niacin has been researched along with Parkinson Disease in 11 studies
Niacin: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.
vitamin B3 : Any member of a group of vitamers that belong to the chemical structural class called pyridines that exhibit biological activity against vitamin B3 deficiency. Vitamin B3 deficiency causes a condition known as pellagra whose symptoms include depression, dermatitis and diarrhea. The vitamers include nicotinic acid and nicotinamide (and their ionized and salt forms).
nicotinic acid : A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.
Parkinson Disease: A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Dysbiosis is implicated by many studies in the pathogenesis of Parkinson's disease (PD)." | 2.66 | Niacin and Butyrate: Nutraceuticals Targeting Dysbiosis and Intestinal Permeability in Parkinson's Disease. ( Karunaratne, TB; Okereke, C; Purohit, S; Seamon, M; Sharma, A; Wakade, C, 2020) |
| "Niacin is a precursor for NAD-NADH which is needed for dopamine production." | 2.50 | A novel treatment target for Parkinson's disease. ( Chong, R; Wakade, C, 2014) |
| "Niacin levels were lower in PD and were associated with increased frequency of experiencing body pain and decreased duration of deep sleep." | 1.40 | Upregulation of GPR109A in Parkinson's disease. ( Bradley, E; Chong, R; Morgan, J; Thomas, B; Wakade, C, 2014) |
| "Interestingly, pellagra and Parkinson's disease could share some basic pathophysiological mechanisms at the level of nicotinamide metabolism, resulting in mitochondrial dysfunction and alterations in dopaminergic pathways." | 1.39 | Parkinsonian features in a case of pellagra: a historical report. ( Cavanna, AE; Nani, A; Williams, AC, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 6 (54.55) | 24.3611 |
| 2020's | 3 (27.27) | 2.80 |
| Authors | Studies |
|---|---|
| Abu-Elfotuh, K | 1 |
| Hamdan, AME | 1 |
| Abbas, AN | 1 |
| Alahmre, ATS | 1 |
| Elewa, MAF | 1 |
| Masoud, RAE | 1 |
| Ali, AA | 1 |
| Othman, M | 1 |
| Kamal, MM | 1 |
| Hassan, FAM | 1 |
| Khalil, MG | 1 |
| El-Sisi, AM | 1 |
| Abdel Hady, MMM | 1 |
| Abd-Elhaleim El Azazy, MK | 1 |
| Awny, MM | 1 |
| Wahid, A | 1 |
| He, D | 1 |
| Fu, S | 1 |
| Ye, B | 1 |
| Wang, H | 1 |
| He, Y | 1 |
| Li, Z | 1 |
| Li, J | 1 |
| Gao, X | 1 |
| Liu, D | 1 |
| Giri, B | 2 |
| Belanger, K | 1 |
| Seamon, M | 2 |
| Bradley, E | 2 |
| Purohit, S | 2 |
| Chong, R | 3 |
| Morgan, JC | 2 |
| Baban, B | 2 |
| Wakade, C | 5 |
| Karunaratne, TB | 1 |
| Okereke, C | 1 |
| Sharma, A | 1 |
| Malik, A | 1 |
| Khodadadi, H | 1 |
| Chong, RK | 1 |
| Thomas, B | 1 |
| Morgan, J | 1 |
| Wallach, I | 1 |
| Jaitly, N | 1 |
| Lilien, R | 1 |
| EHLERS, G | 1 |
| Moriyama, TF | 1 |
| Cavanna, AE | 1 |
| Nani, A | 1 |
| Williams, AC | 1 |
2 reviews available for niacin and Parkinson Disease
| Article | Year |
|---|---|
Niacin and Butyrate: Nutraceuticals Targeting Dysbiosis and Intestinal Permeability in Parkinson's Disease.
Topics: Animals; Butyrates; Dietary Supplements; Dysbiosis; Gastrointestinal Microbiome; Humans; Intestinal | 2020 |
A novel treatment target for Parkinson's disease.
Topics: Aged; Dopamine; Female; Humans; Male; Middle Aged; NAD; Neuroprotective Agents; Niacin; Nicotinic Ag | 2014 |
1 trial available for niacin and Parkinson Disease
| Article | Year |
|---|---|
Niacin modulates macrophage polarization in Parkinson's disease.
Topics: Aged; Dietary Supplements; Female; Humans; Macrophages; Male; Middle Aged; Niacin; Parkinson Disease | 2018 |
8 other studies available for niacin and Parkinson Disease
| Article | Year |
|---|---|
Evaluating the neuroprotective activities of vinpocetine, punicalagin, niacin and vitamin E against behavioural and motor disabilities of manganese-induced Parkinson's disease in Sprague Dawley rats.
Topics: Acetylcholinesterase; Animals; Anti-Inflammatory Agents; Antioxidants; Glycogen Synthase Kinase 3 be | 2022 |
Activation of HCA2 regulates microglial responses to alleviate neurodegeneration in LPS-induced in vivo and in vitro models.
Topics: Animals; Dopaminergic Neurons; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Microglia; Neuro | 2023 |
Niacin Ameliorates Neuro-Inflammation in Parkinson's Disease via GPR109A.
Topics: Animals; Anti-Inflammatory Agents; Humans; Inflammation; Interleukin-1beta; Interleukin-6; Lipopolys | 2019 |
Upregulation of GPR109A in Parkinson's disease.
Topics: Adult; Aged; Case-Control Studies; Female; Humans; Male; Middle Aged; Niacin; Parkinson Disease; Rec | 2014 |
A structure-based approach for mapping adverse drug reactions to the perturbation of underlying biological pathways.
Topics: Breast Neoplasms; Computational Biology; Databases, Factual; Diabetes Mellitus, Type 2; Drug-Related | 2010 |
[On the applicability of cosaldon in the treatment of cerebral sclerotic parkinsonism].
Topics: Drug Combinations; Niacin; Nicotinic Acids; Parkinson Disease; Parkinsonian Disorders; Theobromine; | 1959 |
Corn might prevent Parkinson's Disease.
Topics: Humans; Niacin; Parkinson Disease; Prevalence; Zea mays | 2001 |
Parkinsonian features in a case of pellagra: a historical report.
Topics: History, 20th Century; Humans; Male; Middle Aged; Parkinson Disease; Pellagra; Sciatica | 2013 |