niacin and Depressive Disorder studies

Niacin: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.
vitamin B3 : Any member of a group of vitamers that belong to the chemical structural class called pyridines that exhibit biological activity against vitamin B3 deficiency. Vitamin B3 deficiency causes a condition known as pellagra whose symptoms include depression, dermatitis and diarrhea. The vitamers include nicotinic acid and nicotinamide (and their ionized and salt forms).
nicotinic acid : A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.

Depressive Disorder: An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.

Research Excerpts

Excerpt	Relevance	Reference
"Skin flushing after niacin (methylnicotinate, vitamin B(3)) stimulation is a biological marker of availability of polyunsaturated fatty acids (PUFA)."	7.76	Alterations of niacin skin sensitivity in recurrent unipolar depressive disorder. ( Baur, K; Nenadic, I; Rudolph, N; Sauer, H; Smesny, S, 2010)
"This study compares the skin reactions to the niacin flushing test of 16 schizophrenic patients with those of 17 depressed patients and 16 healthy controls."	7.73	Niacin skin flushing in schizophrenic and depressed patients and healthy controls. ( Bosveld-van Haandel, L; Kluiter, H; Knegtering, R; van den Bosch, RJ, 2006)
" We used niacin-induced dermal erythema as one index of AA metabolism to identify a common C to T single nucleotide polymorphism (SNP) in the first intron of the FACL4 gene (Xq22."	7.72	Association of a long-chain fatty acid-CoA ligase 4 gene polymorphism with depression and with enhanced niacin-induced dermal erythema. ( Covault, J; Kranzler, HR; Moak, D; Mueller, T; Pettinati, H, 2004)
"Skin flushing after niacin (methylnicotinate, vitamin B(3)) stimulation is a biological marker of availability of polyunsaturated fatty acids (PUFA)."	3.76	Alterations of niacin skin sensitivity in recurrent unipolar depressive disorder. ( Baur, K; Nenadic, I; Rudolph, N; Sauer, H; Smesny, S, 2010)
"This study compares the skin reactions to the niacin flushing test of 16 schizophrenic patients with those of 17 depressed patients and 16 healthy controls."	3.73	Niacin skin flushing in schizophrenic and depressed patients and healthy controls. ( Bosveld-van Haandel, L; Kluiter, H; Knegtering, R; van den Bosch, RJ, 2006)
" We used niacin-induced dermal erythema as one index of AA metabolism to identify a common C to T single nucleotide polymorphism (SNP) in the first intron of the FACL4 gene (Xq22."	3.72	Association of a long-chain fatty acid-CoA ligase 4 gene polymorphism with depression and with enhanced niacin-induced dermal erythema. ( Covault, J; Kranzler, HR; Moak, D; Mueller, T; Pettinati, H, 2004)
" However, the existence of a dose-response relationship, with increasing amounts of ingestion resulting in more severe symptoms, needs further observation and studies that include a larger series."	1.30	Acute poisoning with a herbicide containing imazapyr (Arsenal): a report of six cases. ( Chen, KW; Lee, HL; Wu, MH, 1999)

Timeframe	Studies, this research(%)	All Research%
pre-1990	44 (89.80)	18.7374
1990's	1 (2.04)	18.2507
2000's	3 (6.12)	29.6817
2010's	1 (2.04)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Smesny, S	1
Baur, K	1
Rudolph, N	1
Nenadic, I	1
Sauer, H	1
DELAY, J	2
LAINE, B	1
BUISSON, JF	2
BERMANN, S	1
CRANE, GE	2
DEVERTEUIL, RL	1
LEHMANN, HE	1
SCHOPBACH, RR	1
FERREIRA, AJ	1
FREEMAN, H	1
ROBIE, TR	5
AYD, FJ	1
SCANLON, WG	1
WHITE, WM	1
SMARR, ER	1
WOLF, H	1
PRESSMAN, MD	1
DALLY, PJ	2
SANDLER, SA	1
FURST, W	1
BENAIM, S	1
DIXON, MF	1
LEMERE, F	1
ROLLA, E	1
POLITO, R	1
AVENBURG, R	1
RODRIGUEZ ARIAS, M	1
SAUNDERS, JC	2
RADINGER, N	1
ROCHLIN, D	1
KLINE, NS	2
DENIKER, P	1
HAIM, A	1
BOITTELLE, G	1
BOITTELLE-LENTULO, C	1
VANN, D	1
TAVENER, RH	1
VOELKEL, A	1
GALLINEK, A	1
ENGLISH, DC	1
HAUG, JO	1
KOLSTO, F	1
SIRNES, TB	1
WEST, ED	1
HOHEISEL, HP	1
TAUBER, CG	2
POCH, GF	1
STRAAND, A	1
SAINZ, A	1
NEVES, FS	1
MUNARINI, D	1
BERTOLOTTI, P	1
LAWRENCE, RM	1
LEICHMAN, NS	1
SALZER, HM	1
LURIE, ML	1
Covault, J	1
Pettinati, H	1
Moak, D	1
Mueller, T	1
Kranzler, HR	1
Bosveld-van Haandel, L	1
Knegtering, R	1
Kluiter, H	1
van den Bosch, RJ	1
Lee, HL	1
Chen, KW	1
Wu, MH	1
Puri, BK	1
Counsell, SJ	1
Hamilton, G	1
Richardson, AJ	1
Horrobin, DF	1
Bender, DA	1
Abou-Saleh, MT	1
Coppen, A	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
The Role of Tryptophan on Aryl Hydrocarbon Receptor Activation: a Randomized, Double Blind, Placebo-controlled, Crossover Design Pilot Trial[NCT03059862]				20 participants (Actual)	Interventional	2017-11-01	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
Biochemistry of tryptophan in health and disease. Molecular aspects of medicine, 1983, Volume: 6, Issue:2 Topics: Animals; Appetite Regulation; Brain Chemistry; Depressive Disorder; Female; Hartnup Disease; Humans;	1983
The biology of folate in depression: implications for nutritional hypotheses of the psychoses. Journal of psychiatric research, 1986, Volume: 20, Issue:2 Topics: Anorexia Nervosa; Biogenic Amines; Brain; Depressive Disorder; Diet; Folic Acid; Folic Acid Deficien	1986

