niacin and Liver Diseases studies

Niacin: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.
vitamin B3 : Any member of a group of vitamers that belong to the chemical structural class called pyridines that exhibit biological activity against vitamin B3 deficiency. Vitamin B3 deficiency causes a condition known as pellagra whose symptoms include depression, dermatitis and diarrhea. The vitamers include nicotinic acid and nicotinamide (and their ionized and salt forms).
nicotinic acid : A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.

Research Excerpts

Excerpt	Relevance	Reference
"Hyperlipidemia is common in dogs, and can be either primary or secondary to other diseases."	2.46	Lipid metabolism and hyperlipidemia in dogs. ( Steiner, JM; Xenoulis, PG, 2010)
"Niacin has beneficial effects on plasma lipoproteins and has demonstrated clinical benefits in reducing cardiovascular events and atherosclerosis progression."	2.44	Safety considerations with niacin therapy. ( Bays, HE; Guyton, JR, 2007)
"Pretreatment with caffeine, nicotinic acid or non-substituted pyrazinoic acid activated the LPS/D-GalN induced elevation of plasma IL-10 levels at 1 and 2 h, although there were no statistically significant differences in IL-10 levels between control and nicotinic acid or non-substituted pyrazinoic acid treated rats."	1.35	Protective effects of coffee-derived compounds on lipopolysaccharide/D-galactosamine induced acute liver injury in rats. ( Akashi, I; Hirano, T; Kagami, K; Oka, K, 2009)
" Current drug labeling warns of an increased risk of adverse events with statin and niacin combinations."	1.34	Safety of lovastatin/extended release niacin compared with lovastatin alone, atorvastatin alone, pravastatin alone, and simvastatin alone (from the United States Food and Drug Administration adverse event reporting system). ( Alsheikh-Ali, AA; Karas, RH, 2007)
"It is of no value in differentiating Gilbert's syndrome from liver disease."	1.28	The nicotinic acid provocation test and unconjugated hyperbilirubinaemia. ( Callender, ME; Dickey, W; McAleer, JJ, 1991)

Timeframe	Studies, this research(%)	All Research%
pre-1990	48 (84.21)	18.7374
1990's	2 (3.51)	18.2507
2000's	5 (8.77)	29.6817
2010's	2 (3.51)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Mullin, GE	2
PAVEK, J	1
STAROSTENKO, NT	1
ARCHI, G	1
TINACCI, F	1
Xenoulis, PG	1
Steiner, JM	1
Akashi, I	1
Kagami, K	1
Hirano, T	1
Oka, K	1
INDOVINA, I	1
CAUSI, N	1
ORLOWSKI, EH	2
EMMRICH, R	1
PETZOLD, H	1
CAMBA, R	1
COSTA, E	1
MURTAS, L	1
CERESA, C	1
DE BLASIIS, M	1
BARBIERI, LL	2
HAMKE, H	1
LE CLAIRE, B	1
Gershbein, LL	1
MCKENNIS, H	1
YARD, AS	1
PAHNELAS, EV	1
CHIZZOLINI, M	1
DAWSON, AM	2
SHERLOCK, S	2
ZETZEL, L	1
KAPLAN, H	1
BOSELLI, A	2
MORRISON, JE	1
KALAMBOUKIS, Z	1
PARE, CM	1
SANDLER, M	1
NOCCA, G	1
PARDUE, WO	1
ESPOSITO, S	1
NICROSINI, F	1
PETRONIO, L	1
ABBONA, C	1
GATTO, PL	1
CAZZOLA, D	1
MIERES, A	1
BERALDI, MV	1
CIMPEANU, S	1
CUMITRESCU, C	1
BONAPARTE, H	1
MIHALACHE, N	1
PAVEL, I	1
MURABAYASHI, A	1
YAMADA, M	1
PAGLIANI, P	1
GIOSEFFI, G	1
LOTTI, F	1
MASCHERPA, S	1
ROVATI, L	1
CASULA, PL	1
ROSA, L	1
LIMENTANI, A	1
CORA, D	1
Rizakallah, GS	1
Mertens, MK	1
Brown, ML	1
Sanner, L	1
Bertolami, MC	1
Alsheikh-Ali, AA	1
Karas, RH	1
Guyton, JR	1
Bays, HE	1
