Page last updated: 2024-10-19

niacin and Brain Ischemia

niacin has been researched along with Brain Ischemia in 15 studies

Niacin: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.
vitamin B3 : Any member of a group of vitamers that belong to the chemical structural class called pyridines that exhibit biological activity against vitamin B3 deficiency. Vitamin B3 deficiency causes a condition known as pellagra whose symptoms include depression, dermatitis and diarrhea. The vitamers include nicotinic acid and nicotinamide (and their ionized and salt forms).
nicotinic acid : A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.

Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.

Research Excerpts

ExcerptRelevanceReference
"In Atherothrombosis Intervention in Metabolic Syndrome with low HDL/High Triglycerides: Impact on Global Health Outcomes (AIM-HIGH) trial, addition of extended-release niacin (ERN) to simvastatin in participants with established cardiovascular disease, low high-density lipoprotein cholesterol, and high triglycerides had no incremental benefit, despite increases in high-density lipoprotein cholesterol."9.17Extended-release niacin therapy and risk of ischemic stroke in patients with cardiovascular disease: the Atherothrombosis Intervention in Metabolic Syndrome with low HDL/High Triglycerides: Impact on Global Health Outcome (AIM-HIGH) trial. ( Anderson, DC; Boden, WE; Chaitman, BR; Cruz-Flores, S; Goldstein, LB; Grant, S; Kostuk, WJ; Padley, RJ; Sila, CA; Teo, KK; Weintraub, WS, 2013)
"In this study we examined the effect of combination treatment of experimental stroke with Niaspan, a prolonged-release formulation of Niacin (vitamin B3), and Simvastatin, a cholesterol-lowering drug, on functional outcome, axonal damage, axonal density and the of Iba-1 immunoreactive microglia expression in the ischemic brain of rats."7.76Combination treatment of experimental stroke with Niaspan and Simvastatin, reduces axonal damage and improves functional outcome. ( Chen, J; Chopp, M; Cui, X; Lu, M; Roberts, C; Shehadah, A, 2010)
"In Atherothrombosis Intervention in Metabolic Syndrome with low HDL/High Triglycerides: Impact on Global Health Outcomes (AIM-HIGH) trial, addition of extended-release niacin (ERN) to simvastatin in participants with established cardiovascular disease, low high-density lipoprotein cholesterol, and high triglycerides had no incremental benefit, despite increases in high-density lipoprotein cholesterol."5.17Extended-release niacin therapy and risk of ischemic stroke in patients with cardiovascular disease: the Atherothrombosis Intervention in Metabolic Syndrome with low HDL/High Triglycerides: Impact on Global Health Outcome (AIM-HIGH) trial. ( Anderson, DC; Boden, WE; Chaitman, BR; Cruz-Flores, S; Goldstein, LB; Grant, S; Kostuk, WJ; Padley, RJ; Sila, CA; Teo, KK; Weintraub, WS, 2013)
"In this study we examined the effect of combination treatment of experimental stroke with Niaspan, a prolonged-release formulation of Niacin (vitamin B3), and Simvastatin, a cholesterol-lowering drug, on functional outcome, axonal damage, axonal density and the of Iba-1 immunoreactive microglia expression in the ischemic brain of rats."3.76Combination treatment of experimental stroke with Niaspan and Simvastatin, reduces axonal damage and improves functional outcome. ( Chen, J; Chopp, M; Cui, X; Lu, M; Roberts, C; Shehadah, A, 2010)
"It is shown that, in rats with global cerebral ischemia modeled by a complete irreversible occlusion of the common carotid artery and forced hypotension, the hemostasis is characterized by a shift toward hypercoagulation."1.38[Effect of phenibut and its composition with nicotinic acid on hemostasis in rats with brain ischemia]. ( Kurkin, DV; Litvinov, AA; Tarasov, AS; Tiurenkov, IN; Volotova, EV, 2012)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19903 (20.00)18.7374
1990's1 (6.67)18.2507
2000's0 (0.00)29.6817
2010's11 (73.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sun, Y1
Zhang, Y1
Li, Y1
Cheng, J1
Chen, S1
Xiao, Y1
Ao, G1
Nuñez-Figueredo, Y3
Ramírez-Sánchez, J3
Pardo Andreu, GL1
Ochoa-Rodríguez, E3
Verdecia-Reyes, Y3
Souza, DO3
Teo, KK1
Goldstein, LB1
Chaitman, BR2
Grant, S1
Weintraub, WS1
Anderson, DC1
Sila, CA1
Cruz-Flores, S1
Padley, RJ1
Kostuk, WJ1
Boden, WE2
Delgado-Hernández, R2
Porto-Verdecia, M1
Marin-Prida, J1
González-Durruthy, M1
Uyemura, SA1
Rodrigues, FP1
Curti, C1
Pardo-Andreu, GL2
Hansel, G1
Simões Pires, EN1
Merino, N1
Valdes, O1
Parra, AL1
Salbego, C1
Costa, SL1
Gan'shina, TS1
Kim, GA1
Gnezdilova, AV1
Kurdiumov, IN1
Mirzoian, RS1
Offermanns, S1
Schwaninger, M1
Shehadah, A1
Chen, J1
Cui, X1
Roberts, C1
Lu, M1
Chopp, M1
Probstfield, JL1
Anderson, T1
Desvignes-Nickens, P1
Koprowicz, K1
McBride, R1
Teo, K1
Weintraub, W1
Nicholls, SJ1
Tiurenkov, IN1
Volotova, EV1
Kurkin, DV1
Litvinov, AA1
Tarasov, AS1
FAZEKAS, JF2
ALMAN, RW2
WAHAL, PK1
MATHUR, KS1
TICKTIN, HE1
EHRMANTRAUT, WR1
SAVARESE, CJ1
Riasina, TV1
Korshunova, TS1
Polianskiĭ, NB1
Muranov, KO1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
AIM HIGH: Niacin Plus Statin to Prevent Vascular Events[NCT00120289]Phase 33,414 participants (Actual)Interventional2005-09-30Terminated (stopped due to AIM-HIGH was stopped on the recommendation of the DSMB because of lack of efficacy of niacin in preventing primary outcome events.)
Relationships Between Lipoprotein(a) Levels and Aortic Valve Calcification in Patients With Heterozygous Familial Hypercholesterolemia[NCT02976818]173 participants (Actual)Observational2017-04-30Completed
Effect of Pravastatin on Erythrocyte Membrane Fatty Acid Contents in Patients With Chronic Kidney Disease[NCT02992548]Phase 462 participants (Actual)Interventional2015-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Cardiovascular Mortality

