niacin has been researched along with Adverse Drug Event in 24 studies
Niacin: A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties.
vitamin B3 : Any member of a group of vitamers that belong to the chemical structural class called pyridines that exhibit biological activity against vitamin B3 deficiency. Vitamin B3 deficiency causes a condition known as pellagra whose symptoms include depression, dermatitis and diarrhea. The vitamers include nicotinic acid and nicotinamide (and their ionized and salt forms).
nicotinic acid : A pyridinemonocarboxylic acid that is pyridine in which the hydrogen at position 3 is replaced by a carboxy group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A number of pharmacological agents can induce hyperuricaemia, and sometimes gout, usually by interfering with the renal tubular excretion of urate but also in some instances by increasing the formation of uric acid." | 4.78 | Drug-induced gout. ( Scott, JT, 1991) |
| "The main objective was to evaluate the safety and tolerability of prolonged-release nicotinic acid [incidence of adverse events (AE) and serious AE] in the overall population (the safety population)." | 2.72 | Evaluation of the safety and tolerability of prolonged-release nicotinic acid in a usual care setting: the NAUTILUS study. ( Hostalek, U; Kassner, U; Steinhagen-Thiessen, E; Vogt, A, 2006) |
| " The US Food and Drug Administration's (FDA) Adverse Event Reporting System provides 1 mechanism to evaluate the safety of niacin as it is used in common clinical practice." | 2.44 | The safety of niacin in the US Food and Drug Administration adverse event reporting database. ( Alsheikh-Ali, AA; Karas, RH, 2008) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (45.83) | 18.7374 |
| 1990's | 1 (4.17) | 18.2507 |
| 2000's | 4 (16.67) | 29.6817 |
| 2010's | 5 (20.83) | 24.3611 |
| 2020's | 3 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, M | 1 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 2 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 2 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Kimura, H | 1 |
| Umemori, Y | 1 |
| Yuki, D | 1 |
| Tsui, L | 1 |
| Ye, P | 1 |
| Xu, S | 1 |
| Wu, SJ | 1 |
| Chen, SC | 1 |
| Xie, W | 1 |
| Dubrall, D | 1 |
| Pflock, R | 1 |
| Kosinska, J | 1 |
| Schmid, M | 1 |
| Bleich, M | 1 |
| Himmerkus, N | 1 |
| Offermanns, S | 1 |
| Schwaninger, M | 1 |
| Sachs, B | 1 |
| Lamba, N | 1 |
| Anderson-Nelson, S | 1 |
| Kostner, K | 1 |
| Gupta, S | 1 |
| Wallach, I | 1 |
| Jaitly, N | 1 |
| Lilien, R | 1 |
| BLASI, A | 1 |
| CURCI, G | 1 |
| CAMBA, R | 1 |
| BROCKHAUS, J | 2 |
| KURTES, KM | 1 |
| HAND, G | 1 |
| WUNDER, M | 1 |
| FERENBACH, H | 1 |
| MIKES, A | 1 |
| TODOROVIC, D | 1 |
| RISTICH, L | 1 |
| KOURTECHE, K | 1 |
| Vogt, A | 1 |
| Kassner, U | 1 |
| Hostalek, U | 1 |
| Steinhagen-Thiessen, E | 1 |
| Brown, BG | 1 |
| Alsheikh-Ali, AA | 1 |
| Karas, RH | 1 |
| Scott, JT | 1 |
| Stratigos, JD | 1 |
| Katsambas, AD | 1 |
| Sánchez, NP | 1 |
| Sánchez, JL | 1 |
| Vázquez-Botet, M | 1 |
| Epstein, JH | 1 |
6 reviews available for niacin and Adverse Drug Event
| Article | Year |
|---|---|
Medication induced retinal side effects.
Topics: Antimalarials; Canthaxanthin; Deferoxamine; Drug-Related Side Effects and Adverse Reactions; Female; | 2014 |
Expert commentary: niacin safety.
Topics: Cardiovascular Diseases; Drug-Related Side Effects and Adverse Reactions; Expert Testimony; Flushing | 2007 |
The safety of niacin in the US Food and Drug Administration adverse event reporting database.
