niacin has been researched along with Hepatic Insufficiency in 2 studies
Niacin: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.
vitamin B3 : Any member of a group of vitamers that belong to the chemical structural class called pyridines that exhibit biological activity against vitamin B3 deficiency. Vitamin B3 deficiency causes a condition known as pellagra whose symptoms include depression, dermatitis and diarrhea. The vitamers include nicotinic acid and nicotinamide (and their ionized and salt forms).
nicotinic acid : A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.
Hepatic Insufficiency: Conditions in which the LIVER functions fall below the normal ranges. Severe hepatic insufficiency may cause LIVER FAILURE or DEATH. Treatment may include LIVER TRANSPLANTATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This open-label study evaluated the influence of hepatic insufficiency on the pharmacokinetics of laropiprant (LRPT), a prostaglandin D(2) receptor-1 antagonist, to guide clinicians in the event of inadvertent dosing in patients with hepatic insufficiency." | 2.76 | Pharmacokinetics of laropiprant, a selective prostaglandin D2 receptor 1 antagonist, in patients with moderate hepatic impairment. ( Johnson-Levonas, AO; Lai, E; Lasseter, KC; Liu, F; Luk, JA; Lunde, NM; Marbury, TC; Nirula, A; Wagner, JA; Wang, YH, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, YH | 1 |
| Liu, F | 1 |
| Luk, JA | 1 |
| Nirula, A | 1 |
| Johnson-Levonas, AO | 1 |
| Lasseter, KC | 1 |
| Marbury, TC | 1 |
| Lunde, NM | 1 |
| Wagner, JA | 1 |
| Lai, E | 1 |
| BARTOLOMEI, G | 1 |
| ROSSI, M | 1 |
1 trial available for niacin and Hepatic Insufficiency
| Article | Year |
|---|---|
Pharmacokinetics of laropiprant, a selective prostaglandin D2 receptor 1 antagonist, in patients with moderate hepatic impairment.
Topics: Female; Flushing; Half-Life; Hepatic Insufficiency; Humans; Indoles; Male; Middle Aged; Niacin; Prot | 2011 |
1 other study available for niacin and Hepatic Insufficiency
| Article | Year |
|---|---|
[Liver function test in pregnancy; effect of trigonellamide (N1-methylnicotinamide chloride) on pyruvic, lactic, and amino acids in the blood in liver insufficiency in pregnancy].
Topics: Amino Acids; Chlorides; Hepatic Insufficiency; Liver Function Tests; Niacin; Niacinamide; Nicotinic | 1953 |