ALESKER, EM	1
GIORDANO, A	1
RUSSO, L	1
Tatò, F	1
Vega, GL	1
Grundy, SM	1
Dickey, W	1
McAleer, JJ	1
Callender, ME	1
Greenson, JK	1
Mitchell, MC	1
Cayen, MN	1
GILLMAN, J	1
GILLMAN, T	1
HOWARD, FH	1
MERIWETHER, WA	1
SATO, Y	1
ARAKAWA, T	1
EL-NASR, HS	1
EL-HEFNAWI, H	1
Chiancone, FM	1
Gupta, OP	1
Cloete, GN	1
van Rooyen, RJ	1
Caletti, G	1
Serena, A	1

Trial	Enrollment	Study Type	Start Date	Status
The Effect of Niacin Supplementation on Systemic Nicotinamide Adenine Dinucleotide (NAD+) Metabolism, Physiology and Muscle Performance in Healthy Controls and Mitochondrial Myopathy Patients[NCT03973203]	15 participants (Actual)	Interventional	2014-06-01	Completed
NiaMIT (NiaMIT_0001) Continuation for Early-stage Mitochondrial Myopathy Patients to Investigate the Effect of Niacin Supplementation on Systemic Nicotinamide Adenine Dinucleotide (NAD+) Metabolism, Physiology and Muscle Performance[NCT04538521]	3 participants (Actual)	Interventional	2019-02-11	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Lipid metabolism and hyperlipidemia in dogs. Veterinary journal (London, England : 1997), 2010, Volume: 183, Issue:1 Topics: Animals; Diet, Reducing; Dog Diseases; Dogs; Fatty Acids, Omega-3; Hyperlipidemias; Hypertriglycerid	2010
Clinical inquiries. Should liver enzymes be checked in a patient taking niacin? The Journal of family practice, 2005, Volume: 54, Issue:3 Topics: Chemical and Drug Induced Liver Injury; Delayed-Action Preparations; Drug Therapy, Combination; Huma	2005
Safety considerations with niacin therapy. The American journal of cardiology, 2007, Mar-19, Volume: 99, Issue:6A Topics: Cardiovascular Diseases; Chemical and Drug Induced Liver Injury; Chemistry, Pharmaceutical; Clinical	2007
Safety considerations with niacin therapy. The American journal of cardiology, 2007, Mar-19, Volume: 99, Issue:6A Topics: Cardiovascular Diseases; Chemical and Drug Induced Liver Injury; Chemistry, Pharmaceutical; Clinical	2007
Safety considerations with niacin therapy. The American journal of cardiology, 2007, Mar-19, Volume: 99, Issue:6A Topics: Cardiovascular Diseases; Chemical and Drug Induced Liver Injury; Chemistry, Pharmaceutical; Clinical	2007
Safety considerations with niacin therapy. The American journal of cardiology, 2007, Mar-19, Volume: 99, Issue:6A Topics: Cardiovascular Diseases; Chemical and Drug Induced Liver Injury; Chemistry, Pharmaceutical; Clinical	2007
Disposition, metabolism and pharmacokinetics of antihyperlipidemic agents in laboratory animals and man. Pharmacology & therapeutics, 1985, Volume: 29, Issue:2 Topics: Animals; Binding Sites; Biological Availability; Biotransformation; Clofibrate; Drug Interactions; H	1985

Article	Year
The use of complementary and alternative medicine for liver disease: part II. Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition, 2013, Volume: 28, Issue:2 Topics: Dietary Supplements; Humans; Liver; Liver Diseases; Niacin; Phytotherapy; Plant Extracts; Plants, Me	2013
[Possible relation between liver diseases and the duration of sensation of warmth following administration of nicotinic acid]. Gastroenterologia bohema, 1950, Volume: 4, Issue:5-6 Topics: Humans; Liver Diseases; Liver Function Tests; Niacin; Nicotinic Acids; Sensation	1950
