niacin has been researched along with Genetic Predisposition in 12 studies
Niacin: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.
vitamin B3 : Any member of a group of vitamers that belong to the chemical structural class called pyridines that exhibit biological activity against vitamin B3 deficiency. Vitamin B3 deficiency causes a condition known as pellagra whose symptoms include depression, dermatitis and diarrhea. The vitamers include nicotinic acid and nicotinamide (and their ionized and salt forms).
nicotinic acid : A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Niacin, a B-complex vitamin, induces prostaglandin synthesis, vasodilatation, and skin flushing when applied as a solution on the skin or taken orally." | 8.86 | Niacin skin flush test: a research tool for studying schizophrenia. ( Buretić-Tomljanović, A; Gudelj, L; Nadalin, S; Rubesa, G; Tomljanović, D, 2010) |
| " Given this gene's role in niacin metabolism and the evidence for niacin deficiency provoking schizophrenialike symptoms in neuropsychiatric diseases such as pellagra and Hartnup disease, these results suggest that the rs10866912 genotype and niacin status may have implications for schizophrenia susceptibility and treatment." | 7.91 | Association of Schizophrenia Risk With Disordered Niacin Metabolism in an Indian Genome-wide Association Study. ( Bakshi, A; Brown, MA; Filippich, C; Fowdar, J; Giacomotto, J; Gratten, J; Gundugurti, PR; Hemani, G; Holliday, EG; Jegadeesan, J; John, S; Jorde, LB; McLean, D; McRae, A; Mowry, BJ; Nagasundaram, A; Nancarrow, D; Nertney, D; Nyholt, DR; Padmavati, R; Patel, K; Periyasamy, S; Rajendren, P; Selvaraj, K; Smith, H; Suetani, R; Thara, R; Thirunavukkarasu, P; Tirupati, S; Vinkhuyzen, A; Wray, NR, 2019) |
| "Schizophrenia patients frequently display reduced niacin flush responses, and similar characteristics are also observed in their nonpsychotic relatives." | 7.79 | A genome-wide quantitative linkage scan of niacin skin flush response in families with schizophrenia. ( Chen, WJ; Faraone, SV; Huang, SS; Hwu, HG; Lien, YJ; Liu, CM; Tsuang, MT, 2013) |
| " Niacin, a B-complex vitamin, induces prostaglandin synthesis, vasodilatation, and skin flushing when applied as a solution on the skin or taken orally." | 4.86 | Niacin skin flush test: a research tool for studying schizophrenia. ( Buretić-Tomljanović, A; Gudelj, L; Nadalin, S; Rubesa, G; Tomljanović, D, 2010) |
| " Given this gene's role in niacin metabolism and the evidence for niacin deficiency provoking schizophrenialike symptoms in neuropsychiatric diseases such as pellagra and Hartnup disease, these results suggest that the rs10866912 genotype and niacin status may have implications for schizophrenia susceptibility and treatment." | 3.91 | Association of Schizophrenia Risk With Disordered Niacin Metabolism in an Indian Genome-wide Association Study. ( Bakshi, A; Brown, MA; Filippich, C; Fowdar, J; Giacomotto, J; Gratten, J; Gundugurti, PR; Hemani, G; Holliday, EG; Jegadeesan, J; John, S; Jorde, LB; McLean, D; McRae, A; Mowry, BJ; Nagasundaram, A; Nancarrow, D; Nertney, D; Nyholt, DR; Padmavati, R; Patel, K; Periyasamy, S; Rajendren, P; Selvaraj, K; Smith, H; Suetani, R; Thara, R; Thirunavukkarasu, P; Tirupati, S; Vinkhuyzen, A; Wray, NR, 2019) |
| "The Genetics of Evoked Responses to Niacin and Endotoxemia (GENE) study was designed to investigate regulation of inflammatory and metabolic responses during low-grade endotoxemia (LPS 1 ng/kg intravenously) in healthy individuals (median age 24, IQR=7) of European (EA; n=193, 47% female) and African ancestry (AA; n=101, 59% female)." | 3.79 | Race and gender variation in response to evoked inflammation. ( Ferguson, JF; Gadi, R; Master, SR; Mehta, NN; Mulvey, CK; Nijjar, PS; Patel, PN; Propert, KJ; Reilly, MP; Shah, R; Shah, RY; Usman, HM, 2013) |
| "Schizophrenia patients frequently display reduced niacin flush responses, and similar characteristics are also observed in their nonpsychotic relatives." | 3.79 | A genome-wide quantitative linkage scan of niacin skin flush response in families with schizophrenia. ( Chen, WJ; Faraone, SV; Huang, SS; Hwu, HG; Lien, YJ; Liu, CM; Tsuang, MT, 2013) |
