niacin has been researched along with Bipolar Disorder in 14 studies
Niacin: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.
vitamin B3 : Any member of a group of vitamers that belong to the chemical structural class called pyridines that exhibit biological activity against vitamin B3 deficiency. Vitamin B3 deficiency causes a condition known as pellagra whose symptoms include depression, dermatitis and diarrhea. The vitamers include nicotinic acid and nicotinamide (and their ionized and salt forms).
nicotinic acid : A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.
Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Studies to date indicate that niacin skin flushing response (NSFR) could be a biomarker for adult patients with schizophrenia and affective disorders." | 8.12 | Attenuated niacin skin flushing response in children and adolescents with mental disorders: A transdiagnostic early warning marker. ( Ke, X; Liang, J; Qing, Y; Wan, C; Wang, J, 2022) |
| "The skin flush response to niacin is abnormally blunted among a subset of patients with schizophrenia (SZ), preferentially associates with SZ compared to other mental illnesses, occurs frequently in nonpsychotic members of SZ-affected families, appears heritable, and shows evidence of genetic association." | 7.83 | Prevalence and Specificity of the Abnormal Niacin Response: A Potential Endophenotype Marker in Schizophrenia. ( Condray, R; Dougherty, GG; Gautier, CH; Gurklis, JA; Haas, GL; Kasckow, JW; Kisslinger, BL; Messamore, E; Yao, JK, 2016) |
| "The pathway for de novo synthesis of the suite of niacin congeners, the kynurenine pathway, has been shown to be upregulated in prior studies of postmortem brain tissue from individuals with schizophrenia." | 7.74 | The high-affinity niacin receptor HM74A is decreased in the anterior cingulate cortex of individuals with schizophrenia. ( Dulay, JR; Miller, CL, 2008) |
| "This study investigated the differences in niacin skin flush responses between patients with schizophrenia, bipolar mania, and normal controls." | 7.74 | Absent response to niacin skin patch is specific to schizophrenia and independent of smoking. ( Chang, SS; Chen, WJ; Hwang, TJ; Hwu, HG; Liao, SC; Liu, CM; Liu, SK; Shieh, MH, 2007) |
| " Studies to date indicate that niacin skin flushing response (NSFR) could be a biomarker for adult patients with schizophrenia and affective disorders." | 4.12 | Attenuated niacin skin flushing response in children and adolescents with mental disorders: A transdiagnostic early warning marker. ( Ke, X; Liang, J; Qing, Y; Wan, C; Wang, J, 2022) |
| "The skin flush response to niacin is abnormally blunted among a subset of patients with schizophrenia (SZ), preferentially associates with SZ compared to other mental illnesses, occurs frequently in nonpsychotic members of SZ-affected families, appears heritable, and shows evidence of genetic association." | 3.83 | Prevalence and Specificity of the Abnormal Niacin Response: A Potential Endophenotype Marker in Schizophrenia. ( Condray, R; Dougherty, GG; Gautier, CH; Gurklis, JA; Haas, GL; Kasckow, JW; Kisslinger, BL; Messamore, E; Yao, JK, 2016) |
| "The pathway for de novo synthesis of the suite of niacin congeners, the kynurenine pathway, has been shown to be upregulated in prior studies of postmortem brain tissue from individuals with schizophrenia." | 3.74 | The high-affinity niacin receptor HM74A is decreased in the anterior cingulate cortex of individuals with schizophrenia. ( Dulay, JR; Miller, CL, 2008) |
| "This study investigated the differences in niacin skin flush responses between patients with schizophrenia, bipolar mania, and normal controls." | 3.74 | Absent response to niacin skin patch is specific to schizophrenia and independent of smoking. ( Chang, SS; Chen, WJ; Hwang, TJ; Hwu, HG; Liao, SC; Liu, CM; Liu, SK; Shieh, MH, 2007) |
| "Pellagra was once a major cause of three behaviorally different mental disorders-schizophreniform, manic-depressive-like, and phobic neurotic - plus drying dermatoses, autonomic neuropathies, tinnitus, and fatigue." | 1.26 | The major psychoses and neuroses as omega-3 essential fatty acid deficiency syndrome: substrate pellagra. ( Rudin, DO, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (50.00) | 18.7374 |
| 1990's | 1 (7.14) | 18.2507 |
| 2000's | 2 (14.29) | 29.6817 |
| 2010's | 3 (21.43) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Qing, Y | 1 |
| Liang, J | 1 |
| Wang, J | 1 |
| Wan, C | 1 |
| Ke, X | 1 |
| Jonsson, BH | 1 |
| Loebl, T | 1 |
| Raskin, S | 1 |
| Yao, JK | 1 |
| Dougherty, GG | 1 |
| Gautier, CH | 1 |
| Haas, GL | 1 |
| Condray, R | 1 |
| Kasckow, JW | 1 |
| Kisslinger, BL | 1 |
| Gurklis, JA | 1 |
| Messamore, E | 1 |
| Miller, CL | 1 |
| Dulay, JR | 1 |
| SALZER, HM | 2 |
| LURIE, ML | 2 |
| ALLIEZ, J | 1 |
| SAVY, A | 1 |
| VALLADE, L | 1 |
| FERREIRA, AJ | 1 |
| FREEMAN, H | 1 |
| Liu, CM | 1 |
| Chang, SS | 1 |
| Liao, SC | 1 |
| Hwang, TJ | 1 |
| Shieh, MH | 1 |
| Liu, SK | 1 |
| Chen, WJ | 1 |
| Hwu, HG | 1 |
| Hudson, CJ | 1 |
| Lin, A | 1 |
| Cogan, S | 1 |
| Cashman, F | 1 |
| Warsh, JJ | 1 |
| Rudin, DO | 1 |
| Schmitz, W | 1 |
14 other studies available for niacin and Bipolar Disorder
| Article | Year |
|---|---|
Attenuated niacin skin flushing response in children and adolescents with mental disorders: A transdiagnostic early warning marker.