[The treatment of acute parenchymatous hepatitis with nicotinic acid]. Sovetskaia meditsina, 1948, Volume: 12, Issue:1 Topics: Child; Hepatitis; Hepatitis A; Liver; Liver Diseases; Niacin; Nicotinic Acids; Thiamine; Vitamins	1948
On the action of nicotinic amide in the liver due to stasis (heart failure). Settimana medica, 1948, Volume: 36, Issue:9-13 Topics: Heart Failure; Liver Diseases; Niacin; Niacinamide	1948
Protective effects of coffee-derived compounds on lipopolysaccharide/D-galactosamine induced acute liver injury in rats. The Journal of pharmacy and pharmacology, 2009, Volume: 61, Issue:4 Topics: Alanine Transaminase; Alkaloids; Animals; Aspartate Aminotransferases; Caffeine; Chemical and Drug I	2009
[Metabolism of nicotinamide in man. III. Venous tolerance test in liver disease, blood disease, circulatory insufficiency and other morbid conditions]. Bollettino della Societa italiana di biologia sperimentale, 1952, Volume: 28, Issue:7 Topics: Hematologic Diseases; Liver Diseases; Niacin; Niacinamide; Veins	1952
[Investigations on liver damage and disorders of carbohydrate metabolism due to isonicotinic acid hydrazide using the galactose tolerance test]. Klinische Wochenschrift, 1952, Nov-15, Volume: 30, Issue:43-4 Topics: Carbohydrate Metabolism; Carbohydrates; Galactose; Isoniazid; Liver; Liver Diseases; Niacin; Nicotin	1952
[Experimental investigations on liver damage by Rimifon (isonicotinic acid hydrazide)]. Klinische Wochenschrift, 1952, Dec-01, Volume: 30, Issue:45-6 Topics: Abdominal Injuries; Isoniazid; Liver; Liver Diseases; Niacin; Nicotinic Acids	1952
[Supplementary communication on the problem of liver damage during isonicotinic acid therapy]. Klinische Wochenschrift, 1953, May-01, Volume: 31, Issue:17-18 Topics: Abdominal Injuries; Isonicotinic Acids; Liver; Liver Diseases; Niacin; Nicotinic Acids	1953
[Importance of the liver and the kidneys for the convulsant action of isonicotinic acid hydrazide]. Archives internationales de pharmacodynamie et de therapie, 1953, Nov-01, Volume: 96, Issue:2 Topics: Convulsants; Isoniazid; Kidney; Liver Diseases; Niacin; Nicotinic Acids	1953
[Observations on a preparation with cholegogue, antispasmodic, and hepatoprotective actions]. La Riforma medica, 1954, Jun-12, Volume: 68, Issue:24 Topics: Bile Acids and Salts; Biliary Tract; Biliary Tract Diseases; Humans; Liver Diseases; Niacin; Nicotin	1954
[Bilamid-choline]. Il Farmaco; edizione pratica, 1955, Volume: 10, Issue:6 Topics: Choline; Liver Diseases; Niacin; Nicotinic Acids	1955
[Effect of nicotinamide overload on riboflavinuria in subjects without liver lesions and in liver disease patients]. Archivio per le scienze mediche, 1954, Volume: 98, Issue:4 Topics: Body Fluids; Gastrointestinal Diseases; Humans; Liver Diseases; Niacin; Niacinamide; Nicotinic Acids	1954
[The problem of liver lesions caused by isonicotinic acid hydrazide with special reference to blood proteins]. Die Medizinische, 1955, Oct-01, Issue:40 Topics: Blood Proteins; Gastrointestinal Diseases; Isoniazid; Liver Diseases; Niacin; Nicotinic Acids	1955
Effect of nicotinic acid and derivatives on rat liver regeneration. The American journal of physiology, 1956, Volume: 184, Issue:1 Topics: Animals; Liver; Liver Diseases; Liver Regeneration; Niacin; Nicotinic Acids; Rats; Regeneration	1956