| "Though a reduced flush response to niacin has been found in schizophrenic patients, whether it is a vulnerability indicator to schizophrenia remains little known." | 3.74 | Familial aggregation in skin flush response to niacin patch among schizophrenic patients and their nonpsychotic relatives. ( Chang, SS; Chen, WJ; Guo, SC; Hsieh, MH; Hwang, TJ; Hwu, HG; Lin, SH; Liu, CM; Liu, SK, 2007) |
| "Heterozygous familial hypercholesterolemia (HeFH) is an autosomal co-dominant inherited disease associated with increased risk of early cardiovascular disease." | 2.50 | [Heterozygous familial hypercholesterolemia]. ( Güleç, S; Özcan, ÖU, 2014) |
| "Prediction of type 1a autoimmune diabetes can be established by a positive family history or by genetic, immunological or metabolic markers." | 2.47 | [Prediction and prevention of type 1 diabetes mellitus: initial results and recent prospects]. ( Madácsy, L, 2011) |
| "In subjects with prevalent type 2 diabetes, homozygous carriers of the most common SIRT1 haplotype, 1, had 1." | 1.35 | SIRT1 genetic variation and mortality in type 2 diabetes: interaction with smoking and dietary niacin. ( Dehghan, A; Hofman, A; Pols, HA; Rivadeneira, F; Sijbrands, EJ; Uitterlinden, AG; van Duijn, CM; van Leeuwen, JP; van Meurs, JB; Witteman, JC; Zillikens, MC, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (25.00) | 29.6817 |
| 2010's | 8 (66.67) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Kjeldsen, EW | 1 |
| Thomassen, JQ | 1 |
| Frikke-Schmidt, R | 1 |
| Periyasamy, S | 1 |
| John, S | 1 |
| Padmavati, R | 1 |
| Rajendren, P | 1 |
| Thirunavukkarasu, P | 1 |
| Gratten, J | 1 |
| Vinkhuyzen, A | 1 |
| McRae, A | 1 |
| Holliday, EG | 1 |
| Nyholt, DR | 1 |
| Nancarrow, D | 1 |
| Bakshi, A | 1 |
| Hemani, G | 1 |
| Nertney, D | 1 |
| Smith, H | 1 |
| Filippich, C | 1 |
| Patel, K | 1 |
| Fowdar, J | 1 |
| McLean, D | 1 |
| Tirupati, S | 1 |
| Nagasundaram, A | 1 |
| Gundugurti, PR | 1 |
| Selvaraj, K | 1 |
| Jegadeesan, J | 1 |
| Jorde, LB | 1 |
| Wray, NR | 1 |
| Brown, MA | 1 |
| Suetani, R | 1 |
| Giacomotto, J | 1 |
| Thara, R | 1 |
| Mowry, BJ | 1 |
| Ferguson, JF | 1 |
| Patel, PN | 1 |
| Shah, RY | 1 |
| Mulvey, CK | 1 |
| Gadi, R | 1 |
| Nijjar, PS | 1 |
| Usman, HM | 1 |
| Mehta, NN | 1 |
| Shah, R | 1 |
| Master, SR | 1 |
| Propert, KJ | 1 |
| Reilly, MP | 1 |
| Özcan, ÖU | 1 |
| Güleç, S | 1 |
| Mussap, M | 1 |
| Noto, A | 1 |
| Fanos, V | 1 |
| Bińczak-Kuleta, A | 1 |
| Szwed, A | 1 |
| Walter, MR | 1 |
| Kołban, M | 1 |
| Ciechanowicz, A | 1 |
| Clark, JS | 1 |
| Zillikens, MC | 1 |
| van Meurs, JB | 1 |
| Sijbrands, EJ | 1 |
| Rivadeneira, F | 1 |
| Dehghan, A | 1 |
| van Leeuwen, JP | 1 |
| Hofman, A | 1 |
| van Duijn, CM | 1 |
| Witteman, JC | 1 |
| Uitterlinden, AG | 1 |
| Pols, HA | 1 |
| Nadalin, S | 1 |
| Buretić-Tomljanović, A | 1 |
| Rubesa, G | 1 |
| Tomljanović, D | 1 |
| Gudelj, L | 1 |
| Lien, YJ | 1 |
| Huang, SS | 1 |
| Liu, CM | 2 |
| Hwu, HG | 2 |
| Faraone, SV | 1 |
| Tsuang, MT | 1 |
| Chen, WJ | 2 |
| Madácsy, L | 1 |
| Zambon, A | 1 |
| Brown, BG | 1 |
| Hokanson, JE | 1 |
| Motulsky, AG | 1 |
| Brunzell, JD | 1 |
| Lin, SH | 1 |
| Chang, SS | 1 |
| Liu, SK | 1 |
| Hwang, TJ | 1 |
| Hsieh, MH | 1 |
| Guo, SC | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Genetics of Evoked Responses to Niacin and Endotoxemia: The GENE Study[NCT00953667] | 400 participants (Actual) | Interventional | 2007-06-30 | Completed | |||
| Clinical Trial of Fecal Microbiota Transplantation in Children With Autism Spectrum Disorder[NCT04948814] | Phase 1 | 40 participants (Anticipated) | Interventional | 2022-06-01 | Enrolling by invitation | ||
| The Topical Niacin Skin Flush Test: A Means for Longitudinal Monitoring of Two Different Biological Subgroups of Patients With First Episode Psychosis[NCT01324297] | 107 participants (Actual) | Observational | 2011-12-31 | Terminated (stopped due to Unable to secure funding for second phase of study (i.e., niacin skin flush test in early psychosis patients).) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00953667)
