niacinamide has been researched along with Adenoma, Islet Cell in 43 studies
nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.
Adenoma, Islet Cell: A benign tumor of the pancreatic ISLET CELLS. Usually it involves the INSULIN-producing PANCREATIC BETA CELLS, as in INSULINOMA, resulting in HYPERINSULINISM.
| Excerpt | Relevance | Reference |
|---|---|---|
| " High-dose nicotinamide should still, however, be considered as a drug with toxic potential at adult doses in excess of 3 gm/day and unsupervised use should be discouraged." | 2.41 | Safety of high-dose nicotinamide: a review. ( Bingley, PJ; Douek, IF; Gale, EA; Gillmor, HA; Knip, M; McLean, AE; Moore, WP, 2000) |
| "Sorafenib is considered to be a potent inhibitor of tumor angiogenesis and neovascularization in various solid tumors." | 1.38 | Sorafenib inhibits tumor growth and improves survival in a transgenic mouse model of pancreatic islet cell tumors. ( Bartsch, DK; Buchholz, M; Fendrich, V; Holler, JP; Maschuw, K; Rehm, J; Slater, EP; Waldmann, J, 2012) |
| "In stimulated islet cell tumors, an increase of PA was visible in the microsomal fraction, and there was an increase of lysophosphatidylcholine in the mitochondrial fraction." | 1.29 | Lipid composition of glucose-stimulated pancreatic islets and insulin-secreting tumor cells. ( Lenzen, S; Matthies, A; Rustenbeck, I, 1994) |
| "After a long latency, hormone-producing islet cell tumors are induced with high frequency by a single administration of streptozotocin and nicotinamide in the rats." | 1.27 | Streptozotocin-induced functioning islet cell tumor in the rat: high frequency of induction and biological properties of the tumor cells. ( Bergamini, E; Blondel, B; Gori, Z; Masiello, P; Wollheim, CB, 1984) |
| "Pancreatic islet cell tumors were induced in 38 of 44 male Wistar rats (86%), which survived 9 to 14 months following the various treatment schedules." | 1.26 | Tumorigenic action of streptozotocin on the pancreas and kidney in male Wistar rats. ( Baba, S; Fujii, S; Kazumi, T; Yoshino, G, 1978) |
| "Pancreatic islet cell tumors were induced in 32 of 49 male Wistar rats (73%) surviving 9 months or longer following treatment with streptozotocin alone, with streptozotocin and nicotinamide, or with streptozotocin and picolinamide." | 1.26 | Biochemical studies on rats with insulin-secreting islet cell tumors induced by streptozotocin: with special reference to physiological response to oral glucose load in the course of and after tumor induction. ( Baba, S; Doi, K; Kaneko, S; Kazumi, T; Yoshida, M; Yoshida, Y; Yoshino, G, 1978) |
| "At that time pancreatic islet cell tumors were demonstrated in all of the rats in this experiment." | 1.26 | Glucagon secretion during the development of insulin-secreting tumors induced by streptozotocin and nicotinamide. ( Baba, S; Kazumi, T; Kobayashi, N; Morita, S; Terashi, K; Yoshino, G, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 37 (86.05) | 18.7374 |
| 1990's | 3 (6.98) | 18.2507 |
