellitus, Experimental; Down-Regulation; Gene Knockdown Tech | 2017 |
Ameliorating effect of betanin, a natural chromoalkaloid by modulating hepatic carbohydrate metabolic enzyme activities and glycogen content in streptozotocin - nicotinamide induced experimental rats.
Topics: Animals; Betacyanins; Biomarkers; Blood Glucose; Body Weight; Carbohydrate Metabolism; Diabetes Mell | 2017 |
Pancreatoprotective effects of Geniotrigona thoracica stingless bee honey in streptozotocin-nicotinamide-induced male diabetic rats.
Topics: Animals; Apoptosis; Bees; Blood Glucose; Diabetes Mellitus, Experimental; Honey; Hypoglycemic Agents | 2017 |
Antidiabetic properties of the alcoholic extract of Sphaeranthus indicus in streptozotocin-nicotinamide diabetic rats.
Topics: Animals; Asteraceae; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Glycated Hemoglobi | 2008 |
Effects of nicotinamide supplementation on liver and serum contents of amino acids in diabetic rats.
Topics: Amino Acids; Animals; Body Weight; Diabetes Mellitus, Experimental; Glutathione; Humans; Liver; Male | 2008 |
Resveratrol, a natural phytoalexin, normalizes hyperglycemia in streptozotocin-nicotinamide induced experimental diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Glucose Tolerance Test; Hyperglycemia; Hypoglycemic Agents | 2008 |
Chronic inhibition of dipeptidyl peptidase-IV with ASP8497 improved the HbA(1c) level, glucose intolerance, and lipid parameter level in streptozotocin-nicotinamide-induced diabetic mice.
Topics: Administration, Oral; Animals; Diabetes Mellitus, Experimental; Dipeptidyl-Peptidase IV Inhibitors; | 2009 |
Hypoglycaemic effects of antidiabetic drugs in streptozotocin-nicotinamide-induced mildly diabetic and streptozotocin-induced severely diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucose Tolerance Test; Hypoglycemic Agents | 2008 |
Effects of antidiabetic drugs on glucose tolerance in streptozotocin-nicotinamide-induced mildly diabetic and streptozotocin-induced severely diabetic mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucagon-Like Peptide 1; Glucose Intoleranc | 2008 |
Effect of guava (Psidium guajava Linn.) leaf soluble solids on glucose metabolism in type 2 diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose Toleranc | 2008 |
Antidiabetic effect through islet cell protection in streptozotocin diabetes: a preliminary assessment of two thiazolidin-4-ones in Swiss albino mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Islets of Langerhans; | 2009 |
Modulatory effects of resveratrol on attenuating the key enzymes activities of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats.
Topics: Administration, Oral; Animals; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Disease Mod | 2009 |
Production of L-tryptophan-derived catabolites in hepatocytes from streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Carboxy-Lyases; Diabetes Mellitus, Experimental; Hepatocytes; Kynurenine; Ma | 2009 |
Effects of the combination of dipeptidyl peptidase-IV inhibitor ASP8497 and antidiabetic drugs in streptozotocin-nicotinamide-induced mildly diabetic mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl-Pepti | 2009 |
Antidiabetic effects of dipeptidyl peptidase-IV inhibitors and sulfonylureas in streptozotocin-nicotinamide-induced mildly diabetic mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptidyl-Pepti | 2009 |
Effect of nicotinamide on experimental induced diabetes.
Topics: Animals; Apoptosis; Blood Glucose; Body Weight; C-Peptide; Diabetes Mellitus, Experimental; Insulin; | 2009 |
Effect of nicotinamide on early graft failure following intraportal islet transplantation.
Topics: Animals; Blood Glucose; Chemokine CCL2; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; | 2009 |
Construction of adiponectin-encoding plasmid DNA and gene therapy of non-obese type 2 diabetes mellitus.
Topics: Adiponectin; Animals; Blood Glucose; Cell Line; Cell Line, Tumor; Diabetes Mellitus, Experimental; D | 2010 |
1-methylnicotinamide (MNA) in prevention of diabetes-associated brain disorders.
Topics: Animals; Brain Diseases; Diabetes Mellitus, Experimental; Male; Niacinamide; Rats; Serotonin; Signal | 2010 |
Beneficial effects of thymoquinone on hepatic key enzymes in streptozotocin-nicotinamide induced diabetic rats.
Topics: Animals; Benzoquinones; Blood Glucose; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Liver; | 2009 |
Inhibitory effect of glimepiride on nicotinamide-streptozotocin induced nuclear damages and sperm abnormality in diabetic Wistar rats.
Topics: Animals; Cell Nucleus; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Male; Niacinamide; Rats | 2009 |
Antidiabetic activity of cycloart-23-ene-3beta, 25-diol (B2) isolated from Pongamia pinnata (L. Pierre) in streptozotocin-nicotinamide induced diabetic mice.
Topics: Animals; Diabetes Mellitus, Experimental; Glucose Tolerance Test; Glyburide; Hypoglycemic Agents; Mi | 2010 |
Resveratrol attenuates hyperglycemia-mediated oxidative stress, proinflammatory cytokines and protects hepatocytes ultrastructure in streptozotocin-nicotinamide-induced experimental diabetic rats.
