niacin has been researched along with Alveolitis, Fibrosing in 17 studies
Niacin: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.
vitamin B3 : Any member of a group of vitamers that belong to the chemical structural class called pyridines that exhibit biological activity against vitamin B3 deficiency. Vitamin B3 deficiency causes a condition known as pellagra whose symptoms include depression, dermatitis and diarrhea. The vitamers include nicotinic acid and nicotinamide (and their ionized and salt forms).
nicotinic acid : A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Taurine and niacin have been previously found to block the accumulation of collagen in lung in the multidose bleomycin hamster model of pulmonary fibrosis." | 7.69 | Dietary supplementation with taurine and niacin prevents the increase in lung collagen cross-links in the multidose bleomycin hamster model of pulmonary fibrosis. ( Blaisdell, RJ; Giri, SN; Schiedt, MJ, 1994) |
| "Interstitial pulmonary fibrosis induced by bleomycin (BL) involves the production of reactive oxygen species and the impairment of repair of damaged epithelial cells." | 5.28 | Amelioration of bleomycin-induced pulmonary fibrosis in hamsters by combined treatment with taurine and niacin. ( Giri, SN; Hyde, DM; Li, C; Wang, QJ, 1991) |
| "Taurine and niacin have been previously found to block the accumulation of collagen in lung in the multidose bleomycin hamster model of pulmonary fibrosis." | 3.69 | Dietary supplementation with taurine and niacin prevents the increase in lung collagen cross-links in the multidose bleomycin hamster model of pulmonary fibrosis. ( Blaisdell, RJ; Giri, SN; Schiedt, MJ, 1994) |
| "In the multiple-dose bleomycin-hamster model of pulmonary fibrosis, combined treatment with taurine and niacin blocks the increase in lung collagen deposition." | 3.69 | Mechanism of antifibrotic effect of taurine and niacin in the multidose bleomycin-hamster model of lung fibrosis: inhibition of lysyl oxidase and collagenase. ( Blaisdell, RJ; Giri, SN, 1995) |
| "Taurine (T) and niacin (N) have previously been found to block the accumulation of collagen in the bleomycin (BL) model of interstitial pulmonary fibrosis." | 3.69 | Procollagen gene expression is down-regulated by taurine and niacin at the transcriptional level in the bleomycin hamster model of lung fibrosis. ( Giri, SN; Gurujeyalakshmi, G; Hollinger, MA; Iyer, SN, 1996) |
| "Combined treatment with taurine and niacin suppressed BL-induced inflammation and almost completely abrogated pulmonary fibrosis in hamsters." | 3.68 | Abatement of bleomycin-induced increases in vascular permeability, inflammatory cell infiltration, and fibrotic lesions in hamster lungs by combined treatment with taurine and niacin. ( Giri, SN; Hyde, DM; Wang, Q, 1992) |
| " Niacin, a precursor of NAD, was used in the present study to investigate its possible ameliorating effect on BLM-induced pulmonary fibrosis in hamsters." | 3.68 | Niacin attenuates bleomycin-induced lung fibrosis in the hamster. ( Giri, SN; Hyde, DM; Javadi, I; Nakashima, JM; Wang, QJ, 1990) |
| "Treatment with taurine and niacin attenuated the BL-induced increases in proinflammatory cytokines such as IL-1alpha, TNF-alpha, IL-6, and TGF-beta in BALF and lung hydroxyproline content of the mice in BL + TN groups." | 1.31 | Taurine and niacin block lung injury and fibrosis by down-regulating bleomycin-induced activation of transcription nuclear factor-kappaB in mice. ( Giri, SN; Gurujeyalakshmi, G; Wang, Y, 2000) |
| "Taurine and niacin treatment significantly reduced the numbers of neutrophils, lymphocytes, and macrophages in the BL + TN group and caused significant reductions in BL-induced increases in the lung hydroxyproline content at 14 and 21 days in the BL + TN group." | 1.31 | Suppression of bleomycin-induced nitric oxide production in mice by taurine and niacin. ( Giri, SN; Gurujeyalakshmi, G; Wang, Y, 2000) |
| "Interstitial pulmonary fibrosis induced by intratracheal instillation of bleomycin (BL) involves an excess production of reactive oxygen species, unavailability of adequate levels of NAD and ATP to repair the injured pulmonary epithelium, and an overexuberant lung collagen reactivity followed by deposition of highly cross-linked mature collagen fibrils resistant to enzymatic degradation." | 1.29 | Amelioration of bleomycin-induced lung fibrosis in hamsters by dietary supplementation with taurine and niacin: biochemical mechanisms. ( Blaisdell, R; Giri, SN; Hyde, DM; Rucker, RB; Wang, Q, 1994) |
| "Niacin was used in the present study to investigate changes in some biochemical parameters and enzymes involved in the development of BL-induced lung fibrosis in the hamster." | 1.28 | Effects of niacin on bleomycin-induced increases in myeloperoxidase, prolyl hydroxylase, and superoxide dismutase activities and collagen accumulation in the lungs of hamsters. ( Giri, SN; O'Neill, CA, 1992) |
| "Interstitial pulmonary fibrosis induced by bleomycin (BL) involves the production of reactive oxygen species and the impairment of repair of damaged epithelial cells." | 1.28 | Amelioration of bleomycin-induced pulmonary fibrosis in hamsters by combined treatment with taurine and niacin. ( Giri, SN; Hyde, DM; Li, C; Wang, QJ, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (11.76) | 18.7374 |
| 1990's | 11 (64.71) | 18.2507 |
| 2000's | 4 (23.53) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Giri, SN | 14 |
| DAGIANTI, A | 1 |
| CHIAVARO, A | 1 |
| VERDE, AM | 1 |
| GIORDANO, G | 1 |
| ANGRISANI, P | 1 |
| Onyeama, HP | 1 |
| Oehme, FW | 1 |
| Blaisdell, RJ | 2 |
| Schiedt, MJ | 1 |
| Blaisdell, R | 1 |
| Rucker, RB | 1 |
| Wang, Q | 4 |
| Hyde, DM | 4 |
| Gurujeyalakshmi, G | 4 |
| Iyer, SN | 1 |
| Hollinger, MA | 3 |
| Wang, Y | 2 |
| Lasky, JA | 1 |
| Ortiz, LA | 1 |
| O'Neill, CA | 1 |
| Wang, QJ | 2 |
| Nakashima, JM | 1 |
| Javadi, I | 1 |
| Li, C | 1 |
2 reviews available for niacin and Alveolitis, Fibrosing
| Article | Year |
|---|---|
A literature review of paraquat toxicity.