The production of fatty livers in rabbits by isoniazid and other hydrazine derivatives. American review of tuberculosis, 1956, Volume: 73, Issue:6 Topics: Animals; Fatty Liver; Hydrazines; Isoniazid; Liver Diseases; Niacin; Nicotinic Acids; Rabbits	1956
[Trigonelline in hormonal metabolism; fractionated determination of 17-ketosteroids in pregnant liver disease patients before and after administration of trigonelline]. Rivista d'ostetricia e ginecologia pratica, 1957, Volume: 39, Issue:2 Topics: 17-Ketosteroids; Alkaloids; Female; Humans; Liver Diseases; Niacin; Nicotinic Acids; Pregnancy; Preg	1957
Effect of an amine-oxidase inhibitor on arterial ammonium levels in liver disease. Lancet (London, England), 1957, Jun-29, Volume: 272, Issue:6983 Topics: Amines; Ammonia; Ammonium Compounds; Humans; Liver Diseases; Niacin; Nicotinic Acids; Oxidoreductase	1957
Liver damage concurrent with iproniazid administration. The New England journal of medicine, 1958, Jun-12, Volume: 258, Issue:24 Topics: Iproniazid; Isomerism; Liver Diseases; Niacin; Nicotinic Acids	1958
[Necessary supplementation of vitamin B12 with folic acid, ascorbic acid and nicotinamide for purposes of liver protection; posological and therapeutic study]. Minerva medica, 1958, Jun-20, Volume: 49, Issue:49 Topics: Ascorbic Acid; Folic Acid; Humans; Liver Diseases; Niacin; Niacinamide; Nicotinic Acids; Vitamin B 1	1958
The effect of the amine oxidase inhibitor marsilid on ammonium metabolism in liver disease. Clinical science, 1958, Volume: 17, Issue:4 Topics: Amines; Ammonia; Ammonium Compounds; Humans; Liver Diseases; Niacin; Nicotinic Acids; Oxidoreductase	1958
Liver necrosis after iproniazid therapy; report of a case. Connecticut medicine, 1959, Volume: 23, Issue:1 Topics: Iproniazid; Liver Diseases; Niacin; Nicotinic Acids	1959
Acute hepatic necrosis following iproniazid therapy; value of glutamic-oxaloacetic transaminase estimation in early detection. Lancet (London, England), 1959, Feb-07, Volume: 1, Issue:7067 Topics: Aspartate Aminotransferases; Early Diagnosis; Iproniazid; Liver Diseases; Niacin; Nicotinic Acids; T	1959
[Therapy of liver diseases with high protein dit & vitamin B12 combined with folic acid, vitamin PP & vitamin C]. La Riforma medica, 1959, Mar-07, Volume: 73, Issue:10 Topics: Ascorbic Acid; Corrinoids; Folic Acid; Humans; Liver Diseases; Niacin; Niacinamide; Nicotinic Acids;	1959
Severe liver dysfunction during nicotinic acid therapy. JAMA, 1961, Jan-14, Volume: 175 Topics: Edema; Humans; Liver Diseases; Niacin; Nicotinic Acids; Serum Albumin	1961
[The nature and prevention of hepatic steatosis caused by massive doses of nicotinamide and 6-aminonicotinamide]. Archivio per le scienze mediche, 1959, Volume: 108 Topics: 6-Aminonicotinamide; Fatty Liver; Liver Diseases; Niacin; Niacinamide; Nicotinic Acids	1959
[On a combination of a synthetic choleretic and a "mixed" spasmolytic with vitamins B-I and PP, in the therapy of some hepatobiliary diseases. Clinical study]. Minerva medica, 1962, May-12, Volume: 53 Topics: Biliary Tract; Biliary Tract Diseases; Cholagogues and Choleretics; Gastrointestinal Diseases; Human	1962
