niacinamide has been researched along with Acute Kidney Injury in 22 studies
nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.
Acute Kidney Injury: Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Ischemia-reperfusion injury (IRI) is a model for AKI, which results in tubular damage, dysfunction of the mitochondria and autophagy, and in decreased cellular nicotinamide adenine dinucleotide (NAD+) with progressing fibrosis resulting in CKD." | 8.02 | Effect of NAD+ boosting on kidney ischemia-reperfusion injury. ( Andersen, CB; Egstrand, S; Lewin, E; Mace, ML; Morevati, M; Nordholm, A; Olgaard, K; Salmani, R, 2021) |
| " Ischemia-reperfusion injury (IRI) is a model for AKI, which results in tubular damage, dysfunction of the mitochondria and autophagy, and in decreased cellular nicotinamide adenine dinucleotide (NAD+) with progressing fibrosis resulting in CKD." | 4.02 | Effect of NAD+ boosting on kidney ischemia-reperfusion injury. ( Andersen, CB; Egstrand, S; Lewin, E; Mace, ML; Morevati, M; Nordholm, A; Olgaard, K; Salmani, R, 2021) |
| "The study was processed to investigate the effect of astaxanthin (AST; 3,3-dihydroxybeta, beta-carotene-4,4-dione) on the acute kidney injury induced by iohexol and the relationship with SIRT1/FOXO3a signal pathway." | 3.88 | Astaxanthin attenuates contrast agent-induced acute kidney injury in vitro and in vivo via the regulation of SIRT1/FOXO3a expression. ( Chen, J; Gao, D; Li, W; Liu, N; Zheng, D, 2018) |
| "Tumor lysis syndrome is rare in hepatocellular carcinoma (HCC), but it has been reported more frequently recently in response to treatments such as transcatheter arterial chemoembolization (TACE), radiofrequency thermal ablation (RFTA), and sorafenib." | 3.81 | Low-dose steroid-induced tumor lysis syndrome in a hepatocellular carcinoma patient. ( Choi, HS; Hahm, JS; Jun, DW; Kim, JO; Lee, HL; Lee, KN; Lee, OY; Tae, HJ; Yoon, BC, 2015) |
| " NRPT dosing was increased in each Step: Step 1250/50 mg, Step 2500/100 mg, Step 3750/150 mg and Step 41,000/200 mg." | 2.94 | Nicotinamide riboside with pterostilbene (NRPT) increases NAD ( Dellinger, R; Guarente, LP; Parikh, SM; Rhee, EP; Simic, P; Vela Parada, XF, 2020) |
| "Although both reached severe aplasia of the bone marrow without blastic infiltration, death occurred with neutropenic sepsis." | 2.52 | Hypertension and Life-Threatening Bleeding in Children with Relapsed Acute Myeloblastic Leukemia Treated with FLT3 Inhibitors. ( Aydınok, Y; Balkan, C; Karadaş, N; Kavaklı, K; Önder Siviş, Z; Yılmaz Karapınar, D, 2015) |
| "Recently, cancer therapies have been supplemented by vascular endothelial growth factor (VEGF) inhibitors as anti-angiogenic agents." | 2.50 | Clinicopathological spectrum of kidney diseases in cancer patients treated with vascular endothelial growth factor inhibitors: a report of 5 cases and review of literature. ( Chandran, CB; Flombaum, CD; Glezerman, IG; Salvatore, SP; Seshan, SV; Usui, J, 2014) |
