niacin has been researched along with Metabolic Diseases in 24 studies
Niacin: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.
vitamin B3 : Any member of a group of vitamers that belong to the chemical structural class called pyridines that exhibit biological activity against vitamin B3 deficiency. Vitamin B3 deficiency causes a condition known as pellagra whose symptoms include depression, dermatitis and diarrhea. The vitamers include nicotinic acid and nicotinamide (and their ionized and salt forms).
nicotinic acid : A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.
Metabolic Diseases: Generic term for diseases caused by an abnormal metabolic process. It can be congenital due to inherited enzyme abnormality (METABOLISM, INBORN ERRORS) or acquired due to disease of an endocrine organ or failure of a metabolically important organ such as the liver. (Stedman, 26th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fifty patients with the metabolic syndrome (Adult Treatment Panel (ATP) III criteria) were randomised to either extended-release niacin (1000 mg/day) or placebo." | 9.12 | The effects of extended-release niacin on carotid intimal media thickness, endothelial function and inflammatory markers in patients with the metabolic syndrome. ( Hammoud, R; Khan, BV; Nagamia, S; Oguchi, A; Thoenes, M; Umpierrez, GE; Vaccari, CS, 2007) |
| "Fifty patients with the metabolic syndrome (Adult Treatment Panel (ATP) III criteria) were randomised to either extended-release niacin (1000 mg/day) or placebo." | 5.12 | The effects of extended-release niacin on carotid intimal media thickness, endothelial function and inflammatory markers in patients with the metabolic syndrome. ( Hammoud, R; Khan, BV; Nagamia, S; Oguchi, A; Thoenes, M; Umpierrez, GE; Vaccari, CS, 2007) |
| " Many of these patients, as well as persons at heightened risk for cardiovascular disease because of a range of heritable conditions (eg, familial hypercholesterolemia, familial combined hyperlipidemia), will undoubtedly require binary or ternary regimens involving statins in concert with niacin, fibric-acid derivatives, or bile acid resins." | 4.81 | Combination lipid-altering therapy: an emerging treatment paradigm for the 21st century. ( Jacobson, TA, 2001) |
| "Ecological evidence suggests that niacin (nicotinamide and nicotinic acid) fortification may be involved in the increased prevalence of obesity and type 2 diabetes, both of which are associated with insulin resistance and epigenetic changes." | 3.79 | Nicotinamide supplementation induces detrimental metabolic and epigenetic changes in developing rats. ( Cao, JM; Cao, Y; Gong, XJ; Guo, J; Guo, M; Li, D; Lun, YZ; Luo, N; Sun, WP; Tian, YJ; Zhou, SS, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (75.00) | 18.7374 |
| 1990's | 1 (4.17) | 18.2507 |
| 2000's | 3 (12.50) | 29.6817 |
| 2010's | 1 (4.17) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Li, X | 1 |
| Yang, H | 1 |
| Jin, H | 1 |
| Turkez, H | 1 |
| Ozturk, G | 1 |
| Doganay, HL | 1 |
| Zhang, C | 1 |
| Nielsen, J | 1 |
| Uhlén, M | 1 |
| Borén, J | 1 |
| Mardinoglu, A | 1 |
| Li, D | 1 |
| Tian, YJ | 1 |
| Guo, J | 1 |
| Sun, WP | 1 |
| Lun, YZ | 1 |