Timeframe: Baseline ( -15 min, -5 min), and 1, 2, 4, 6, 12, 18, and 24 hours post LPS
| Intervention | mg/L (Median) | |||||||
|---|---|---|---|---|---|---|---|---|
| Baseline CRP in EA males | Peak CRP in EA males | Baseline CRP in AA males | Peak CRP in AA males | Baseline CRP in EA females | Peak CRP in EA females | Baseline CRP in AA females | Peak CRP in AA females | |
| Niacin/Endotoxin | 0.34 | 17.8 | 0.54 | 14.25 | 0.62 | 15.9 | 0.71 | 10.8 |
(NCT00953667)
Timeframe: Baseline (-15 min, -5 min), and 1, 2, 4, 6, 12, 18, and 24 hours post LPS
| Intervention | pg/ml (Median) | |||||||
|---|---|---|---|---|---|---|---|---|
| Baseline TNF-alpha in EA males (n=102) | Peak TNF-alpha in EA males (n=102) | Baseline TNF-alpha in AA males (n=41) | Peak TNF-alpha in AA males (n=41) | Baseline TNF-alpha in EA females (n=91) | Peak TNF-alpha in EA females (n=91) | Baseline TNF-alpha in AA females (n=60) | Peak TNF-alpha in AA females (n=60) | |
| Niacin/Endotoxin | 1.08 | 43.48 | 1.03 | 37.28 | 1.06 | 43.23 | 1.13 | 34.01 |
5 reviews available for niacin and Genetic Predisposition
| Article | Year |
|---|---|
HDL cholesterol concentrations and risk of atherosclerotic cardiovascular disease - Insights from randomized clinical trials and human genetics.
Topics: Adaptor Protein Complex 3; Adaptor Protein Complex beta Subunits; Atherosclerosis; Cholesterol Ester | 2022 |
[Heterozygous familial hypercholesterolemia].
Topics: Azetidines; Early Diagnosis; Ezetimibe; Genetic Predisposition to Disease; Genetic Testing; Heterozy | 2014 |
Metabolomics of autism spectrum disorders: early insights regarding mammalian-microbial cometabolites.
Topics: Amino Acids; Antioxidants; Autism Spectrum Disorder; Biomarkers; Child; Environment; Gastrointestina | 2016 |
Niacin skin flush test: a research tool for studying schizophrenia.
Topics: Administration, Cutaneous; Administration, Oral; Arachidonic Acid; Biomarkers; Brain; Docosahexaenoi | 2010 |
[Prediction and prevention of type 1 diabetes mellitus: initial results and recent prospects].
Topics: Autoantibodies; Biomarkers; Diabetes Mellitus, Type 1; Enterovirus Infections; Genetic Predispositio | 2011 |
1 trial available for niacin and Genetic Predisposition
| Article | Year |
|---|---|
Genetically determined apo B levels and peak LDL density predict angiographic response to intensive lipid-lowering therapy.
Topics: Adult; Analysis of Variance; Apolipoproteins B; Colestipol; Coronary Angiography; Coronary Stenosis; | 2006 |
6 other studies available for niacin and Genetic Predisposition
| Article | Year |
|---|---|
Association of Schizophrenia Risk With Disordered Niacin Metabolism in an Indian Genome-wide Association Study.
Topics: Adult; Animals; Case-Control Studies; Cell Line, Tumor; Chromosomes, Human, Pair 8; Disease Models, | 2019 |
Race and gender variation in response to evoked inflammation.
Topics: Adolescent; Adult; Biomarkers; Black People; Cardiovascular Diseases; Endotoxemia; Ethnicity; Female | 2013 |
Missense splice variant (g.20746A>G, p.Ile183Val) of interferon gamma receptor 1 (IFNGR1) coincidental with mycobacterial osteomyelitis - a screen of osteoarticular lesions.
Topics: Adolescent; Alternative Splicing; Amino Acid Substitution; Biopsy; Bone and Bones; Cartilage, Articu | 2016 |
SIRT1 genetic variation and mortality in type 2 diabetes: interaction with smoking and dietary niacin.
Topics: Aged; Aging; Cohort Studies; Cytoprotection; Diabetes Mellitus, Type 2; Dietary Supplements; Female; | 2009 |
A genome-wide quantitative linkage scan of niacin skin flush response in families with schizophrenia.
Topics: Adult; Female; Flushing; Genetic Linkage; Genetic Loci; Genetic Predisposition to Disease; Genome-Wi | 2013 |
Familial aggregation in skin flush response to niacin patch among schizophrenic patients and their nonpsychotic relatives.
Topics: Administration, Cutaneous; Adult; Aged; Dose-Response Relationship, Drug; Female; Flushing; Genetic | 2007 |