niacin has been researched along with Alloxan Diabetes in 46 studies
Niacin: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.
vitamin B3 : Any member of a group of vitamers that belong to the chemical structural class called pyridines that exhibit biological activity against vitamin B3 deficiency. Vitamin B3 deficiency causes a condition known as pellagra whose symptoms include depression, dermatitis and diarrhea. The vitamers include nicotinic acid and nicotinamide (and their ionized and salt forms).
nicotinic acid : A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Niacin was shown to inhibit acute vascular inflammation and improves endothelial dysfunction independent of changes in plasma lipids." | 5.38 | Niacin improves ischemia-induced neovascularization in diabetic mice by enhancement of endothelial progenitor cell functions independent of changes in plasma lipids. ( Chen, JS; Chen, JW; Chiang, CH; Huang, PH; Leu, HB; Lin, CP; Lin, FY; Lin, SJ; Tsai, HY; Wang, CH; Wu, TC, 2012) |
| " The aim of the present study is to evaluate the efficacy of coenzyme Q10 (CoQ10), niacin, as well as their combination in ameliorating brain disorders associated with streptozotocin (STZ)-induced diabetes in rats." | 3.85 | A Therapeutic Insight of Niacin and Coenzyme Q10 Against Diabetic Encephalopathy in Rats. ( Darwish, HA; El-Rigal, NS; Hamed, MA; Motawi, TK; Naser, AFA, 2017) |
| "Niacin has antidyslipidemic properties in diabetic patients." | 1.48 | Effect of pharmacological doses of niacin on testicular structure and function in normal and diabetic rats. ( Dalvand, M; Namazi, F; Shomali, T; Taherianfard, M, 2018) |
| "Diabetic encephalopathy is an important complication of diabetes characterized by cognitive impairment, neurochemical and structural abnormalities." | 1.46 | Coenzyme Q10 and niacin mitigate streptozotocin- induced diabetic encephalopathy in a rat model. ( Aboul Naser, AF; Darwish, HA; El-Rigal, NS; Hamed, MA; Motawi, TK, 2017) |
| "Early diabetic retinopathy is characterized by a loss of pericytes and vascular endothelial cells, a breakdown of the blood-retinal barrier, vascular dysfunction and vascular-neuroinflammation." | 1.43 | MicroRNA-126 contributes to Niaspan treatment induced vascular restoration after diabetic retinopathy. ( Wang, Y; Yan, H, 2016) |
| "Combination treatment of stroke with BMSCs and Niaspan in T1DM rats increases white matter remodeling and additively increases BMSC monotherapy induced myelination and synaptic plasticity after stroke in T1DM rats." | 1.39 | Combination BMSC and Niaspan treatment of stroke enhances white matter remodeling and synaptic protein expression in diabetic rats. ( Chen, J; Chopp, M; Ning, R; Roberts, C; Venkat, P; Yan, T; Ye, X; Zacharek, A, 2013) |
