niacinamide has been researched along with Abnormalities, Drug-Induced in 80 studies
nicotinamide : A pyridinecarboxamide that is pyridine in which the hydrogen at position 3 is replaced by a carboxamide group.
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a search for genetic differences in susceptibility to cleft palate, congenic and recombinant inbred strains of mice were treated with 6-aminonicotinamide or control injections." | 7.67 | Genetics of susceptibility to 6-aminonicotinamide-induced cleft palate in the mouse: studies in congenic and recombinant inbred strains. ( Erickson, RP; Karolyi, J; Liu, S, 1988) |
| "The A/J strain of mice is more reactive than C57BL/6J to both cortisone- and 6-aminonicotinamide-induced cleft palate." | 7.66 | Genetic independence of the embryonic reactivity difference to cortisone- and 6-aminonicotinamide-induced cleft palate in the mouse. ( Biddle, FG; Fraser, FC, 1979) |
| "A single injection of the niacin antimetabolite 6-aminonicotinamide (6-AN) late in gestation produces cleft palate in the rat." | 7.66 | Correlation between mandibular retrognathia and induction of cleft palate with 6-aminonicotinamide in the rat. ( Diewert, VM, 1979) |
| "Cleft palate induction by 6-aminonicotinamide (6-AN) was examined in the A/J and C57BL/6J strains of mice to determine the nature of the strain difference in frequency of cleft-palate response." | 7.65 | 6-Aminonicotinamide-induced cleft palate in the mouse: the nature of the difference between the A/J and C57Bl/6J strains in frequency of response and its genetic basis. ( Biddle, FG, 1977) |
| "In a search for genetic differences in susceptibility to cleft palate, congenic and recombinant inbred strains of mice were treated with 6-aminonicotinamide or control injections." | 3.67 | Genetics of susceptibility to 6-aminonicotinamide-induced cleft palate in the mouse: studies in congenic and recombinant inbred strains. ( Erickson, RP; Karolyi, J; Liu, S, 1988) |
| "The A/J strain of mice is more reactive than C57BL/6J to both cortisone- and 6-aminonicotinamide-induced cleft palate." | 3.66 | Genetic independence of the embryonic reactivity difference to cortisone- and 6-aminonicotinamide-induced cleft palate in the mouse. ( Biddle, FG; Fraser, FC, 1979) |
| "A single injection of the niacin antimetabolite 6-aminonicotinamide (6-AN) late in gestation produces cleft palate in the rat." | 3.66 | Correlation between mandibular retrognathia and induction of cleft palate with 6-aminonicotinamide in the rat. ( Diewert, VM, 1979) |
| "Cleft palate induction by 6-aminonicotinamide (6-AN) was examined in the A/J and C57BL/6J strains of mice to determine the nature of the strain difference in frequency of cleft-palate response." | 3.65 | 6-Aminonicotinamide-induced cleft palate in the mouse: the nature of the difference between the A/J and C57Bl/6J strains in frequency of response and its genetic basis. ( Biddle, FG, 1977) |
| " High-dose nicotinamide should still, however, be considered as a drug with toxic potential at adult doses in excess of 3 gm/day and unsupervised use should be discouraged." | 2.41 | Safety of high-dose nicotinamide: a review. ( Bingley, PJ; Douek, IF; Gale, EA; Gillmor, HA; Knip, M; McLean, AE; Moore, WP, 2000) |
| "Fetal hydrocephalus was induced by single intraperitoneal injection of 8 mg/kg 6-aminonicotinamide (6-AN), a niacinamide antagonist, in Sprague-Dawley rat on day 13 of gestation." | 1.28 | Congenital hydrocephalus mimicking Dandy-Walker syndrome induced by 6-aminonicotinamide injection in pregnant rat. ( Matsumoto, S; Oi, S; Tamaki, N; Taomoto, K; Yamada, H, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 78 (97.50) | 18.7374 |
