niacin has been researched along with Infarction, Middle Cerebral Artery in 7 studies
Niacin: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.
vitamin B3 : Any member of a group of vitamers that belong to the chemical structural class called pyridines that exhibit biological activity against vitamin B3 deficiency. Vitamin B3 deficiency causes a condition known as pellagra whose symptoms include depression, dermatitis and diarrhea. The vitamers include nicotinic acid and nicotinamide (and their ionized and salt forms).
nicotinic acid : A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.
Infarction, Middle Cerebral Artery: NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In this study we examined the effect of combination treatment of experimental stroke with Niaspan, a prolonged-release formulation of Niacin (vitamin B3), and Simvastatin, a cholesterol-lowering drug, on functional outcome, axonal damage, axonal density and the of Iba-1 immunoreactive microglia expression in the ischemic brain of rats." | 7.76 | Combination treatment of experimental stroke with Niaspan and Simvastatin, reduces axonal damage and improves functional outcome. ( Chen, J; Chopp, M; Cui, X; Lu, M; Roberts, C; Shehadah, A, 2010) |
| "In this study we examined the effect of combination treatment of experimental stroke with Niaspan, a prolonged-release formulation of Niacin (vitamin B3), and Simvastatin, a cholesterol-lowering drug, on functional outcome, axonal damage, axonal density and the of Iba-1 immunoreactive microglia expression in the ischemic brain of rats." | 3.76 | Combination treatment of experimental stroke with Niaspan and Simvastatin, reduces axonal damage and improves functional outcome. ( Chen, J; Chopp, M; Cui, X; Lu, M; Roberts, C; Shehadah, A, 2010) |
| "Niaspan, an extended-release formulation of Niacin (vitamin B3), has been widely used to increase high density lipoprotein (HDL) cholesterol and to prevent cardiovascular diseases and stroke." | 3.76 | Niaspan treatment induces neuroprotection after stroke. ( Chen, J; Chopp, M; Cui, Y; Ion, M; Kapke, A; Roberts, C; Shehadah, A; Zacharek, A, 2010) |
| "Niacin treatment of PCN significantly increased Ang1 expression under high glucose condition." | 1.38 | Niaspan increases axonal remodeling after stroke in type 1 diabetes rats. ( Buller, B; Chen, J; Chopp, M; Cui, Y; Liu, Z; Roberts, C; Yan, T; Ye, X; Zacharek, A, 2012) |
| "T1DM-rats were subjected to transient middle cerebral artery occlusion (MCAo) and treated without or with Niaspan." | 1.37 | Niaspan enhances vascular remodeling after stroke in type 1 diabetic rats. ( Chen, J; Chopp, M; Cui, X; Cui, Y; Liu, X; Lu, M; Roberts, C; Shehadah, A; Yan, T; Ye, X; Zacharek, A, 2011) |
| "Niacin treatment significantly increased arterial sprouting and VSMC migration compared with control nontreated arterial cells." | 1.35 | Niaspan treatment increases tumor necrosis factor-alpha-converting enzyme and promotes arteriogenesis after stroke. ( Chen, J; Chopp, M; Cui, X; Ding, GL; Jiang, Q; Lu, M; Shehadah, A; Zacharek, A, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 6 (85.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ramírez-Sánchez, J | 2 |
| Pires, ENS | 1 |
| Meneghetti, A | 1 |
| Hansel, G | 2 |
| Nuñez-Figueredo, Y | 2 |
| Pardo-Andreu, GL | 2 |
| Ochoa-Rodríguez, E | 2 |
| Verdecia-Reyes, Y | 2 |
| Delgado-Hernández, R | 2 |
| Salbego, C | 2 |
| Souza, DO | 2 |
| Simões Pires, EN | 1 |
| Merino, N | 1 |
| Valdes, O | 1 |
| Parra, AL | 1 |
| Costa, SL | 1 |
| Chen, J | 5 |
| Cui, X | 3 |
| Zacharek, A | 4 |
| Ding, GL | 1 |
| Shehadah, A | 4 |
| Jiang, Q | 1 |
| Lu, M | 3 |
| Chopp, M | 5 |
| Roberts, C | 4 |
| Cui, Y | 3 |
| Ion, M | 1 |
| Kapke, A | 1 |
| Ye, X | 2 |
| Yan, T | 2 |
| Liu, X | 1 |
| Liu, Z | 1 |
| Buller, B | 1 |
7 other studies available for niacin and Infarction, Middle Cerebral Artery
| Article | Year |
|---|---|
JM-20 Treatment After MCAO Reduced Astrocyte Reactivity and Neuronal Death on Peri-infarct Regions of the Rat Brain.
Topics: Animals; Astrocytes; Benzodiazepines; Brain; Brain Infarction; CA3 Region, Hippocampal; Cell Death; | 2019 |
A novel multi-target ligand (JM-20) protects mitochondrial integrity, inhibits brain excitatory amino acid release and reduces cerebral ischemia injury in vitro and in vivo.
Topics: Animals; Benzodiazepines; Brain; Brain Ischemia; Cell Death; Disease Models, Animal; Excitatory Amin | 2014 |
Niaspan treatment increases tumor necrosis factor-alpha-converting enzyme and promotes arteriogenesis after stroke.
Topics: ADAM Proteins; ADAM17 Protein; Animals; Brain; Cells, Cultured; Cerebrovascular Circulation; Delayed | 2009 |
Combination treatment of experimental stroke with Niaspan and Simvastatin, reduces axonal damage and improves functional outcome.
Topics: Amyloid beta-Protein Precursor; Animals; Axons; Brain; Brain Ischemia; Calcium-Binding Proteins; Del | 2010 |
Niaspan treatment induces neuroprotection after stroke.
Topics: Animals; Brain Infarction; Delayed-Action Preparations; Disease Models, Animal; Infarction, Middle C | 2010 |
Niaspan enhances vascular remodeling after stroke in type 1 diabetic rats.
Topics: Angiotensin I; Angiotensin II; Animals; Blood Glucose; Blood-Brain Barrier; Cerebral Hemorrhage; Cer | 2011 |
Niaspan increases axonal remodeling after stroke in type 1 diabetes rats.
Topics: Animals; Axons; Diabetes Mellitus, Type 1; Disease Models, Animal; Female; Infarction, Middle Cerebr | 2012 |