Page last updated: 2024-10-19

niacin and Non-alcoholic Fatty Liver Disease

niacin has been researched along with Non-alcoholic Fatty Liver Disease in 9 studies

Niacin: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.
vitamin B3 : Any member of a group of vitamers that belong to the chemical structural class called pyridines that exhibit biological activity against vitamin B3 deficiency. Vitamin B3 deficiency causes a condition known as pellagra whose symptoms include depression, dermatitis and diarrhea. The vitamers include nicotinic acid and nicotinamide (and their ionized and salt forms).
nicotinic acid : A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.

Non-alcoholic Fatty Liver Disease: Fatty liver finding without excessive ALCOHOL CONSUMPTION.

Research Excerpts

ExcerptRelevanceReference
"NAFLD was defined using the United States fatty liver index (US-FLI)."5.91Association between Dietary Niacin Intake and Nonalcoholic Fatty Liver Disease: NHANES 2003-2018. ( Hu, Y; Pan, J; Pang, N; Yang, L, 2023)
"Non-alcoholic fatty liver disease (NAFLD) is a common disorder characterized by excessive hepatic fat accumulation, production of reactive oxygen species (ROS), inflammation and potentially resulting in non-alcoholic steatohepatitis (NASH), cirrhosis and end-stage liver disease."5.42Niacin inhibits fat accumulation, oxidative stress, and inflammatory cytokine IL-8 in cultured hepatocytes: Impact on non-alcoholic fatty liver disease. ( Ganji, SH; Kamanna, VS; Kashyap, ML, 2015)
"Niacin treatment to rats with preexisting hepatic steatosis induced by the HF diet significantly regressed steatosis."5.40Therapeutic role of niacin in the prevention and regression of hepatic steatosis in rat model of nonalcoholic fatty liver disease. ( Ganji, SH; Kamanna, VS; Kashyap, ML; Kukes, GD; Lambrecht, N, 2014)
"NAFLD was defined using the United States fatty liver index (US-FLI)."1.91Association between Dietary Niacin Intake and Nonalcoholic Fatty Liver Disease: NHANES 2003-2018. ( Hu, Y; Pan, J; Pang, N; Yang, L, 2023)
"Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease in the world."1.56Niacin Ameliorates Hepatic Steatosis by Inhibiting De Novo Lipogenesis Via a GPR109A-Mediated PKC-ERK1/2-AMPK Signaling Pathway in C57BL/6 Mice Fed a High-Fat Diet. ( Cao, Z; Lai, X; Shi, Y; Ye, L; Zhou, N, 2020)
"Niacin treatment was started from week 5 until the end of the study."1.56Niacin increases diet-induced hepatic steatosis in B6129 mice. ( Fang, H; Graff, EC; Judd, RL; Li, Z; McCafferty, KJ, 2020)
"Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disorder in industrialized countries, yet its pathophysiology is incompletely understood."1.42Metabolomic tissue signature in human non-alcoholic fatty liver disease identifies protective candidate metabolites. ( Becker, T; Beldi, G; Brosch, M; Brückner, S; Erhart, W; Fahrner, R; Gruodyte, A; Hampe, J; Hinrichsen, H; Itzel, T; Landrock, A; Patsenker, E; Richter, K; Röcken, C; Schafmayer, C; Schreiber, S; Sipos, B; Stickel, F; Teufel, A; Vollnberg, B; von Schönfels, W, 2015)
"Non-Alcoholic Fatty Liver Disease (NAFLD) is a common liver disorder, characterized by an excessive lipids deposition within the hepatic tissue."1.42Raman spectroscopy analysis of lipid droplets content, distribution and saturation level in Non-Alcoholic Fatty Liver Disease in mice. ( Baranska, M; Chlopicki, S; Kochan, K; Kostogrys, R; Krafft, C; Maslak, E, 2015)
"Non-alcoholic fatty liver disease (NAFLD) is a common disorder characterized by excessive hepatic fat accumulation, production of reactive oxygen species (ROS), inflammation and potentially resulting in non-alcoholic steatohepatitis (NASH), cirrhosis and end-stage liver disease."1.42Niacin inhibits fat accumulation, oxidative stress, and inflammatory cytokine IL-8 in cultured hepatocytes: Impact on non-alcoholic fatty liver disease. ( Ganji, SH; Kamanna, VS; Kashyap, ML, 2015)
"Niacin treatment to rats with preexisting hepatic steatosis induced by the HF diet significantly regressed steatosis."1.40Therapeutic role of niacin in the prevention and regression of hepatic steatosis in rat model of nonalcoholic fatty liver disease. ( Ganji, SH; Kamanna, VS; Kashyap, ML; Kukes, GD; Lambrecht, N, 2014)

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (55.56)24.3611
2020's4 (44.44)2.80

