niacin has been researched along with Primary Ovarian Insufficiency in 3 studies
Niacin: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.
vitamin B3 : Any member of a group of vitamers that belong to the chemical structural class called pyridines that exhibit biological activity against vitamin B3 deficiency. Vitamin B3 deficiency causes a condition known as pellagra whose symptoms include depression, dermatitis and diarrhea. The vitamers include nicotinic acid and nicotinamide (and their ionized and salt forms).
nicotinic acid : A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.
Primary Ovarian Insufficiency: Cessation of ovarian function after MENARCHE but before the age of 40, without or with OVARIAN FOLLICLE depletion. It is characterized by the presence of OLIGOMENORRHEA or AMENORRHEA, elevated GONADOTROPINS, and low ESTRADIOL levels. It is a state of female HYPERGONADOTROPIC HYPOGONADISM. Etiologies include genetic defects, autoimmune processes, chemotherapy, radiation, and infections. The most commonly known genetic cause is the expansion of a CGG repeat to 55 to 199 copies in the 5' untranslated region in the X-linked FMR1 gene.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Administration of niacin to treat premature ovarian failure (POF) in mouse models showed inhibition of follicular apoptosis under harmful conditions, such as radiation and chemotherapy damage, by markedly reducing cumulus cell apoptosis." | 1.48 | Niacin Inhibits Apoptosis and Rescues Premature Ovarian Failure. ( Sun, M; Wang, D; Wang, S; Wang, Y; Yao, Y; Yu, L, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 2 (66.67) | 2.80 |
| Authors | Studies |
|---|---|
| Ovayolu, A | 1 |
| Bostancieri, N | 1 |
| Zhao, C | 1 |
| Hu, P | 1 |
| Bai, YL | 1 |
| Xia, C | 1 |
| Wang, S | 1 |
| Sun, M | 1 |
| Yu, L | 1 |
| Wang, Y | 1 |
| Yao, Y | 1 |
| Wang, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Soluble Fms-like Tyrosine Kinase-1, Proangiogenic Protein Placental Growth Factor, and Niacin Levels in Women With Premature Ovarian Insufficiency[NCT04641624] | 90 participants (Actual) | Observational | 2020-11-20 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 other studies available for niacin and Primary Ovarian Insufficiency
| Article | Year |
|---|---|
A prospective and comparative investigation of blood sFlt-1, P1GF, and niacin concentrations in women with premature ovarian insufficiency.
Topics: Biomarkers; Female; Humans; Niacin; Placenta; Placenta Growth Factor; Pre-Eclampsia; Pregnancy; Prim | 2023 |
Plasma metabolic differences in cows affected by inactive ovaries or normal ovarian function post partum.
Topics: Amino Acids; Animals; Carbohydrate Metabolism; Cattle; Cattle Diseases; Female; Least-Squares Analys | 2020 |
Niacin Inhibits Apoptosis and Rescues Premature Ovarian Failure.
Topics: Animals; Apoptosis; Cell Cycle Checkpoints; Cyclophosphamide; DEAD-box RNA Helicases; Disease Models | 2018 |