Topics: Adverse Drug Reaction Reporting Systems; Anticholesteremic Agents; Delayed-Action Preparations; Drug | 2008 |
Drug-induced gout.
Topics: Cyclosporins; Cytotoxins; Diuretics; Drug-Related Side Effects and Adverse Reactions; Ethambutol; Et | 1991 |
Pellagra: "A reappraisal".
Topics: Alcoholism; Child; Child, Preschool; Diet; Drug-Related Side Effects and Adverse Reactions; Global H | 1982 |
Mechanisms of hyperpigmentation.
Topics: Dermatitis, Contact; Drug-Related Side Effects and Adverse Reactions; Erythema; Hemochromatosis; Hum | 1986 |
1 trial available for niacin and Adverse Drug Event
| Article | Year |
|---|---|
Evaluation of the safety and tolerability of prolonged-release nicotinic acid in a usual care setting: the NAUTILUS study.
Topics: Adult; Aged; Aged, 80 and over; Delayed-Action Preparations; Drug Evaluation; Drug-Related Side Effe | 2006 |
17 other studies available for niacin and Adverse Drug Event
| Article | Year |
|---|---|
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
Anaphylactic shock-like symptoms due to niacin overdose: A case report.
Topics: Anaphylaxis; Drug-Related Side Effects and Adverse Reactions; Humans; Niacin | 2022 |
Adverse drug reactions of non-statin antihyperlipidaemic drugs in China from 1989 to 2019: a national database analysis.
Topics: Cholestyramine Resin; Drug-Related Side Effects and Adverse Reactions; Fibric Acids; Gemfibrozil; Hu | 2023 |
Do dimethyl fumarate and nicotinic acid elicit common, potentially HCA
Topics: Adverse Drug Reaction Reporting Systems; Animals; Databases, Factual; Dimethyl Fumarate; Drug-Relate | 2021 |
Niacin: a lipid polypill?
Topics: Chemistry, Pharmaceutical; Drug-Related Side Effects and Adverse Reactions; Humans; Lipids; Niacin; | 2008 |
A structure-based approach for mapping adverse drug reactions to the perturbation of underlying biological pathways.
Topics: Breast Neoplasms; Computational Biology; Databases, Factual; Diabetes Mellitus, Type 2; Drug-Related | 2010 |
[Acute and chronic isonicotinic acid hydrazide poisoning; experimental research on the guinea pig].
Topics: Drug-Related Side Effects and Adverse Reactions; Guinea Pigs; Isomerism; Isoniazid; Niacin; Nicotini | 1952 |
[On a case of fatal isoniazid poisoning].
Topics: Drug-Related Side Effects and Adverse Reactions; Isomerism; Isoniazid; Niacin; Nicotinic Acids; Pois | 1953 |
[INH poisoning in small child].
Topics: Drug-Related Side Effects and Adverse Reactions; Isomerism; Niacin; Nicotinic Acids; Poisoning | 1953 |
[A case of intentional isoniazid poisoning].
Topics: Drug-Related Side Effects and Adverse Reactions; Isoniazid; Niacin; Nicotinic Acids; Poisoning; Suic | 1954 |
[INH poisoning in a small child].
Topics: Child; Drug-Related Side Effects and Adverse Reactions; Humans; Infant; Niacin; Nicotinic Acids; Tub | 1954 |
[Crush syndrome caused by isoniazid poisoning].
Topics: Crush Syndrome; Drug-Related Side Effects and Adverse Reactions; Isomerism; Isoniazid; Niacin; Nicot | 1954 |
[Effect of 6-aminonicotamide on the liver in guinea pigs. Protective effect of nicotamide and of prednisolone. I. Acute intoxication].
Topics: Animals; Drug-Related Side Effects and Adverse Reactions; Guinea Pigs; Liver; Niacin; Nicotinic Acid | 1959 |
[A case of acute isoniazid poisoning].
Topics: Drug-Related Side Effects and Adverse Reactions; Isomerism; Isoniazid; Niacin; Nicotinic Acids; Pois | 1954 |
Actinic manifestations. Cutaneous diseases induced by the sun.
Topics: Administration, Topical; Anti-Infective Agents; Autoimmune Diseases; Cosmetics; Drug-Related Side Ef | 1974 |