niacin has been researched along with Multiple Sclerosis in 13 studies
Niacin: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.
vitamin B3 : Any member of a group of vitamers that belong to the chemical structural class called pyridines that exhibit biological activity against vitamin B3 deficiency. Vitamin B3 deficiency causes a condition known as pellagra whose symptoms include depression, dermatitis and diarrhea. The vitamers include nicotinic acid and nicotinamide (and their ionized and salt forms).
nicotinic acid : A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.
Multiple Sclerosis: An autoimmune disorder mainly affecting young adults and characterized by destruction of myelin in the central nervous system. Pathologic findings include multiple sharply demarcated areas of demyelination throughout the white matter of the central nervous system. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia, and bladder dysfunction. The usual pattern is one of recurrent attacks followed by partial recovery (see MULTIPLE SCLEROSIS, RELAPSING-REMITTING), but acute fulminating and chronic progressive forms (see MULTIPLE SCLEROSIS, CHRONIC PROGRESSIVE) also occur. (Adams et al., Principles of Neurology, 6th ed, p903)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Remyelination following CNS demyelination restores rapid signal propagation and protects axons; however, its efficiency declines with increasing age." | 5.56 | Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system. ( Alaeiilkhchi, N; Calvert, F; Franklin, RJM; Gaffney, DJ; Ghosh, T; Kappen, J; Kaushik, DK; Keough, MB; Knights, AJ; Kolehmainen, KL; Lozinski, B; Michaels, NJ; Mirzaei, R; Mishra, MK; Plemel, JR; Pu, A; Rawji, KS; Tang, W; Tetzlaff, W; Yong, VW; Young, AMH; Zein, S, 2020) |
| "Remyelination following CNS demyelination restores rapid signal propagation and protects axons; however, its efficiency declines with increasing age." | 1.56 | Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system. ( Alaeiilkhchi, N; Calvert, F; Franklin, RJM; Gaffney, DJ; Ghosh, T; Kappen, J; Kaushik, DK; Keough, MB; Knights, AJ; Kolehmainen, KL; Lozinski, B; Michaels, NJ; Mirzaei, R; Mishra, MK; Plemel, JR; Pu, A; Rawji, KS; Tang, W; Tetzlaff, W; Yong, VW; Young, AMH; Zein, S, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (76.92) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (15.38) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Rawji, KS | 1 |
| Young, AMH | 1 |
| Ghosh, T | 1 |
| Michaels, NJ | 1 |
| Mirzaei, R | 1 |
| Kappen, J | 1 |
| Kolehmainen, KL | 1 |
| Alaeiilkhchi, N | 1 |
| Lozinski, B | 1 |
| Mishra, MK | 1 |
| Pu, A | 1 |
| Tang, W | 1 |
| Zein, S | 1 |
| Kaushik, DK | 1 |
| Keough, MB | 1 |
| Plemel, JR | 1 |
| Calvert, F | 1 |
| Knights, AJ | 1 |
| Gaffney, DJ | 1 |
| Tetzlaff, W | 1 |
| Franklin, RJM | 1 |
| Yong, VW | 1 |
| Evans, E | 1 |
| Piccio, L | 1 |
| Cross, AH | 1 |
| Offermanns, S | 1 |
| Schwaninger, M | 1 |
| KURTZKE, JF | 1 |
| BERLIN, L | 1 |
| DEKABAN, A | 1 |
| KORENGOLD, MC | 1 |
| HAASE, GR | 1 |
| BERG, LR | 1 |
| MAGEE, KR | 1 |
| LONNUM, A | 1 |
| HINTERBUCHNER, LP | 1 |
| GOLDNER, MG | 1 |
| ROGOFF, JB | 1 |
| RABINER, AM | 1 |
| AHRINGSMANN, H | 1 |
| ANGST, J | 1 |
| STERN, FH | 1 |
| TSCHABITSCHER, H | 1 |
| WANKO, T | 1 |
| SCHINKO, H | 1 |
| FUST, B | 1 |
| MONTGOMERY, RD | 1 |
| CRUICKSHANK, EK | 1 |
| ROBERTSON, WB | 1 |
| MCMENEMEY, WH | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Adjuvant Effects of Vitamin A and Vitamin D Supplementation on Treatment of Children With ADHD:A Randomized, Double Blind, Placebo-controlled, Multicentric Trial.[NCT04284059] | Phase 4 | 504 participants (Anticipated) | Interventional | 2021-02-25 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for niacin and Multiple Sclerosis
| Article | Year |
|---|---|
Use of Vitamins and Dietary Supplements by Patients With Multiple Sclerosis: A Review.
Topics: Acetylcarnitine; Animals; Ascorbic Acid; Biotin; Caffeine; Creatine; Curcumin; Dietary Supplements; | 2018 |
Nutritional or pharmacological activation of HCA(2) ameliorates neuroinflammation.
Topics: 3-Hydroxybutyric Acid; Adenylyl Cyclases; Animals; Brain; Brain Ischemia; Diet, Ketogenic; Dimethyl | 2015 |
11 other studies available for niacin and Multiple Sclerosis
| Article | Year |
|---|---|
Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system.
Topics: Aging; Animals; Axons; Demyelinating Diseases; Humans; Macrophages; Mice, Transgenic; Microglia; Mul | 2020 |
The effects of isoniazid on patients with multiple sclerosis; preliminary report.
Topics: Isomerism; Isoniazid; Multiple Sclerosis; Niacin; Nicotinic Acids; Psychotherapy, Multiple | 1954 |
Failure in treatment of multiple sclerosis patients with isoniazid.
Topics: Isomerism; Isoniazid; Multiple Sclerosis; Niacin; Nicotinic Acids; Psychotherapy, Multiple | 1955 |
Isonicotinic acid hydrazide in multiple sclerosis.
Topics: Isoniazid; Multiple Sclerosis; Niacin; Nicotinic Acids | 1955 |
[Isoniazid in the treatment of multiple sclerosis].
Topics: Isomerism; Isoniazid; Multiple Sclerosis; Niacin; Nicotinic Acids; Psychotherapy, Multiple | 1955 |
Effect of isoniazid in multiple sclerosis with chronic symptomatology.
Topics: Isomerism; Isoniazid; Multiple Sclerosis; Niacin; Nicotinic Acids; Psychotherapy, Multiple | 1956 |
[The presently possible therapy of multiple sclerosis and its significance for the etiology of the disease].
Topics: Diet; Isomerism; Multiple Sclerosis; Niacin; Nicotinic Acids; Psychotherapy, Multiple; Rest | 1955 |
[Treatment of multiple sclerosis with rimifon and marsilid].
Topics: Isomerism; Isoniazid; Multiple Sclerosis; Niacin; Nicotinic Acids; Psychotherapy, Multiple | 1956 |
COMPARISON OF THREE AGENTS (TIGACOL, DRAMAMINE AND ANTIVERT) FOR THE CONTROL OF DIZZINESS IN GERIATRIC PATIENTS.
Topics: Alcohols; Benzamides; Cochlear Nerve; Dimenhydrinate; Dizziness; Geriatrics; Humans; Intracranial Ar | 1963 |
[Therapy and etiology of multiple sclerosis; preliminary report].
Topics: Isomerism; Multiple Sclerosis; Niacin; Nicotinic Acids; Psychotherapy, Multiple | 1955 |
CLINICAL AND PATHOLOGICAL OBSERVATIONS ON JAMAICAN NEUROPATHY; A REPORT ON 206 CASES.
Topics: Amblyopia; Arachnoid; Ataxia; Central Nervous System Diseases; Humans; Lathyrism; Meningitis; Multip | 1964 |