Topics: Animals; Antioxidants; Cytokines; Diabetes Mellitus, Experimental; Gliclazide; Hepatocytes; Hypergly | 2010 |
Ameliorative potential of resveratrol on proinflammatory cytokines, hyperglycemia mediated oxidative stress, and pancreatic beta-cell dysfunction in streptozotocin-nicotinamide-induced diabetic rats.
Topics: Animals; Antioxidants; Blood Glucose; Cytokines; Diabetes Mellitus, Experimental; Fasting; Hyperglyc | 2010 |
Comparative and combined effect of chlorogenic acid and tetrahydrocurcumin on antioxidant disparities in chemical induced experimental diabetes.
Topics: Animals; Antioxidants; Chlorogenic Acid; Curcumin; Diabetes Mellitus, Experimental; Diabetes Mellitu | 2010 |
A comparative study of flavonoid analogues on streptozotocin-nicotinamide induced diabetic rats: quercetin as a potential antidiabetic agent acting via 11beta-hydroxysteroid dehydrogenase type 1 inhibition.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Animals; Blood Glucose; Computational Biology; Database | 2010 |
Antihyperglycemic effect of diosmin on hepatic key enzymes of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats.
Topics: Animals; Blood Glucose; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Diosmin; Dose-Resp | 2010 |
Combined treatment of tetrahydrocurcumin and chlorogenic acid exerts potential antihyperglycemic effect on streptozotocin-nicotinamide-induced diabetic rats.
Topics: Animals; Chlorogenic Acid; Curcumin; Diabetes Mellitus, Experimental; Drug Combinations; Feasibility | 2010 |
Differentiation of mesenchymal stem cells to insulin-producing cells and their impact on type 1 diabetic rats.
Topics: Alloxan; Animals; Cell Differentiation; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; | 2010 |
Persistent correction of hyperglycemia in streptozotocin-nicotinamide-induced diabetic mice by a non-conventional radical scavenger.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Free Radical Scavengers; Glucose Tolerance | 2010 |
Antihyperglycemic effects of baicalin on streptozotocin - nicotinamide induced diabetic rats.
Topics: Adiponectin; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Flavonoids; Glycogen; Hexokina | 2011 |
Antihyperlipidemic effect of chlorogenic acid and tetrahydrocurcumin in rats subjected to diabetogenic agents.
Topics: Animals; Chlorogenic Acid; Curcumin; Diabetes Mellitus, Experimental; Drug Combinations; Hydroxymeth | 2010 |
Comparative study of the binding characteristics to and inhibitory potencies towards PARP and in vivo antidiabetogenic potencies of taurine, 3-aminobenzamide and nicotinamide.
Topics: Animals; Benzamides; Blood Glucose; Catalytic Domain; Cholesterol; Diabetes Mellitus, Experimental; | 2010 |
Ursolic acid ameliorates thymic atrophy and hyperglycemia in streptozotocin-nicotinamide-induced diabetic mice.
Topics: Animals; Atrophy; Blood Glucose; Body Weight; Cell Proliferation; Cytokines; Diabetes Mellitus, Expe | 2010 |
Antidiabetic potential of α-amylase inhibitor from the seeds of Macrotyloma uniflorum in streptozotocin-nicotinamide-induced diabetic mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Enzyme Inhibitor | 2011 |
Inhibition of soluble epoxide hydrolase attenuates endothelial dysfunction in animal models of diabetes, obesity and hypertension.
Topics: Adamantane; Administration, Oral; Animals; Aorta; Diabetes Mellitus, Experimental; Diabetes Mellitus | 2011 |
Effects of antidiabetic drugs in high-fat diet and streptozotocin-nicotinamide-induced type 2 diabetic mice.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dietary Fats; Drug Administrati | 2011 |
Antidiabetic activity of standardized extract of Quassia amara in nicotinamide-streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Glucose Tolerance Test; Glybur | 2011 |
Effects of dietary glutamine on inflammatory mediator gene expressions in rats with streptozotocin-induced diabetes.
Topics: Animals; Blood Glucose; Chemokine CCL2; Diabetes Mellitus, Experimental; Dietary Supplements; Diseas | 2012 |
Differentiation of human labia minora dermis-derived fibroblasts into insulin-producing cells.
Topics: Animals; Biomarkers; Cell Culture Techniques; Cell Differentiation; Cell Proliferation; Cell Separat | 2012 |
Ameliorative effect of diosmin, a citrus flavonoid against streptozotocin-nicotinamide generated oxidative stress induced diabetic rats.
Topics: Administration, Oral; Animals; Ascorbic Acid; Catalase; Diabetes Mellitus, Experimental; Diosmin; Gl | 2012 |
Antidiabetic activity of alcoholic leaves extract of Alangium lamarckii Thwaites on streptozotocin-nicotinamide induced type 2 diabetic rats.
Topics: Alangiaceae; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitus | 2011 |
Effects of N1-methylnicotinamide on oxidative and glycooxidative stress markers in rats with streptozotocin-induced diabetes mellitus.