| "Niacin was shown to inhibit acute vascular inflammation and improves endothelial dysfunction independent of changes in plasma lipids." | 1.38 | Niacin improves ischemia-induced neovascularization in diabetic mice by enhancement of endothelial progenitor cell functions independent of changes in plasma lipids. ( Chen, JS; Chen, JW; Chiang, CH; Huang, PH; Leu, HB; Lin, CP; Lin, FY; Lin, SJ; Tsai, HY; Wang, CH; Wu, TC, 2012) |
| "Niaspan treatment of stroke in T1DM rats inhibits HMGB1/RAGE, TLR4 and MMP-9 expression which may contribute to the reduced inflammatory response after stroke in T1DM rats." | 1.37 | Niaspan reduces high-mobility group box 1/receptor for advanced glycation endproducts after stroke in type-1 diabetic rats. ( Chen, J; Chopp, M; Cui, X; Liu, X; Roberts, C; Yan, T; Ye, X; Zacharek, A, 2011) |
| "T1DM-rats were subjected to transient middle cerebral artery occlusion (MCAo) and treated without or with Niaspan." | 1.37 | Niaspan enhances vascular remodeling after stroke in type 1 diabetic rats. ( Chen, J; Chopp, M; Cui, X; Cui, Y; Liu, X; Lu, M; Roberts, C; Shehadah, A; Yan, T; Ye, X; Zacharek, A, 2011) |
| "Also dyslipidemia seems to be involved in enzyme activity variations of the tryptophan metabolism along the kynurenine pathway." | 1.31 | Enzyme activities along the tryptophan-nicotinic acid pathway in alloxan diabetic rabbits. ( Allegri, G; Bertazzo, A; Biasiolo, M; Caparrotta, L; Costa, CV; Ragazzi, E, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (34.78) | 18.7374 |
| 1990's | 9 (19.57) | 18.2507 |
| 2000's | 6 (13.04) | 29.6817 |
| 2010's | 14 (30.43) | 24.3611 |
| 2020's | 1 (2.17) | 2.80 |
| Authors | Studies |
|---|---|
| Tykhonenko, T | 1 |
| Guzyk, M | 1 |
| Tykhomyrov, A | 1 |
| Korsa, V | 1 |
| Yanitska, L | 1 |
| Kuchmerovska, T | 1 |
| Motawi, TK | 2 |
| Darwish, HA | 2 |
| Hamed, MA | 2 |
| El-Rigal, NS | 2 |
| Aboul Naser, AF | 1 |
| Xie, YD | 1 |
| Chen, ZZ | 1 |
| Li, N | 2 |
| Lu, WF | 1 |
| Xu, YH | 1 |
| Lin, YY | 1 |
| Shao, LH | 1 |
| Wang, QT | 1 |
| Guo, LY | 1 |
| Gao, YQ | 1 |
| Yang, GD | 1 |
| Li, YP | 1 |
| Bian, XL | 1 |
| El-Bahy, AAZ | 1 |
| Aboulmagd, YM | 1 |
| Zaki, M | 1 |
| Shomali, T | 1 |
| Taherianfard, M | 1 |
| Dalvand, M | 1 |
| Namazi, F | 1 |
| Gu, HF | 1 |
| Tang, YL | 1 |
| Yan, CQ | 1 |
| Shi, Z | 1 |
| Yi, SN | 1 |
| Zhou, HL | 1 |
| Liao, DF | 1 |
| OuYang, XP | 1 |
| Narender, T | 1 |
| Madhur, G | 1 |
| Jaiswal, N | 1 |
| Agrawal, M | 1 |
| Maurya, CK | 1 |
| Rahuja, N | 1 |
| Srivastava, AK | 1 |
| Tamrakar, AK | 1 |
| Ye, X | 3 |
| Yan, T | 3 |
| Chopp, M | 3 |
| Zacharek, A | 3 |
| Ning, R | 1 |
| Venkat, P | 1 |
| Roberts, C | 3 |
| Chen, J | 3 |
| Naser, AFA | 1 |
| Ošiņa, K | 1 |
| Rostoka, E | 1 |
| Isajevs, S | 1 |
| Sokolovska, J | 1 |
| Sjakste, T | 1 |
| Sjakste, N | 1 |