| Guo, M | 1 |
| Luo, N | 1 |
| Cao, Y | 1 |
| Cao, JM | 1 |
| Gong, XJ | 1 |
| Zhou, SS | 1 |
| HALVORSEN, K | 1 |
| HALVORSEN, S | 1 |
| WOOLF, LI | 1 |
| DEMEULEMEESTER, F | 1 |
| RIEKE, JA | 1 |
| DELAEY, P | 3 |
| HOOFT, C | 3 |
| TIMMERMANS, J | 3 |
| SNOECK, J | 3 |
| BROUET, G | 1 |
| MARCHE, J | 1 |
| KOMROWER, GM | 1 |
| WILSON, V | 1 |
| CLAMP, JR | 1 |
| WESTALL, RG | 1 |
| MIYAJI, K | 1 |
| Thoenes, M | 1 |
| Oguchi, A | 1 |
| Nagamia, S | 1 |
| Vaccari, CS | 1 |
| Hammoud, R | 1 |
| Umpierrez, GE | 1 |
| Khan, BV | 1 |
| Jacobson, TA | 1 |
| Hoffman, RS | 1 |
| Goldfrank, LR | 1 |
| MILNE, MD | 2 |
| CRAWFORD, MA | 1 |
| GIRAO, CB | 1 |
| LOUGHRIDGE, LW | 1 |
| MURTAGH, JJ | 1 |
| RAPPALLINI, C | 1 |
| Reid, G | 1 |
| Gopalan, C | 1 |
| Srikantia, SG | 1 |
| Ban, TA | 1 |
| Samitz, MH | 1 |
| Dana, AS | 1 |
| Calandra, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| ER Niacin/Laropiprant Impact on Cardiovascular Markers and Atheroprogression in HIV-infected Individuals on cART[NCT01683656] | Phase 4 | 4 participants (Actual) | Interventional | 2012-08-31 | Terminated (stopped due to Withdrawal of IMP from the market. Data on risk-benefit ratio pending.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for niacin and Metabolic Diseases
| Article | Year |
|---|---|
[COMPLICATIONS OF A METABOLIC AND ENDOCRINE NATURE PRODUCED BY ANTIBACILLARY CHEMOTHERAPY].
Topics: Aminosalicylic Acid; Aminosalicylic Acids; Avitaminosis; Cycloserine; Endocrinology; Ethionamide; Is | 1964 |
Combination lipid-altering therapy: an emerging treatment paradigm for the 21st century.
Topics: Coronary Disease; Drug Interactions; Drug Therapy, Combination; Humans; Hypercholesterolemia; Hyperl | 2001 |
Ethanol-associated metabolic disorders.
Topics: Acidosis; Alcoholism; Beriberi; Ethanol; Humans; Hypoglycemia; Magnesium Deficiency; Metabolic Disea | 1989 |
[RENAL TUBULAR DISEASES, WITH SPECIAL REFERENCE TO AMINOACIDURIA].
Topics: Cystinosis; Cystinuria; Galactosemias; Genetics, Medical; Glycine; Hepatolenticular Degeneration; Hu | 1964 |
Nutrition and disease.
Topics: Adult; Anemia, Hypochromic; Anemia, Macrocytic; Antibody Formation; Blood Bactericidal Activity; Chi | 1973 |
Nicotinic acid and psychiatry.
Topics: Aged; Anxiety; Avitaminosis; Brain Diseases; Child; Child, Preschool; Clinical Trials as Topic; Deme | 1971 |
3 trials available for niacin and Metabolic Diseases
| Article | Year |
|---|---|
The acute effect of different NAD
Topics: Humans; Metabolic Diseases; NAD; Neurodegenerative Diseases; Niacin; Niacinamide; Nicotinamide Monon | 2023 |
The effects of extended-release niacin on carotid intimal media thickness, endothelial function and inflammatory markers in patients with the metabolic syndrome.
Topics: Adult; Atherosclerosis; Biomarkers; Blood Glucose; Carotid Arteries; Cholesterol, HDL; Delayed-Actio | 2007 |
Nicotinic acid and psychiatry.
Topics: Aged; Anxiety; Avitaminosis; Brain Diseases; Child; Child, Preschool; Clinical Trials as Topic; Deme | 1971 |
16 other studies available for niacin and Metabolic Diseases
| Article | Year |
|---|---|
Nicotinamide supplementation induces detrimental metabolic and epigenetic changes in developing rats.