| 1990's | 1 (1.25) | 18.2507 |
| 2000's | 1 (1.25) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| INGALLS, TH | 3 |
| INGENITO, EF | 1 |
| CURLEY, FJ | 2 |
| CHAMBERLAIN, JG | 9 |
| NELSON, MM | 1 |
| SMITHBERG, M | 1 |
| RUNNER, MN | 4 |
| FELISATI, D | 1 |
| KRAKOFF, IH | 1 |
| ROGER, JC | 2 |
| CHAMBERS, H | 1 |
| CASIDA, JE | 3 |
| LANDAUER, W | 7 |
| CLARK, EM | 1 |
| Honda, A | 2 |
| Iwama, M | 1 |
| Umeda, T | 1 |
| Mori, Y | 2 |
| Sheffield, VC | 1 |
| Seegmiller, RE | 4 |
| Knip, M | 1 |
| Douek, IF | 1 |
| Moore, WP | 1 |
| Gillmor, HA | 1 |
| McLean, AE | 1 |
| Bingley, PJ | 1 |
| Gale, EA | 1 |
| Kochhar, DM | 1 |
| Ritter, EJ | 2 |
| Scott, WJ | 2 |
| Wilson, JG | 2 |
| Wolpert, L | 1 |
| Meiniel, R | 4 |
| Scheil, HG | 2 |
| Claussen, U | 2 |
| Grote, W | 8 |
| Biddle, FG | 2 |
| Autissier-Navarro, C | 2 |
| Fraser, FC | 5 |
| Diewert, VM | 1 |
| Quan, DQ | 1 |
| Caujolle, R | 1 |
| Bernadou, J | 1 |
| Overman, DO | 3 |
| Graham, MN | 1 |
| Roy, WA | 1 |
| Yamada, H | 1 |
| Oi, S | 1 |
| Tamaki, N | 1 |
| Matsumoto, S | 1 |
| Taomoto, K | 1 |
| Kazuno, S | 1 |
| Kimata, K | 1 |
| Suzuki, S | 1 |
| Gotoh, H | 1 |
| Nomura, T | 1 |
| Nakajima, H | 1 |
| Hasegawa, C | 1 |
| Sakamoto, Y | 1 |
| Karolyi, J | 1 |
| Erickson, RP | 1 |
| Liu, S | 1 |
| Kawashima, K | 1 |
| Tanuma, S | 1 |
| Endo, H | 1 |
| Kushaba-Rugaaju, S | 1 |
| Kitos, PA | 1 |
| Caplan, AI | 6 |
| Schardein, JL | 1 |
| Woosley, ET | 1 |
| Peltzer, MA | 1 |
| Kaump, DH | 1 |
| Wakasugi, N | 1 |
| Nogami, H | 2 |
| Verrusio, AC | 1 |
| Pollard, DR | 3 |
| Zappasodi, P | 1 |
| Zwilling, E | 1 |
| Kaplan, NO | 1 |
| Martin, C | 1 |
| Turbow, MM | 2 |
| Yamane, H | 1 |
| Kato, T | 1 |
| Funayama, Y | 1 |
| Yamashita, H | 1 |
| Merker, HJ | 4 |
| Novák, L | 1 |
| Sopher, D | 1 |
| Barrach, HJ | 1 |
| Köhler, E | 1 |
| Novack, L | 1 |
| Zimmermann, B | 1 |
| Clark, WH | 1 |
| Dipaolo, JA | 1 |
| Kasahara, M | 2 |
| Lyons, WR | 1 |
| Kabarity, A | 1 |
| Salam, N | 1 |
| Beaudoin, AR | 1 |
| Flockhart, IR | 1 |
| Neubert, D | 1 |
| Zens, P | 1 |
| Rothenwallner, A | 1 |
| Sudeck, M | 3 |
| Trasler, DG | 1 |
| Fratta, ID | 1 |
| Courtney, KD | 1 |
| Valerio, DA | 1 |
| Heinz, D | 1 |
| Upshall, DG | 1 |
| Goldyne, ME | 1 |
| Schweichel, JU | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Three-Day Dosing NAD + Study[NCT03707652] | 8 participants (Actual) | Interventional | 2018-03-12 | Completed | |||
| Randomized Double-blinded Comparative Trial to Study the Add-on Activity of Combination Treatment of Nicotinamide on Progression Free Survival for EGFR Mutated Lung Cancer Terminal Stage Patients Being Treated With Gefitinib or Erlotinib[NCT02416739] | Phase 2/Phase 3 | 110 participants (Actual) | Interventional | 2015-03-31 | Active, not recruiting | ||
| A Study of the Pharmacology of 17-Hydroxyprogesterone Caproate in Pregnancy[NCT00409825] | Phase 2 | 61 participants (Actual) | Interventional | 2006-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Change in the area under the concentration vs. time curve in the second and third trimesters of pregnancy.~We compared AUC at each PK study visit. Measurements were obtained at 0, 1, 2, 3, 4, 5, 6, 7 days." (NCT00409825)
Timeframe: Second and third trimesters of pregnancy
| Intervention | ng/ML/day (Mean) | |
|---|---|---|
| AUC -1 | AUC - 2 | |
| Part 1 | 115 | 136 |
3 reviews available for niacinamide and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Safety of high-dose nicotinamide: a review.
