niacin has been researched along with Huntington Disease in 3 studies
Niacin: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.
vitamin B3 : Any member of a group of vitamers that belong to the chemical structural class called pyridines that exhibit biological activity against vitamin B3 deficiency. Vitamin B3 deficiency causes a condition known as pellagra whose symptoms include depression, dermatitis and diarrhea. The vitamers include nicotinic acid and nicotinamide (and their ionized and salt forms).
nicotinic acid : A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.
Huntington Disease: A familial disorder inherited as an autosomal dominant trait and characterized by the onset of progressive CHOREA and DEMENTIA in the fourth or fifth decade of life. Common initial manifestations include paranoia; poor impulse control; DEPRESSION; HALLUCINATIONS; and DELUSIONS. Eventually intellectual impairment; loss of fine motor control; ATHETOSIS; and diffuse chorea involving axial and limb musculature develops, leading to a vegetative state within 10-15 years of disease onset. The juvenile variant has a more fulminant course including SEIZURES; ATAXIA; dementia; and chorea. (From Adams et al., Principles of Neurology, 6th ed, pp1060-4)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 2 (66.67) | 18.2507 |
2000's | 1 (33.33) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Harris, CA | 1 |
Miranda, AF | 1 |
Tanguay, JJ | 1 |
Boegman, RJ | 1 |
Beninger, RJ | 1 |
Jhamandas, K | 1 |
Puri, BK | 1 |
Hankes, LV | 1 |
Coenen, HH | 1 |
Rota, E | 1 |
Langen, KJ | 1 |
Herzog, H | 1 |
Wutz, W | 1 |
Stoecklin, G | 1 |
Feinendegen, LE | 1 |
3 other studies available for niacin and Huntington Disease
Article | Year |
---|---|
Modulation of striatal quinolinate neurotoxicity by elevation of endogenous brain kynurenic acid.
Topics: Alanine; Animals; Anticonvulsants; Corpus Striatum; Dose-Response Relationship, Drug; Drug Synergism | 1998 |
Impaired phospholipid-related signal transduction in advanced Huntington's disease.
Topics: Adult; Female; Flushing; Humans; Huntington Disease; Male; Middle Aged; Niacin; Nicotinic Acids; Pho | 2001 |
Effect of Huntington's and Alzheimer's diseases on the transport of nicotinic acid or nicotinamide across the human blood-brain barrier.
Topics: Alzheimer Disease; Blood-Brain Barrier; Brain; Humans; Huntington Disease; Niacin; Niacinamide; Tomo | 1991 |