| Wang, Y | 1 |
| Yan, H | 1 |
| Penumathsa, SV | 1 |
| Thirunavukkarasu, M | 1 |
| Samuel, SM | 1 |
| Zhan, L | 1 |
| Maulik, G | 1 |
| Bagchi, M | 1 |
| Bagchi, D | 1 |
| Maulik, N | 1 |
| McNamara, DB | 1 |
| Murthy, SN | 1 |
| Fonseca, AN | 1 |
| Desouza, CV | 1 |
| Kadowitz, PJ | 1 |
| Fonseca, VA | 1 |
| JANES, RG | 1 |
| MYERS, L | 1 |
| Liu, X | 2 |
| Cui, X | 2 |
| Cui, Y | 1 |
| Shehadah, A | 1 |
| Lu, M | 1 |
| Gambhir, D | 1 |
| Ananth, S | 1 |
| Veeranan-Karmegam, R | 1 |
| Elangovan, S | 1 |
| Hester, S | 1 |
| Jennings, E | 1 |
| Offermanns, S | 1 |
| Nussbaum, JJ | 1 |
| Smith, SB | 1 |
| Thangaraju, M | 1 |
| Ganapathy, V | 1 |
| Martin, PM | 1 |
| Huang, PH | 1 |
| Lin, CP | 1 |
| Wang, CH | 1 |
| Chiang, CH | 1 |
| Tsai, HY | 1 |
| Chen, JS | 1 |
| Lin, FY | 1 |
| Leu, HB | 1 |
| Wu, TC | 1 |
| Chen, JW | 1 |
| Lin, SJ | 1 |
| Crozier, SJ | 1 |
| Anthony, JC | 1 |
| Schworer, CM | 1 |
| Reiter, AK | 1 |
| Anthony, TG | 1 |
| Kimball, SR | 1 |
| Jefferson, LS | 1 |
| KLUPSCH, E | 1 |
| HEUCHEL, G | 1 |
| ESER, S | 2 |
| TEKMAN, S | 2 |
| ARAZ, A | 2 |
| OJI, N | 1 |
| KOJIMA, K | 1 |
| MEHLER, AH | 1 |
| YANO, K | 1 |
| MAY, EL | 1 |
| OSTMAN, J | 4 |
| ROOT, MA | 1 |
| ASHMORE, J | 1 |
| CARLSON, LA | 1 |
| LAW, LW | 1 |
| TING, RC | 1 |
| Ragazzi, E | 2 |
| Costa, CV | 2 |
| Comai, S | 1 |
| Bertazzo, A | 2 |
| Caparrotta, L | 2 |
| Allegri, G | 2 |
| Shin, M | 1 |
| Maeda, S | 1 |
| Hashimoto, Y | 1 |
| Sano, K | 1 |
| Umezawa, C | 1 |
| Egashira, Y | 2 |
| Nakazawa, A | 1 |
| Ohta, T | 1 |
| Shibata, K | 3 |
| Sanada, H | 2 |
| Ishikawa, A | 1 |
| Kondo, T | 1 |
| Yuan, M | 1 |
| Yu, B | 1 |
| Liang, Y | 1 |
| Biasiolo, M | 1 |
| Tanabe, A | 1 |
| Fukuoka, S | 1 |
| Kahn, SE | 1 |
| McCulloch, DK | 1 |
| Schwartz, MW | 1 |
| Palmer, JP | 1 |
| Porte, D | 1 |
| Saggerson, D | 1 |
| Orford, M | 1 |
| Chatzipanteli, K | 1 |
| Shepherd, J | 1 |
| Ar'Rajab, A | 1 |
| Ahrén, B | 1 |
| Strassheim, D | 1 |
| Milligan, G | 1 |
| Houslay, MD | 1 |
| Gagliardi, AR | 1 |
| Goldstein, S | 1 |
| Phillips, LS | 1 |
| Reaven, GM | 2 |
| Chang, H | 2 |
| Ho, H | 1 |
| Jeng, CY | 1 |
| Hoffman, BB | 2 |
| Wright, JR | 1 |
| Mendola, J | 1 |
| Lacy, PE | 1 |
1 review available for niacin and Alloxan Diabetes
| Article | Year |
|---|---|
Animal models of catheter-induced intimal hyperplasia in type 1 and type 2 diabetes and the effects of pharmacologic intervention.
Topics: Animals; Biguanides; Catheterization; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Di | 2009 |
45 other studies available for niacin and Alloxan Diabetes
| Article | Year |
|---|---|
Modulatory effects of vitamin B3 and its derivative on the levels of apoptotic and vascular regulators and cytoskeletal proteins in diabetic rat brain as signs of neuroprotection.