Topics: Animals; Antioxidants; Biomarkers; Diabetes Mellitus, Experimental; DNA Damage; Drug Evaluation, Pre | 2012 |
Difference in glucose intolerance between C57BL/6J and ICR strain mice with streptozotocin/nicotinamide-induced diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Glucose Intolerance | 2012 |
The effect of hydro alcoholic extract of Juglans regia leaves in streptozotocin-nicotinamide induced diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Juglans; Male; Niacinamide; Phytotherapy; P | 2012 |
In vitro (α-glucosidase and α-amylase inhibition) and in vivo antidiabetic property of phytic acid (IP6) in streptozotocin- nicotinamide-induced type 2 diabetes mellitus (NIDDM) in rats.
Topics: alpha-Amylases; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Free Radical S | 2011 |
Immunostimulant, cerebroprotective & nootropic activities of Andrographis paniculata leaves extract in normal & type 2 diabetic rats.
Topics: Andrographis; Animals; Antioxidants; Diabetes Mellitus, Experimental; Immunization; Lipid Peroxidati | 2012 |
Protective effect of Luffa acutangula extracts on gastric ulceration in NIDDM rats: role of gastric mucosal glycoproteins and antioxidants.
Topics: Animals; Antioxidants; Aspirin; Biomarkers; Catalase; Diabetes Mellitus, Experimental; Dose-Response | 2012 |
The aqueous extract of Withania coagulans fruit partially reverses nicotinamide/streptozotocin-induced diabetes mellitus in rats.
Topics: Animals; Diabetes Mellitus, Experimental; Fruit; Glucose; Glycated Hemoglobin; Humans; Hypoglycemic | 2012 |
Experimentally induced rodent models of type 2 diabetes.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Fetal | 2012 |
Antidiabetic effects of SGLT2-selective inhibitor ipragliflozin in streptozotocin-nicotinamide-induced mildly diabetic mice.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glucose; Glucose Tolerance Test | 2012 |
Meliacinolin: a potent α-glucosidase and α-amylase inhibitor isolated from Azadirachta indica leaves and in vivo antidiabetic property in streptozotocin-nicotinamide-induced type 2 diabetes in mice.
Topics: alpha-Amylases; Animals; Azadirachta; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Di | 2012 |
Cycloart-23-ene-3β, 25-diol stimulates GLP-1 (7-36) amide secretion in streptozotocin-nicotinamide induced diabetic Sprague Dawley rats: a mechanistic approach.
Topics: Animals; Biomarkers; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Drinking; Gene Exp | 2013 |
Nicotinamide supplementation protects gestational diabetic rats by reducing oxidative stress and enhancing immune responses.
Topics: Animals; Blood Glucose; Catalase; Cell Proliferation; Diabetes Mellitus, Experimental; Diabetes, Ges | 2012 |
Long-term treatment with resveratrol attenuates oxidative stress pro-inflammatory mediators and apoptosis in streptozotocin-nicotinamide-induced diabetic rats.
Topics: Animals; Apoptosis; Cytokines; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Inflammation Me | 2012 |
Antidiabetic actions of an estrogen receptor β selective agonist.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Experimental; Enzyme-Linked Immunosorbent Assay; Estrog | 2013 |
Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells.
Topics: Androstadienes; Animals; Biomarkers; Cell Aggregation; Cell Differentiation; Cell Line; Diabetes Mel | 2002 |
Isulinotropic properties of Nigella sativa oil in Streptozotocin plus Nicotinamide diabetic hamster.
Topics: Animals; Blood Glucose; Cricetinae; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Immu | 2002 |
Measurements of insulin secretory capacity and glucose tolerance to predict pancreatic beta-cell mass in vivo in the nicotinamide/streptozotocin Göttingen minipig, a model of moderate insulin deficiency and diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Forecasting; Glucose Tolerance Test; Insulin; Insulin Secr | 2003 |
Augmented lipopolysaccharide-induction of the histamine-forming enzyme in streptozotocin-induced diabetic mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Histamine; Histidine Decarboxylase; Lipopol | 2003 |
Reduced tubular cation transport in diabetes: prevented by ACE inhibition.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Biological Transport; Cations; Diabetes Mellitus, | 2003 |
Human amnion-isolated cells normalize blood glucose in streptozotocin-induced diabetic mice.
Topics: Amniotic Fluid; Animals; beta 2-Microglobulin; Blastocyst; Blood Glucose; Diabetes Mellitus, Experim | 2003 |
[Effects of nicotinamide on ketone metabolism by liver of alloxan diabetic rats in vitro. II. Study of acetoacetate utilization by distillation method].
Topics: Acetoacetates; Alloxan; Animals; Diabetes Mellitus, Experimental; Distillation; In Vitro Techniques; | 1958 |
[Effects of nicotinamide on ketone metabolism by liver of aloxan diabetic rats in vitro. III. Study of acetoacetate utilization by colorimetric method].
Topics: Acetoacetates; Animals; Colorimetry; Diabetes Mellitus, Experimental; In Vitro Techniques; Liver; Ni | 1958 |
The inactivation of cortisol in experimental diabetic animals.
Topics: Anatomy; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Diabetes M | 1963 |
THE EFFECT OF DIFFERENT HORMONAL CONDITIONS ON THE CONCENTRATION AND OXIDOREDUCTION STATE OF THE NICOTINAMIDE NUCLEOTIDES OF RAT LIVER.
Topics: Adrenalectomy; Animals; Carbohydrate Metabolism; Cortisone; Diabetes Mellitus, Experimental; Glucago | 1965 |
The anti-hyperglycemic activity of the fruiting body of Cordyceps in diabetic rats induced by nicotinamide and streptozotocin.