(NCT00120289)
Timeframe: Time to first event measured from date of randomization through last follow-up visit (common termination), for an average of 36 months follow-up, maximum 66 months.

Interventionparticipants (Number)
ERN + Simvastatin45
Placebo + Simvastatin38

Composite End Point of CHD Death, Nonfatal MI, Ischemic Stroke, Hospitalization for Non-ST Segment Elevation Acute Coronary Syndrome (ACS), or Symptom-driven Coronary or Cerebral Revascularization

(NCT00120289)
Timeframe: Time to first event measured from date of randomization through last follow-up visit (common termination) for an average of 36 months follow-up, maximum 66 months.

Interventionparticipants (Number)
ERN + Simvastatin282
Placebo + Simvastatin274

Composite Endpoint of CHD Death, Non-fatal MI, High-risk ACS or Ischemic Stroke

(NCT00120289)
Timeframe: Time to first event measured from date of randomization through last follow-up visit (common termination) for an average of 36 months follow-up, maximum 66 months

Interventionparticipants (Number)
ERN + Simvastatin171
Placebo + Simvastatin158

Composite Endpoint of CHD Death, Non-fatal MI, or Ischemic Stroke

(NCT00120289)
Timeframe: Time to first event measured from date of randomization through last follow-up visit (common termination) for an average of 36 months follow-up, maximum 66 months

Interventionparticipants (Number)
ERN + Simvastatin156
Placebo + Simvastatin138

Reviews

3 reviews available for niacin and Brain Ischemia

ArticleYear
Multi-targeting effects of a new synthetic molecule (JM-20) in experimental models of cerebral ischemia.
    Pharmacological reports : PR, 2018, Volume: 70, Issue:4

    Topics: Animals; Benzodiazepines; Brain Ischemia; Drug Evaluation, Preclinical; Neuroprotective Agents; Niac

2018
Nutritional or pharmacological activation of HCA(2) ameliorates neuroinflammation.
    Trends in molecular medicine, 2015, Volume: 21, Issue:4

    Topics: 3-Hydroxybutyric Acid; Adenylyl Cyclases; Animals; Brain; Brain Ischemia; Diet, Ketogenic; Dimethyl

2015
CURRENT THERAPEUTIC CONCEPTS OF CEREBRAL AND MYOCARDIAL VASCULAR DISEASE.
    Angiology, 1964, Volume: 15

    Topics: Acetazolamide; Anticoagulants; Brain Ischemia; Cerebrovascular Disorders; Coronary Disease; Histamin

1964

Trials

2 trials available for niacin and Brain Ischemia

ArticleYear
Extended-release niacin therapy and risk of ischemic stroke in patients with cardiovascular disease: the Atherothrombosis Intervention in Metabolic Syndrome with low HDL/High Triglycerides: Impact on Global Health Outcome (AIM-HIGH) trial.
    Stroke, 2013, Volume: 44, Issue:10

    Topics: Aged; Atherosclerosis; Brain Ischemia; Delayed-Action Preparations; Female; Follow-Up Studies; Human

2013
Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy.
    The New England journal of medicine, 2011, Dec-15, Volume: 365, Issue:24

    Topics: Aged; Atherosclerosis; Brain Ischemia; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL;

2011
Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy.
    The New England journal of medicine, 2011, Dec-15, Volume: 365, Issue:24

    Topics: Aged; Atherosclerosis; Brain Ischemia; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL;