Topics: Abnormalities, Drug-Induced; Adenoma, Islet Cell; Animals; Chemical and Drug Induced Liver Injury; D | 2000 |
Safety of high-dose nicotinamide: a review.
Topics: Abnormalities, Drug-Induced; Adenoma, Islet Cell; Animals; Chemical and Drug Induced Liver Injury; D | 2000 |
Safety of high-dose nicotinamide: a review.
Topics: Abnormalities, Drug-Induced; Adenoma, Islet Cell; Animals; Chemical and Drug Induced Liver Injury; D | 2000 |
Safety of high-dose nicotinamide: a review.
Topics: Abnormalities, Drug-Induced; Adenoma, Islet Cell; Animals; Chemical and Drug Induced Liver Injury; D | 2000 |
Mechanisms of limb development and malformation.
Topics: Abnormalities, Drug-Induced; Animals; Cell Differentiation; Chick Embryo; Extremities; Genetics; Lim | 1976 |
Is insulin a teratogen?
Topics: Abnormalities, Drug-Induced; Animals; Beak; Brain; Chick Embryo; Congenital Abnormalities; Drug Inte | 1972 |
77 other studies available for niacinamide and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
ACQUIRED CHROMOSOMAL ANOMALIES INDUCED IN MICE BY INJECTION OF A TERATOGEN IN PREGNANCY.
Topics: Abnormalities, Drug-Induced; Animals; Chromosome Aberrations; Female; Humans; Injections; Mice; Niac | 1963 |
CONGENITAL ABNORMALITIES IN THE RAT RESULTING FROM SINGLE INJECTIONS OF 6-AMINONICOTINAMIDE DURING PREGNANCY.
Topics: 6-Aminonicotinamide; Abnormalities, Drug-Induced; Animals; Antimetabolites; Brain; Cardiovascular Sy | 1963 |
TERATOGENIC EFFECTS OF HYPOGLYCEMIC TREATMENTS IN INBRED STRAINS OF MICE.
Topics: Abnormalities, Drug-Induced; Animals; Hypoglycemic Agents; Insulin; Mice; Mice, Inbred Strains; Niac | 1963 |
TERATOGENIC ACTION OF THALIDOMIDE.
Topics: Abnormalities, Drug-Induced; Female; Folic Acid; Glutamine; Niacinamide; Pregnancy; Pregnancy Compli | 1964 |
PURINE METABOLISM IN THE CHICK EMBRYO: INFLUENCE OF 2-SUBSTITUTED THIADIAZOLES.
Topics: Abnormalities, Drug-Induced; Allantoin; Animals; Carbon Isotopes; Chick Embryo; Chromatography; Form | 1964 |
NICOTINIC ACID ANALOGS: EFFECTS ON RESPONSE OF CHICK EMBRYOS AND HENS TO ORGANOPHOSPHATE TOXICANTS.
Topics: Abnormalities, Drug-Induced; Animals; Biological Assay; Carbamates; Central Nervous System; Chick Em | 1964 |
TERATOGENIC RISKS OF DRUG SYNERGISM.
Topics: Abnormalities, Drug-Induced; Animals; Drug Synergism; Niacin; Niacinamide; Pharmacology; Poultry; Re | 1964 |
The teratogenic mechanism of 6-aminonicotinamide on limb formation of chick embryos: abnormalities in the biosynthesis of glycosaminoglycans and proteoglycans in micromelia.
Topics: 6-Aminonicotinamide; Abnormalities, Drug-Induced; Adenosine Triphosphate; Animals; Chick Embryo; Gly | 1982 |
Impaired energy metabolism as an initial step in the mechanism for 6-aminonicotinamide-induced limb malformation.