Topics: Animals; Brain; Cytoskeletal Proteins; Diabetes Mellitus, Experimental; gamma-Aminobutyric Acid; Hyp | 2022 |
Coenzyme Q10 and niacin mitigate streptozotocin- induced diabetic encephalopathy in a rat model.
Topics: Animals; Antioxidants; Blood Glucose; Brain Diseases; Cholinesterase Inhibitors; Diabetes Mellitus, | 2017 |
Hydroxytyrosol nicotinate, a new multifunctional hypolipidemic and hypoglycemic agent.
Topics: Animals; Antioxidants; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Hy | 2018 |
Diabetex: A novel approach for diabetic wound healing.
Topics: Alanine; Animals; Ascorbic Acid; Blood Coagulation; Blood Glucose; Collagen; Diabetes Mellitus, Expe | 2018 |
Effect of pharmacological doses of niacin on testicular structure and function in normal and diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Humans; Hypolipidemic Agents; Male; Niacin; | 2018 |
Nicotinate-curcumin ameliorates cognitive impairment in diabetic rats by rescuing autophagic flux in CA1 hippocampus.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Autophagy; CA1 Region, Hippocampal; Cognitive Dysf | 2019 |
Synthesis of novel triterpene and N-allylated/N-alkylated niacin hybrids as α-glucosidase inhibitors.
Topics: alpha-Glucosidases; Animals; Blood Glucose; Circular Dichroism; Diabetes Mellitus, Experimental; Dos | 2013 |
Combination BMSC and Niaspan treatment of stroke enhances white matter remodeling and synaptic protein expression in diabetic rats.
Topics: Animals; Brain; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Lipoproteins, HDL; Mesen | 2013 |
A Therapeutic Insight of Niacin and Coenzyme Q10 Against Diabetic Encephalopathy in Rats.
Topics: Animals; Blood Glucose; Brain Diseases; Diabetes Mellitus, Experimental; Drug Therapy, Combination; | 2017 |
Effects of an Antimutagenic 1,4-Dihydropyridine AV-153 on Expression of Nitric Oxide Synthases and DNA Repair-related Enzymes and Genes in Kidneys of Rats with a Streptozotocin Model of Diabetes Mellitus.
Topics: Animals; Antimutagenic Agents; Diabetes Mellitus, Experimental; Dihydropyridines; DNA Repair; Gene E | 2016 |
MicroRNA-126 contributes to Niaspan treatment induced vascular restoration after diabetic retinopathy.
Topics: Angiogenesis Inducing Agents; Angiogenic Proteins; Animals; Apoptosis; Ascorbic Acid; Blood Glucose; | 2016 |
Niacin bound chromium treatment induces myocardial Glut-4 translocation and caveolar interaction via Akt, AMPK and eNOS phosphorylation in streptozotocin induced diabetic rats after ischemia-reperfusion injury.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Biological Transport, Active; Cardiotonic Agents; | 2009 |
Production of ketosis in alloxan diabetic rats with nicotinic acid.
Topics: Acidosis; Alloxan; Animals; Diabetes Mellitus; Diabetes Mellitus, Experimental; Ketosis; Niacin; Nic | 1946 |
Niaspan reduces high-mobility group box 1/receptor for advanced glycation endproducts after stroke in type-1 diabetic rats.
Topics: Animals; Brain; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; HMGB Proteins; Male; Nia | 2011 |
Niaspan enhances vascular remodeling after stroke in type 1 diabetic rats.
Topics: Angiotensin I; Angiotensin II; Animals; Blood Glucose; Blood-Brain Barrier; Cerebral Hemorrhage; Cer | 2011 |
GPR109A as an anti-inflammatory receptor in retinal pigment epithelial cells and its relevance to diabetic retinopathy.
Topics: 3-Hydroxybutyric Acid; Aged; Animals; Cell Line; Chemokine CCL2; Diabetes Mellitus, Experimental; Di | 2012 |
Niacin improves ischemia-induced neovascularization in diabetic mice by enhancement of endothelial progenitor cell functions independent of changes in plasma lipids.
