Page last updated: 2024-10-19

niacin and Idiopathic Parkinson Disease

niacin has been researched along with Idiopathic Parkinson Disease in 11 studies

Niacin: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.
vitamin B3 : Any member of a group of vitamers that belong to the chemical structural class called pyridines that exhibit biological activity against vitamin B3 deficiency. Vitamin B3 deficiency causes a condition known as pellagra whose symptoms include depression, dermatitis and diarrhea. The vitamers include nicotinic acid and nicotinamide (and their ionized and salt forms).
nicotinic acid : A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.

Research Excerpts

ExcerptRelevanceReference
"Dysbiosis is implicated by many studies in the pathogenesis of Parkinson's disease (PD)."2.66Niacin and Butyrate: Nutraceuticals Targeting Dysbiosis and Intestinal Permeability in Parkinson's Disease. ( Karunaratne, TB; Okereke, C; Purohit, S; Seamon, M; Sharma, A; Wakade, C, 2020)
"Niacin is a precursor for NAD-NADH which is needed for dopamine production."2.50A novel treatment target for Parkinson's disease. ( Chong, R; Wakade, C, 2014)
"Niacin levels were lower in PD and were associated with increased frequency of experiencing body pain and decreased duration of deep sleep."1.40Upregulation of GPR109A in Parkinson's disease. ( Bradley, E; Chong, R; Morgan, J; Thomas, B; Wakade, C, 2014)
"Interestingly, pellagra and Parkinson's disease could share some basic pathophysiological mechanisms at the level of nicotinamide metabolism, resulting in mitochondrial dysfunction and alterations in dopaminergic pathways."1.39Parkinsonian features in a case of pellagra: a historical report. ( Cavanna, AE; Nani, A; Williams, AC, 2013)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19901 (9.09)18.7374
1990's0 (0.00)18.2507
2000's1 (9.09)29.6817
2010's6 (54.55)24.3611
2020's3 (27.27)2.80

Authors

AuthorsStudies
Abu-Elfotuh, K1
Hamdan, AME1
Abbas, AN1
Alahmre, ATS1
Elewa, MAF1
Masoud, RAE1
Ali, AA1
Othman, M1
Kamal, MM1
Hassan, FAM1
Khalil, MG1
El-Sisi, AM1
Abdel Hady, MMM1
Abd-Elhaleim El Azazy, MK1
Awny, MM1
Wahid, A1
He, D1
Fu, S1
Ye, B1
Wang, H1
He, Y1
Li, Z1
Li, J1
Gao, X1
Liu, D1
Giri, B2
Belanger, K1
Seamon, M2
Bradley, E2
Purohit, S2
Chong, R3
Morgan, JC2
Baban, B2
Wakade, C5
Karunaratne, TB1
Okereke, C1
Sharma, A1
Malik, A1
Khodadadi, H1
Chong, RK1
Thomas, B1
Morgan, J1
Wallach, I1
Jaitly, N1
Lilien, R1
EHLERS, G1
Moriyama, TF1
Cavanna, AE1
Nani, A1
Williams, AC1

Reviews

2 reviews available for niacin and Idiopathic Parkinson Disease

ArticleYear
Niacin and Butyrate: Nutraceuticals Targeting Dysbiosis and Intestinal Permeability in Parkinson's Disease.
    Nutrients, 2020, Dec-23, Volume: 13, Issue:1

    Topics: Animals; Butyrates; Dietary Supplements; Dysbiosis; Gastrointestinal Microbiome; Humans; Intestinal

2020
A novel treatment target for Parkinson's disease.
    Journal of the neurological sciences, 2014, Dec-15, Volume: 347, Issue:1-2

    Topics: Aged; Dopamine; Female; Humans; Male; Middle Aged; NAD; Neuroprotective Agents; Niacin; Nicotinic Ag

2014

Trials

1 trial available for niacin and Idiopathic Parkinson Disease

ArticleYear
Niacin modulates macrophage polarization in Parkinson's disease.
    Journal of neuroimmunology, 2018, 07-15, Volume: 320

    Topics: Aged; Dietary Supplements; Female; Humans; Macrophages; Male; Middle Aged; Niacin; Parkinson Disease

2018

Other Studies

8 other studies available for niacin and Idiopathic Parkinson Disease

ArticleYear
Evaluating the neuroprotective activities of vinpocetine, punicalagin, niacin and vitamin E against behavioural and motor disabilities of manganese-induced Parkinson's disease in Sprague Dawley rats.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2022, Volume: 153

    Topics: Acetylcholinesterase; Animals; Anti-Inflammatory Agents; Antioxidants; Glycogen Synthase Kinase 3 be

2022
Activation of HCA2 regulates microglial responses to alleviate neurodegeneration in LPS-induced in vivo and in vitro models.
    Journal of neuroinflammation, 2023, Mar-29, Volume: 20, Issue:1

    Topics: Animals; Dopaminergic Neurons; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Microglia; Neuro

2023
Niacin Ameliorates Neuro-Inflammation in Parkinson's Disease via GPR109A.
    International journal of molecular sciences, 2019, Sep-14, Volume: 20, Issue:18

    Topics: Animals; Anti-Inflammatory Agents; Humans; Inflammation; Interleukin-1beta; Interleukin-6; Lipopolys

2019
Upregulation of GPR109A in Parkinson's disease.
    PloS one, 2014, Volume: 9, Issue:10

    Topics: Adult; Aged; Case-Control Studies; Female; Humans; Male; Middle Aged; Niacin; Parkinson Disease; Rec

2014
A structure-based approach for mapping adverse drug reactions to the perturbation of underlying biological pathways.
    PloS one, 2010, Aug-23, Volume: 5, Issue:8

    Topics: Breast Neoplasms; Computational Biology; Databases, Factual; Diabetes Mellitus, Type 2; Drug-Related

2010
[On the applicability of cosaldon in the treatment of cerebral sclerotic parkinsonism].
    Munchener medizinische Wochenschrift (1950), 1959, Aug-07, Volume: 101

    Topics: Drug Combinations; Niacin; Nicotinic Acids; Parkinson Disease; Parkinsonian Disorders; Theobromine;

1959
Corn might prevent Parkinson's Disease.
    Clinical nutrition (Edinburgh, Scotland), 2001, Volume: 20, Issue:6

    Topics: Humans; Niacin; Parkinson Disease; Prevalence; Zea mays

2001
Parkinsonian features in a case of pellagra: a historical report.
    Journal of Parkinson's disease, 2013, Volume: 3, Issue:4

    Topics: History, 20th Century; Humans; Male; Middle Aged; Parkinson Disease; Pellagra; Sciatica

2013