Article	Year
Alterations of niacin skin sensitivity in recurrent unipolar depressive disorder. Journal of affective disorders, 2010, Volume: 124, Issue:3 Topics: Adult; Biomarkers; Depressive Disorder; Depressive Disorder, Major; Diagnostic and Statistical Manua	2010
[The action of isonicotinyl-hydrazide used in the treatment of depressive states]. Annales medico-psychologiques, 1952, Volume: 110, Issue:2 5 Topics: Anti-Bacterial Agents; Depression; Depressive Disorder; Isomerism; Niacin; Nicotinic Acids	1952
[Isoniazid in the depressive states; preliminary report]. Prensa medica argentina, 1955, Jul-08, Volume: 42, Issue:27 Topics: Depression; Depressive Disorder; Isomerism; Isoniazid; Niacin; Nicotinic Acids	1955
Further studies on iproniazid phosphate; isonicotinil-isopropyl-hydrazine phosphate marsilid. The Journal of nervous and mental disease, 1956, Volume: 124, Issue:3 Topics: Depression; Depressive Disorder; Humans; Hydrazines; Iproniazid; Niacin; Nicotinic Acids; Phosphates	1956
Therapeutic trial of iproniazid (marsilid) in depressed and apathetic patients. Canadian Medical Association journal, 1958, Jan-15, Volume: 78, Issue:2 Topics: Apathy; Depression; Depressive Disorder; Iproniazid; Niacin; Nicotinic Acids; Psychotic Disorders	1958
Clinical note concerning iproniazid (marsilid). The American journal of psychiatry, 1958, Volume: 114, Issue:9 Topics: Depression; Depressive Disorder; Iproniazid; Niacin; Nicotinic Acids	1958
A clinical trial of marsilid in psychotic depressed patients. The American journal of psychiatry, 1958, Volume: 114, Issue:10 Topics: Depression; Depressive Disorder; Mental Disorders; Niacin; Nicotinic Acids; Psychotic Disorders	1958
Marsilid in depression. The American journal of psychiatry, 1958, Volume: 114, Issue:10 Topics: Depression; Depressive Disorder; Niacin; Nicotinic Acids	1958
The treatment of depression and debilitation with marsilid. Bulletin of the School of Medicine (Baltimore, Md.), 1958, Volume: 43, Issue:1 Topics: Depression; Depressive Disorder; Fatigue; Isomerism; Niacin; Nicotinic Acids	1958
Iproniazid (marsilid): its use in office treatment of depression. The American journal of psychiatry, 1958, Volume: 114, Issue:11 Topics: Depression; Depressive Disorder; Iproniazid; Niacin; Nicotinic Acids	1958
Experiences with marsilid with report of one death. The American journal of psychiatry, 1958, Volume: 114, Issue:12 Topics: Death; Depression; Depressive Disorder; Niacin; Nicotinic Acids	1958
Indications for use of iproniazid in psychiatric practice. British medical journal, 1958, Jun-07, Volume: 1, Issue:5083 Topics: Depression; Depressive Disorder; Iproniazid; Isomerism; Niacin; Nicotinic Acids; Thinness	1958
Iproniazid: an effective treatment for depressions. The Journal of the Medical Society of New Jersey, 1958, Volume: 55, Issue:6 Topics: Depression; Depressive Disorder; Iproniazid; Isomerism; Niacin; Nicotinic Acids; Treatment Outcome	1958
Iproniazid in depression. Diseases of the nervous system, 1958, Volume: 19, Issue:7, Part 2 Topics: Depression; Depressive Disorder; Iproniazid; Isomerism; Niacin; Nicotinic Acids	1958
An effective oral chemotherapy for melancholia; iproniazid. Diseases of the nervous system, 1958, Volume: 19, Issue:7, Part 2 Topics: Depression; Depressive Disorder; Iproniazid; Isomerism; Niacin; Nicotinic Acids	1958
Iproniazid chemotherapy in melancholia. The American journal of psychiatry, 1958, Volume: 115, Issue:5 Topics: Depression; Depressive Disorder; Iproniazid; Niacin; Nicotinic Acids	1958
Jaundice associated with administration of iproniazid; report of two cases. British medical journal, 1958, Nov-01, Volume: 2, Issue:5104 Topics: Depression; Depressive Disorder; Iproniazid; Isomerism; Jaundice; Niacin; Nicotinic Acids	1958
