Page last updated: 2024-10-19

niacin and Itching

niacin has been researched along with Itching in 10 studies

Niacin: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.
vitamin B3 : Any member of a group of vitamers that belong to the chemical structural class called pyridines that exhibit biological activity against vitamin B3 deficiency. Vitamin B3 deficiency causes a condition known as pellagra whose symptoms include depression, dermatitis and diarrhea. The vitamers include nicotinic acid and nicotinamide (and their ionized and salt forms).
nicotinic acid : A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.

Research Excerpts

ExcerptRelevanceReference
" To increase the probability of flushing, subjects were administered niacin ER at the upper limit of the approved dosage range (2,000 mg), and were precluded from using aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) during the study."9.12Improved control of niacin-induced flushing using an optimized once-daily, extended-release niacin formulation. ( Cefali, EA; Shamp, TR; Simmons, PD; Stanek, EJ, 2006)
"We conducted a double-blind, randomized, parallel group study to examine and compare the antipruritic effects of promethazine, niacin, prednisolone and their combination on pruritus induced by chloroquine, in 28 historical itching patients with parasitologically proven malaria fever."9.08Chloroquine-induced pruritus in malaria fever: contribution of malaria parasitaemia and the effects of prednisolone, niacin, and their combination, compared with antihistamine. ( Adebayo, RA; Ajayi, AA; Onayemi, O; Sofowora, GG; Udoh, SJ, 1997)
"Chloroquine chemotherapy of malaria fever induces severe generalised pruritus in a large proportion of black Africans."9.07The effects of prednisolone and niacin on chloroquine-induced pruritus in malaria. ( Ajayi, AA; Ajayi, OO; Akinleye, AO; Ijaware, CO; Oyelese, O; Udoh, SJ, 1991)
"The relationship of the exanthematous eruption with lower body weight and the increase in dosage suggests a pharmacokinetic effect that may be related to increased exposure to niacin or its metabolites and provoked by inhibition of the DP1 receptor with laropiprant, as we have not seen this rash with niacin used alone."7.79A high incidence of exanthematous eruption associated with niacin/laropiprant combination in Hong Kong Chinese patients. ( Chang, M; Hu, M; Tomlinson, B; Yang, YL, 2013)
" To increase the probability of flushing, subjects were administered niacin ER at the upper limit of the approved dosage range (2,000 mg), and were precluded from using aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) during the study."5.12Improved control of niacin-induced flushing using an optimized once-daily, extended-release niacin formulation. ( Cefali, EA; Shamp, TR; Simmons, PD; Stanek, EJ, 2006)
"We conducted a double-blind, randomized, parallel group study to examine and compare the antipruritic effects of promethazine, niacin, prednisolone and their combination on pruritus induced by chloroquine, in 28 historical itching patients with parasitologically proven malaria fever."5.08Chloroquine-induced pruritus in malaria fever: contribution of malaria parasitaemia and the effects of prednisolone, niacin, and their combination, compared with antihistamine. ( Adebayo, RA; Ajayi, AA; Onayemi, O; Sofowora, GG; Udoh, SJ, 1997)
"The symptom scores for flushing, itching, tingling, and warmth were all significantly reduced by both aspirin regimens (p < ."5.08Effect of two aspirin pretreatment regimens on niacin-induced cutaneous reactions. ( Campbell, JR; Jungnickel, PW; Maloley, PA; Peddicord, TE; Vander Tuin, EL, 1997)
"It appears from this pilot study that preceding niacin with 325 mg of aspirin will decrease the warmth and flushing associated with niacin."5.07The effect of aspirin on niacin-induced cutaneous reactions. ( Fowler, SF; Hainer, BL; Price, SO; Whelan, AM, 1992)
"Chloroquine chemotherapy of malaria fever induces severe generalised pruritus in a large proportion of black Africans."5.07The effects of prednisolone and niacin on chloroquine-induced pruritus in malaria. ( Ajayi, AA; Ajayi, OO; Akinleye, AO; Ijaware, CO; Oyelese, O; Udoh, SJ, 1991)
"The relationship of the exanthematous eruption with lower body weight and the increase in dosage suggests a pharmacokinetic effect that may be related to increased exposure to niacin or its metabolites and provoked by inhibition of the DP1 receptor with laropiprant, as we have not seen this rash with niacin used alone."3.79A high incidence of exanthematous eruption associated with niacin/laropiprant combination in Hong Kong Chinese patients. ( Chang, M; Hu, M; Tomlinson, B; Yang, YL, 2013)
" There is a need for further research in order to come to a clear conclusion regarding combined therapies of aspirin and laropiprant pretreatment, as well as exact dosage requirements."2.45Mechanisms of flushing due to niacin and abolition of these effects. ( Arora, R; Sood, A, 2009)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (50.00)18.2507
2000's2 (20.00)29.6817
2010's2 (20.00)24.3611
2020's1 (10.00)2.80