Topics: Administration, Oral; Animals; Blood Glucose; Cordyceps; Diabetes Mellitus, Experimental; Diet; Dise | 2004 |
Alterations in vascular endothelial function in the aorta and mesenteric artery in type II diabetic rats.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Biological Factors; Chlorides; Diabetes Mellitus, Experimen | 2004 |
Insulinotropic agent ID-1101 (4-hydroxyisoleucine) activates insulin signaling in rat.
Topics: Animals; Diabetes Mellitus, Experimental; Diet; Enzyme Activation; Glucose; Glucose Clamp Technique; | 2004 |
The role of advanced glycation in reduced organic cation transport associated with experimental diabetes.
Topics: Animals; Cations; Diabetes Mellitus, Experimental; Glycation End Products, Advanced; Guanidines; Mal | 2004 |
Beta-cell function and islet morphology in normal, obese, and obese beta-cell mass-reduced Göttingen minipigs.
Topics: Animals; Blood Glucose; Cells, Cultured; Diabetes Mellitus, Experimental; Dietary Fats; Insulin; Ins | 2005 |
Cholecystokinin octapeptide: a potential growth factor for pancreatic beta cells in diabetic rats.
Topics: Animals; Blood Glucose; Cell Division; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; D | 2004 |
Reduction of beta cell mass: partial insulin secretory compensation from the residual beta cell population in the nicotinamide-streptozotocin Göttingen minipig after oral glucose in vivo and in the perfused pancreas.
Topics: Animals; Area Under Curve; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; D | 2004 |
Effect of glucagon-like peptide-1(7-36) and exendin-4 on the vascular reactivity in streptozotocin/nicotinamide-induced diabetic rats.
Topics: Animals; Aorta, Thoracic; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship | 2005 |
Measurements of insulin responses as predictive markers of pancreatic beta-cell mass in normal and beta-cell-reduced lean and obese Göttingen minipigs in vivo.
Topics: Animals; Arginine; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Glucose Tolerance Te | 2006 |
Effects of ingested fruiting bodies, submerged culture biomass, and acidic polysaccharide glucuronoxylomannan of Tremella mesenterica Retz.:Fr. on glycemic responses in normal and diabetic rats.
Topics: Agaricales; Animals; Biomass; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dia | 2006 |
Effect of pterostilbene on hepatic key enzymes of glucose metabolism in streptozotocin- and nicotinamide-induced diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Dose-Response Relationsh | 2006 |
Establishment and pathophysiological characterization of type 2 diabetic mouse model produced by streptozotocin and nicotinamide.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dietary Fats; Do | 2006 |
Antioxidant effect of tetrahydrocurcumin in streptozotocin-nicotinamide induced diabetic rats.
Topics: Animals; Antioxidants; Ascorbic Acid; Blood Glucose; Curcumin; Diabetes Mellitus, Experimental; Glut | 2006 |
Sexual dimorphism in insulin sensitivity and susceptibility to develop diabetes in rats.
Topics: Animals; Biomarkers; Blood Glucose; Body Composition; Diabetes Mellitus, Experimental; Disease Susce | 2006 |
Succinic acid monoethyl ester prevents oxidative stress in streptozotocin-nicotinamide-induced type2 diabetic rats.
Topics: Animals; Antioxidants; Ascorbic Acid; Blood Glucose; Catalase; Diabetes Mellitus, Experimental; Diab | 2006 |
Effect of tetrahydrocurcumin on lipid peroxidation and lipids in streptozotocin-nicotinamide-induced diabetic rats.
Topics: Animals; Blood Glucose; Cholesterol; Curcumin; Diabetes Mellitus, Experimental; Fatty Acids, Noneste | 2006 |
Antihyperglycemic effect of aporphines and their derivatives in normal and diabetic rats.
Topics: Animals; Aporphines; Blood Glucose; Diabetes Mellitus, Experimental; Hypoglycemic Agents; Insulin; M | 2006 |
Nicotinamide reverses neurological and neurovascular deficits in streptozotocin diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Lipid P | 2007 |
The association of acetyl-l-carnitine and nicotinamide remits the experimental diabetes in mice by multiple low-dose streptozotocin.
Topics: Acetylcarnitine; Animals; Blood Glucose; Body Weight; Cells, Cultured; Diabetes Mellitus, Experiment | 2006 |
Anti-hyperglycemic activity of natural and fermented Cordyceps sinensis in rats with diabetes induced by nicotinamide and streptozotocin.
Topics: Animals; Biological Products; Blood Glucose; Cordyceps; Culture Media, Conditioned; Diabetes Mellitu | 2006 |
The antioxidant role of pterostilbene in streptozotocin-nicotinamide-induced type 2 diabetes mellitus in Wistar rats.
Topics: Administration, Oral; Animals; Antioxidants; Blood Glucose; Catalase; Diabetes Mellitus, Experimenta | 2006 |
Changes in glycoprotein components in streptozotocin--nicotinamide induced type 2 diabetes: influence of tetrahydrocurcumin from Curcuma longa.
Topics: Animals; Blood Glucose; Curcuma; Curcumin; Diabetes Mellitus, Experimental; Glycoproteins; Insulin; | 2007 |
Effect of tetrahydrocurcumin on plasma antioxidants in streptozotocin-nicotinamide experimental diabetes.