Topics: 6-Aminonicotinamide; Abnormalities, Drug-Induced; Adenosine Triphosphate; Animals; Cartilage; Chick | 1980 |
The use of in vitro procedures in teratology.
Topics: Abnormalities, Drug-Induced; Aminopropionitrile; Aminopterin; Animals; Azaserine; Bromodeoxyuridine; | 1975 |
Inhibition of ATP synthesis associated with 6-aminonicotinamide (6-AN) teratogenesis in rat embryos.
Topics: 6-Aminonicotinamide; Abnormalities, Drug-Induced; Adenosine Triphosphate; Animals; Dinitrophenols; F | 1975 |
[Plurality in the determinism of organophosphorus teratogenic effects (author's transl)].
Topics: Abnormalities, Drug-Induced; Animals; Female; Niacinamide; Organophosphorus Compounds; Ovum; Parathi | 1976 |
[Prevention of abnormalities induced by 2 organophosphate insecticides (parathion and bidrin) in quail embryos].
Topics: Abnormalities, Drug-Induced; Animals; Cholinesterase Inhibitors; Drug Interactions; Insecticides; Mo | 1976 |
Effect of 6-aminonicotinamide in teratogenic doses on the DNA- and RNA-concentration in rabbit embryos.
Topics: 6-Aminonicotinamide; Abnormalities, Drug-Induced; Animals; DNA; Dose-Response Relationship, Drug; Em | 1977 |
6-Aminonicotinamide-induced cleft palate in the mouse: the nature of the difference between the A/J and C57Bl/6J strains in frequency of response and its genetic basis.
Topics: 6-Aminonicotinamide; Abnormalities, Drug-Induced; Animals; Cleft Palate; Dose-Response Relationship, | 1977 |
On teratogenic syndromes of unitary causation but heterologous systemic consequences.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Carbamates; Chick Embryo; Insulin; Ni | 1977 |
[Action of dicrotophos on the development in vitro of the tibia of chick embryo].
Topics: Abnormalities, Drug-Induced; Animals; Chick Embryo; Niacinamide; Organophosphorus Compounds; Tibia | 1977 |
Genetic independence of the embryonic reactivity difference to cortisone- and 6-aminonicotinamide-induced cleft palate in the mouse.
Topics: 6-Aminonicotinamide; Abnormalities, Drug-Induced; Animals; Cleft Palate; Cortisone; Dose-Response Re | 1979 |
Correlation between mandibular retrognathia and induction of cleft palate with 6-aminonicotinamide in the rat.
Topics: 6-Aminonicotinamide; Abnormalities, Drug-Induced; Animals; Cleft Palate; Dose-Response Relationship, | 1979 |
[On the plurifactorial determinism of the organophosphorous-induced teratogenesis on bird embryos; trials of protection by various compounds: oximes, hydroxamic acids and nicotinamide analogs (author's transl)].
Topics: Abnormalities, Drug-Induced; Animals; Hydroxamic Acids; Insecticides; Niacinamide; Oximes; Parathion | 1979 |
Ascorbate inhibition of 6-aminonicotinamide teratogenesis in chicken embryos.
Topics: 6-Aminonicotinamide; Abnormalities, Drug-Induced; Animals; Body Weight; Cartilage; Chick Embryo; Fet | 1976 |
Congenital hydrocephalus mimicking Dandy-Walker syndrome induced by 6-aminonicotinamide injection in pregnant rat.
Topics: 6-Aminonicotinamide; Abnormalities, Drug-Induced; Animals; Brain; Dandy-Walker Syndrome; Disease Mod | 1991 |
Altered proteoglycan synthesis by micromelial limbs induced by 6-aminonicotinamide. Appearance of abnormal forms of cartilage-characteristic proteoglycan (PG-H).
Topics: 6-Aminonicotinamide; Abnormalities, Drug-Induced; Animals; Carbohydrates; Centrifugation, Density Gr | 1987 |
Inhibiting effects of nicotinamide on urethane-induced malformations and tumors in mice.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Lip; Cleft Palate; Dose-Response Relationship, Drug; Fem | 1988 |
Genetics of susceptibility to 6-aminonicotinamide-induced cleft palate in the mouse: studies in congenic and recombinant inbred strains.
Topics: 6-Aminonicotinamide; Abnormalities, Drug-Induced; Animals; Cleft Palate; Female; Male; Mice; Mice, I | 1988 |
Early changes in parathyroid hormone response and proteoglycan synthesis of chick embryonic femur produced by exposure to 6-aminonicotinamide in ovo.