2011
Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy.
    The New England journal of medicine, 2011, Dec-15, Volume: 365, Issue:24

    Topics: Aged; Atherosclerosis; Brain Ischemia; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL;

2011
Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy.
    The New England journal of medicine, 2011, Dec-15, Volume: 365, Issue:24

    Topics: Aged; Atherosclerosis; Brain Ischemia; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL;

2011
Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy.
    The New England journal of medicine, 2011, Dec-15, Volume: 365, Issue:24

    Topics: Aged; Atherosclerosis; Brain Ischemia; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL;

2011
Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy.
    The New England journal of medicine, 2011, Dec-15, Volume: 365, Issue:24

    Topics: Aged; Atherosclerosis; Brain Ischemia; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL;

2011
Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy.
    The New England journal of medicine, 2011, Dec-15, Volume: 365, Issue:24

    Topics: Aged; Atherosclerosis; Brain Ischemia; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL;

2011
Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy.
    The New England journal of medicine, 2011, Dec-15, Volume: 365, Issue:24

    Topics: Aged; Atherosclerosis; Brain Ischemia; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL;

2011
Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy.
    The New England journal of medicine, 2011, Dec-15, Volume: 365, Issue:24

    Topics: Aged; Atherosclerosis; Brain Ischemia; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL;

2011

Other Studies

10 other studies available for niacin and Brain Ischemia

ArticleYear
Synthesis and biological evaluation of novel hydrogen sulfide releasing nicotinic acid derivatives.
    Bioorganic & medicinal chemistry, 2016, 11-01, Volume: 24, Issue:21

    Topics: Animals; Brain Ischemia; Cell Line; Cell Survival; Disease Models, Animal; Dose-Response Relationshi

2016
JM-20, a novel benzodiazepine–dihydropyridine hybrid molecule, protects mitochondria and prevents ischemic insult-mediated neural cell death in vitro.
    European journal of pharmacology, 2014, Mar-05, Volume: 726

    Topics: Animals; Benzodiazepines; Brain Ischemia; Calcium; Cell Death; Cerebellum; Cytochromes c; Dihydropyr

2014
A novel multi-target ligand (JM-20) protects mitochondrial integrity, inhibits brain excitatory amino acid release and reduces cerebral ischemia injury in vitro and in vivo.
    Neuropharmacology, 2014, Volume: 85

    Topics: Animals; Benzodiazepines; Brain; Brain Ischemia; Cell Death; Disease Models, Animal; Excitatory Amin

2014
[Effect of S-amlodipine nicotinate on the cerebral circulation in rats under conditions of ischemic and hemorrhagic brain injury].
    Eksperimental'naia i klinicheskaia farmakologiia, 2014, Volume: 77, Issue:9

    Topics: Amlodipine; Animals; Animals, Outbred Strains; Brain; Brain Edema; Brain Injuries; Brain Ischemia; L

2014
Combination treatment of experimental stroke with Niaspan and Simvastatin, reduces axonal damage and improves functional outcome.
    Journal of the neurological sciences, 2010, Jul-15, Volume: 294, Issue:1-2

    Topics: Amyloid beta-Protein Precursor; Animals; Axons; Brain; Brain Ischemia; Calcium-Binding Proteins; Del

2010
Is niacin ineffective? Or did AIM-HIGH miss its target?
    Cleveland Clinic journal of medicine, 2012, Volume: 79, Issue:1

    Topics: Brain Ischemia; Cholesterol, HDL; Cholesterol, LDL; Coronary Artery Disease; Dyslipidemias; Female;

2012
[Effect of phenibut and its composition with nicotinic acid on hemostasis in rats with brain ischemia].
    Eksperimental'naia i klinicheskaia farmakologiia, 2012, Volume: 75, Issue:4

    Topics: Animals; Anticonvulsants; Brain Ischemia; gamma-Aminobutyric Acid; Hemostasis; Male; Niacin; Rats; R

2012
THERAPEUTIC MODALITIES IN THE MANAGEMENT OF CEREBRAL VASCULAR INSUFFICIENCY.
    American heart journal, 1963, Volume: 66

    Topics: Anticoagulants; Brain Ischemia; Cerebral Infarction; Cerebrovascular Disorders; Classification; Hist

1963
IMMEDIATE TREATMENT OF OCCLUSIVE CEREBROVASCULAR DISEASE--A COMPARATIVE EVALUATION OF DIFFERENT REGIMES OF TREATMENT.
    The Journal of the Association of Physicians of India, 1963, Volume: 11

    Topics: Adrenocorticotropic Hormone; Anesthesia; Anesthesia, Conduction; Anesthesia, Spinal; Anticoagulants;

1963
[Anti-ischemic effect of a new derivative of oxynicotinic acid].
    Biulleten' eksperimental'noi biologii i meditsiny, 1994, Volume: 118, Issue:7

    Topics: Animals; Arterial Occlusive Diseases; Brain Ischemia; Carotid Artery Diseases; Free Radicals; Lipid

1994