Topics: Animals; Anticarcinogenic Agents; Antioxidants; Ascorbic Acid; Blood Glucose; Ceruloplasmin; Curcumi | 2006 |
Nongenetic model of type 2 diabetes: a comparative study.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dietary Fats; Male; Niacinamide | 2007 |
Beneficial effect of succinic acid monoethyl ester on erythrocyte membrane bound enzymes and antioxidant status in streptozotocin-nicotinamide induced type 2 diabetes.
Topics: Adenosine Triphosphatases; Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Di | 2007 |
GLUT2 protein at the rat proximal tubule brush border membrane correlates with protein kinase C (PKC)-betal and plasma glucose concentration.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Enzyme Activation; Glucose Transporter Type | 2007 |
Influence of tetrahydrocurcumin on hepatic and renal functional markers and protein levels in experimental type 2 diabetic rats.
Topics: Animals; Antioxidants; Biomarkers; Chemoprevention; Curcumin; Diabetes Mellitus, Experimental; Diabe | 2007 |
Beneficial effect of heme oxygenase-1 expression on myocardial ischemia-reperfusion involves an increase in adiponectin in mildly diabetic rats.
Topics: Adiponectin; Animals; bcl-X Protein; Cardiovascular Agents; Coronary Vessels; Diabetes Mellitus, Exp | 2007 |
Influence of tetrahydrocurcumin on tail tendon collagen contents and its properties in rats with streptozotocin-nicotinamide-induced type 2 diabetes.
Topics: Animals; Collagen; Curcumin; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Hydroxyprol | 2007 |
Reduction of oxidative stress by a new low-molecular-weight antioxidant improves metabolic alterations in a nonobese mouse diabetes model.
Topics: Animals; Antioxidants; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Diabetes Mellitu | 2007 |
Nicotinamide induces differentiation of embryonic stem cells into insulin-secreting cells.
Topics: Animals; C-Peptide; Cell Differentiation; Cell Transplantation; Diabetes Mellitus, Experimental; Emb | 2008 |
Aminoguanidine prevents the impairment of cardiac pumping mechanics in rats with streptozotocin and nicotinamide-induced type 2 diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Disease Models, Animal; Enzyme | 2008 |
Submerged culture mycelium and broth of Grifola frondosa improve glycemic responses in diabetic rats.
Topics: Administration, Oral; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Anima | 2008 |
Effect of succinic acid monoethyl ester on hemoglobin glycation and tail tendon collagen properties in type 2 diabetic rats.
Topics: Animals; Blood Glucose; Collagen; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Glycat | 2008 |
In vitro renal transport functions of the progeny of rats with streptozotocin-induced diabetes.
Topics: Aging; Aminoisobutyric Acids; Animals; Biological Transport; Diabetes Mellitus, Experimental; Female | 1982 |
[Prevention and therapy for diabetes associated with insulitis in non-obese diabetic mice].
Topics: Animals; Diabetes Mellitus, Experimental; Female; Islets of Langerhans; Male; Mice; Mice, Inbred ICR | 1982 |
Effects of nicotinamide and insulin on glycosylated hemoglobin and blood glucose in thyroidectomized streptozotocin-diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Glycated Hemoglobin; Insulin; | 1982 |
Preventive and therapeutic effects of large-dose nicotinamide injections on diabetes associated with insulitis. An observation in nonobese diabetic (NOD) mice.
Topics: Animals; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Glucose Tolerance Test; In | 1982 |
Hormonal and environmental factors in the pathogenesis of BB rat diabetes.
Topics: 3-O-Methylglucose; Animals; Body Weight; Castration; Diabetes Mellitus, Experimental; Diabetes Melli | 1983 |
Characteristics of nicotinamide and N1-methylnicotinamide protection from alloxan diabetes in mice.
Topics: Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; | 1983 |
Nicotinamide does not protect islet B-cell metabolism against alloxan toxicity.
Topics: Alloxan; Animals; Diabetes Mellitus, Experimental; Glucose; Insulin; Insulin Secretion; Islets of La | 1984 |
Protection by picolinamide, a novel inhibitor of poly (ADP-ribose) synthetase, against both streptozotocin-induced depression of proinsulin synthesis and reduction of NAD content in pancreatic islets.
Topics: Amides; Animals; Cell Nucleus; Diabetes Mellitus, Experimental; Islets of Langerhans; Male; NAD; NAD | 1980 |
Reversal of diabetes by the isotransplantation of nicotinamide-streptozotocin-induced islet adenoma in rats.
Topics: Adenoma; Adenoma, Islet Cell; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; | 1982 |
Effect of poly(ADP-ribose) synthetase inhibitor administration to rats before and after injection of alloxan and streptozotocin on islet proinsulin synthesis.
Topics: Animals; Benzamides; Diabetes Mellitus, Experimental; Glucose; Islets of Langerhans; Male; NAD+ Nucl | 1983 |
Amelioration of diabetes mellitus in partially depancreatized rats by poly(ADP-ribose) synthetase inhibitors. Evidence of islet B-cell regeneration.
Topics: Animals; Benzamides; Blood Glucose; Diabetes Mellitus, Experimental; Insulin; Islets of Langerhans; | 1984 |
Regulation of tryptophan-niacin metabolism in diabetic rats.