Topics: 6-Aminonicotinamide; Abnormalities, Drug-Induced; Animals; Bucladesine; Chick Embryo; Extremities; L | 1987 |
Effects of diazinon on nucleotide and amino acid contents of chick embryos. Teratogenic considerations.
Topics: Abnormalities, Drug-Induced; Amino Acids; Animals; Chick Embryo; Diazinon; Insecticides; NAD; Niacin | 1985 |
Effects of a nicotinamide-sensitive teratogen 6-aminonicotinamide on chick limb cells in culture.
Topics: Abnormalities, Drug-Induced; Amines; Animals; Bone and Bones; Carbon Isotopes; Cartilage; Cells, Cul | 1972 |
Gene and phenocopy: selection experiments and tests with 6-aminonicotinamide.
Topics: Abnormalities, Drug-Induced; Animals; Chick Embryo; Genes; Mutation; Niacinamide; Osteochondrodyspla | 1965 |
Effects of acute vitamin replacement therapy on 6-aminonicotinamide induced cleft palate late in rat pregnancy.
Topics: Abnormalities, Drug-Induced; Animals; Antimetabolites; Cleft Palate; Female; Niacinamide; Pregnancy; | 1967 |
Congenital malformations induced by 6-aminonicotinamide in rabbit kits.
Topics: Abnormalities, Drug-Induced; Animals; Eye Abnormalities; Female; Niacinamide; Pregnancy; Pregnancy, | 1967 |
Development of cleft palate induced by 6-aminonicotinamide late in rat gestation.
Topics: Abnormalities, Drug-Induced; Animals; Antimetabolites; Cleft Palate; Female; Niacinamide; Pregnancy; | 1966 |
Failure of steroid hormones to reverse the toxic effects of 6-aminonicotinamide given early in pregnancy.
Topics: Abnormalities, Drug-Induced; Animals; Antimetabolites; Estrone; Female; Fetal Death; Mice; Niacinami | 1967 |
Problems of acetazolamide and N-ethylnicotinamide as teratogens.
Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Chick Embryo; Niacinamide | 1967 |
Pathogenesis of spinal malformations induced in the embryos of mice.
Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Lumbar Vertebrae; Mice; Niacinamide | 1967 |
A cytoplasmically transmitted, diet-dependent difference in response to the teratogenic effects of 6-aminonicotinamide.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Diet; Extrachromosomal Inheritance; Female; Hybr | 1968 |
6-aminonicotinamide-induced skeletal malformations in mice.
Topics: Abnormalities, Drug-Induced; Animals; Antimetabolites; Bone and Bones; Cleft Palate; Female; Fetal D | 1968 |
3-acetylpyridine: effects in vitro related to teratogenic activity in chicken embryos.
Topics: Abnormalities, Drug-Induced; Animals; Cartilage; Cell Differentiation; Chick Embryo; Culture Techniq | 1968 |
[Action of paraminobenzenesulfamide and nicotinamide on the development of the embryos of Leghorn and Creeper strain chickens].
Topics: Abnormalities, Drug-Induced; Animals; Chick Embryo; Female; Niacinamide; Ovum; Phenotype; Sulfonamid | 1968 |
Direct effects of 6-aminonicotinamide on the developing rat embryo in vitro and in vivo.
Topics: Abnormalities, Drug-Induced; Amnion; Animals; Antimetabolites; Cleft Palate; Culture Media; Culture | 1968 |
[Experimental studies on the development of malformations of the extremities. 2. On the process of the development of tibia defects].
Topics: Abnormalities, Drug-Induced; Animals; Female; Maternal-Fetal Exchange; Mice; Niacinamide; Pregnancy; | 1968 |
[Clinical and experimental studies of delta phalanx of the hallux].
Topics: Abnormalities, Drug-Induced; Animals; Child; Child, Preschool; Female; Hallux; Humans; Infant, Newbo | 1969 |
[Disturbances of tooth development in rat embryos following administration of 6-aminonicotinamide].
Topics: Abnormalities, Drug-Induced; Animals; Embryo, Mammalian; Female; Incisor; Microscopy, Electron; Niac | 1970 |
Succinate, glycerophosphate and ascorbate as sources of cellular energy and as antiteratogens.
Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Ascorbic Acid; Chick Embryo; Drug Synergism; Gl | 1970 |
Further studies on a cytoplasmically transmitted difference in response to the teratogen 6-aminonicotinamide.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Cytoplasm; Diet; Extrachromosomal Inheritance; F | 1968 |
Biochemical studies of the embryotoxic action of 6-aminonicotinamide.
Topics: Abnormalities, Drug-Induced; Acetates; Aspartic Acid; Carbon Isotopes; DNA; Embryo, Mammalian; Embry | 1970 |
Electron microscope studies on the effect of 6-aminonicotinamide on mammalian embryos.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Culture Techniques; Ectoderm; Embryo, Mammalian; Female | 1970 |
The teratogenic action of the nicotinamide analgos 3-acetylpyridine and 6-aminonicotinamide on developing chick embryos.
Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Chick Embryo; Gestational Age; Ketones; Muscle | 1971 |
Embryonic abnormalities in hamsters following intrauterine injection of 6-aminonicotinamide.
Topics: Abnormalities, Drug-Induced; Amniotic Fluid; Animals; Anophthalmos; Brain; Cleft Palate; Cricetinae; | 1971 |
The effects of intraamniotic injection of dexamethasone in rats.
Topics: Abnormalities, Drug-Induced; Animals; Birth Weight; Cleft Palate; Dexamethasone; Drug Synergism; Ext | 1971 |
Influence of maternal age and parity on fetal mortality and congenital abnormalities induced in rats.
Topics: Abnormalities, Drug-Induced; Animals; Antimetabolites; Cleft Palate; Eye Abnormalities; Female; Feta | 1971 |
[Disturbed embryonic mitosis in rabbits after administration of 6-aminonicotinic acid amide].
Topics: Abnormalities, Drug-Induced; Amines; Animals; Embryo, Mammalian; Female; Fibroblasts; Liver; Mitosis | 1972 |
Comparison of the capacity of nicotinamide and nicotinic acid to relieve the effects of muscle and cartilage teratogens in developing chick embryos.
Topics: Abnormalities, Drug-Induced; Acetates; Amines; Animals; Bone and Bones; Cartilage; Chick Embryo; Mes | 1972 |
[Experiments on the induction and prevention of malformations in rabbits].
Topics: Abnormalities, Drug-Induced; Amines; Animals; Animals, Newborn; Antimetabolites; Cell Division; Cong | 1972 |
The effects of the nicotinamide sensitive teratogen 3-acetylpyridine on chick limb mesodermal cells in culture: biochemical parameters.
Topics: Abnormalities, Drug-Induced; Animals; Carbon Isotopes; Cartilage; Cell Differentiation; Cells, Cultu | 1972 |
Aspects of dimethyl sulfoxide as solvent for teratogens.
Topics: Abnormalities, Drug-Induced; Acetates; Amines; Animals; Butyrates; Chick Embryo; Dimethyl Sulfoxide; | 1972 |
The site and sequence of action of 6-aminonicotinamide in causing bone malformations of embryonic chick limb and its relationship to normal development.
Topics: Abnormalities, Drug-Induced; Amines; Animals; Bone and Bones; Cartilage; Chick Embryo; Hindlimb; Nia | 1972 |
Histological and fine structural changes during chondrogenesis in micromelia induced by 6-aminonicotinamide.
Topics: Abnormalities, Drug-Induced; Animals; Cartilage; Cell Differentiation; Chick Embryo; Endoplasmic Ret | 1972 |
Coenzyme competition and precursor specificity during teratogenesis induced by 6-aminonicotinamide.
Topics: Abnormalities, Drug-Induced; Animals; Autoradiography; Chick Embryo; Coenzymes; Energy Transfer; Enz | 1972 |
6-Aminonicotinamide (6-AN)-induced abnormalities of the developing ependyma and choroid plexus as seen with the scanning electron microscope.
Topics: Abnormalities, Drug-Induced; Animals; Cell Membrane; Choroid Plexus; Cilia; Ependyma; Female; Fetus; | 1972 |
Teratogenic activity of 2-amino-1,3,4-thiadiazole hydrochloride in Wistar rats and the protection afforded by nicotinamide.