| 2000's | 1 (2.33) | 29.6817 |
| 2010's | 2 (4.65) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kato, Y | 1 |
| Masuno, K | 1 |
| Fujisawa, K | 1 |
| Tsuchiya, N | 1 |
| Torii, M | 1 |
| Hishikawa, A | 1 |
| Izawa, T | 1 |
| Kuwamura, M | 1 |
| Yamate, J | 1 |
| Fendrich, V | 1 |
| Maschuw, K | 1 |
| Rehm, J | 1 |
| Buchholz, M | 1 |
| Holler, JP | 1 |
| Slater, EP | 1 |
| Bartsch, DK | 1 |
| Waldmann, J | 1 |
| Johnson, DE | 3 |
| Dixit, PK | 8 |
| Michels, JE | 3 |
| Bauer, GE | 8 |
| Masiello, P | 2 |
| Wollheim, CB | 2 |
| Blondel, B | 2 |
| Renold, AE | 1 |
| Gori, Z | 1 |
| Bergamini, E | 1 |
| Chick, WL | 1 |
| Appel, MC | 1 |
| Weir, GC | 1 |
| Like, AA | 1 |
| Lauris, V | 1 |
| Porter, JG | 1 |
| Chute, RN | 1 |
| Kazumi, T | 9 |
| Yoshino, G | 8 |
| Baba, S | 8 |
| Yagihashi, S | 1 |
| Nagai, K | 1 |
| Morita, S | 3 |
| Kobayashi, N | 2 |
| Terashi, K | 2 |
| Younoszai, R | 1 |
| Hegre, O | 1 |
| Yamamoto, H | 2 |
| Okamoto, H | 4 |
| Williams, FG | 2 |
| Sakamoto, C | 1 |
| Otsuki, M | 1 |
| Ohki, A | 1 |
| Yamasaki, T | 1 |
| Yuu, H | 1 |
| Maeda, M | 1 |
| Rustenbeck, I | 1 |
| Matthies, A | 1 |
| Lenzen, S | 2 |
| Baczako, K | 1 |
| Dolderer, M | 1 |
| Knip, M | 1 |
| Douek, IF | 1 |
| Moore, WP | 1 |
| Gillmor, HA | 1 |
| McLean, AE | 1 |
| Bingley, PJ | 1 |
| Gale, EA | 1 |
| Schoental, R | 2 |
| Doi, K | 2 |
| Rakieten, N | 3 |
| Gordon, BS | 3 |
| Beaty, A | 3 |
| Cooney, DA | 2 |
| Schein, PS | 3 |
| Dixon, RL | 1 |
| Bates, RW | 1 |
| Standaert, FG | 1 |
| Itoh, N | 2 |
| Korec, R | 1 |
| Fujii, S | 2 |
| Yoshida, Y | 2 |
| Yoshida, M | 1 |
| Kaneko, S | 1 |
| Taniguchi, H | 1 |
| Nose, K | 1 |
| Dunne, MJ | 1 |
| Sorenson, RL | 1 |
| Wobken, JD | 1 |
| Yamagami, T | 1 |
| Miwa, A | 1 |
| Takasawa, S | 1 |
| Klöppel, G | 1 |
| Zielmann, S | 1 |
| Panten, U | 1 |
| Johnson, D | 1 |
| Horányi, J | 1 |
| Keszthelyi, LM | 1 |
| Kiss, IB | 1 |
| Gerö, L | 1 |
| Duffek, L | 1 |
| Totpál, G | 1 |
| Alánt, O | 1 |
| Hirose, Y | 1 |
| Ishihara, K | 1 |
| Makimura, H | 1 |
| Utsumi, M | 1 |
| Davis, RD | 1 |
| Vogel, TT | 1 |
| Hayashi, Y | 1 |
| Volk, BW | 1 |
| Wellmann, KF | 1 |
| Brancato, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Three-Day Dosing NAD + Study[NCT03707652] | 8 participants (Actual) | Interventional | 2018-03-12 | Completed | |||
| Randomized Double-blinded Comparative Trial to Study the Add-on Activity of Combination Treatment of Nicotinamide on Progression Free Survival for EGFR Mutated Lung Cancer Terminal Stage Patients Being Treated With Gefitinib or Erlotinib[NCT02416739] | Phase 2/Phase 3 | 110 participants (Actual) | Interventional | 2015-03-31 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for niacinamide and Adenoma, Islet Cell
| Article | Year |
|---|---|
Safety of high-dose nicotinamide: a review.
Topics: Abnormalities, Drug-Induced; Adenoma, Islet Cell; Animals; Chemical and Drug Induced Liver Injury; D | 2000 |
Safety of high-dose nicotinamide: a review.