| "Sorafenib is an orally available kinase inhibitor with activity at Raf, PDGFβ and VEGF receptors that is licensed for the treatment of advanced renal cell carcinoma (RCC) and hepatocellular carcinoma (HCC)." | 1.38 | Fatal case of sorafenib-associated idiosyncratic hepatotoxicity in the adjuvant treatment of a patient with renal cell carcinoma. ( Collier, J; Eisen, T; Fairfax, BP; Kaplan, R; Macaulay, VM; Meade, AM; Pratap, S; Protheroe, A; Ritchie, AW; Roberts, IS, 2012) |
| "Effect of experimental acute renal failure (EARF) on the intrinsic renal tubular secretory clearance (CLscnint) of tetraethylammonium bromide (TEA) and N1-methylnicotinamide (NMN) was examined in rats treated with glycerol, folate, salicylate, uranium and gentamicin." | 1.27 | Effect of experimental acute renal failure on intrinsic renal tubular secretory clearance of organic cations in rats. ( Hanano, M; Iga, T; Sawada, Y; Shim, CK, 1983) |
| "And the effect of experimental acute renal failure (ERF) on RBF was also examined in rats treated with glycerol, folate, salicylate, uranium and gentamicin by using this method." | 1.27 | Estimation of renal blood flow by use of endogenous N1-methylnicotinamide in rats. ( Hanano, M; Iga, T; Sawada, Y; Shim, CK, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (22.73) | 18.7374 |
| 1990's | 3 (13.64) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 9 (40.91) | 24.3611 |
| 2020's | 5 (22.73) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, J | 1 |
| Cui, X | 1 |
| Guo, F | 1 |
| Li, X | 1 |
| Li, L | 1 |
| Pan, J | 1 |
| Tao, S | 1 |
| Huang, R | 1 |
| Feng, Y | 1 |
| Ma, L | 1 |
| Fu, P | 1 |
| Simic, P | 1 |
| Vela Parada, XF | 1 |
| Parikh, SM | 2 |
| Dellinger, R | 1 |
| Guarente, LP | 1 |
| Rhee, EP | 2 |
| Faivre, A | 1 |
| Katsyuba, E | 1 |
| Verissimo, T | 1 |
| Lindenmeyer, M | 1 |
| Rajaram, RD | 1 |
| Naesens, M | 1 |
| Heckenmeyer, C | 1 |
| Mottis, A | 1 |
| Feraille, E | 1 |
| Cippà, P | 1 |
| Cohen, C | 1 |
| Longchamp, A | 1 |
| Allagnat, F | 1 |
| Rutkowski, JM | 1 |
| Legouis, D | 1 |
| Auwerx, J | 1 |
| de Seigneux, S | 1 |
| Wu, W | 1 |
| Fu, Y | 1 |
| Liu, Z | 1 |
| Shu, S | 1 |
| Wang, Y | 1 |
| Tang, C | 1 |
| Cai, J | 1 |
| Dong, Z | 1 |
| Davidson, JA | 1 |
| Frank, BS | 1 |
| Urban, TT | 1 |
| Twite, M | 1 |
| Jaggers, J | 1 |
| Khailova, L | 1 |
| Klawitter, J | 1 |
| Morevati, M | 1 |
| Egstrand, S | 1 |
| Nordholm, A | 1 |
| Mace, ML | 1 |
| Andersen, CB | 1 |
| Salmani, R | 1 |
| Olgaard, K | 1 |
| Lewin, E | 1 |
| Liu, N | 1 |
| Chen, J | 1 |
| Gao, D | 1 |
| Li, W | 1 |
| Zheng, D | 1 |
| Zhang, Q | 1 |
| Liu, X | 1 |
| Li, N | 1 |
| Zhang, J | 1 |
| Yang, J | 1 |
| Bu, P | 1 |
| Usui, J | 1 |
| Glezerman, IG | 1 |
| Salvatore, SP | 1 |
| Chandran, CB | 1 |
| Flombaum, CD | 1 |
| Seshan, SV | 1 |
| Kim, JO | 1 |
| Jun, DW | 1 |
| Tae, HJ | 1 |
| Lee, KN | 1 |
| Lee, HL | 1 |
| Lee, OY | 1 |
| Choi, HS | 1 |
| Yoon, BC | 1 |
| Hahm, JS | 1 |
| Yılmaz Karapınar, D | 1 |
| Karadaş, N | 1 |
| Önder Siviş, Z | 1 |
| Balkan, C | 1 |
| Kavaklı, K | 1 |
| Aydınok, Y | 1 |
| Tran, MT | 1 |
| Zsengeller, ZK | 1 |
| Berg, AH | 1 |
| Khankin, EV | 1 |