Topics: Acetylcysteine; Animals; Butylated Hydroxytoluene; Clofibrate; Collagen; Diquat; Drug Synergism; Hum | 1984 |
Antifibrotic therapy for the treatment of pulmonary fibrosis.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Inflammatory Agents; Clinical Trials as Topi | 2001 |
15 other studies available for niacin and Alveolitis, Fibrosing
| Article | Year |
|---|---|
The combined treatment with taurine and niacin blocks the bleomycin-induced activation of nuclear factor-kappaB and lung fibrosis.
Topics: Animals; Base Sequence; Bleomycin; Blotting, Western; Bronchoalveolar Lavage Fluid; Cytokines; Disea | 2003 |
[STUDY OF PULMONARY DIFFUSION IN NORMAL SUBJECTS AND SUBJECTS WITH CHRONIC BRONCHOPNEUMOPATHY DURING THE PHARMACODYNAMIC ACTION INDUCED BY NICOTINIC ACID].
Topics: Blood Gas Analysis; Heart Function Tests; Humans; Hypoxia; Niacin; Pharmacology; Physiology; Pulmona | 1964 |
Dietary supplementation with taurine and niacin prevents the increase in lung collagen cross-links in the multidose bleomycin hamster model of pulmonary fibrosis.
Topics: Animals; Bleomycin; Collagen; Cricetinae; Diet; Dipeptides; Disease Models, Animal; Male; Mesocricet | 1994 |
Amelioration of bleomycin-induced lung fibrosis in hamsters by dietary supplementation with taurine and niacin: biochemical mechanisms.
Topics: Animals; Bleomycin; Bronchoalveolar Lavage Fluid; Collagen; Cricetinae; Diet; Hydroxyproline; Lung; | 1994 |
Mechanism of antifibrotic effect of taurine and niacin in the multidose bleomycin-hamster model of lung fibrosis: inhibition of lysyl oxidase and collagenase.
Topics: Animals; Bleomycin; Cricetinae; Hydroxyproline; Male; Matrix Metalloproteinase Inhibitors; Mesocrice | 1995 |
Procollagen gene expression is down-regulated by taurine and niacin at the transcriptional level in the bleomycin hamster model of lung fibrosis.
Topics: Animals; Bleomycin; Collagen; Cricetinae; Gene Expression Regulation; Male; Mesocricetus; Niacin; Pr | 1996 |
Regulation of transforming growth factor-beta1 mRNA expression by taurine and niacin in the bleomycin hamster model of lung fibrosis.
Topics: Animals; Bleomycin; Bronchoalveolar Lavage Fluid; Collagen; Cricetinae; Diet; Disease Models, Animal | 1998 |
Taurine and niacin block lung injury and fibrosis by down-regulating bleomycin-induced activation of transcription nuclear factor-kappaB in mice.
Topics: Animals; Anti-Bacterial Agents; Bleomycin; Blotting, Western; Bronchoalveolar Lavage Fluid; Down-Reg | 2000 |
Suppression of bleomycin-induced nitric oxide production in mice by taurine and niacin.
Topics: Animals; Bleomycin; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Gene Expression Regulation | 2000 |
Effects of niacin on bleomycin-induced increases in myeloperoxidase, prolyl hydroxylase, and superoxide dismutase activities and collagen accumulation in the lungs of hamsters.
Topics: Animals; Bleomycin; Body Weight; Calcium; Collagen; Cricetinae; Hydroxyproline; Lung; Male; Mesocric | 1992 |
Abatement of bleomycin-induced increases in vascular permeability, inflammatory cell infiltration, and fibrotic lesions in hamster lungs by combined treatment with taurine and niacin.
Topics: Animals; Bleomycin; Bronchoalveolar Lavage Fluid; Cell Membrane Permeability; Cricetinae; Drug Thera | 1992 |
Taurine and niacin offer a novel therapeutic modality in prevention of chemically-induced pulmonary fibrosis in hamsters.
Topics: Amiodarone; Animals; Bleomycin; Cricetinae; Drug Therapy, Combination; Niacin; Pulmonary Fibrosis; T | 1992 |
Attenuation of amiodarone-induced lung fibrosis and phospholipidosis in hamsters by taurine and/or niacin treatment.
Topics: Administration, Oral; Amiodarone; Animals; Collagen; Cricetinae; Drug Combinations; Hydroxyproline; | 1992 |
Niacin attenuates bleomycin-induced lung fibrosis in the hamster.
Topics: Animals; Bleomycin; Body Weight; Bronchoalveolar Lavage Fluid; Collagen; Cricetinae; Lung; Male; Mes | 1990 |
Amelioration of bleomycin-induced pulmonary fibrosis in hamsters by combined treatment with taurine and niacin.
Topics: Administration, Oral; Animals; Bleomycin; Calcium; Cricetinae; Drug Therapy, Combination; Hydroxypro | 1991 |