Topics: Abnormalities, Drug-Induced; Adenoma, Islet Cell; Animals; Chemical and Drug Induced Liver Injury; D | 2000 |
Safety of high-dose nicotinamide: a review.
Topics: Abnormalities, Drug-Induced; Adenoma, Islet Cell; Animals; Chemical and Drug Induced Liver Injury; D | 2000 |
Safety of high-dose nicotinamide: a review.
Topics: Abnormalities, Drug-Induced; Adenoma, Islet Cell; Animals; Chemical and Drug Induced Liver Injury; D | 2000 |
42 other studies available for niacinamide and Adenoma, Islet Cell
| Article | Year |
|---|---|
Characterization of pancreatic islet cell tumors and renal tumors induced by a combined treatment of streptozotocin and nicotinamide in male SD rats.
Topics: Adenoma, Islet Cell; Animals; Antibiotics, Antineoplastic; Disease Models, Animal; Kidney Neoplasms; | 2017 |
Sorafenib inhibits tumor growth and improves survival in a transgenic mouse model of pancreatic islet cell tumors.
Topics: Adenoma, Islet Cell; Animals; Antigens, Polyomavirus Transforming; Apoptosis; Disease Progression; F | 2012 |
Immunochemical identification of endocrine cell types in the streptozotocin nicotinamide-induced rat islet adenoma.
Topics: Adenoma, Islet Cell; Animals; Glucagon; Histocytochemistry; Immunochemistry; Insulin; Insulinoma; Ni | 1982 |
Studies in vivo and in vitro on chemically-induced primary islet cell tumours and non-tumour endocrine pancreatic tissue.
Topics: Adenoma, Islet Cell; Animals; Blood Glucose; Cells, Cultured; Glucagon; Glucose Tolerance Test; Insu | 1983 |
Streptozotocin-induced functioning islet cell tumor in the rat: high frequency of induction and biological properties of the tumor cells.
Topics: Adenoma, Islet Cell; Animals; Blood Glucose; Insulin; Niacinamide; Pancreatic Neoplasms; Rats; Rats, | 1984 |
Serially transplantable chemically induced rat islet cell tumor.
Topics: Adenoma, Islet Cell; Animals; Female; Male; Neoplasm Transplantation; Neoplasms, Experimental; Niaci | 1980 |
Pancreatic islet cell tumors found in rats given alloxan and nicotinamide.
Topics: Adenoma, Islet Cell; Alloxan; Animals; Glycosuria; Islets of Langerhans; Male; Niacinamide; Pancreat | 1980 |
Immunohistochemical and ultrastructural studies on rat islet cell tumours induced by streptozotocin and nicotinamide.
Topics: Adenoma, Islet Cell; Animals; Antibodies, Neoplasm; Cell Differentiation; Male; Niacinamide; Pancrea | 1981 |
Effect of propranolol on glucose-induced insulin response in rats with insulinomas.
Topics: Adenoma, Islet Cell; Animals; Blood Glucose; Glucose; Glucose Tolerance Test; Insulin; Niacinamide; | 1980 |
Reversal of diabetes by the isotransplantation of nicotinamide-streptozotocin-induced islet adenoma in rats.
Topics: Adenoma; Adenoma, Islet Cell; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; | 1982 |
Poly(ADP-ribose) synthetase inhibitors enhance streptozotocin-induced killing of insulinoma cells by inhibiting the repair of DNA strand breaks.
Topics: Adenoma, Islet Cell; Animals; Benzamides; Cell Line; Cell Survival; Cricetinae; DNA Repair; Insulino | 1982 |
The effect of glucose on insulin and proinsulin synthesis in the streptozotocin-nicotinamide--induced rat islet adenoma.
Topics: Adenoma; Adenoma, Islet Cell; Animals; Electrophoresis, Polyacrylamide Gel; Glucose; Insulin; Male; | 1984 |
The synthesis of insulin and proinsulin in a cell-free system derived from the streptozotocin-nicotinamide--induced rat islet adenoma.