| Bhasin, MK | 1 |
| Kim, W | 1 |
| Clish, CB | 1 |
| Stillman, IE | 1 |
| Karumanchi, SA | 1 |
| Nagasawa, T | 1 |
| Hye Khan, MA | 1 |
| Imig, JD | 1 |
| Fairfax, BP | 1 |
| Pratap, S | 1 |
| Roberts, IS | 1 |
| Collier, J | 1 |
| Kaplan, R | 1 |
| Meade, AM | 1 |
| Ritchie, AW | 1 |
| Eisen, T | 1 |
| Macaulay, VM | 1 |
| Protheroe, A | 1 |
| Elliott, WC | 1 |
| Houghton, DC | 2 |
| Gilbert, DN | 2 |
| Baines-Hunter, J | 1 |
| Bennett, WM | 2 |
| Shim, CK | 3 |
| Sawada, Y | 3 |
| Iga, T | 3 |
| Hanano, M | 3 |
| Plamp, CE | 1 |
| Parker, RA | 1 |
| Porter, GA | 1 |
| Maiza, A | 2 |
| Daley-Yates, PT | 3 |
| Nasseri, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Randomized, Double-blind, Placebo-controlled, Stepwise Study of the Pharmacokinetics, Pharmacodynamics & Safety of Escalating Doses of Basis (Nicotinamide Riboside and Pterostilbene) in Patients With Acute Kidney Injury (AKI)[NCT03176628] | 24 participants (Actual) | Interventional | 2017-11-01 | Completed | |||
| SORCE: A Phase III Randomised Double-Blind Study Comparing Sorafenib With Placebo in Patients With Resected Primary Renal Cell Carcinoma at High or Intermediate Risk of Relapse[NCT00492258] | Phase 3 | 1,656 participants (Anticipated) | Interventional | 2007-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for niacinamide and Acute Kidney Injury
| Article | Year |
|---|---|
Clinicopathological spectrum of kidney diseases in cancer patients treated with vascular endothelial growth factor inhibitors: a report of 5 cases and review of literature.
Topics: Acute Kidney Injury; Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplasti | 2014 |
Hypertension and Life-Threatening Bleeding in Children with Relapsed Acute Myeloblastic Leukemia Treated with FLT3 Inhibitors.
Topics: Acidosis; Acute Kidney Injury; Adenine Nucleotides; Antineoplastic Combined Chemotherapy Protocols; | 2015 |
1 trial available for niacinamide and Acute Kidney Injury
| Article | Year |
|---|---|
Nicotinamide riboside with pterostilbene (NRPT) increases NAD
Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Creatinine; Dose-Response Relationship, Drug; Double-B | 2020 |
19 other studies available for niacinamide and Acute Kidney Injury
| Article | Year |
|---|---|
2-methylquinazoline derivative F7 as a potent and selective HDAC6 inhibitor protected against rhabdomyolysis-induced acute kidney injury.
Topics: Acetylation; Acute Kidney Injury; Animals; Apoptosis; Cells, Cultured; Cytokines; Histone Deacetylas | 2019 |
Differential role of nicotinamide adenine dinucleotide deficiency in acute and chronic kidney disease.
Topics: Acute Kidney Injury; Animals; Antineoplastic Agents; Cisplatin; Disease Models, Animal; Disease Prog | 2021 |
NAM protects against cisplatin-induced acute kidney injury by suppressing the PARP1/p53 pathway.
Topics: Acute Kidney Injury; Animals; Apoptosis; Cell Line; Cisplatin; Disease Models, Animal; Histones; Kid | 2021 |
Serum metabolic profile of postoperative acute kidney injury following infant cardiac surgery with cardiopulmonary bypass.