Topics: Animals; Carboxy-Lyases; Diabetes Mellitus, Experimental; Insulin; Liver; Male; Niacinamide; Nicotin | 1980 |
The effects of nicotinamide and glimepiride on diabetes prevention in BB rats.
Topics: Administration, Oral; Age Factors; Animals; Body Weight; Diabetes Mellitus, Experimental; Hypoglycem | 1995 |
Protective effect of gamma-hydroxybutyrate and nicotinamide on low-dose streptozotocin-induced diabetes in mice.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Drug Synergism; Insulin; Insulin Secretion; | 1995 |
The amelioration of hyperglycemia in streptozotocin-induced diabetic rats after the intraportal transplantation of an insufficient number of islets by nicotinamide treatment.
Topics: Animals; Diabetes Mellitus, Experimental; Hyperglycemia; Insulin; Islets of Langerhans Transplantati | 1995 |
Effect of dietary linoleic acid on the tryptophan-niacin metabolism in streptozotocin diabetic rats.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Diet; Eating; Linoleic Acid; Linoleic Acids; | 1995 |
Protection of intrahepatic islet grafts from hyperglycemic toxicity by nicotinamide treatment.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Hyperglycemia; Insulin; Islets of Langerhan | 1995 |
Protection of mouse islet isografts from early transplantation damage by nicotinamide treatment of recipients.
Topics: Animals; Blood Glucose; Cells, Cultured; Diabetes Mellitus, Experimental; Glucose Tolerance Test; Is | 1994 |
Pretreatment of fetal porcine pancreas in culture with nicotinamide accelerates reversal of diabetes after transplantation to nude mice.
Topics: Alloxan; Animals; Blood Glucose; Cell Differentiation; Cells, Cultured; Diabetes Mellitus, Experimen | 1993 |
Protective effects of nicotinamide on renal subcapsular islet isografts with a marginal mass from sustained hyperglycemia in the streptozotocin-induced diabetic rats.
Topics: Animals; Blood Glucose; Cell Degranulation; Diabetes Mellitus, Experimental; Hyperglycemia; Islets o | 1995 |
Assessment of pore size of a semipermeable membrane for immunoisolation on xenoimplantation of pancreatic B cells using a diffusion chamber.
Topics: Animals; Blood Glucose; Cell Line; Diabetes Mellitus, Experimental; Diffusion Chambers, Culture; Hum | 1995 |
Islet protective effect of pravastatin from nonspecific inflammation in mouse pancreatic islet isografts.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents, Non-Steroidal; Blood Glucose; Diabetes Mellitus | 1996 |
Orally given nicotinamide inhibits the decreasing of glutathione content in the pancreas of streptozotocin diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glutathione; Glutathione Peroxidase; Lipid | 1996 |
Effects of nicotinamide on prevention and treatment of streptozotocin-induced diabetes mellitus in rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Female; Free Radical Scavengers | 1996 |
Effects of nicotinamide on xenotransplantation.
Topics: Animals; Diabetes Mellitus, Experimental; Graft Survival; Injections, Intravenous; Islets of Langerh | 1998 |
Generation of nitric oxide from streptozotocin (STZ) in the presence of copper(II) plus ascorbate: implication for the development of STZ-induced diabetes.
Topics: Animals; Ascorbic Acid; Chelating Agents; Copper; Diabetes Mellitus, Experimental; Disease Models, A | 1998 |
Corticotropin-releasing hormone facilitates early survival of discordant (bovine-to-rat) islet xenografts.
Topics: Animals; Blood Glucose; Cattle; Cells, Cultured; Diabetes Mellitus, Experimental; Gonadotropin-Relea | 1998 |
A role of nicotinamide-induced increase in pancreatic beta-cell mass on blood glucose control after discontinuation of the treatment in partially pancreatectomized OLETF rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Insulin; Islets | 1998 |
Report for the EASD-Bayer Travel Fellowship for Young Scientists 1997. European Association for the Study of Diabetes.
Topics: Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Europe; Fell | 1998 |
Nicotinamide decreases MHC class II but not MHC class I expression and increases intercellular adhesion molecule-1 structures in non-obese diabetic mouse pancreas.
Topics: Animals; Blood Glucose; Bromodeoxyuridine; Diabetes Mellitus, Experimental; Female; Histocompatibili | 1999 |
Nicotinamide prevents the development of diabetes in the cyclophosphamide-induced NOD mouse model by reducing beta-cell apoptosis.
Topics: Animals; Apoptosis; Cyclophosphamide; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Is | 2000 |
Lipid peroxidation in nicotinamide-deficient and nicotinamide-supplemented rats with streptozotocin-induced diabetes.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glutathione; Lipid Peroxidation; Liver; Mal | 2000 |
Combined effect of nicotinamide and streptozotocin on diabetic status in partially pancreatectomized adult BALB/c mice.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Disease Models, Animal; Female | 2000 |
Enhanced maturation of porcine neonatal pancreatic cell clusters with growth factors fails to improve transplantation outcome.
Topics: Animals; Animals, Newborn; Blood Glucose; C-Peptide; Cattle; Cell Culture Techniques; Culture Media; | 2001 |
Delayed treatment with nicotinamide (vitamin B3) reduces the infarct volume following focal cerebral ischemia in spontaneously hypertensive rats, diabetic and non-diabetic Fischer 344 rats.