Clinical and pharmacological studies of marsilid and theoretical considerations concerning its antidepressant action. The Journal of nervous and mental disease, 1958, Volume: 127, Issue:3 Topics: Antidepressive Agents; Depression; Depressive Disorder; Humans; Niacin; Nicotinic Acids; Research	1958
JB-516 and iproniazid. The American journal of psychiatry, 1958, Volume: 115, Issue:6 Topics: Amphetamine; Amphetamines; Depression; Depressive Disorder; Hydrazines; Iproniazid; Niacin; Nicotini	1958
[Experiences with iproniazid (marsilid) in depressions]. Prensa medica argentina, 1958, Apr-04, Volume: 45, Issue:14 Topics: Depression; Depressive Disorder; Iproniazid; Isomerism; Niacin; Nicotinic Acids	1958
Treatment of depressed and regressed patients with iproniazid and reserpine. Diseases of the nervous system, 1959, Volume: 20, Issue:1 Topics: Depression; Depressive Disorder; Iproniazid; Isomerism; Niacin; Nicotinic Acids; Reserpine	1959
[Treatment of depressive states by the isonicotinic acid derivatives isoniazid & iproniazid]. Annales medico-psychologiques, 1959, Volume: 117, Issue:1 Topics: Depression; Depressive Disorder; Iproniazid; Isomerism; Isoniazid; Isonicotinic Acids; Niacin; Nicot	1959
[Initial results of iproniazid therapy of depressive states]. Annales medico-psychologiques, 1959, Volume: 117, Issue:1 Topics: Depression; Depressive Disorder; Iproniazid; Isomerism; Niacin; Nicotinic Acids	1959
Promazine-iproniazid: a brief report. The American journal of psychiatry, 1959, Volume: 115, Issue:9 Topics: Depression; Depressive Disorder; Iproniazid; Niacin; Nicotinic Acids; Phenothiazines; Promazine	1959
Iproniazid; observations on its use in 30 cases. Canadian Psychiatric Association journal, 1959, Volume: 4, Issue:1 Topics: Depression; Depressive Disorder; Iproniazid; Isomerism; Niacin; Nicotinic Acids	1959
[Treatment of psychomotor inhibition states with the aminoxydase inhibitor marsilid]. Klinische Wochenschrift, 1959, Jan-15, Volume: 37, Issue:2 Topics: Depression; Depressive Disorder; Isomerism; Niacin; Nicotinic Acids	1959
Marsilid (iproniazid) and electroshock. The American journal of psychiatry, 1959, Volume: 115, Issue:11 Topics: Depression; Depressive Disorder; Electroconvulsive Therapy; Electroshock; Iproniazid; Niacin; Nicoti	1959
Marsilid and pacatal in the treatment of depressive schizophrenic reactions. Journal - Michigan State Medical Society, 1959, Volume: 58, Issue:2 Topics: Autonomic Agents; Depression; Depressive Disorder; Niacin; Nicotinic Acids; Psychotic Disorders; Sch	1959
Drugs for treatment of depression. Neurology, 1959, Volume: 9, Issue:4 Topics: Depression; Depressive Disorder; Niacin; Nicotinic Acids; Tranquilizing Agents	1959
A new pharmacotherapeutic approach to melancholia. Research publications - Association for Research in Nervous and Mental Disease, 1959, Volume: 37 Topics: Depression; Depressive Disorder; Isomerism; Niacin; Nicotinic Acids	1959
[Iproniazid treatment of depression; theoretical basis & preliminary report on clinical experiences]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1959, Mar-01, Volume: 79, Issue:5 Topics: Depression; Depressive Disorder; Iproniazid; Niacin; Nicotinic Acids	1959
Effects of iproniazid in depressive syndromes. British medical journal, 1959, Jun-13, Volume: 1, Issue:5136 Topics: Depression; Depressive Disorder; Iproniazid; Isomerism; Niacin; Nicotinic Acids	1959
Psychoenergetics. Diseases of the nervous system, 1959, Volume: 20, Issue:4 Topics: Depression; Depressive Disorder; Isomerism; Niacin; Nicotinic Acids	1959