[Vitamin B12 associated with folic acid, ascorbic acid and nicotibine for liver protection. Posological and therapeutic study]. El Dia medico, 1962, Jul-30, Volume: 34 Topics: Ascorbic Acid; Corrinoids; Folic Acid; Liver Diseases; Niacin; Nicotinic Acids; Vitamin B 12; Vitami	1962
[On the treatment of the premenstrual syndrome and menstruation disorders by means of hepatic therapy]. La Riforma medica, 1963, Jan-19, Volume: 77 Topics: Cysteine; Female; Gluconates; Humans; Liver Diseases; Liver Extracts; Menstruation Disturbances; Met	1963
[GENERALIZED VISCERAL MONILIASIS]. Pediatria panamericana, 1964, Volume: 9 Topics: Adrenocorticotropic Hormone; Aminosalicylic Acid; Aminosalicylic Acids; Anti-Bacterial Agents; Antib	1964
[THE CLEARANCE OF ENDOGENOUS IRON IN LIVER DISEASES]. Medicina interna, 1964, Volume: 16 Topics: Humans; Iron; Kinetics; Liver; Liver Diseases; Niacin; Nicotinic Acids; Pharmacology	1964
[EFFECTS OF THE ORAL ADMINISTRATION OF HEPATOPROTECTIVE DRUGS ON THE PREVENTION OF HEPATIC DISORDERS AFTER LUNG SURGERY]. Kyobu geka. The Japanese journal of thoracic surgery, 1964, Volume: 17 Topics: Administration, Oral; Humans; Liver Diseases; Niacin; Nicotinic Acids; Pantothenic Acid; Pharmacolog	1964
[PHARMACOLOGICAL EXPERIMENTS WITH A COMBINATION OF KALLIKREIN AND MESO-INOSITOL HEXANICOTINATE]. Bollettino chimico farmaceutico, 1964, Volume: 103 Topics: Blood Pressure; Blood Pressure Determination; Blood Vessels; Coronary Vessels; Inositol; Kallikreins	1964
On the action of high doses of vitamin B 12 combined with folic acid, vitamin PP and ascorbic acid in treatment of infantile liver diseases La Clinica pediatrica, 1959, Volume: 41 Topics: Ascorbic Acid; Child; Corrinoids; Folic Acid; Infant; Liver Diseases; Niacin; Niacinamide; Nicotinic	1959
[Pharmacological evaluation of a new hepato-protective agent]. Gazzetta medica italiana, 1961, Volume: 120 Topics: Choline; Diet; Fats; Glucuronates; Liver Diseases; Niacin; Nicotinic Acids; Nutrition Assessment; Nu	1961
[Urinary elimination of thiamine under nicotinamide load in subjects with and without hepatic diseases]. Archivio per le scienze mediche, 1950, Volume: 90, Issue:1 Topics: Liver Diseases; Niacin; Niacinamide; Nicotinic Acids; Thiamine	1950
[Clinico-statistical observations on the functional treatment of acute and subacute diseases of the liver]. Minerva medica, 1950, Jun-23, Volume: 41, Issue:30 Topics: Humans; Liver Diseases; Niacin; Nicotinic Acids	1950
[Hyperbilirubinemia provoked by sodium nicotinate in regressive chronic liver diseases]. Archivio per le scienze mediche, 1950, Volume: 90, Issue:3 Topics: Bilirubin; Blood; Humans; Hyperbilirubinemia; Jaundice; Liver Diseases; Niacin; Nicotinic Acids; Sod	1950
[Mechanisms of hepatotoxicity]. Arquivos brasileiros de cardiologia, 2005, Volume: 85 Suppl 5 Topics: Chemical and Drug Induced Liver Injury; Clofibrate; Drug Interactions; Humans; Hydroxymethylglutaryl	2005
Safety of lovastatin/extended release niacin compared with lovastatin alone, atorvastatin alone, pravastatin alone, and simvastatin alone (from the United States Food and Drug Administration adverse event reporting system). The American journal of cardiology, 2007, Feb-01, Volume: 99, Issue:3 Topics: Adverse Drug Reaction Reporting Systems; Atorvastatin; Chemical and Drug Induced Liver Injury; Drug	2007