Topics: Animals; Blood Gas Analysis; Brain Ischemia; Cerebral Infarction; Cerebrovascular Circulation; Diabe | 2002 |
Mild streptozotocin diabetes in the Göttingen minipig. A novel model of moderate insulin deficiency and diabetes.
Topics: Animals; Arginine; Blood Glucose; Diabetes Mellitus, Experimental; Disease Models, Animal; Fasting; | 2002 |
Induced and spontaneous diabetes mellitus and suppression of cell-mediated immunologic responses. Granuloma formation, delayed dermal reactivity and allograft rejection.
Topics: Animals; Diabetes Mellitus, Experimental; Female; Foreign-Body Reaction; Graft Rejection; Hypersensi | 1976 |
Increased aryl hydrocarbon hydroxylase activity in hepatic microsomes from streptozotocin-diabetic female rats.
Topics: Animals; Antimetabolites; Aryl Hydrocarbon Hydroxylases; Blood Glucose; Cytochrome P-450 Enzyme Syst | 1978 |
Reduction of streptozotocin toxicity by 3-O-methyl-D-glucose with enhancement of antitumor activity in murine L1210 leukemia.
Topics: Animals; Diabetes Mellitus, Experimental; Drug Interactions; Drug Therapy, Combination; Leukemia L12 | 1977 |
Experimental hypoglycemizing tumor of B-cells of Langerhans islets produced by the combined action of streptozotocin annd nicotinamide in the rat.
Topics: Adenoma, Islet Cell; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Hypoglycemia; | 1978 |
Changes in responsiveness of the aorta to vasorelaxant agents in genetically diabetic rats: a study in WBN/Kob rats.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Colforsin; Cromakalim; Diabetes Mellitus, Experimental; Endot | 1992 |
Comparison of the development of tolerance to nitroglycerin in aortic preparations isolated from non-diabetic and diabetic rats.
Topics: Acetylcysteine; Animals; Aorta, Thoracic; Blood Glucose; Culture Techniques; Diabetes Mellitus, Expe | 1992 |
Effects of poly (ADP-ribose) synthetase inhibitor on B-cells of a canine pancreas after massive pancreatectomy.
Topics: Animals; Diabetes Mellitus, Experimental; Dogs; Glucose Tolerance Test; Insulin; Islets of Langerhan | 1991 |
Streptozotocin-induced suppression of FAD-linked glycerophosphate dehydrogenase in pancreatic islets of adult rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Flavin-Adenine Dinucleotide; Glycer | 1991 |
Nicotinamide and 3-aminobenzamide reduce interferon-gamma-induced class II MHC (HLA-DR and -DP) molecule expression on cultured human endothelial cells and fibroblasts.
Topics: Animals; Benzamides; Cells, Cultured; Diabetes Mellitus, Experimental; Endothelium, Vascular; Fibrob | 1991 |
The effects of type 1 diabetes mellitus and of tobacco smoke on dissipation of catecholamines in pulmonary endothelial cells--a non-neuronal site of uptake1.
Topics: Animals; Biological Transport; Catechol O-Methyltransferase; Diabetes Mellitus, Experimental; Diabet | 1991 |
Induction of cytochrome P450III and P450IV family proteins in streptozotocin-induced diabetes.
Topics: Animals; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Experimental; Enzyme Induction; Insulin; | 1990 |
Inhibition of cytokine-induced MHC class II but not class I molecule expression on mouse islet cells by niacinamide and 3-aminobenzamide.
Topics: Animals; Benzamides; Biological Factors; Cells, Cultured; Cytokines; Diabetes Mellitus, Experimental | 1990 |
Protection by 3-aminobenzamide and nicotinamide against streptozotocin-induced beta-cell toxicity in vivo and in vitro.
Topics: Animals; Benzamides; Blood Glucose; Diabetes Mellitus, Experimental; In Vitro Techniques; Insulin; I | 1990 |
Diabetes-related changes in brain beta adrenoreceptors in rats as assessed by quantitative autoradiography: relationship to hypothalamic norepinephrine metabolism and pituitary-gonadal hormone secretion.
Topics: Animals; Autoradiography; Brain; Diabetes Mellitus, Experimental; Gonadotropins, Pituitary; Hypothal | 1990 |
Changes in the somatostatin, substance P and vasoactive intestinal polypeptide content of the gastrointestinal tract following streptozotocin-induced diabetes in the rat.
Topics: Animals; Diabetes Mellitus, Experimental; Digestive System; Duodenum; Gastric Mucosa; Ileum; Intesti | 1985 |
Oxygen free-radical scavengers and immune destruction of murine islets in allograft rejection and multiple low-dose streptozocin-induced insulitis.
Topics: Animals; Deferoxamine; Diabetes Mellitus, Experimental; Free Radicals; Graft Rejection; Islets of La | 1989 |
Metabolic activation of chemical carcinogens by hepatic preparations from streptozotocin-treated rats.
Topics: Animals; Benzo(a)pyrene; Biotransformation; Carcinogens; Diabetes Mellitus, Experimental; Imidazoles | 1989 |
Functional changes in potassium channels in aortas from rats with streptozotocin-induced diabetes.
