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niacin and Alveolitis, Fibrosing

niacin has been researched along with Alveolitis, Fibrosing in 17 studies

Niacin: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.
vitamin B3 : Any member of a group of vitamers that belong to the chemical structural class called pyridines that exhibit biological activity against vitamin B3 deficiency. Vitamin B3 deficiency causes a condition known as pellagra whose symptoms include depression, dermatitis and diarrhea. The vitamers include nicotinic acid and nicotinamide (and their ionized and salt forms).
nicotinic acid : A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.

Research Excerpts

ExcerptRelevanceReference
"Taurine and niacin have been previously found to block the accumulation of collagen in lung in the multidose bleomycin hamster model of pulmonary fibrosis."7.69Dietary supplementation with taurine and niacin prevents the increase in lung collagen cross-links in the multidose bleomycin hamster model of pulmonary fibrosis. ( Blaisdell, RJ; Giri, SN; Schiedt, MJ, 1994)
"Interstitial pulmonary fibrosis induced by bleomycin (BL) involves the production of reactive oxygen species and the impairment of repair of damaged epithelial cells."5.28Amelioration of bleomycin-induced pulmonary fibrosis in hamsters by combined treatment with taurine and niacin. ( Giri, SN; Hyde, DM; Li, C; Wang, QJ, 1991)
"Taurine and niacin have been previously found to block the accumulation of collagen in lung in the multidose bleomycin hamster model of pulmonary fibrosis."3.69Dietary supplementation with taurine and niacin prevents the increase in lung collagen cross-links in the multidose bleomycin hamster model of pulmonary fibrosis. ( Blaisdell, RJ; Giri, SN; Schiedt, MJ, 1994)
"In the multiple-dose bleomycin-hamster model of pulmonary fibrosis, combined treatment with taurine and niacin blocks the increase in lung collagen deposition."3.69Mechanism of antifibrotic effect of taurine and niacin in the multidose bleomycin-hamster model of lung fibrosis: inhibition of lysyl oxidase and collagenase. ( Blaisdell, RJ; Giri, SN, 1995)
"Taurine (T) and niacin (N) have previously been found to block the accumulation of collagen in the bleomycin (BL) model of interstitial pulmonary fibrosis."3.69Procollagen gene expression is down-regulated by taurine and niacin at the transcriptional level in the bleomycin hamster model of lung fibrosis. ( Giri, SN; Gurujeyalakshmi, G; Hollinger, MA; Iyer, SN, 1996)
"Combined treatment with taurine and niacin suppressed BL-induced inflammation and almost completely abrogated pulmonary fibrosis in hamsters."3.68Abatement of bleomycin-induced increases in vascular permeability, inflammatory cell infiltration, and fibrotic lesions in hamster lungs by combined treatment with taurine and niacin. ( Giri, SN; Hyde, DM; Wang, Q, 1992)
" Niacin, a precursor of NAD, was used in the present study to investigate its possible ameliorating effect on BLM-induced pulmonary fibrosis in hamsters."3.68Niacin attenuates bleomycin-induced lung fibrosis in the hamster. ( Giri, SN; Hyde, DM; Javadi, I; Nakashima, JM; Wang, QJ, 1990)
"Treatment with taurine and niacin attenuated the BL-induced increases in proinflammatory cytokines such as IL-1alpha, TNF-alpha, IL-6, and TGF-beta in BALF and lung hydroxyproline content of the mice in BL + TN groups."1.31Taurine and niacin block lung injury and fibrosis by down-regulating bleomycin-induced activation of transcription nuclear factor-kappaB in mice. ( Giri, SN; Gurujeyalakshmi, G; Wang, Y, 2000)
"Taurine and niacin treatment significantly reduced the numbers of neutrophils, lymphocytes, and macrophages in the BL + TN group and caused significant reductions in BL-induced increases in the lung hydroxyproline content at 14 and 21 days in the BL + TN group."1.31Suppression of bleomycin-induced nitric oxide production in mice by taurine and niacin. ( Giri, SN; Gurujeyalakshmi, G; Wang, Y, 2000)
"Interstitial pulmonary fibrosis induced by intratracheal instillation of bleomycin (BL) involves an excess production of reactive oxygen species, unavailability of adequate levels of NAD and ATP to repair the injured pulmonary epithelium, and an overexuberant lung collagen reactivity followed by deposition of highly cross-linked mature collagen fibrils resistant to enzymatic degradation."1.29Amelioration of bleomycin-induced lung fibrosis in hamsters by dietary supplementation with taurine and niacin: biochemical mechanisms. ( Blaisdell, R; Giri, SN; Hyde, DM; Rucker, RB; Wang, Q, 1994)
"Niacin was used in the present study to investigate changes in some biochemical parameters and enzymes involved in the development of BL-induced lung fibrosis in the hamster."1.28Effects of niacin on bleomycin-induced increases in myeloperoxidase, prolyl hydroxylase, and superoxide dismutase activities and collagen accumulation in the lungs of hamsters. ( Giri, SN; O'Neill, CA, 1992)
"Interstitial pulmonary fibrosis induced by bleomycin (BL) involves the production of reactive oxygen species and the impairment of repair of damaged epithelial cells."1.28Amelioration of bleomycin-induced pulmonary fibrosis in hamsters by combined treatment with taurine and niacin. ( Giri, SN; Hyde, DM; Li, C; Wang, QJ, 1991)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19902 (11.76)18.7374
1990's11 (64.71)18.2507
2000's4 (23.53)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Giri, SN14
DAGIANTI, A1
CHIAVARO, A1
VERDE, AM1
GIORDANO, G1
ANGRISANI, P1
Onyeama, HP1
Oehme, FW1
Blaisdell, RJ2
Schiedt, MJ1
Blaisdell, R1
Rucker, RB1
Wang, Q4
Hyde, DM4
Gurujeyalakshmi, G4
Iyer, SN1
Hollinger, MA3
Wang, Y2
Lasky, JA1
Ortiz, LA1
O'Neill, CA1
Wang, QJ2
Nakashima, JM1
Javadi, I1
Li, C1