Topics: Animals; Diabetes Mellitus, Experimental; Endothelial Cells; Flow Cytometry; In Situ Nick-End Labeli | 2012 |
Tissue-specific regulation of protein synthesis by insulin and free fatty acids.
Topics: Animals; Diabetes Mellitus, Experimental; Eukaryotic Initiation Factor-2B; Fatty Acids, Nonesterifie | 2003 |
[Effects of isoniazid on alloxan diabetes in rats].
Topics: Animals; Diabetes Mellitus, Experimental; Isoniazid; Niacin; Nicotinic Acids; Rats | 1956 |
[Effects of nicotinamide on ketone metabolism by liver of alloxan diabetic rats in vitro. II. Study of acetoacetate utilization by distillation method].
Topics: Acetoacetates; Alloxan; Animals; Diabetes Mellitus, Experimental; Distillation; In Vitro Techniques; | 1958 |
[Effects of nicotinamide on ketone metabolism by liver of aloxan diabetic rats in vitro. III. Study of acetoacetate utilization by colorimetric method].
Topics: Acetoacetates; Animals; Colorimetry; Diabetes Mellitus, Experimental; In Vitro Techniques; Liver; Ni | 1958 |
The inactivation of cortisol in experimental diabetic animals.
Topics: Anatomy; Animals; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Diabetes M | 1963 |
[DIABETES MELLITUS AND EYE CHANGES].
Topics: Adenosine Triphosphate; Animals; Blood Pressure Determination; Diabetes Mellitus, Experimental; Diab | 1963 |
NICOTONIC ACID BIOSYNTHESIS: CONTROL BY AN ENZYME THAT COMPETES WITH A SPONTANEOUS REACTION.
Topics: Adenosine Triphosphate; Animals; Carbon Dioxide; Carbon Isotopes; Carbon Radioisotopes; Carboxy-Lyas | 1964 |
EFFECT OF NICOTINIC ACID ON THE FATTY ACID METABOLISM OF ADIPOSE TISSUE IN ALLOXAN DIABETIC RATS.
Topics: Adipose Tissue; Alloxan; Animals; Carbon Isotopes; Diabetes Mellitus, Experimental; Epididymis; Fatt | 1964 |
THE HYPOGLYCEMIC ACTIVITY OF NICOTINIC ACID IN RATS.
Topics: Adrenalectomy; Animals; Carbohydrate Metabolism; Diabetes Mellitus, Experimental; Hypoglycemia; Hypo | 1964 |
(INHIBITORY EFFECT OF NICOTINIC ACID ON FFA MOBILIZATION IN ALLOXAN-DIABETIC RATS. I. IN VITRO STUDIES ON THE FATTY ACID METABOLISM IN ADIPOSE TISSUE AFTER NICOTINIC ACID ADMINISTRATION TO DONOR ANIMALS.)
Topics: Adipose Tissue; Alloxan; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Fatty Acids; Glyce | 1965 |
INHIBITORY EFFECT OF NICOTINIC ACID ON FFA MOBILIZATION IN ALLOXAN-DIABETIC RATS. II. A COMPARISON OF THE EFFECT OF NICOTINIC ACID AND SALICYLATE ON THE FATTY ACID METABOLISM AND GLUCOSE UPTAKE BY ADIPOSE TISSUE IN VITRO.
Topics: Adipose Tissue; Alloxan; Animals; Carbohydrate Metabolism; Carbon Isotopes; Diabetes Mellitus, Exper | 1965 |
INHIBITION OF THE MOBILIZATION OF FREE FATTY ACIDS FROM ADIPOSE TISSUE IN DIABETES. I. EFFECT OF NICOTINIC ACID ON THE ALLOXAN-DIABETIC STATE IN RATS.
Topics: Adipose Tissue; Alloxan; Animals; Blood Glucose; Body Weight; Carbohydrate Metabolism; Cholesterol; | 1965 |
IMMUNOLOGIC COMPETENCE AND INDUCTION OF NEOPLASMS BY POLYOMA VIRUS.