Topics: Adolescent; Adult; Autism Spectrum Disorder; Biomarkers; Bipolar Disorder; Child; Flushing; Humans; | 2022 |
Nicotinic Acid Long-Term Effectiveness in a Patient with Bipolar Type II Disorder: A Case of Vitamin Dependency.
Topics: Aged; Anticonvulsants; Antidepressive Agents; Bipolar Disorder; Depression; Dose-Response Relationsh | 2018 |
A novel case report: acute manic psychotic episode after treatment with niacin.
Topics: Bipolar Disorder; Humans; Hypolipidemic Agents; Male; Middle Aged; Niacin; Psychoses, Substance-Indu | 2013 |
Prevalence and Specificity of the Abnormal Niacin Response: A Potential Endophenotype Marker in Schizophrenia.
Topics: Adult; Bipolar Disorder; Endophenotypes; Female; Flushing; Humans; Laser-Doppler Flowmetry; Male; Mi | 2016 |
The high-affinity niacin receptor HM74A is decreased in the anterior cingulate cortex of individuals with schizophrenia.
Topics: Adult; Bipolar Disorder; Blotting, Western; Brain; Female; Gene Expression; Gyrus Cinguli; Humans; M | 2008 |
Anxiety and depressive states treated with isonicotinyl hydrazide (isoniazid).
Topics: Anxiety; Anxiety Disorders; Bipolar Disorder; Depression; Isoniazid; Neurotic Disorders; Niacin; Nic | 1953 |
[Symptomatic manias and recent therapies].
Topics: Adrenocorticotropic Hormone; Amphetamine; Amphetamines; Bipolar Disorder; Cortisone; Humans; Mental | 1954 |
[Mania caused by a new chemotherapeutic agent for tuberculosis].
Topics: Bipolar Disorder; Mental Disorders; Niacin; Nicotinic Acids; Psychoses, Substance-Induced; Psychotic | 1954 |
A clinical study of Marsilid in psychotic depressed patients.
Topics: Bipolar Disorder; Mental Disorders; Niacin; Nicotinic Acids; Psychotic Disorders | 1958 |
Depressive states treated with isonicotinyl hydrazide (isoniazid); a follow-up study.
Topics: Bipolar Disorder; Depression; Depressive Disorder; Follow-Up Studies; Isoniazid; Mental Disorders; N | 1955 |
Absent response to niacin skin patch is specific to schizophrenia and independent of smoking.
Topics: Administration, Cutaneous; Adult; Bipolar Disorder; Female; Flushing; Humans; Male; Niacin; Schizoph | 2007 |
The niacin challenge test: clinical manifestation of altered transmembrane signal transduction in schizophrenia?
Topics: Adolescent; Adult; Aged; Bipolar Disorder; Female; Humans; Male; Membrane Potentials; Middle Aged; N | 1997 |
The major psychoses and neuroses as omega-3 essential fatty acid deficiency syndrome: substrate pellagra.
Topics: Adult; Agoraphobia; Bipolar Disorder; Fatty Acids, Essential; Fatty Acids, Unsaturated; Female; Huma | 1981 |
[Psychopathology of pellagra in children].
Topics: Bipolar Disorder; Brain Damage, Chronic; Child; Depression; Electroencephalography; Hallucinations; | 1971 |