Topics: Abnormalities, Drug-Induced; Animals; Female; Fetus; Niacinamide; Rats; Thiadiazoles | 1973 |
Relationship of the acylation of membrane esterases and proteins to the teratogenic action of organophosphorus insecticides and eserine in developing hen eggs.
Topics: Abnormalities, Drug-Induced; Acylation; Animals; Binding Sites; Chick Embryo; Chickens; Electrophore | 1972 |
DNA synthesis inhibition, cytotoxicity and their relationship to teratogenesis following administration of a nicotinamide antagonist, aminothiadiazole, to pregnant rats.
Topics: Abnormalities, Drug-Induced; Animals; Cleft Palate; Cytarabine; Depression, Chemical; DNA; Female; F | 1973 |
A survey of the embryotoxic effects of TCDD in mammalian species.
Topics: 2,4,5-Trichlorophenoxyacetic Acid; Abnormalities, Drug-Induced; Amines; Animals; Cleft Palate; Cyclo | 1973 |
[Preliminary teratological experiments with mini-pigs ("Göttinger miniaturschwein") (author's transl)].
Topics: Abnormalities, Drug-Induced; Animals; Disease Models, Animal; Female; Gestational Age; Niacinamide; | 1973 |
[Experimental studies on the boundary sensitive phase of embryonal development of "Göttingen miniature pigs"].
Topics: Abnormalities, Drug-Induced; Animals; Dose-Response Relationship, Drug; Embryonic and Fetal Developm | 1973 |
[Phase-specific pattern of malformation in the Goettinger miniature pig following administration of 6-amino-nicotinamide].
Topics: Abnormalities, Drug-Induced; Animals; Animals, Laboratory; Female; Fetus; Injections, Intraperitonea | 1974 |
[Effect of 6-aminonicotinic acid amide in teratogenic dosis on the ATP-concentration in rabbit embryos].
Topics: Abnormalities, Drug-Induced; Adenosine Triphosphate; Amines; Animals; Embryo, Mammalian; Female; Nia | 1974 |
Normal incorporation rates for precursors of collagen and mucopolysaccharide during expression of micromelia induced by 6-aminonicotinamide.
Topics: Abnormalities, Drug-Induced; Amines; Animals; Carbon Radioisotopes; Chick Embryo; Collagen; Depressi | 1974 |
Reduction of 6-aminonicotinamide teratogenicity in mice by etherization.
Topics: Abnormalities, Drug-Induced; Anesthesia, Inhalation; Animals; Cleft Lip; Ether; Ethyl Ethers; Female | 1970 |
Induction of a cytoplasmic factor increasing resistance to the teratogenic effect of 6-aminonicotinamide in mice.
Topics: 6-Aminonicotinamide; Abnormalities, Drug-Induced; Animals; Cleft Palate; Cytoplasm; Enzyme Induction | 1973 |
Nicotinamide deficiency and thalidomide: potential teratogenic disturbances in Long-Evans rats.
Topics: Abnormalities, Drug-Induced; Adrenal Cortex Hormones; Animal Feed; Animals; Birth Weight; Chlorproma | 1969 |
Teratology in the Macaca mulatta.
Topics: Abnormalities, Drug-Induced; Animals; Aspirin; Clomiphene; Encephalocele; Female; Fetal Death; Haplo | 1968 |
[Induction and prevention of developmental abnormalities in rabbits by administration of 6-aminonicotinic acid and nicotinic acid amide].
Topics: Abnormalities, Drug-Induced; Amines; Animals; Female; Fetus; Gestational Age; Microphthalmos; Mouth | 1971 |
Structure--activity and metabolism studies on organophosphate teratogens and their alleviating agents in developing hen eggs with special emphasis on Bidrin.
Topics: Abnormalities, Drug-Induced; Abnormalities, Multiple; Animals; Butyrates; Chick Embryo; Cholinestera | 1969 |
Intra-amniotic injection of pyridine nucleotides or adenosine triphosphate as countertherapy for 6-aminonicotinamide (6-AN) teratogenesis.
Topics: Abnormalities, Drug-Induced; Adenosine Triphosphate; Amnion; Animals; Female; Fetus; Injections; Mal | 1970 |
The morphology of various types of cell death in prenatal tissues.
Topics: Abnormalities, Drug-Induced; Animals; Cell Survival; Cyclophosphamide; Dactinomycin; Embryo, Mammali | 1973 |