[Treatment of disorders of mental impulse with marsilid]. Die Medizinische, 1959, Mar-21, Volume: 4, Issue:12 Topics: Depression; Depressive Disorder; Isomerism; Niacin; Nicotinic Acids	1959
[Marsilid in the treatment of depressive states]. Praxis, 1959, May-14, Volume: 48, Issue:20 Topics: Depression; Depressive Disorder; Isomerism; Niacin; Nicotinic Acids	1959
[Marsilid in the treatment of depressive states]. Praxis, 1959, May-21, Volume: 48, Issue:21 Topics: Depression; Depressive Disorder; Isomerism; Niacin; Nicotinic Acids	1959
[Iproniazid in the treatment of endogenous depression]. La Semana medica, 1959, Jan-22, Volume: 114, Issue:4 Topics: Depression; Depressive Disorder; Iproniazid; Isomerism; Niacin; Nicotinic Acids	1959
[Clinical experiences with marsilid (iproniazid) in acute states of depression]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1959, Apr-15, Volume: 79, Issue:8 Topics: Depression; Depressive Disorder; Iproniazid; Niacin; Nicotinic Acids	1959
Clarification of the action of successful treatment in the depressions. Diseases of the nervous system, 1959, Volume: 20, Issue:5, Part 2 Topics: Convulsive Therapy; Depression; Depressive Disorder; Electricity; Electroconvulsive Therapy; Niacin;	1959
[Iproniazid in depressive syndromes]. Jornal do medico, 1959, May-23, Volume: 39, Issue:852 Topics: Depression; Depressive Disorder; Iproniazid; Isomerism; Niacin; Nicotinic Acids	1959
[Clinical experience on the use of iproniazid in depressive syndromes]. Rivista sperimentale di freniatria e medicina legale delle alienazioni mentali, 1959, Mar-31, Volume: 83, Issue:1 Topics: Depression; Depressive Disorder; Iproniazid; Isomerism; Niacin; Nicotinic Acids	1959
COMPARISON OF THE EFFECTS OF HEPARIN SODIUM, XANTHINOL NIACINATE (COMPLAMIN) AND 2-DIMETHYL-AMINOETHANOL (DEANER) IN INSTITUTIONALIZED GERIATRIC GROUPS. Journal of the American Geriatrics Society, 1965, Volume: 13 Topics: Antidepressive Agents; Behavior; Biomedical Research; Cerebrovascular Disorders; Deanol; Depression;	1965
Depressive states treated with isonicotinyl hydrazide (isoniazid); a follow-up study. The Ohio State medical journal, 1955, Volume: 51, Issue:5 Topics: Bipolar Disorder; Depression; Depressive Disorder; Follow-Up Studies; Isoniazid; Mental Disorders; N	1955
Association of a long-chain fatty acid-CoA ligase 4 gene polymorphism with depression and with enhanced niacin-induced dermal erythema. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, 2004, May-15, Volume: 127B, Issue:1 Topics: Alleles; Arachidonic Acid; Coenzyme A Ligases; Depressive Disorder; DNA; Erythema; Gene Frequency; G	2004
Niacin skin flushing in schizophrenic and depressed patients and healthy controls. Psychiatry research, 2006, Aug-30, Volume: 143, Issue:2-3 Topics: Adult; Depressive Disorder; Diagnosis, Differential; Female; Flushing; Humans; Male; Middle Aged; Ni	2006
Acute poisoning with a herbicide containing imazapyr (Arsenal): a report of six cases. Journal of toxicology. Clinical toxicology, 1999, Volume: 37, Issue:1 Topics: Adult; Aged; Alcoholism; Child, Preschool; Depressive Disorder; Female; Glasgow Coma Scale; Herbicid	1999
Eicosapentaenoic acid in treatment-resistant depression associated with symptom remission, structural brain changes and reduced neuronal phospholipid turnover. International journal of clinical practice, 2001, Volume: 55, Issue:8 Topics: Adult; Antidepressive Agents; Brain Diseases; Depressive Disorder; Eicosapentaenoic Acid; Humans; Ma	2001

niacin and Depressive Disorder

Research Excerpts

Research

Studies (49)

Authors

Clinical Trials (1)

Trial Overview

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