Reviews

2 reviews available for niacin and Alveolitis, Fibrosing

ArticleYear
A literature review of paraquat toxicity.
    Veterinary and human toxicology, 1984, Volume: 26, Issue:6

    Topics: Acetylcysteine; Animals; Butylated Hydroxytoluene; Clofibrate; Collagen; Diquat; Drug Synergism; Hum

1984
Antifibrotic therapy for the treatment of pulmonary fibrosis.
    The American journal of the medical sciences, 2001, Volume: 322, Issue:4

    Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Inflammatory Agents; Clinical Trials as Topi

2001

Other Studies

15 other studies available for niacin and Alveolitis, Fibrosing

ArticleYear
The combined treatment with taurine and niacin blocks the bleomycin-induced activation of nuclear factor-kappaB and lung fibrosis.
    Advances in experimental medicine and biology, 2003, Volume: 526

    Topics: Animals; Base Sequence; Bleomycin; Blotting, Western; Bronchoalveolar Lavage Fluid; Cytokines; Disea

2003
[STUDY OF PULMONARY DIFFUSION IN NORMAL SUBJECTS AND SUBJECTS WITH CHRONIC BRONCHOPNEUMOPATHY DURING THE PHARMACODYNAMIC ACTION INDUCED BY NICOTINIC ACID].
    Atti della Societa italiana di cardiologia, 1964, Volume: 25

    Topics: Blood Gas Analysis; Heart Function Tests; Humans; Hypoxia; Niacin; Pharmacology; Physiology; Pulmona

1964
Dietary supplementation with taurine and niacin prevents the increase in lung collagen cross-links in the multidose bleomycin hamster model of pulmonary fibrosis.
    Journal of biochemical toxicology, 1994, Volume: 9, Issue:2

    Topics: Animals; Bleomycin; Collagen; Cricetinae; Diet; Dipeptides; Disease Models, Animal; Male; Mesocricet

1994
Amelioration of bleomycin-induced lung fibrosis in hamsters by dietary supplementation with taurine and niacin: biochemical mechanisms.
    Environmental health perspectives, 1994, Volume: 102 Suppl 10