Topics: Animals; Aorta, Thoracic; Benzopyrans; Blood Glucose; Cromakalim; Diabetes Mellitus, Experimental; I | 1989 |
Effects of very mild versus overt diabetes on vascular haemodynamics and barrier function in rats.
Topics: Animals; Blood Glucose; Blood Pressure; Diabetes Mellitus, Experimental; Eating; Glomerular Filtrati | 1989 |
High dose nicotinamide fails to prevent diabetes in BB rats.
Topics: Age Factors; Animals; Autoimmune Diseases; Blood Glucose; Cyclosporine; Deferoxamine; Diabetes Melli | 1989 |
Protective effect of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase, against streptozotocin-induced diabetes.
Topics: Animals; Benzamides; Blood Glucose; Diabetes Mellitus, Experimental; Insulin; Insulin Secretion; Isl | 1985 |
Protective effect of nicotinamide against nephropathy in diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Fluorescent Antibody Technique; Hi | 1985 |
Nicotinamide prevents lymphocytic infiltration in submandibular glands but not the appearance of anti-salivary duct antibodies in non-obese diabetic (NOD) mice.
Topics: Animals; Antibody Formation; Diabetes Mellitus, Experimental; Disease Models, Animal; Female; Inflam | 1985 |
Elevated antibody-dependent cell-mediated cytotoxicity and its inhibition by nicotinamide in the diabetic NOD mouse.
Topics: Animals; Antibody-Dependent Cell Cytotoxicity; Diabetes Mellitus, Experimental; Diabetes Mellitus, T | 1986 |
[Changes in the content and structure of the coenzyme A moiety in the liver of diabetic mice (db/db) administered a regimen of nicotinamide].
Topics: Acetylation; Animals; Blood Glucose; Coenzyme A; Diabetes Mellitus, Experimental; Drug Evaluation, P | 1987 |
[Changes in pentobarbital hypnosis and hepatic metabolism in streptozotocin-diabetic mice].
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Insulin; Male; Mice; Microsomes, Liver; Nia | 1987 |
Influence of diabetes on susceptibility to experimental pancreatic cancer.
Topics: Animals; Blood Glucose; Cricetinae; Diabetes Mellitus, Experimental; Disease Susceptibility; Male; M | 1988 |
Effect of niacin/nicotinamide deficiency on the diabetogenic effect of streptozotocin.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Male; Mice; Niacin; Niacinamide; Streptozoc | 1988 |
Stimulation of cell replication in transplanted pancreatic islets by nicotinamide treatment.
Topics: Animals; Cell Division; Diabetes Mellitus, Experimental; Islets of Langerhans; Islets of Langerhans | 1988 |
Streptozotocin-induced diabetes modulates the metabolic activation of chemical carcinogens.
Topics: Animals; Biotransformation; Carbolines; Carcinogens; Cytochrome P-450 Enzyme System; Diabetes Mellit | 1988 |
Chemically induced microencapsulated rat insuloma as a bioartificial endocrine pancreas.
Topics: Adenoma, Islet Cell; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucose Tolerance Test | 1986 |
Effect of streptozotocin on the glutathione S-transferases of mouse liver cytosol.
Topics: Animals; Antineoplastic Agents; Cytosol; Diabetes Mellitus, Experimental; Glutathione Transferase; I | 1985 |
Modulation of streptozotocin-induced insulitis and hyperglycaemia in the mouse.
Topics: Animals; Diabetes Mellitus, Experimental; Hyperglycemia; Inflammation; Islets of Langerhans; Male; M | 1985 |
Influence of nicotinamide and pyridine nucleotides on streptozotocin and alloxan-induced pancreatic B cell cytotoxicity.
Topics: Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Islets of Langerhans; Male; Mice; NAD; | 1973 |
[Experimental studies on the effects of various vitamins on blood sugar in rats and the mechanism of action].
Topics: Animals; Ascorbic Acid; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Female; Flavono | 1966 |
[Antidiabetic action of niamide].
Topics: Animals; Diabetes Mellitus, Experimental; Glucagon; Niacinamide; Rabbits | 1967 |
[The effect of insulin on the transport of potassium in skeletal muscles].
Topics: Adrenalectomy; Animals; Biological Transport; Diabetes Mellitus, Experimental; Epinephrine; Glycogen | 1966 |
Streptozotocin diabetes: time course of irreversible B-cell damage; further observations on prevention by nicotinamide.
Topics: Animals; Blood Glucose; Diabetes Mellitus; Diabetes Mellitus, Experimental; Injections, Intraperiton | 1970 |
The bioelectrical properties of pancreatic islet cells: effects of diabetogenic agents.
Topics: Action Potentials; Alloxan; Animals; Anti-Bacterial Agents; Diabetes Mellitus, Experimental; Female; | 1972 |
Hypoglycaemic effect of Trigonella foenum graecum and Lupinus termis (leguminosae) seeds and their major alkaloids in alloxan-diabetic and normal rats.
Topics: Alkaloids; Animals; Azocines; Blood Glucose; Carbon Radioisotopes; Coumarins; Diabetes Mellitus, Exp | 1974 |
Effects of streptozotocin on carbohydrate and lipid metabolism in the rat.
Topics: Acetoacetates; Animals; Antibiotics, Antineoplastic; Blood Glucose; Carbamates; Diabetes Mellitus; D | 1971 |