Topics: Animals; Blood Glucose; Cholesterol; Diabetes Mellitus, Experimental; Dogs; Fatty Acids; Immunocompe | 1965 |
Cloricromene effect on the enzyme activities of the tryptophan-nicotinic acid pathway in diabetic/hyperlipidemic rabbits.
Topics: Animals; Cholesterol, Dietary; Chromonar; Diabetes Mellitus, Experimental; Free Radical Scavengers; | 2006 |
NAD synthesis from nicotinic acid by the hepatocytes prepared from diabetic rats.
Topics: 3-Hydroxybutyric Acid; Acetoacetates; Animals; Blood Glucose; Carbon Radioisotopes; Cells, Cultured; | 1995 |
Effect of dietary linoleic acid on the tryptophan-niacin metabolism in streptozotocin diabetic rats.
Topics: Animals; Body Weight; Diabetes Mellitus, Experimental; Diet; Eating; Linoleic Acid; Linoleic Acids; | 1995 |
Effects of dietary pyrazinamide on the metabolism of tryptophan to niacin in streptozotocin-diabetic rats.
Topics: Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Experimental; Glycosuria; Male; Niacin; Poly | 1997 |
Effects of peroxovanadate complexes on reducing glycemia in diabetic rats and translocation of glucose transporter.
Topics: Animals; Biological Transport; Blood Glucose; Chelating Agents; Diabetes Mellitus, Experimental; Fem | 1997 |
Enzyme activities along the tryptophan-nicotinic acid pathway in alloxan diabetic rabbits.
Topics: 3-Hydroxyanthranilate 3,4-Dioxygenase; Animals; Carboxy-Lyases; Cholesterol, Dietary; Diabetes Melli | 2002 |
Expression of rat hepatic 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase is affected by a high protein diet and by streptozotocin-induced diabetes.
Topics: Animals; Carboxy-Lyases; Diabetes Mellitus, Experimental; Dietary Proteins; Gene Expression Regulati | 2002 |
Effect of insulin resistance and hyperglycemia on proinsulin release in a primate model of diabetes mellitus.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Hyperglycemia; Insulin; Insulin Resistance; | 1992 |
Diabetes decreases sensitivity of adipocyte lipolysis to inhibition by Gi-linked receptor agonists.
Topics: Adipose Tissue; Animals; Cell Membrane; Colforsin; Diabetes Mellitus, Experimental; Dinoprostone; El | 1991 |
Effects of yohimbine and nicotinic acid on insulin secretion in islet transplanted streptozotocin-diabetic rats.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Insulin; Insulin Secretion; Islets of Lange | 1991 |
Diabetes abolishes the GTP-dependent, but not the receptor-dependent inhibitory function of the inhibitory guanine-nucleotide-binding regulatory protein (Gi) on adipocyte adenylate cyclase activity.
Topics: Adenylyl Cyclases; Adipose Tissue; Animals; Blotting, Western; Cell Membrane; Colforsin; Diabetes Me | 1990 |
Nutrition and somatomedin. XXI. Insulin-like growth factor-I and somatomedin inhibitor in streptozotocin-diabetic rats: relation to ketogenesis and gluconeogenesis.
Topics: Animals; Diabetes Mellitus, Experimental; Energy Metabolism; Epoxy Compounds; Fatty Acids; Gluconeog | 1990 |
Lowering of plasma glucose in diabetic rats by antilipolytic agents.
Topics: Adenosine; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Fatty Acids, Nonesterified; Insu | 1988 |
Effect of niacin/nicotinamide deficiency on the diabetogenic effect of streptozotocin.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Male; Mice; Niacin; Niacinamide; Streptozoc | 1988 |
Additive hypoglycemic effects of drugs that modify free-fatty acid metabolism by different mechanisms in rats with streptozocin-induced diabetes.
Topics: Adipose Tissue; Animals; Blood Glucose; Diabetes Mellitus, Experimental; Drug Interactions; Drug The | 1988 |