Topics: Animals; Betaine; Choline; CpG Islands; Dietary Supplements; DNA; DNA Damage; DNA Methylation; Epige | 2013 |
Bibliography. Current world literature. HDL cholesterol.
Topics: Atherosclerosis; Cholesterol Ester Transfer Proteins; Cholesterol, HDL; Clofibric Acid; Humans; Hypo | 2008 |
Hartnup disease.
Topics: Amino Acids; Hartnup Disease; Humans; Indoles; Metabolic Diseases; Niacin; Niacinamide; Pellagra; Pr | 1963 |
Hartnup syndrome.
Topics: Amino Acids; Child; Humans; Indican; Infant; Metabolic Diseases; Niacin; Nicotinic Acids; Pellagra; | 1962 |
[THE CLINICAL FORM OF HARTNUP'S DISEASE].
Topics: Diagnosis, Differential; Friedreich Ataxia; Hartnup Disease; Humans; Indican; Indoles; Infant; Metab | 1963 |
INHERITANCE OF GENE DIFFERENCES IN NEUROSPORA CRASSA.
Topics: Arginine; Culture Media; Heredity; Metabolic Diseases; Mutation; Neurospora; Neurospora crassa; Niac | 1963 |
BIOCHEMICAL ASPECTS OF THE HARTNUP DISEASE. I. RESULTS OF INTRAVENOUS AND ORAL TRYPTOPHAN LOADING TESTS IN A CASE OF HARTNUP DISEASE.
Topics: Amino Acid Metabolism, Inborn Errors; Biomedical Research; Friedreich Ataxia; Genetics, Medical; Har | 1964 |
BIOCHEMICAL ASPECTS OF THE HARTNUP DISEASE. II. SOME OBSERVATIONS ON RATS ABOUT TRYPTOPHAN METABOLISM.
Topics: Child; Clinical Enzyme Tests; Hartnup Disease; Humans; Indican; Indoles; Kidney; Kynurenine; Metabol | 1964 |
BIOCHEMICAL ASPECTS OF THE HARTNUP DISEASE. III. GENERAL DISCUSSION AND CONCLUSIONS.
Topics: Amino Acid Metabolism, Inborn Errors; Child; Drug Therapy; Feces; Hartnup Disease; Humans; Indican; | 1964 |
HYDROXYKYNURENINURIA: A CASE OF ABNORMAL TRYPTOPHAN METABOLISM PROBABLY DUE TO A DEFICIENCY OF KYNURENINASE.
Topics: Amino Acid Metabolism, Inborn Errors; Child; Chromatography; Electrophoresis; Humans; Hydrolases; Ky | 1964 |
[CLINICAL STUDY OF VITAMIN B DEFICIENCY].
Topics: Diagnosis; Folic Acid Deficiency; Humans; Metabolic Diseases; Niacin; Nicotinic Acids; Riboflavin De | 1964 |
The metabolic disorder in Hartnup disease.
Topics: Ataxia; Hartnup Disease; Humans; Metabolic Diseases; Pellagra; Tryptophan | 1960 |
[SEROTONIN AND 5-HYDROXYINDOLACETIC ACID IN THE NEWBORN INFANT].
Topics: Anemia; Anemia, Aplastic; Cardiovascular System; Gastrointestinal Tract; Humans; Hydroxyindoleacetic | 1964 |
Metabolic disorders of cattle.
Topics: Animals; Cattle; Cattle Diseases; Diarrhea; Endorphins; Female; Hypocalcemia; Linoleic Acid; Linolei | 1993 |
Some dermatologic aspects of oral medicine.
Topics: Amyloidosis; Collagen Diseases; Dermatitis, Contact; Drug Hypersensitivity; Humans; Interprofessiona | 1967 |
[New viewpoints on the pathogenesis of pellagra].
Topics: Humans; Kynurenine; Metabolic Diseases; Pellagra; Pyridoxine; Riboflavin; Tryptophan | 1970 |