Topics: Acute Kidney Injury; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Humans; Infant; Kynurenine | 2021 |
Effect of NAD+ boosting on kidney ischemia-reperfusion injury.
Topics: Acute Kidney Injury; Animals; Autophagy; Disease Progression; Fibrosis; Glucuronidase; Kidney; Kloth | 2021 |
Astaxanthin attenuates contrast agent-induced acute kidney injury in vitro and in vivo via the regulation of SIRT1/FOXO3a expression.
Topics: Acute Kidney Injury; Animals; Apoptosis; bcl-2-Associated X Protein; Blood Urea Nitrogen; Caspase 3; | 2018 |
Sirtuin 3 deficiency aggravates contrast-induced acute kidney injury.
Topics: Acute Kidney Injury; Animals; Apoptosis; Cell Line; Contrast Media; Cytoprotection; Disease Models, | 2018 |
Low-dose steroid-induced tumor lysis syndrome in a hepatocellular carcinoma patient.
Topics: Acute Kidney Injury; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Hepatocellular; Chemoembol | 2015 |
PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection.
Topics: 3-Hydroxybutyric Acid; Acute Kidney Injury; Adipose Tissue; Amino Acids; Animals; Cytokines; Dinopro | 2016 |
Captopril attenuates hypertension and renal injury induced by the vascular endothelial growth factor inhibitor sorafenib.
Topics: Acute Kidney Injury; Animals; Benzenesulfonates; Captopril; Growth Inhibitors; Hypertension; Male; N | 2012 |
Fatal case of sorafenib-associated idiosyncratic hepatotoxicity in the adjuvant treatment of a patient with renal cell carcinoma.
Topics: Acute Kidney Injury; Antineoplastic Agents; Carcinoma, Renal Cell; Chemotherapy, Adjuvant; Fatal Out | 2012 |
Gentamicin nephrotoxicity. I. Degree and permanence of acquired insensitivity.
Topics: Acute Kidney Injury; Animals; Gentamicins; Inulin; Kidney; Kidney Cortex; Male; Necrosis; Niacinamid | 1982 |
Effect of experimental acute renal failure on intrinsic renal tubular secretory clearance of organic cations in rats.
Topics: Acute Kidney Injury; Animals; Cations; Kidney Glomerulus; Kidney Tubules; Niacinamide; Rats; Tetraet | 1983 |
Estimation of renal secretory function for organic cations by endogenous N1-methylnicotinamide in rats with experimental renal failure.
Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Cations; Glomerular Filtration Rate; Kidney; Kidn | 1984 |
Renal transport of organic acids and bases in aminoglycoside nephrotoxicity.
Topics: Acute Kidney Injury; Aminoglycosides; Animals; Biological Transport; Gentamicins; Kidney; Kidney Fun | 1979 |
Prediction of the renal clearance of cimetidine using endogenous N-1-methylnicotinamide.
Topics: Acute Kidney Injury; Animals; Cimetidine; Glomerular Filtration Rate; Kidney; Kidney Tubules, Proxim | 1991 |
A comparison of N-1-methylnicotinamide clearance with 5 other markers of renal function in models of acute and chronic renal failure.
Topics: Acetylglucosaminidase; Acute Kidney Injury; Animals; Biomarkers; Kidney Failure, Chronic; Kidney Tub | 1990 |
Estimation of the renal clearance of drugs using endogenous N-1-methylnicotinamide.
Topics: Acute Kidney Injury; Animals; Cephalexin; Cimetidine; Glomerular Filtration Rate; Inulin; Kidney; Ki | 1990 |
Estimation of renal blood flow by use of endogenous N1-methylnicotinamide in rats.
Topics: Acute Kidney Injury; Animals; Kidney; Male; Metabolic Clearance Rate; Niacinamide; p-Aminohippuric A | 1985 |