    Topics: Animals; Bleomycin; Bronchoalveolar Lavage Fluid; Collagen; Cricetinae; Diet; Hydroxyproline; Lung;

1994
Mechanism of antifibrotic effect of taurine and niacin in the multidose bleomycin-hamster model of lung fibrosis: inhibition of lysyl oxidase and collagenase.
    Journal of biochemical toxicology, 1995, Volume: 10, Issue:4

    Topics: Animals; Bleomycin; Cricetinae; Hydroxyproline; Male; Matrix Metalloproteinase Inhibitors; Mesocrice

1995
Procollagen gene expression is down-regulated by taurine and niacin at the transcriptional level in the bleomycin hamster model of lung fibrosis.
    The Journal of pharmacology and experimental therapeutics, 1996, Volume: 277, Issue:2

    Topics: Animals; Bleomycin; Collagen; Cricetinae; Gene Expression Regulation; Male; Mesocricetus; Niacin; Pr

1996
Regulation of transforming growth factor-beta1 mRNA expression by taurine and niacin in the bleomycin hamster model of lung fibrosis.
    American journal of respiratory cell and molecular biology, 1998, Volume: 18, Issue:3

    Topics: Animals; Bleomycin; Bronchoalveolar Lavage Fluid; Collagen; Cricetinae; Diet; Disease Models, Animal

1998
Taurine and niacin block lung injury and fibrosis by down-regulating bleomycin-induced activation of transcription nuclear factor-kappaB in mice.
    The Journal of pharmacology and experimental therapeutics, 2000, Volume: 293, Issue:1

    Topics: Animals; Anti-Bacterial Agents; Bleomycin; Blotting, Western; Bronchoalveolar Lavage Fluid; Down-Reg

2000
Suppression of bleomycin-induced nitric oxide production in mice by taurine and niacin.
    Nitric oxide : biology and chemistry, 2000, Volume: 4, Issue:4

    Topics: Animals; Bleomycin; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Gene Expression Regulation

2000
Effects of niacin on bleomycin-induced increases in myeloperoxidase, prolyl hydroxylase, and superoxide dismutase activities and collagen accumulation in the lungs of hamsters.
    Journal of biochemical toxicology, 1992,Winter, Volume: 7, Issue:4

    Topics: Animals; Bleomycin; Body Weight; Calcium; Collagen; Cricetinae; Hydroxyproline; Lung; Male; Mesocric

1992
Abatement of bleomycin-induced increases in vascular permeability, inflammatory cell infiltration, and fibrotic lesions in hamster lungs by combined treatment with taurine and niacin.
    Laboratory investigation; a journal of technical methods and pathology, 1992, Volume: 67, Issue:2

    Topics: Animals; Bleomycin; Bronchoalveolar Lavage Fluid; Cell Membrane Permeability; Cricetinae; Drug Thera

1992
Taurine and niacin offer a novel therapeutic modality in prevention of chemically-induced pulmonary fibrosis in hamsters.
    Advances in experimental medicine and biology, 1992, Volume: 315

    Topics: Amiodarone; Animals; Bleomycin; Cricetinae; Drug Therapy, Combination; Niacin; Pulmonary Fibrosis; T

1992
Attenuation of amiodarone-induced lung fibrosis and phospholipidosis in hamsters by taurine and/or niacin treatment.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 262, Issue:1

    Topics: Administration, Oral; Amiodarone; Animals; Collagen; Cricetinae; Drug Combinations; Hydroxyproline;

1992
Niacin attenuates bleomycin-induced lung fibrosis in the hamster.
    Journal of biochemical toxicology, 1990,Spring, Volume: 5, Issue:1

    Topics: Animals; Bleomycin; Body Weight; Bronchoalveolar Lavage Fluid; Collagen; Cricetinae; Lung; Male; Mes

1990
Amelioration of bleomycin-induced pulmonary fibrosis in hamsters by combined treatment with taurine and niacin.
    Biochemical pharmacology, 1991, Aug-08, Volume: 42, Issue:5

    Topics: Administration, Oral; Animals; Bleomycin; Calcium; Cricetinae; Drug Therapy, Combination; Hydroxypro

1991