Authors

AuthorsStudies
Yano, H1
Kinjo, M1
Hagiwara, A1
Fujimura, T1
Furudate, S1
Kambayashi, Y1
Numata, Y1
Haga, T1
Aiba, S1
Yang, YL1
Hu, M1
Chang, M1
Tomlinson, B1
Sood, A1
Arora, R1
Cefali, EA1
Simmons, PD1
Stanek, EJ1
Shamp, TR1
Adebayo, RA1
Sofowora, GG1
Onayemi, O1
Udoh, SJ2
Ajayi, AA2
Jungnickel, PW1
Maloley, PA1
Vander Tuin, EL1
Peddicord, TE1
Campbell, JR1
Long, CC1
Marks, R1
Whelan, AM1
Price, SO1
Fowler, SF1
Hainer, BL1
Akinleye, AO1
Ajayi, OO1
Oyelese, O1
Ijaware, CO1

Reviews

1 review available for niacin and Itching

ArticleYear
Mechanisms of flushing due to niacin and abolition of these effects.
    Journal of clinical hypertension (Greenwich, Conn.), 2009, Volume: 11, Issue:11

    Topics: Aspirin; Dose-Response Relationship, Drug; Dyslipidemias; Humans; Hypolipidemic Agents; Indoles; Nia

2009

Trials

5 trials available for niacin and Itching

ArticleYear
Improved control of niacin-induced flushing using an optimized once-daily, extended-release niacin formulation.
    International journal of clinical pharmacology and therapeutics, 2006, Volume: 44, Issue:12

    Topics: Administration, Oral; Adolescent; Adult; Aged; Body Mass Index; Cross-Over Studies; Delayed-Action P

2006
Chloroquine-induced pruritus in malaria fever: contribution of malaria parasitaemia and the effects of prednisolone, niacin, and their combination, compared with antihistamine.
    British journal of clinical pharmacology, 1997, Volume: 44, Issue:2

    Topics: Adult; Animals; Antimalarials; Area Under Curve; Chloroquine; Double-Blind Method; Drug Therapy, Com

1997
Effect of two aspirin pretreatment regimens on niacin-induced cutaneous reactions.
    Journal of general internal medicine, 1997, Volume: 12, Issue:10

    Topics: Adult; Aged; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cross-Over Stud

1997
The effect of aspirin on niacin-induced cutaneous reactions.
    The Journal of family practice, 1992, Volume: 34, Issue:2

    Topics: Adult; Aspirin; Double-Blind Method; Drug Therapy, Combination; Female; Flushing; Humans; Hyperlipid

1992
The effects of prednisolone and niacin on chloroquine-induced pruritus in malaria.
    European journal of clinical pharmacology, 1991, Volume: 41, Issue:4

    Topics: Adult; Chloroquine; Double-Blind Method; Female; Follow-Up Studies; Humans; Malaria, Falciparum; Mal

1991

Other Studies

4 other studies available for niacin and Itching

ArticleYear
Pruritic Rash and Diarrhea.
    JAMA, 2021, Mar-16, Volume: 325, Issue:11

    Topics: Aged, 80 and over; Diarrhea; Exanthema; Fatal Outcome; Female; Humans; Niacin; Pellagra; Pruritus; S

2021
Generalized granulomatous dermatitis accompanied by myelodysplastic syndrome.
    Acta dermato-venereologica, 2014, Volume: 94, Issue:2

    Topics: Aged; Anemia, Refractory, with Excess of Blasts; Anti-Bacterial Agents; Dermatitis; Doxycycline; For

2014
A high incidence of exanthematous eruption associated with niacin/laropiprant combination in Hong Kong Chinese patients.
    Journal of clinical pharmacy and therapeutics, 2013, Volume: 38, Issue:6

    Topics: Adult; Aged; Anti-Inflammatory Agents; Biopsy; Body Weight; Drug Combinations; Drug Eruptions; Exant

2013
Stratum corneum changes in patients with senile pruritus.
    Journal of the American Academy of Dermatology, 1992, Volume: 27, Issue:4

    Topics: Aged; Aged, 80 and over; Baths; Benzocaine; Circadian Rhythm; Cornea; Drug Combinations; Electric Co

1992