Authors

AuthorsStudies
Cardoso-Lezama, I1
Fuentes-Figueroa, MÁ1
Ramos-Tovar, E1
Márquez-Quiroga, LV1
Ortiz-Fernández, A1
Vargas-Pozada, EE1
Arellanes-Robledo, J1
Tsutsumi, V1
Muriel, P1
Pan, J1
Hu, Y1
Pang, N1
Yang, L1
Ye, L1
Cao, Z1
Lai, X1
Shi, Y1
Zhou, N1
Fang, H1
Li, Z1
Graff, EC1
McCafferty, KJ1
Judd, RL1
Ganji, SH2
Kukes, GD1
Lambrecht, N1
Kashyap, ML2
Kamanna, VS2
van den Hoek, AM1
van der Hoorn, JW1
Maas, AC1
van den Hoogen, RM1
van Nieuwkoop, A1
Droog, S1
Offerman, EH1
Pieterman, EJ1
Havekes, LM1
Princen, HM1
von Schönfels, W1
Patsenker, E1
Fahrner, R1
Itzel, T1
Hinrichsen, H1
Brosch, M1
Erhart, W1
Gruodyte, A1
Vollnberg, B1
Richter, K1
Landrock, A1
Schreiber, S1
Brückner, S1
Beldi, G1
Sipos, B1
Becker, T1
Röcken, C1
Teufel, A1
Stickel, F1
Schafmayer, C1
Hampe, J1
Kochan, K1
Maslak, E1
Krafft, C1
Kostogrys, R1
Chlopicki, S1
Baranska, M1

Other Studies

9 other studies available for niacin and Non-alcoholic Fatty Liver Disease

ArticleYear
Nicotinic acid attenuates experimental non-alcoholic steatohepatitis by inhibiting the NLRP3 inflammasome/pyroptosis pathway.
    Biochemical pharmacology, 2023, Volume: 216

    Topics: Animals; Humans; Inflammasomes; Mice; Mice, Inbred C57BL; Niacin; NLR Family, Pyrin Domain-Containin

2023
Association between Dietary Niacin Intake and Nonalcoholic Fatty Liver Disease: NHANES 2003-2018.
    Nutrients, 2023, Sep-25, Volume: 15, Issue:19

    Topics: Diet; Humans; Niacin; Non-alcoholic Fatty Liver Disease; Nutrition Surveys; Nutritional Status; Unit

2023
Niacin Ameliorates Hepatic Steatosis by Inhibiting De Novo Lipogenesis Via a GPR109A-Mediated PKC-ERK1/2-AMPK Signaling Pathway in C57BL/6 Mice Fed a High-Fat Diet.
    The Journal of nutrition, 2020, 04-01, Volume: 150, Issue:4

    Topics: Adenylate Kinase; Animals; Diet, High-Fat; Gene Knockdown Techniques; Hep G2 Cells; Humans; Lipogene

2020
Niacin increases diet-induced hepatic steatosis in B6129 mice.
    Biochimica et biophysica acta. Molecular and cell biology of lipids, 2020, Volume: 1865, Issue:9

    Topics: Animals; Diet, High-Fat; Hypolipidemic Agents; Insulin Resistance; Lipid Metabolism; Lipoproteins, V

2020
Therapeutic role of niacin in the prevention and regression of hepatic steatosis in rat model of nonalcoholic fatty liver disease.
    American journal of physiology. Gastrointestinal and liver physiology, 2014, Feb-15, Volume: 306, Issue:4

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Disease Models, Animal; Disease Progression; Fatty

2014
APOE*3Leiden.CETP transgenic mice as model for pharmaceutical treatment of the metabolic syndrome.
    Diabetes, obesity & metabolism, 2014, Volume: 16, Issue:6

    Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Animals; Apolipoprotein E3; Atorvastatin; Cholesterol E

2014
Metabolomic tissue signature in human non-alcoholic fatty liver disease identifies protective candidate metabolites.
    Liver international : official journal of the International Association for the Study of the Liver, 2015, Volume: 35, Issue:1

    Topics: Animals; Biopsy; Dietary Supplements; Gas Chromatography-Mass Spectrometry; Humans; Hydroquinones; L

2015
Raman spectroscopy analysis of lipid droplets content, distribution and saturation level in Non-Alcoholic Fatty Liver Disease in mice.
    Journal of biophotonics, 2015, Volume: 8, Issue:7

    Topics: Animals; Apolipoproteins E; Diet, High-Fat; Dietary Carbohydrates; Dietary Proteins; Lipid Droplets;

2015
Niacin inhibits fat accumulation, oxidative stress, and inflammatory cytokine IL-8 in cultured hepatocytes: Impact on non-alcoholic fatty liver disease.
    Metabolism: clinical and experimental, 2015, Volume: 64, Issue:9

    Topics: Diacylglycerol O-Acyltransferase; Hepatocytes; Humans; Hypolipidemic Agents; Interleukin-8; Lipid Me

2015