[Effect of nicotinic acid on the blood sugar level in parenchymatous hepatitis]. Klinicheskaia meditsina, 1949, Volume: 27, Issue:2 Topics: Blood Glucose; Hepatitis; Hepatitis A; Humans; Liver Diseases; Niacin; Nicotinic Acids	1949
Vitamin PP and liver disease. La Riforma medica, 1949, Jan-22, Volume: 63, Issue:3 Topics: Liver Diseases; Niacin; Nicotinic Acids	1949
Effects of crystalline nicotinic acid-induced hepatic dysfunction on serum low-density lipoprotein cholesterol and lecithin cholesteryl acyl transferase. The American journal of cardiology, 1998, Mar-15, Volume: 81, Issue:6 Topics: Acyltransferases; Chemical and Drug Induced Liver Injury; Cholesterol, LDL; Humans; Liver; Liver Dis	1998
The nicotinic acid provocation test and unconjugated hyperbilirubinaemia. The Ulster medical journal, 1991, Volume: 60, Issue:1 Topics: Bilirubin; Chronic Disease; Gilbert Disease; Humans; Hyperbilirubinemia; Injections, Intravenous; Li	1991
Fulminant hepatic failure after ingestion of sustained-release nicotinic acid. Annals of internal medicine, 1989, Aug-01, Volume: 111, Issue:3 Topics: Adult; Chemical and Drug Induced Liver Injury; Delayed-Action Preparations; Hepatic Encephalopathy;	1989
Liver disease in Johannesburg; relation to pellagra. Lancet (London, England), 1948, Jan-31, Volume: 1, Issue:6492 Topics: Humans; Liver Diseases; Pellagra; South Africa	1948
Fat disease of the liver in infants on the Isthmus of Panama. Pediatrics, 1952, Volume: 10, Issue:2 Topics: Child; Deficiency Diseases; Humans; Infant; Liver Diseases; Panama; Pellagra	1952
Hepatomegalic liver in children with chronic miliary tuberculosis and liver biopsy findings; studies upon the nutrition of children in Hirosaki area. 11th Report. The Tohoku journal of experimental medicine, 1952, Volume: 56, Issue:1-2 Topics: Biopsy; Child; Humans; Infant; Liver Diseases; Nutritional Status; Pellagra; Tuberculosis; Tuberculo	1952
SPOTLIGHTS ON THE CUTANEOUS MANIFESTATIONS OF GASTRO-INTESTINAL DISEASE. The Journal of the Egyptian Medical Association, 1963, Volume: 46 Topics: Celiac Disease; Dermatology; Gastrointestinal Diseases; Gastrointestinal Hemorrhage; Gastrointestina	1963
[Notes for a study on vitaminology in Italy]. Acta vitaminologica et enzymologica, 1979, Volume: 1, Issue:1-6 Topics: Beriberi; Heart; Hemoptysis; History, 20th Century; Humans; Italy; Liver Diseases; Niacinamide; Nico	1979
Study of anaemia in cases of pellagra with hemosiderosis of liver. The Journal of the Association of Physicians of India, 1977, Volume: 25, Issue:4 Topics: Adolescent; Adult; Anemia; Child; Female; Folic Acid Deficiency; Hemosiderosis; Humans; Liver Diseas	1977
A case of polycystic disease of the liver and kidneys. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1974, Feb-02, Volume: 48, Issue:5 Topics: Adult; Cysts; Female; Humans; Liver Diseases; Pellagra; Polycystic Kidney Diseases	1974
[Study of pellagra. Scintiscanning of the liver]. Archivio italiano di dermatologia, venereologia, e sessuologia, 1969, Volume: 35, Issue:6 Topics: Adult; Alcoholism; Female; Hepatomegaly; Humans; Liver Diseases; Liver Function Tests; Male; Methion	1969

niacin and Liver Diseases

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