Topics: Adenoma; Adenoma, Islet Cell; Animals; Carps; Cell-Free System; Heparin; Insulin; Liver; Male; Neopl | 1984 |
Exocrine and endocrine secretion from isolated perfused rat pancreas with islet cell tumors induced by streptozotocin and nicotinamide.
Topics: Adenoma, Islet Cell; Animals; Culture Techniques; Glucose; Insulin; Insulin Secretion; Male; Niacina | 1984 |
Lipid composition of glucose-stimulated pancreatic islets and insulin-secreting tumor cells.
Topics: Adenoma, Islet Cell; Animals; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Lipids; Mic | 1994 |
Polyarteritis nodosa-like inflammatory vascular changes in the pancreas and mesentery of rats treated with streptozotocin and nicotinamide.
Topics: Adenoma, Islet Cell; Animals; Blood Vessels; Male; Mesentery; Niacinamide; Pancreas; Pancreatic Neop | 1997 |
Pancreatic islet-cell and other tumors in rats given heliotrine, a monoester pyrrolizidine alkaloid, and nicotinamide.
Topics: Adenoma; Adenoma, Islet Cell; Animals; Carcinoma, Hepatocellular; Hyperplasia; Liver Neoplasms; Male | 1975 |
[Studies on the mechanism of the diabetogenic activity of streptozotocin and on the ability of compounds to block the diabetogenic activity of streptozotocin (author's transl)].
Topics: Adenoma, Islet Cell; Amides; Animals; Blood Glucose; Cats; Cystine; Deoxyglucose; Diabetes Mellitus; | 1975 |
Proceedings: Pancreatic islet cell and other tumours induced in rats by heliotrine- a mono-ester pyrrolizidine alkaloid; the effects of additional treatment with nicotinamide.
Topics: Adenoma, Islet Cell; Animals; Neoplasms, Experimental; Niacinamide; Pancreatic Neoplasms; Pyrrolizid | 1975 |
Modification of renal tumorigenic effect of streptozotocin by nicotinamide: spontaneous reversibility of streptozotocin diabetes.
Topics: Adenocarcinoma; Adenoma; Adenoma, Islet Cell; Animals; Diabetes Mellitus; Dose-Response Relationship | 1976 |
Streptozotocin treatment of streptozotocin-induced islet cell adenomas in rats.
Topics: Adenoma, Islet Cell; Animals; Blood Glucose; Insulin; Niacinamide; Rats; Streptozocin | 1976 |
Studies on rats with islet beta cell tumors induced by nicotinamide and streptozotocin.
Topics: Adenoma; Adenoma, Islet Cell; Animals; Disease Models, Animal; Glucose Tolerance Test; Insulin; Neop | 1976 |
Synthesis of preproinsulin with RNA preparation of streptozotocin--nicotinamide induced B-cell tumor.
Topics: Adenoma, Islet Cell; Animals; In Vitro Techniques; Islets of Langerhans; Kinetics; Male; Niacinamide | 1977 |
Experimental hypoglycemizing tumor of B-cells of Langerhans islets produced by the combined action of streptozotocin annd nicotinamide in the rat.
Topics: Adenoma, Islet Cell; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Female; Hypoglycemia; | 1978 |
Tumorigenic action of streptozotocin on the pancreas and kidney in male Wistar rats.
Topics: Adenoma, Islet Cell; Animals; Carcinogens; Kidney Neoplasms; Liver; Male; Neoplasms, Experimental; N | 1978 |
[Biochemical studies on rats in the course of the induction of insulin-secreting islet cell tumors by streptozotocin (author's transl)].
Topics: Adenoma, Islet Cell; Animals; Blood Glucose; Carcinogens; Glucagon; Glucose Tolerance Test; Insulin; | 1978 |
Biochemical studies on rats with insulin-secreting islet cell tumors induced by streptozotocin: with special reference to physiological response to oral glucose load in the course of and after tumor induction.
Topics: Adenoma, Islet Cell; Amides; Animals; Blood Glucose; Glucose Tolerance Test; Insulin; Male; Niacinam | 1978 |
Effect of calcium antagonist on glucose-induced insulin and glucagon secretion in rats with insulin-secreting tumors induced by streptozotocin and nicotinamide.
Topics: Adenoma, Islet Cell; Animals; Calcium; Diltiazem; Glucagon; Glucose; Glucose Tolerance Test; Insulin | 1979 |
Purification and characterization of proinsulin mRNA from rat B-cell tumor.
Topics: Adenoma, Islet Cell; Animals; Kinetics; Male; Niacinamide; Nucleic Acid Hybridization; Peptide Fragm | 1979 |
Glucagon secretion during the development of insulin-secreting tumors induced by streptozotocin and nicotinamide.
Topics: Adenoma, Islet Cell; Animals; Blood Glucose; Glucagon; Glucose Tolerance Test; Insulin; Insulin Secr | 1979 |
Effects of pinacidil, RP 49356 and nicorandil on ATP-sensitive potassium channels in insulin-secreting cells.
Topics: Adenoma, Islet Cell; Adenosine Triphosphate; Diazoxide; Glucose; Guanidines; Humans; Insulin; Insuli | 1990 |
Glucose-stimulated hormone release in rats bearing streptozotocin/nicotinamide-induced islet adenomas: evidence for slow and fast responders.
Topics: Adenoma, Islet Cell; Animals; Blood Glucose; Glucose; Insulin; Insulin Secretion; Male; Niacinamide; | 1989 |
Induction of rat pancreatic B-cell tumors by the combined administration of streptozotocin or alloxan and poly(adenosine diphosphate ribose) synthetase inhibitors.
Topics: Adenoma, Islet Cell; Alloxan; Amides; Animals; Insulinoma; Male; NAD+ Nucleosidase; Niacinamide; Pan | 1985 |
Secretory, enzymatic, and morphological characterization of rat pancreatic endocrine tumours induced by streptozotocin and nicotinamide.
Topics: Adenoma, Islet Cell; Animals; Blood Glucose; Insulin; Insulin Secretion; Male; Niacinamide; Pancreat | 1985 |
Morphometric analysis of the endocrine cell composition of rat pancreas following treatment with streptozotocin and nicotinamide.
Topics: Adenoma; Adenoma, Islet Cell; Animals; Blood Glucose; Glucose Tolerance Test; Insulin; Islets of Lan | 1986 |
Chemically induced microencapsulated rat insuloma as a bioartificial endocrine pancreas.
Topics: Adenoma, Islet Cell; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Glucose Tolerance Test | 1986 |
Thyrotropin-releasing hormone and insulin in chemically induced pancreatic islet cell tumors in rats.
Topics: Adenoma, Islet Cell; Animals; Chromatography, Gel; Insulin; Niacinamide; Pancreatic Neoplasms; Rats; | 1986 |
On the origin of induced pancreatic islet tumors: a radioautographic study.
Topics: Adenoma, Islet Cell; Animals; Autoradiography; DNA Replication; Male; Niacinamide; Pancreatic Neopla | 1987 |
Pancreatic islet cell tumors produced by the combined action of streptozotocin and nicotinamide.
Topics: Adenoma, Islet Cell; Animals; Blood Glucose; Carbamates; Drug Synergism; Glucosamine; Injections, In | 1971 |
Notes on streptozotocin in metastatic insulinoma.
Topics: Adenoma, Islet Cell; Adult; Antibiotics, Antineoplastic; Autopsy; Blood Glucose; Bone Marrow; Brain; | 1971 |
[Experimental pancreatic tumor].
Topics: Adenoma, Islet Cell; Animals; Carcinogens; Cyclic N-Oxides; Dogs; Guinea Pigs; Methylation; Neoplasm | 1972 |
Fine structure of rat islet cell tumors induced by streptozotocin and nicotinamide.
Topics: Adenoma, Islet Cell; Animals; Blood Glucose; Drug Synergism; Insulin; Male; Microscopy, Electron; Ne | 1974 |